The epidemiological relationship between the current prevalence and monthly reinfection rate of Ascaris lumbricoides was observed in rural communities in Korea by measns of blanket mass chemotherapy and worm collection for measurement of the prevalence and reinfection rates. During the period from 1975 to 1980, a total of 4,466 inhabitants in 10 different localities were treated with 10 mg/kg of pyrantel pamoate and 2 days' whole stools were collected from 2,547 inhabitants. The stools were examined for the presence of expelled adult and/or young worms, which represent the prevalence and reinfection rates for past 2 months respectively. After then, the obtained rates were correlated each other applying the time-prevalence curve proposed by Hayashi. It was observed that the prevalence (overall worm positive rate) and worm burden per individual ranged by areas from 13.6 to 72.3% and 1.4-10.2 respectively. The calculated monthly reinfection rates (X) (from young worm positive rates) according to areas were in the range, 2.6~16.2%, and clearly correlated with the current prevalence (Y) under the equation, Y=1-(1-X)(7.2) where 7.2 is time in month. The equation means that after one time mass chemotherapy the period needed to attain equilibrium of prevalence again would be about 7~8 months.
And it is inferred that the majority of reinfected worms in human host turn over every 7~8 months.
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What was the main factor in successful control of ascariasis in Korea? Seung-Yull Cho, Sung-Tae Hong Parasites, Hosts and Diseases.2023; 61(2): 103. CrossRef
The relationship between the frequency distribution of Ascaris lumbricoides and the prevalence and intensity of infection in human communities H. L. Guyatt, D. A. P. Bundy, G. F. Medley, B. T. Grenfell Parasitology.1990; 101(1): 139. CrossRef
Epidemiology and control of ascariasis in Korea B S Seo The Korean Journal of Parasitology.1990; 28(Suppl): 49. CrossRef
Prevalence, worm burden and other epidemiological parameters of Ascaris lumbricoides infection in rural communities in Korea Jong Yil Chai, Koo Soo Kim, Sung Tae Hong, Soon Hyung Lee, Byong Seol Seo The Korean Journal of Parasitology.1985; 23(2): 241. CrossRef
Epidemiological studies on the reinfection pattern of Ascaris lumbricoides were undertaken by means of blanket mass chemotherapy and worm collection in a rural village in Korea, during 1977~1980. The study objective s were to determine the age(sex)-specific reinfection rate during 2, 4, 6 and 12 months through repeated mass chemotherapy with pyrantel pamoate, and to observe the familial aggregation tendency of the reinfected cases. The results obtained are as follows: The age(sex)-reinfection curve revealed that the reinfection rate is much higher in younger individuals than in olders in all of 4 kinds of interval chemotherapy groups. The highest reinfection rate and the highest burden of reinfected worms were observed in preschool childen, followed by primary school students. Such fluctuation in the age-specific reinfection rates was more pronounced in males than in females.
There was noted a significant tendency of familial aggregation among the reinfected cases. It is suggested that reinfection occurs never randomly but preferably to the members of certain household families. From these reinfection analyses, it is inferred that the principal mode of A. lumbricoides transmission in the surveyed rural area is likely to be of 'dooryard type', in which case childen and certain family members are more preferably reinfected.
It is also suggested that the preschool childen should be included in the primary targets of mass control programme.
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Aggregation and predisposition to Ascaris lumbricoides and Trichuris trichiura at the familial level L. Chan, D.A.P. Bundy, S.P. Kan Transactions of the Royal Society of Tropical Medicine and Hygiene.1994; 88(1): 46. CrossRef
Epidemiology and control of ascariasis in Korea B S Seo The Korean Journal of Parasitology.1990; 28(Suppl): 49. CrossRef
The antibody recognition profiles of humans naturally infected with Ascaris lumbricoides MELISSA R. HASWELL–ELKINS, MALCOLM W. KENNEDY, RICK M. MAIZELS, DAVID B. ELKINS, ROY M. ANDERSON Parasite Immunology.1989; 11(6): 615. CrossRef
The influence of individual, social group and household factors on the distribution of Ascaris lumbricoides within a community and implications for control strategies Melissa Haswell-Elkins, D. Elkins, R. M. Anderson Parasitology.1989; 98(1): 125. CrossRef
The importance of host age and sex to patterns of reinfection with Ascaris lumbricoides following mass anthelmintic treatment in a South Indian fishing community D. B. Elkins, Melissa Haswell-Elkins, R. M. Anderson Parasitology.1988; 96(1): 171. CrossRef
Clustering of Ascaris lumbricoides and Trichuris trichiura infections within households J.E. Forrester, M.E. Scott, D.A.P. Bundy, M.H.N. Golden Transactions of the Royal Society of Tropical Medicine and Hygiene.1988; 82(2): 282. CrossRef
Effect of age and initial infection intensity on the rate of reinfection with Trichuris trichiura after treatment D. A. P. Bundy, E. S. Cooper, D. E. Thompson, J. M. Didier, I. Simmons Parasitology.1988; 97(3): 469. CrossRef
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Five cases of Diphyllobothrium latum infection were proved by collection of worms after treatment with bithionol, niclosamide or praziquantel, during 1975-1983. The patients were 4 males and one female aged 10-64 years residing in Seoul or Wando-gun, Chollanam-do, Korea. All of them remembered the history of eating several kinds of raw marine fish and 2 persons said they ate the raw flesh of perch, Lateolabrax japonicus. Three among them experienced abdominal pain, 2 natural discharge of a chain of segments, but none revealed any sign of anemia. The average egg size in stool varied 59-67 x 41-48 micrometer according to cases.
