Parasites, Hosts and Diseases

"Fataneh Mansoori"

Brief Communication

Effects of Toxoplasma gondii and Toxocara canis Antigens on WEHI-164 Fibrosarcoma Growth in a Mouse Model: Hossein Yousofi Darani, Hedayatollah Shirzad, Fataneh Mansoori, Nozhat Zabardast, Mahdi Mahmoodzadeh; Korean J Parasitol 2009;47(2):175-177.
Published online May 27, 2009; DOI: https://doi.org/10.3347/kjp.2009.47.2.175

Abstract
PDF

Cancer is the main cause of death in developed countries. However, in underdeveloped countries infections and parasitic diseases are the main causes of death. There are raising scientific evidences indicating that parasitic infections induce antitumor activity against certain types of cancers. In this study, the effects of Toxoplasma gondii and Toxocara canis egg antigens in comparison with Bacillus Calmette Guerin (BCG) (known to have anticancer distinctive) on WEHI-164 fibosarcoma transplanted to BALB/c mice was investigated. Groups of 6 male BALB/c mice injected with T. gondii antigen, BCG, or T. canis egg antigen as case groups and alum alone as control groups. All mice were then challenged with WEHI-164 fibrosarcoma cells. The mice were examined for growth of the solid tumor and the tumor sizes were measured every other day up to 4 wk. The mean tumor area in T. gondii, BCG, or alum alone injected mice in 4 different days of measurements was 25 mm², 23 mm², and 186 mm² respectively. Also the mean tumor area in T. canis injected mice in 4 different days was 25.5 mm² compared to the control group (alum treated) which was 155 mm². T. gondii parasites and T. canis egg antigens induced inhibition of the tumor growth in the fibrosarcoma mouse model. We need further study to clarify the mechanisms of anti-cancer effects.

