The vir genes are antigenic genes and are considered to be possible vaccine targets. Since India is highly endemic to Plasmodium vivax, we sequenced 5 different vir genes and investigated DNA sequence variations in 93 single-clonal P. vivax isolates. High variability was observed in all the 5 vir genes; the vir 1/9 gene was highly diverged across Indian populations. The patterns of genetic diversity do not follow geographical locations, as geographically distant populations were found to be genetically similar. The results in general present complex genetic diversity patterns in India, requiring further in-depth population genetic and functional studies.
Citations
Citations to this article as recorded by
Genomic dynamics of clinical Plasmodium vivax: comparative genomic hybridization in severe malaria cases Sampreeti Tahbildar, Pon Arunachalam Boopathi, Sanjay Kumar Kochar, Dhanpat Kumar Kochar, Mohamed Aiyaz, Raja C. Mugasimangalam, Sudha N. Rao, Ashis Das Frontiers in Malaria.2025;[Epub] CrossRef
Population genetic analysis of Plasmodium vivax vir genes in Pakistan Sylvatrie-Danne Dinzouna-Boutamba, Zin Moon, Sanghyun Lee, Sahib Gul Afridi, Hương Giang Lê, Yeonchul Hong, Byoung-Kuk Na, Youn-Kyoung Goo Parasites, Hosts and Diseases.2024; 62(3): 313. CrossRef
Misidentification of Plasmodium Species by Cross-Reacting Primers and Cerebral Malaria Caused by Plasmodium vivax
Anoopkrishna Rai, Deepak Sebastian Pinto, Praveen Rai, Srinivas Teerthanath, Indrani Karunasagar, Rama Adiga Journal of Health and Allied Sciences NU.2023; 13(04): 563. CrossRef
Vivax Malaria and the Potential Role of the Subtelomeric Multigene vir Superfamily Youn-Kyoung Goo Microorganisms.2022; 10(6): 1083. CrossRef
Humoral and cellular immune response to Plasmodium vivax VIR recombinant and synthetic antigens in individuals naturally exposed to P. vivax in the Republic of Korea Sanghyun Lee, Young-Ki Choi, Youn-Kyoung Goo Malaria Journal.2021;[Epub] CrossRef
Diversity of vir Genes in Plasmodium vivax from Endemic Regions in the Republic of Korea: an Initial Evaluation Ui-han Son, Sylvatrie-Danne Dinzouna-Boutamba, Sanghyun Lee, Hae Soo Yun, Jung-Yeon Kim, So-Young Joo, Sookwan Jeong, Man Hee Rhee, Yeonchul Hong, Dong-Il Chung, Dongmi Kwak, Youn-Kyoung Goo The Korean Journal of Parasitology.2017; 55(2): 149. CrossRef
Clinical manifestations and molecular mechanisms in the changing paradigm of vivax malaria in India Purva Gupta, Rajni Sharma, Jagdish Chandra, Virender Kumar, Ruchi Singh, Veena Pande, Vineeta Singh Infection, Genetics and Evolution.2016; 39: 317. CrossRef
Acute kidney injury in malaria: An update Anand Chellappan, D.S. Bhadauria Clinical Queries: Nephrology.2016; 5(1): 26. CrossRef
Plasmodium vivax msp-3α polymorphisms: analysis in the Indian subcontinent Anju Verma, Hema Joshi, Vineeta Singh, Anup Anvikar, Neena Valecha Malaria Journal.2016;[Epub] CrossRef
Design, construction and validation of a Plasmodium vivax microarray for the transcriptome profiling of clinical isolates Pon Arunachalam Boopathi, Amit Kumar Subudhi, Sheetal Middha, Jyoti Acharya, Raja Chinnadurai Mugasimangalam, Sanjay Kumar Kochar, Dhanpat Kumar Kochar, Ashis Das Acta Tropica.2016; 164: 438. CrossRef
Mitochondrial genome sequence of malaria parasites has served as a potential marker for inferring evolutionary history of the Plasmodium genus. In Plasmodium falciparum, the mitochondrial genome sequences from around the globe have provided important evolutionary understanding, but no Indian sequence has yet been utilized. We have sequenced the whole mitochondrial genome of a single P. falciparum field isolate from India using novel primers and compared with the 3D7 reference sequence and 1 previously reported Indian sequence. While the 2 Indian sequences were highly divergent from each other, the presently sequenced isolate was highly similar to the reference 3D7 strain.
Citations
Citations to this article as recorded by
Preventing malaria by administering a monoclonal antibody PRAGYAN ACHARYA The National Medical Journal of India.2025; 37: 259. CrossRef
Long-read DNA sequencing reveals the organization of the mitochondrial genome in the early-branching dinoflagellate Oxyrrhis marina. Ronie Haro, Nikita Walunjkar, Soham Jorapur, Claudio H. Slamovits Protist.2024; 175(6): 126071. CrossRef
Striking Diversity of Mitochondria-Specific Translation Processes across Eukaryotes Florent Waltz, Philippe Giegé Trends in Biochemical Sciences.2020; 45(2): 149. CrossRef
Mitochondrial Inheritance in Phytopathogenic Fungi—Everything Is Known, or Is It? Hector Mendoza, Michael H. Perlin, Jan Schirawski International Journal of Molecular Sciences.2020; 21(11): 3883. CrossRef
Mitochondrial population genomic analyses reveal population structure and demography of Indian Plasmodium falciparum Suchi Tyagi, Aparup Das Mitochondrion.2015; 24: 9. CrossRef
New insights into the evolutionary history of Plasmodium falciparum from mitochondrial genome sequence analyses of Indian isolates Suchi Tyagi, Veena Pande, Aparup Das Molecular Ecology.2014; 23(12): 2975. CrossRef
Mitochondrial genome sequence diversity of Indian Plasmodium falciparum isolates Suchi Tyagi, Veena Pande, Aparup Das Memórias do Instituto Oswaldo Cruz.2014; 109(4): 494. CrossRef
First
Prev