The eggs were characterized by ovoid to elliptical shape, terminal operculum, and distinct abopercular protuberance.
One naturally discharged segment (30 cm) and 4 complete strobilae (320~680 cm) with scolices obtained after treatments were examined. The morphological characters of proglottids such as rosette-form uterus with 3-6 loops, vaginal pore included in the cirrus sac, separated seminal vesicle from cirrus sac etc. were all compatible with D.
latum. These are the 7th~11th cases of D. latum infection proved by worms in Korea.
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In an attempt to clarify the epidemiological feature of C.
sinensis in Mangyeong riverside area, the prevalence of clonorchiasis, infestation rate of the cercariae in Parafossarulus manchouricus, and detection rate of the metacercariae in fresh-water fishes were investigated from March 1 to September 30, 1983 at the upper, middle and lower reaches of the river. The results obtained were summarized as follows:Detection rate of C. sinensis egg among inhabitants was 8.2 percent out of a total of 1,266 persons.
but the differences in detection rates were not statistically signifcant among upper, middle and 1ower reaches. According to sex, the detection rates were 10.3 percent in male and 6.1 percent in female (p<0.05), but by age groups, increases of the rates were observed as increase in age (p<0.05). Out of a total of 380 fresh-water fishes of 32 different species, 93 fishes (25 percent) of 12 species were found positive with Clonorchis metacercariae, and there were differences in infection rates of the metacercariae among the fishes in 3 parts of the river; 11 percent in upper, 35 percent in middle, and 34 percent in lower reaches respectively. The metacercarial detection rates from various fishes were 97 percent in Pseudorasbora parva, Cultriculus eigenmanni (85 percent), Gnathopogon strigatus (67 percent), Microphysogobio yaluensis (50 percent), Gnathopogon coreanus (47 percent), Pungtungia herzi(44 percent), Abbottina rivularis (40 percent), Moroco oxycephalus (33 percent), Coreoleuciscus splendidus (32 percent), Gnathopogon majimae (26 percent), Rhodeus ocellatus (7 percent), and Aphyocypris chinensis (3 percent) respectively. Although very few P.
manchouricus were collected at upper reach, 12 snails (0.7 percent) among a total of 1,713 were found infected with Clonorchis cercariae. Also the cercariae of Echinochasmus japonicus (7.99 percent), Lexogenes liberum (0.99 percent), Cyathocotyle orientalis (0.75 percent), Exorchis oviformis (0.23 percent) and Asymphylodora japonica (0.05 percent) were detected from the snails.
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Metacercariae of Echinochasmus japonicus encysted in a fresh water fish, Pseudorasbora parva, and their development in experimental mice Jong Yil Chai, Song Jong Hong, Dong Woo Son, Soon Hyung Lee, Byong Seol Seo The Korean Journal of Parasitology.1985; 23(2): 221. CrossRef
The wormicidal substance of fresh water fishes on Clonorchis sinensis V. Purification and chemical characterization of clonorchicidal substance from epidermal mucus of Cyprinus carpio Jae Ku Rhee, Sang Bork Lee, Byung Zun Ahn The Korean Journal of Parasitology.1984; 22(1): 127. CrossRef
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The prevalence of C. sinensis infection along the Nam river, Korea, was 38.7% of 5,291 people examined. Prevalence rates varied from 42% at the upper stream to 34% at the middle stream and 40% at the down stream region. Rates were highest (53.4-54.3%) in the 30-59 years of age group. The positive rates in primary school chidren, school students, teachers and local officers, and other inhabitants were 16.5%, 22.6%, 46.2% and 49.6% respectively. 53.6% of cases were light infected, i.e. less than 4,000/EPG. The cercarial expulsion rate of 5,005 Parafossarulus sp. was 0.34%. Snails naturally infected with C. sinensis expelled about 788 cercariae/day.
Ten of 18 species of freshwater fish examined had C.
sinensis metacercariae. To prevent clonorchiasis in the endemic areas, the effective health education system is suggested as a control measure. [retyped from English summary]
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In order to clarify infestation pattern for the encysted larvae of digenetic trematodes from fresh-water fishes, this survey was carried out from March to September, 1983. A total of 380 fishes of 32 species were collected with netting at the three reaches, upper, middle and lower in Mangyeong riverside area. After the fishes were dissected into small scraps, they were pressed under cover glass and examined for the presence of those of digenetic trematodes with a microscope. The results obtained were as follows: Out of a total of 380 fishes inspected, 320 fishes (84 percent) from 31 species were found positive with digenetic trematode metacercariae; more than 10 species of the metacercariae were detected in Pseudorasbora parva; Gnathopogon majimae, Microphysogobio yaluensis, Cultriculus eigenmanni and Gnathopogon coreanus (more than 8 species); Aphyocypris chinensis(8 species) and etc. respectively. Clonorchis sinensis metacercariae were found positive from 93 fishes (25 percent) from 12 species detection rates in other species of digenetic trematode metacercariae from various fishes were; Exorchis oviformis, 261 fishes (57 percent) from 28 species; Cyathocotyle orientalis, 47 fishes (12 percent) from 12 species; Metorchis orientalis, 21 fishes (6 percent) from 12 species; Metagonimus yokogawai, 164 fishes (43 percent) from 26 species; Pseudexorchis major, 71 fishes (19 percent) from 18 species; Metacercaria hasegawai, 77 fishes (20 percent) from 25 species; Centrocestus armatus, 24 fishes (6 percent) from 7 species; Echinochasmus japonicus, 2 fishes (0.5 percent) from 2 species, and unidentified species, 34 fishes (9 percent) from 15 species respectively. The sums of average number of the encysted larvae of all species found in fish body/gram showed 83 in P. parva, Cobitis taenia (74.2), A. chinensis (28.5), Pseudoperilampus uyekii (26.6), G. majimae (19.6) and etc.
respectively and the average peak number of each metacercaria in fish body/gram showed 21.7 C. sinensis, 24 E. oviformis , 15.3 M. orientalis and 6.1 E. japonicus in P.
parva ; 42.7 C. orientalis and 25.1 M. yokogawai in C.
taenia; 8.3 C. armatus and 8.3 M. hasegawai in P. uyekii; 6.3 P. major in Carassius carassius, and 2.9 unidentified species in G. majimae respectively.