Citations

Citations to this article as recorded by

Bug as a drug: Unveiling anti-cancer properties of Toxoplasma gondii and its therapeutic prospects in cancer immunotherapy
Yie Wei Chua, Sek Chuen Chow
Acta Tropica.2025; 267: 107684. CrossRef
From pathogen to cure: exploring the antitumor potential of Toxoplasma gondii
Parisa Alipanahi, Arezou Khosrojerdi, Abdol Satar Pagheh, Kareem Hatam-Nahavandi, Ehsan Ahmadpour
Infectious Agents and Cancer.2025;[Epub] CrossRef
Effect of Nematodes-Bacteria Complex Metabolites on Cancer and Tumor Progression
Aisa Bahar, Malihe Parsa Sefat, Meisam Khazaei, Hamed Tahmasebi, Valentyn Oksenych
Biomolecules.2025; 15(8): 1165. CrossRef
Evaluation of Antitumor Effects of Toxoplasma gondii Different Antigens on Ehrlich Solid Carcinoma in Mice
Salwa S. Younis, Basma M. Elmansory, Hend A. Elrefaey, Nahla A. Nasef, Sara H. Elakshar, Radwa A. Awad, Ghada A. Gamea
Parasite Immunology.2025;[Epub] CrossRef
Parasites’ immunomodulators: a breakthrough in immunotherapeutics displaying antineoplastic activity against human colorectal and hepatocellular carcinoma cells
Nahla El Skhawy, Ahmed Shehata, Maha M. Eissa
Infectious Agents and Cancer.2025;[Epub] CrossRef
A novel enemy of cancer: recent investigations into protozoan anti-tumor properties
Zhi Zheng, Xiao Lu, Dong Zhou, Xu-feng Deng, Quan-xing Liu, Xiao-bing Liu, Jiao Zhang, Yan-qi Li, Hong Zheng, Ji-gang Dai
Frontiers in Cellular and Infection Microbiology.2024;[Epub] CrossRef
Convergence between helminths and breast cancer: intratumoral injection of the excretory/secretory antigens of the human parasite Toxocara canis (EST) increase lung macro and micro metastasis
Raúl Aragón-Franco, Rocío Alejandra Ruiz-Manzano, Karen Elizabeth Nava-Castro, Víctor Hugo Del Rìo Araiza, Claudia Angelica Garay-Canales, Armando Pérez-Torres, Romel Chacón-Salinas, Manuel Iván Girón-Pérez, Jorge Morales-Montor
Frontiers in Immunology.2024;[Epub] CrossRef
Mining parasites for their potential as novel therapeutic agents against cancer
Neha Sylvia Walter, Shalmoli Bhattacharyya
Medical Oncology.2024;[Epub] CrossRef
Parasite-enhanced immunotherapy: transforming the “cold” tumors to “hot” battlefields
Yujun Xie, Jinyan Wang, Yafei Wang, Yalin Wen, Yanping Pu, Benfan Wang
Cell Communication and Signaling.2024;[Epub] CrossRef
Parasites revive hope for cancer therapy
Maha M. Eissa, Ahmed Ebada Salem, Nahla El Skhawy
European Journal of Medical Research.2024;[Epub] CrossRef
The role of helminths and their antigens in cancer therapy: insights from cell line models
Gita Alizadeh, Ali Kheirandish, Maryam Alipour, Mahnaz Jafari, Mahdis Radfar, Tina Bybordi, Raheleh Rafiei-Sefiddashti
Infectious Agents and Cancer.2024;[Epub] CrossRef
Association of Neuroblastoma (NB) SH-SY5Y Cells with Antibodies of Parasitic Origin (Anti-Acanthamoeba and Anti-Toxocara canis)
Víctor Alberto Maravelez Acosta, Maria de Lourdes Caballero Garcia, Genaro Patiño López, María del Pilar Crisóstomo Vázquez, Luz Ofelia Franco Sandoval, Leticia Eligio García
International Journal of Molecular Sciences.2024; 25(24): 13577. CrossRef
Inhibition of mouse colon cancer growth following immunotherapy with a fraction of hydatid cyst fluid
Shahla Rostamirad, Shima Daneshpour, Mohammad Reza Mofid, Alireza Andalib, Abbasali Eskandariyan, Somayeh Mousavi, Hossein Yousofi Darani
Experimental Parasitology.2023; 249: 108501. CrossRef
Prophylactic antineoplastic activity of Toxoplasma gondii RH derived antigen against ehrlich solid carcinoma with evidence of shared antigens by comparative immunoblotting
Maha M. Eissa, Maha R. Gaafar, Layla K. Younis, Cherine A. Ismail, Nahla El Skhawy
Infectious Agents and Cancer.2023;[Epub] CrossRef
Parasites as potential targets for cancer immunotherapy
Morteza Yousefi, Mohammadesmail Akbari, Mahboubeh hadipour, Azar Balouti Dehkordi, Zohreh Farahbakhsh, Hossein Yousofi Darani
Journal of Cancer Research and Clinical Oncology.2023; 149(10): 8027. CrossRef
Toxoplasma gondii-derived antigen modifies tumor microenvironment of Ehrlich solid carcinoma murine model and enhances immunotherapeutic activity of cyclophosphamide
Cherine A. Ismail, Maha M. Eissa, Maha R. Gaafar, Layla K. Younis, Nahla El Skhawy
Medical Oncology.2023;[Epub] CrossRef
Shedding light on a mysterious link between Toxoplasma gondii and cancer: A review
Nahla El Skhawy, Maha M. Eissa
Experimental Parasitology.2023; 250: 108544. CrossRef
Using Helminths to Fight Cancer: An Innovative Approach
Nima Ameli, Alireza Masoumi, Mahnaz Kerachi, Niloufar Sheidaeimehneh, Naghmeh Layegh Khavidaki, Melika Zamanian
World's Veterinary Journal.2023; 13(4): 606. CrossRef
In vitro anti-gastrointestinal cancer activity of Toxocara canis-derived peptide: Analyzing the expression level of factors related to cell proliferation and tumor growth
Saeed Bahadory, Javid Sadraei, Mohammad Zibaei, Majid Pirestani, Abdolhossein Dalimi
Frontiers in Pharmacology.2022;[Epub] CrossRef
Toxoplasma gondii infection possibly reverses host immunosuppression to restrain tumor growth
Jiating Chen, Wenzhong Liao, HongJuan Peng
Frontiers in Cellular and Infection Microbiology.2022;[Epub] CrossRef
Effect of Hydatid Cyst Antigens Polyspecific Antisera on Breast Cancer Cells (4T1) Growth in Cell Culture Medium
Hossein Yousofi Darani, Seyedeh Maryam Sharafi
International Journal of Environmental Health Engineering.2022; 11(1): 15. CrossRef
Anti-cancer immunoprotective effects of immunization with hydatid cyst wall antigens in a non-immunogenic and metastatic triple-negative murine mammary carcinoma model
Mahshid Shakibapour, Amirhosein Kefayat, Mohammad Reza Mofid, Behrokh Shojaie, Fereshteh Mohamadi, Seydeh Maryam Sharafi, Mahdi Mahmoudzadeh, Hossein Yousofi Darani
International Immunopharmacology.2021; 99: 107955. CrossRef
Effect of Toxoplasma gondii on colon cancer growth in mouse model
Farideh Zavareh, Mahboubeh Hadiipour, Reza Kalantari, Somayeh Mousavi
American Journal of BioMedicine.2021; 9(2): 168. CrossRef
Gamma Radiation-Attenuated Toxoplasma gondii Provokes Apoptosis in Ehrlich Ascites Carcinoma-Bearing Mice Generating Long-Lasting Immunity
Eman N. Hafez, Fatma S. M. Moawed, Gehan R. Abdel-Hamid, Nermeen M. Elbakary
Technology in Cancer Research & Treatment.2020;[Epub] CrossRef
Immunization with Hydatid Cyst Wall Antigens Can Inhibit Breast Cancer through Changes in Serum Levels of Th1/Th2 Cytokines
Mahshid Shakibapour, Behrokh Shojaie, Hossein Yousofi Darani
International Journal of Preventive Medicine.2020;[Epub] CrossRef
Identifying the Most Effective Hydatid Cyst Fluid Fraction for Anticancer Vaccination of 4T1 Breast Tumor-Bearing Mice
Shima Daneshpour, Shahla Rostamirad, Amirhosein Kefayat, MohammadReza Mofid, Ashkan Safavi, Hossein Yousofi Darani
International Journal of Preventive Medicine.2019;[Epub] CrossRef
Anti-Toxoplasma gondii antibodies attach to mouse cancer cell lines but not normal mouse lymphocytes
Fereshteh Mohamadi, Mahshid Shakibapour, Seyedeh Sharafi, Ali Andalib, Sepideh Tolouei, Hossein Yousofi Darani
Biomedical Reports.2019;[Epub] CrossRef
Plasmodium yoelii infection inhibits murine leukaemia WEHI-3 cell proliferation in vivo by promoting immune responses
Zhen-Zhen Tong, Zheng-Ming Fang, Qi Zhang, Yun Zhan, Yue Zhang, Wan-Fang Jiang, Xiao Hou, Yong-Long Li, Ting Wang
Infectious Diseases of Poverty.2018;[Epub] CrossRef
GADD45β Loss Ablates Innate Immunosuppression in Cancer
Daniela Verzella, Jason Bennett, Mariafausta Fischietti, Anil K. Thotakura, Camilla Recordati, Fabio Pasqualini, Daria Capece, Davide Vecchiotti, Daniel D'Andrea, Barbara Di Francesco, Marcella De Maglie, Federica Begalli, Laura Tornatore, Salvatore Papa,