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Studies on intestinal trematodes in Korea XX. Four cases of natural human infection by Echinochasmus japonicus Byong Seol Seo, Soon Hyung Lee, Jong Yil Chai, Sung Jong Hong The Korean Journal of Parasitology.1985; 23(2): 214. CrossRef
Survey on encysted cercaria of trematodes from fresh-water fishes in Tongjin riverside areas in Korea Jae Ku Rhee, Moon Ho Rim, Byeong Kirl Baek, Ho Il Lee The Korean Journal of Parasitology.1984; 22(2): 190. CrossRef
The Jinyang Lake is dammed up Nam River, and surrounded by Jinju city and four counties; Jinyang, Sanchong, Hadong, and Sachon in Kyongsang-Nam-Do, Korea. The area around this man-made lake have been known as an endemic focus of clonorchiasis in Korea. The present study was first aimed to know the distribution of freshwater mollusks including medically important snails, and larval trematodes shed from Parafossarulus manchouricus and Semisulcospira libertina. In addtion to above studies, water analyses in each snail habitat were carried out in order to figure out a part of their environmental factors. This malaco-ecological survey was done at the six areas around upper, middle and lower parts of the lake for 4 months, August-November, 1983. Total nine species of freshwater mollusks were collected throughout the study: 4 species of gastropods; Semisulcospira libertina, Cipangopaludina chinensis, Parafossarulus manchouricus and Radix auricularia, and 5 species of bivalves; Unio douglasiae, Anodonta woodiana, Lamprotula gottschei, Corbicula fluminea and Limnoperma lucustris. Out of nine species of freshwater mollusks, three species of gastropods; S. libertina, P. manchouricus and R.
auricularia were medically important in terms of the transmission of digenetic trematodes to humans. P.
manchouricus and R. auricularia were mainly collected from the shallow ponds and the irrigation channels with the muddy basin, but S. libertina and the bivalves were only collected from the stream of Nam river where the gravels and rocks were dominant. The levels of dissolved oxygen(D.O.) and biochemical oxygen demand (B.O.D.(5)) of the water specimens sampled from the study areas ranged from 6.0 to 9.6 ppm and from 0.4 to 1.6 ppm respectively. As a result, it is considered that water system around the Jinyang Lake might be relatively clean without any heavy pollution of aquatic microorganisms and organic materials during the period of this study. On the other hand, eight metalic constituents from the water samples were also assayed, and all metalic ions detected were remarkably low below the legal criteria.
However, calcium ion in the water samples from the habitats of P. manchouricus was considerably higher than others.
Infection rates of digenetic trematodes in the snails were 6.9 percent in P. manchouricus and 4.8 poercent in S.
libertina, respectively. P. manchouricus snails harboring with the cercariae of Clonorchis sinensis were only 0.14 percent among the snails examined and other trematode cercariae except cercaria of C. sinensis were; furcocercus cercariae, cercaria of Loxogenes liberum type I and II. S.
libertina snails parasitized with the cercariae of Metagonimus yokogawai were 1.5 percent out of the snails examined and no cercaria of Paragonimus westermani was found in S. libertina snails in the present study. Digenetic trematode cercariae other then M. yokogawai in S. libertina snails were: Cercaria yoshidae (B type), Cercaria cristata, Cercaria innominatum, Cercaria of Centrocestus formosanus and Cercaria nipponensis.
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Second report on intestinal parasites among the patients of Seoul Paik Hospital (1984-1992) S K Lee, B M Shin, N S Chung, J Y Chai, S H Lee The Korean Journal of Parasitology.1994; 32(1): 27. CrossRef
A case of echinostomiasis with ulcerative lesions in the duodenum J Y Chai, S T Hong, S H Lee, G C Lee, Y I Min The Korean Journal of Parasitology.1994; 32(3): 201. CrossRef
Intestinal trematode infections in the villagers in Koje-myon, Kochang-gun, Kyongsangnam-do, Korea W Y Son, S Huh, S U Lee, H C Woo, S J Hong The Korean Journal of Parasitology.1994; 32(3): 149. CrossRef
Experimental life history of Echinostoma hortense S H Lee, S W Hwang, W M Sohn, W G Kho, S T Hong, J Y Chai The Korean Journal of Parasitology.1991; 29(2): 161. CrossRef
Intestinal trematodes of humans in Korea: Metagonimus, heterophyids and echinostomes J Y Chai, S H Lee The Korean Journal of Parasitology.1990; 28(Suppl): s103. CrossRef
Chronological observation of intestinal lesions of rats experimentally infected with Echinostoma hortense S H Lee, T Y Noh, W M Sohn, W G Kho, S T Hong, J Y Chai The Korean Journal of Parasitology.1990; 28(1): 45. CrossRef
Studies on Echinostoma spp. in the Chungju Reservoir and upper streams of the Namhan River Y S Ryang The Korean Journal of Parasitology.1990; 28(4): 221. CrossRef
An epidemiological suryey of Echinostoma hortense infection in Chongsong-gun, Kyongbuk province Sang Kum Lee, Nak Seung Chung, Ill Hyang Ko, Woon Mok Sohn, Sung Tae Hong, Jong Yil Chai, Soon Hyung Lee The Korean Journal of Parasitology.1988; 26(3): 199. CrossRef
Tegumental ultrastructures of Echinostoma hortense observed by scanning electron microscopy Soon Hyung Lee, Sung Jong Hong, Jong Yil Chai, Sung Tae Hong, Byong Seol Seo The Korean Journal of Parasitology.1986; 24(1): 63. CrossRef
Experimental and epidemiological studies on the life cycle of Echinostoma hortense Asada, 1926 (Trematoda:Echinostomatidae) Yung Kyum Ahn, Yong Suk Ryang The Korean Journal of Parasitology.1986; 24(2): 121. CrossRef
Two cases of natural human infection by Echinostoma hortense Sang Kum Lee, Nak Seung Chung, Ill Hyang Ko, Haeng Ill Ko, Jong Yil Chai The Korean Journal of Parasitology.1986; 24(1): 77. CrossRef
Clinical and pathological effects of Echinostoma revolutum (Digenea: Echinostomatidae) in the golden hamster, Mesocricetus auratus Jane E. Huffman, C. Michos, B. Fried Parasitology.1986; 93(3): 505. CrossRef
Two cases of human infection by Echinostoma cinetorchis Yong Suk Ryang, Kyum Yung Ahn, Won Tsen Kim, Kye Chul Shin, Kyung Won Lee, Tai Seung Kim The Korean Journal of Parasitology.1986; 24(1): 71. CrossRef
A survey on intestinal parasites of soldiers in Korea Sung Tae Hong The Korean Journal of Parasitology.1986; 24(2): 213. CrossRef
Echinostoma hortense metacercariae naturally encysted in Odontobutis obscura interrupta (a freshwater fish) and experimental infection to rats Yung Kyum Ahn, Yong Suk Ryang, Pyung Rim Chung, Keun Tae Lee The Korean Journal of Parasitology.1985; 23(2): 230. CrossRef
Studies on intestinal tematodes in Korea XVI. Infection status of loaches with the metacercariae of Echinostoma hortense Jong Yil Chai, Sung Jong Hong, Woon Mok Sohn, Soon Hyung Lee, Byong Seol Seo The Korean Journal of Parasitology.1985; 23(1): 18. CrossRef
Studies on intestinal trematodes in Korea XX. Four cases of natural human infection by Echinochasmus japonicus Byong Seol Seo, Soon Hyung Lee, Jong Yil Chai, Sung Jong Hong The Korean Journal of Parasitology.1985; 23(2): 214. CrossRef
Studies on intestinal trematodes in Korea XVII. Development of egg lying capacity of Echinostoma hortense in albino rats and human experimental infection Byong Seol Seo, Kwang Seon Chun, Jong Yil Chai, Sung Jong Hong, Soon Hyung Lee The Korean Journal of Parasitology.1985; 23(1): 24. CrossRef
Two cases of natural human infection by Echinostoma hortense and its second intermediate host in Wonju area Yong Suk Ryang, Yung Kyum Ahn, Kyung Won Lee, Tai Seung Kim, Min Hee Hhan The Korean Journal of Parasitology.1985; 23(1): 33. CrossRef
Metacercariae of Echinochasmus japonicus encysted in a fresh water fish, Pseudorasbora parva, and their development in experimental mice Jong Yil Chai, Song Jong Hong, Dong Woo Son, Soon Hyung Lee, Byong Seol Seo The Korean Journal of Parasitology.1985; 23(2): 221. CrossRef
Studies on intestinal trematodes in Korea XIV. Infection status of loaches with metacercariae of Echinostoma cinetorchis and their development in albino rats Byong Seol Seo, Yang Hee Park, Jong Yil Chai, Sung Jong Hong, Soon Hyung Lee The Korean Journal of Parasitology.1984; 22(2): 181. CrossRef
An experimental study was carried out to observe the susceptibility of several kinds of laboratory animals to Fibricola seoulensis infection, a diplostomatid fluke of mammals. The metacercariae were obtained from the viscera of the snakes, Natrix tigrina lateralis and 50-2,000 in number each was artificially fed to a total of 127 animals; albino rats, mice, dogs, cats, rabbits and chickens. After 3 days to 8 weeks the animals were sacrificed and the recovery rate of worms as well as their maturity was observed. The results are as follows: The overall wom recovery rates throughout the experimental period was highest in albino rats(40.0 %) followed by mice(33.9%), cats(20.9 %), dogs(11.4 %), rabbits(0.05 %) and chickens(0 %). However, the recovery rates in the same host decreased as infection progressed longer and variable by the amount of metacercariae given.
From albino rats and mice, the highest recovery rates were obtained in 1,000 and 200 metacercariae infection groups repectively, and it is considerd that such amount should be the optimum dose for experimental infection of these animals.
The main location of F. seoulensis in experimental animals was small intestine especially the duodenum.
The maturity index (No. mature worms/No. examined) was 100% in albino rats and mice, while only 22.7% or 0% in dogs or cats respectively. From the results, it is concluded that albino rats and mice are the most susceptible hosts for F.
seoulensis infection among six kinds of laboratory animals examined.