Cancer Research.2018; 78(5): 1275. CrossRef
Study on the mitochondrial apoptosis pathways of small cell lung cancer H446 cells induced by Trichinella spiralis muscle larvae ESPs
JINGMEI LUO, LI YU, GUANGCHENG XIE, DAN LI, MENG SU, XUERONG ZHAO, LUANYING DU
Parasitology.2017; 144(6): 793. CrossRef
Parasites and immunotherapy: with or against?
Hossein Yousofi Darani, Morteza Yousefi, Marzieh Safari, Rasool Jafari
Journal of Parasitic Diseases.2016; 40(2): 217. CrossRef
Effect of two hydatid cyst antigens on the growth of melanoma cancer in C57/black mice
Milad Badri Chookami, Seyedeh Maryam Sharafi, Raheleh Rafiei Sefiddashti, Rasool Jafari, Mehran Bahadoran, Nader Pestechian, Hossein Yousofi Darani
Journal of Parasitic Diseases.2016; 40(4): 1170. CrossRef
Influence of Toxoplasma gondii on in vitro proliferation and apoptosis of hepatoma carcinoma H7402 cell
Gang Wang, Ming Gao
Asian Pacific Journal of Tropical Medicine.2016; 9(1): 63. CrossRef
A Nonglycosylated 27 KDa Molecule as Common Antigen between Human Breast Cancer and Echinococcus granulosus Hydatid Cyst Wall
Seyedeh Maryam Sharafi, Raheleh Rafiei, Raheleh Rafiei, Mahboubeh Hadipour, Hedayat Shirzad, Hossein Khanahmad, Hossein Yousofi Darani
Advances in Breast Cancer Research.2016; 05(02): 90. CrossRef
Puzzling and ambivalent roles of malarial infections in cancer development and progression
ERIC FAURE
Parasitology.2016; 143(14): 1811. CrossRef
Common antigens between hydatid cyst and cancers
Shima Daneshpour, Mehran Bahadoran, Seyed Hossein Hejazi, Abas Ali Eskandarian, Mehdi Mahmoudzadeh, Hossein Yousofi Darani
Advanced Biomedical Research.2016;[Epub] CrossRef
Preliminary study on association between toxoplasmosis and breast cancer in Iran
Narges Kalantari, Salman Ghaffari, Masomeh Bayani, Maryam Mitra Elmi, Daryush Moslemi, Novin Nikbakhsh, Fariedh Ghavipanjeh
Asian Pacific Journal of Tropical Biomedicine.2015; 5(1): 44. CrossRef
Mutual Action of Anticancer and Antiparasitic Drugs: Are there any Shared Targets?
Zahra Dorosti, Morteza Yousefi, Seyedeh Maryam Sharafi, Hossein Yousofi Darani
Future Oncology.2014; 10(15): 2529. CrossRef
Targeting tumors with nonreplicating Toxoplasma gondii uracil auxotroph vaccines
Barbara A. Fox, Kiah L. Sanders, Shan Chen, David J. Bzik
Trends in Parasitology.2013; 29(9): 431. CrossRef
Trichinella spiralis infection reduces tumor growth and metastasis of B16-F10 melanoma cells
Yun-Jeong Kang, Jin-Ok Jo, Min-Kyoung Cho, Hak-Sun Yu, Sun-Hee Leem, Kyoung Seob Song, Mee Sun Ock, Hee-Jae Cha
Veterinary Parasitology.2013; 196(1-2): 106. CrossRef
Hydatid Cyst Protoscolices Induce Cell Death in WEHI-164 Fibrosarcoma Cells and Inhibit the Proliferation of Baby Hamster Kidney FibroblastsIn Vitro
Hossein Yousofi Darani, Narges Soozangar, Soliman Khorami, Fatomeh Taji, Mortaza Yousofi, Hedayatollah Shirzad
Journal of Parasitology Research.2012; 2012: 1. CrossRef
Parasites and Cancers: Parasite Antigens as Possible Targets for Cancer Immunotherapy
Hossein Yousofi Darani, Morteza Yousefi
Future Oncology.2012; 8(12): 1529. CrossRef
Toxoplasma gondii But Not Leishmania major or Trichomonas vaginalis Decreases Cell Proliferation and Increases Cell Death on Fibrosarcoma Cancer Cells in Culture Medium
Hedayatollah Shirzad, Soleiman Khorami, Narges Soozangar, Mortaza Yousefi, Hossein Yousofi Darani
World Journal of Vaccines.2012; 02(02): 105. CrossRef
Natural Cytotoxicity of NC‐2+ Cells Against the Growth and Metastasis of WEHI‐164 Fibrosarcoma
H. Shirzad, R. C. Burton, Y. C. Smart, M. Rafieian‐kopaei, M. Shirzad
Scandinavian Journal of Immunology.2011; 73(2): 85. CrossRef
Suppressed CD31 Expression in Sarcoma-180 Tumors after Injection with Toxoplasma gondii Lysate Antigen in BALB/c Mice
Kyoung-Ho Pyo, Bong-Kwang Jung, Jong-Yil Chai, Eun-Hee Shin
The Korean Journal of Parasitology.2010; 48(2): 171. CrossRef