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The pathogenicity of free-living amoeba, Naegleria fowleri, is influenced according to the strain, cultural condition and host (Culbertson et al., 1968; Carter, 1970; Wong et al., 1975). Phillips (1973) demonstrated that Entamoeba histolytica became avirulent after more than 2 year maintenance in axenic culture in vitro. This study was carried out to compare the difference in pathogenicity between two strains of N. fowleri, one of a prolonged maintenance in axenic medium and the other one obtained by serial brain passage in mice. The 0 strain was that N.
fowleri had cultivated axenically more than 7 years in CGVS medium. The 2-1 strain was obtained from the brain of mouse inoculated intranasally with a strain, which was from the mouse brain infected with 0 strain, and cultured for 15 weeks until the beginning of this experiment. White male mice weighing 18-22 g were used. Mice were anesthetized by an intraperitoneal injection of about 1 mg secobarbital, and inoculated intranasally with 10 x 10(4) live N. fowleri trophozoites in a 5 microliter cell suspension. Sluggish behaviour, nervousness, rotation and leg paralysis were developed earlier and more frequently in the 2-1 experimental group than the control 0 group. Pathological changes such as inflammatory and necrotic lesion were observed in the olfactory and anterior portion of brain, and these changes were more extensive in the 2-1 group. The edematous and inflammatory changes in lung were demonstrated in mice died after 13th day post-inoculation. The experimental mice of 2-1 group began to die suddenly from 7th day post-inoculation, and the survival time in 2-1 group mice was shorter than 0 group mice. The typical primary amoebic meningoencephalitis was developed in the mice inoculated intranasally with N. fowleri. The prolonged maintenance of N. fowleri amoebae in axenic CGVS medium was observed to have lost their original pathogenicity for mice, but their pathogenicity was restored by serial brain passage in mice.
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Pathogenic free-living amoebae K I Im The Korean Journal of Parasitology.1990; 28(Suppl): 29. CrossRef
Experimental meningoencephalitis by Naegleria fowleri in mice Myoung Hee Ahn, Kyung Il Im The Korean Journal of Parasitology.1984; 22(2): 253. CrossRef
Praziquantel(Distocide), the Korean product, was tested for its safety and efficacy in treatment of Clonorchis sinensis infection during the period from April to September, 1983 in Korea. A total of 55 egg positive cases were selected and treated with the regimen of 25 mg/kg t.i.d. for 1 day (total 75 mg/kg). The follow-up stool examination was done in 47 cases by cellophane think smear and Stoll's egg counting techniques. The 8 uncured cases were treated again with the same regimen. The laboratory tests for blood picture and liver function were done in 27 cases and compared before and after the treatment. The results obtained are as follows: After single course treatment, the cure and egg reduction rates were 83.0% and 99.1% respectively. With the second treatment, excellent results of 100% in both rates were obtained.
Several kinds of side effects such as dizziness, headache, etc. were complained by 29 cases (61.7%), however, those were so mild and transient that no special treatment was necessary.
No significant chang in laboratory findings was recognizable before and after the treatment. From the above results, it is concluded that Distocide is as effective and safe as Biltricide and highly recommendable in treatment of C.
sinensis infection.
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Accuracy of the Kato-Katz method and formalin-ether concentration technique for the diagnosis of Clonorchis sinensis, and implication for assessing drug efficacy Men-Bao Qian, Peiling Yap, Yi-Chao Yang, Hai Liang, Zhi-Hua Jiang, Wei Li, Jürg Utzinger, Xiao-Nong Zhou, Jennifer Keiser Parasites & Vectors.2013;[Epub] CrossRef
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Correlation between Discharged Worms and Fecal Egg Counts in Human Clonorchiasis Jae-Hwan Kim, Min-Ho Choi, Young Mee Bae, Jin-Kyoung Oh, Min Kyung Lim, Sung-Tae Hong, Akira Ito PLoS Neglected Tropical Diseases.2011; 5(10): e1339. CrossRef
Collection of Clonorchis sinensis adult worms from infected humans after praziquantel treatment Chenghua Shen, Jae-hwan Kim, Jeong-Keun Lee, Young Mee Bae, Min-Ho Choi, Jin-Kyoung Oh, Min Kyung Lim, Hai-Rim Shin, Sung-Tae Hong The Korean Journal of Parasitology.2007; 45(2): 149. CrossRef
Therapeutic evaluation of sustained-releasing praziquantel (SRP) for clonorchiasis: Phase 1 and 2 clinical studies Min-Ho Choi, Byung-Chan Chang, Seung-Jin Lee, In-Jin Jang, Sang-Goo Shin, Weon-Gyu Kho, Jin-Ho Chun, Sung-Tae Hong The Korean Journal of Parasitology.2006; 44(4): 361. CrossRef
PURIFICATION AND CHARACTERIZATION OF A 7-KDA PROTEIN FROM CLONORCHIS SINENSIS ADULT WORMS Hye-Jeong Lee, Chang-Seok Lee, Beom-Su Kim, Kyoung-Hwan Joo, Joon-Sang Lee, Tong-Soo Kim, Hak R. Kim Journal of Parasitology.2002; 88(3): 499. CrossRef
Control of clonorchiasis by repeated treatments with praziquantel Sung-Tae Hong, Han-Jong Rim, Duk-Young Min, Xueming Li, Jingxian Xu, Zheng Feng, Soon-Hyung Lee The Korean Journal of Parasitology.2001; 39(4): 285. CrossRef
Secretions of the biliary mucosa in experimental clonorchiasis S H Lee, J I Lee, S Huh, J R Yu, S W Chung, J Y Chai, S T Hong The Korean Journal of Parasitology.1993; 31(1): 13. CrossRef
A survey on the epidemiological factors of clonorchiasis in the Pohang industrial belt along the Hyungsan river, Kyongsangbuk-do S S Kim, M H Han, S G Park, H S Lim, S T Hong The Korean Journal of Parasitology.1990; 28(4): 213. CrossRef
Changes of anti-Clonorchis sinensis IgG antibody in serum after praziquantel treatment in human clonorchiasis Sung Tae Hong The Korean Journal of Parasitology.1988; 26(1): 1. CrossRef
Histopathological changes of the liver after praziquantel treatment in Clonorchis sinensis infected rabbits Soon Hyung Lee, Sung Tae Hong, Chong Soon Kim, Woon Mok Sohn, Jong Yil Chai, Yoon Seong Lee The Korean Journal of Parasitology.1987; 25(2): 110. CrossRef
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As epidemiological parameters of human paragonimiasis, the positive rates of intradermal test and the sputum/stool examination have long been employed in population surveys.
However, both the specificity of the intradermal test and the sensitivity of sputum/stool examination have been gradually declined as the endemicity was lowered; thus the gap between above two parameters widened. In such context, the development of a new epidemiological parameter or tool which makes it possible to accurately discriminate the active paragonimiasis cases was necessary. In the present study, the detection rate of Paragonimus-specific IgG antibody by micro-ELISA was evaluated as an indicator of epidemiologic status of human paragonimiasis in a population. A total of 4,285 students and inhabitants living in Bukpyeong Myeon and Bukil Myeon, Haenam Gun, Jeonlanam Do was surveyed in October 1983 by intradermal test first. Out of them, 244 case (5.7 percent) were found positively reacted to VBS antigen of P. wetermani. Out of 168 positive reactors, 7 cases (4.2 percent) were egg positive either by two times of sputum examination or by one stool examination.
That indicated that only 0.16 percent of total surveyed were confirmed as active paragonimiasis by egg detection. When sera collected from 239 positive reactors of intradermal test were tested by micro-ELISA for their specific IgG antibody, 40 cases (16.7 percent) were found to be positive.
All of 7 eggs positive cases were again positive for specific IgG antibody. Among remaining 232 intradermal test positive cases, 33 cases were positive for IgG antibody. In contrast to those, none of 42 positive reactors to intradermal test for Clonorchis and of 128 intradermal test negative cases showed positive for Paragonimus- specific IgG antibody. The rate of specific IgG antibody as detected by micro-ELISA appeared to be increased with the wheal size of the intradermal test. When the wheal size was over 13 mm in diameter, about 50 percent of them were positive for specific IgG antibody. Thirty-one specific antibody positive cases were clinically evaluated by laboratory examinations (repeated sputum examination, peripheral eosinophil count and chest roentgenogram) and by history taking. Out of them 24 cases were associated with one or more positive laboratory findings; thus considered as active paragonimiasis cases. Out of 7 lab. finding-free cases 3 revealed past history of typical paragonimiasis symptoms, suggesting that they were in chronic or in convalescent stages. The remaining 4 cases were considered as either mild or ectopic infection cases; the possibility of cross-reaction with other helminthiases could not be ruled out. From the above results, it was inferred that the detection of Paragonimus-specific IgG antibogy by micro-ELISA was very much helpful in detecting the active cases as well as in proper evaluation of the endemicity of human paragonimiasis in a population. The convenience of mass handling of sera in micro-ELISA was considered another superiority as an epidemiologic tool.
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A Case of Intra-abdominal Heterotopic Paragonimiasis Combined with Rectal Cancer Soo Hong Kim, Hyung Jin Kim, Jae Im Lee, Bong Hyeon Kye, Soon Nam Oh, Chan Kwon Jung, Won Kyung Kang, Jun Gi Kim, Seong Taek Oh Journal of the Korean Society of Coloproctology.2010; 26(2): 157. CrossRef
A Case of Pulmonary Paragonimiasis Mimicking Pulmonary Tuberculosis Hyun Soo Kim, Young Sun Ko, Hyun Jung Kwak, Hee Kyung Lee, Sang Heon Kim, Tae-Hyung Kim, Jang Won Sohn, Ho Joo Yoon, Dong Ho Shin, Sung Soo Park Tuberculosis and Respiratory Diseases.2007; 63(5): 440. CrossRef
A case of pelvic paragonimiasis combined with myoma uteri and pelvic inflammatory disease Y H Lee, E H Park, W C Kim, Y D Choi, J H Park The Korean Journal of Parasitology.1993; 31(3): 295. CrossRef
Serodiagnosis of human paragonimiasis by ELISA-inhibition test using monoclonal antibodies T S Yong, J H Seo, I S Yeo The Korean Journal of Parasitology.1993; 31(2): 141. CrossRef
Molecular weight of major component proteins in crude saline extract of adult Paragonimus westermani Y Kong, WB Kim, SY Kang, SY Cho The Korean Journal of Parasitology.1991; 29(2): 113. CrossRef
Paragonimus and paragonimiasis in Korea D W Choi The Korean Journal of Parasitology.1990; 28(Suppl): 79. CrossRef
Immunohistochemical study on the antigenicity of body compartments of Paragonimus westermani S H Lee, S H Sung, J Y Chai The Korean Journal of Parasitology.1989; 27(2): 109. CrossRef
Antibody changes in paragonimiasis patients after praziquantel treatment as observed by ELISA and immunoblot S Y Cho, S I Kim, S Y Kang, Y Kong, S K Han, Y S Shim, Y C Han The Korean Journal of Parasitology.1989; 27(1): 15. CrossRef
Immunoblot observation of antigenic protein fractions in Paragonimus westermani reacting with human patients sera Sung Hwan Kim, Yoon Kong, Suk Il Kim, Shin Yong Kang, Seung Yull Cho The Korean Journal of Parasitology.1988; 26(4): 239. CrossRef
Purification of antigenic proteins of Paragonimus westermani and their applicability to experimental cat paragonimiasis Won Young Choi, Jae Eul Yoo, Ho Woo Nam, Hyung Rak Choi The Korean Journal of Parasitology.1986; 24(2): 177. CrossRef
In order to obtain more specific antigenic preparation for the diagnosis of human paragonimasis, crude saline extract of whole worm (=PwWWE), secretory-excretory components (PwSEC) and secretion-excretion-free somatic extract (PwSM) of 12 week-old Paragonimus westermani were filtrated through Sephadex G-200 gel column. The adult Paragonimus worms were obtained from experimentally infected dogs. A total of 11 antigenic solutions was lyophilized or diluted to adjust protein content of 1 mg/ml. To evaluate the antigenicity of crude antigens and fractions, micro-ELISA was done with the sera from P. westermani infected cases, C. sinensis infected cases and non-infected control cases to detect Paragonimus specific IgG antibody. The results were as follows: When the PwWWE was filtrated through Sephadex G-200 gel, it was separated into three fractions; PwWWE Fr. 1, PwWWE Fr. 2 and PwWWE Fr. 3. The percentage of protein content was 28.0 percent, 21.6 percent and 50.4 percent respectively. The PwSM was also separated into three fractions; PwSM Fr. 1, PwSM Fr. 2, PwSM Fr. 3 and their percentage of protein content was 41.3 percent, 38.6 percent and 20.1 percent.
However, the PwSEC showed different fractionation pattern; i.e. fraction 1 (=PwSEC Fr. 1) and 3 (PwSEC Fr. 3) without fraction 2. The percentage of protein content was 14.0 percent in PwSEC Fr. 1 and 86.0 percent in PwSEC Fr. 3. When the antigenicity of each Paragonimus crude antigen and fractionated antigen was evaluated for specific IgG antibody by micro-ELISA in 10 human paragonimiasis sera, PwSEC Fr. 1 was the most potent antigen showing the mean absorbance 1.98. The PwWWE Fr. 1, PwSEC, PwWWE were next to that; their mean absorbance were 1.72, 1.38 and 0.83, respectively. The antigenicity of fractions 2 and 3 was much weaker in binding specific IgG antibody. When the antigens were reacted in micro-ELISA with 10 human clonorchiasis sera, most antigens showed weak reactivity. Each fraction 1 of crude antigens reacted higher than other fractions or crude antigens; the mean absorbance was 0.17 in fraction 1, but in others the absorbances were about 0.06. With non-infected control sera, the result of micro-ELISA revealed almost same pattern with those of the clonorchiasis sera. From the above results, it became apparent that PwWWE Fr. 1, especially PwSEC Fr. 1 was the most potent antigen reacted with Paragonimus specifc IgG antibody.
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Immunohistochemical study on the antigenicity of each organ structure of Clonorchis sinensis J Kim, J Y Chai, W G Kho, K H Cho, S H Lee The Korean Journal of Parasitology.1991; 29(1): 21. CrossRef
Paragonimus and paragonimiasis in Korea D W Choi The Korean Journal of Parasitology.1990; 28(Suppl): 79. CrossRef
Analysis of antigenic specificities of Paragonimus westermani developmental stages using immunoblot technique K H Joo, S C Hong, M S Chung, H J Rim The Korean Journal of Parasitology.1989; 27(1): 1. CrossRef
Demonstration of species-specific and cross reactive components of Paragonimus westermani crude worm antigen by EITB K H Joo, H Ahn, M S Chung, H J Rim The Korean Journal of Parasitology.1989; 27(1): 9. CrossRef
Immunohistochemical study on the antigenicity of body compartments of Paragonimus westermani S H Lee, S H Sung, J Y Chai The Korean Journal of Parasitology.1989; 27(2): 109. CrossRef
Immunoblot observation of antigenic protein fractions in Paragonimus westermani reacting with human patients sera Sung Hwan Kim, Yoon Kong, Suk Il Kim, Shin Yong Kang, Seung Yull Cho The Korean Journal of Parasitology.1988; 26(4): 239. CrossRef
Purification of antigenic proteins of Paragonimus westermani and their applicability to experimental cat paragonimiasis Won Young Choi, Jae Eul Yoo, Ho Woo Nam, Hyung Rak Choi The Korean Journal of Parasitology.1986; 24(2): 177. CrossRef
Antigenicity of the soluble egg antigen of Paragonimus westermani Suk Il Kim, Eng Ku Ko, Shin Yong Kang, Seung Yull Cho The Korean Journal of Parasitology.1986; 24(1): 49. CrossRef
ELISA of paragonimiasis in cat by crude and purified antigens of Paragonimus westermani Ok Ran Lee, Jae Kyung Chang The Korean Journal of Parasitology.1986; 24(2): 187. CrossRef
Electrophoretic patterns of proteins from Paragonimus westermani in early developmental stages Boong Huer, Suk Il Kim, Shin Yong Kang, Seung Yull Cho The Korean Journal of Parasitology.1985; 23(2): 189. CrossRef
A comparison was made of a new serological method, thin layer immunoassay (TIA), and an established method, enzyme-linked immunosorbent assay (ELISA), in the detection and quantification of antibodies in clonorchiasis. Saline extract of lyophilized Clonorchis sinensis adult worm was used as antigen, and TIA by the method of Elwing et al.
(1976) and ELISA by Voller et al. (1974) were performed.
Using sera from known clonorchiasis cases, 100 percent of the sera tested were positive by TIA and 88.3 percent by ELISA. TIA produced false positive results in 14 out of 36 cases, which were 10 amoebiasis cases, 16 paragonimiasis cases and 10 healthy controls. ELISA, however, produced a small number of false positives, 7 out of 55 cases. There was correlation between immunoglobulin G level in sera and ELISA value (correlation coefficient, 0.69), whereas no correlation between immunoglobulin G level and TIA result.
The performance of TIA and ELISA was not correlated in the results using homologous antigen.
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Comparison of Two Enzyme-Linked Immunosorbent Assays for Detecting Parasitic Diseases Hye Ryoun Kim, Mi Kyung Lee, Sung Tae Hong, Jong Yil Chai Korean Journal of Clinical Microbiology.2008; 11(1): 56. CrossRef
Molecular cloning and immunological characterization of phosphoglycerate kinase from Clonorchis sinensis Sung-Jong Hong, Kee-Young Seong, Woon-Mok Sohn, Kye-Yong Song Molecular and Biochemical Parasitology.2000; 108(2): 207. CrossRef
Changes of anti-Clonorchis sinensis IgG antibody in serum after praziquantel treatment in human clonorchiasis Sung Tae Hong The Korean Journal of Parasitology.1988; 26(1): 1. CrossRef
Purification of antigenic proteins of Paragonimus westermani and their applicability to experimental cat paragonimiasis Won Young Choi, Jae Eul Yoo, Ho Woo Nam, Hyung Rak Choi The Korean Journal of Parasitology.1986; 24(2): 177. CrossRef
Agar-gel diffusion test (AGD), counterimmunoelectrophoresis (CIEP) and enzyme-linked immunosorbent assay(ELISA) were examined with the sera of skin test positives for paragonimiasis. The crude antigen(Paragonimus whole worm extracts: protein concentration, 7.56mg/ml) and human sera were used in AGD and CIEP. And in ELISA test, diluted antigen with 1:40,000 of crude antigen and diluted sera with 1:100, 1:200 were used in the test. The positive identical ratio between AGD and CIEP reactions is 98 percent and negative identical ratio is 100 percent. One or three precipitin bands are observed in AGD. One to seven precipitin bands are also revealed in CIEP. Especially, deeply stained bands are observed in CIEP than those of AGD.
The positive identical ratios between AGD and ELISA tests are 96 percent in 1:100 diluted sera, and 94 percent in 1:200 diluted sera. But the negative identical ratios between AGD and ELISA tests are 97 percent and 99 percent respectively in 1:100 and 1:200 diluted sera. The positive identical ratios between CIEP and ELISA tests are 98 percent and 96 percent respectively in 1:100 and 1:200 diluted sera, but also 97 percent and 99 percent in 1:100 and 1:200.
Control sera, such as clonorchiasis, amoebiasis and toxoplasmosis, revealed all negatives with Paragonimus antigen in AGD, CIEP and ELISA tests. By above results, ELISA was most sensitive, next CIEP and AGD. But AGD test appears to be more useful when used to crude antigen without cross reaction with other parasitic infections. CIEP test is basically equal in terms of precipitin reaction, but CIEP is able to be detected more sensitively and rapidly though less simple in handiwork than AGD. Consequently, three methods for immunological tests of paragonimiasis have good correlations with one another. Also, each of these has both merits and demerits in immunological test for paragonimiasis. But the ELISA test was proved to be the most sensitive and convenient tool for mass screening test, especially in case of using purified antigen.
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Antibody changes in paragonimiasis patients after praziquantel treatment as observed by ELISA and immunoblot S Y Cho, S I Kim, S Y Kang, Y Kong, S K Han, Y S Shim, Y C Han The Korean Journal of Parasitology.1989; 27(1): 15. CrossRef
Immunoblot observation of antigenic protein fractions in Paragonimus westermani reacting with human patients sera Sung Hwan Kim, Yoon Kong, Suk Il Kim, Shin Yong Kang, Seung Yull Cho The Korean Journal of Parasitology.1988; 26(4): 239. CrossRef
Purification of antigenic proteins of Paragonimus westermani and their applicability to experimental cat paragonimiasis Won Young Choi, Jae Eul Yoo, Ho Woo Nam, Hyung Rak Choi The Korean Journal of Parasitology.1986; 24(2): 177. CrossRef
ELISA of paragonimiasis in cat by crude and purified antigens of Paragonimus westermani Ok Ran Lee, Jae Kyung Chang The Korean Journal of Parasitology.1986; 24(2): 187. CrossRef
A total of 573 patients hospitalized in National Seoul Mental Hospital and 76 of healthy persons as control were examined by indirect latex agglutination test in order to evaluate Toxoplasma antibody titers in mental patients.
Throughout this survey, 1:32 or more titers of diluted sera were regarded as positive. The 573 samples of test sera showed negative in 386 cases (67.4 percent), 1:2 in 93 cases (16.2 percent), 1:4 in 57 cases (9.9 percent), 1:8 in 14 cases (2.4 percent), 1:16 in 12 cases (2.1 percent), 1:32 in 5 cases (0.9 percent), 1:64 in 1 case (0.2 percent), 1:128 in 3 cases (0.5 percent) and 1:256 in 2 cases (0.3 percent) respectively. Among total 573 mental patients, 11 cases (19 percent) showed positive, and they were 9 cases (1.8 percent) of schizophrenia and 2 cases (7.4 percent) of manic depression. One case (1.3 percent) out of 76 control sera showed positive result.
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