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"Giti Sadeghian"

Brief Communication

Distribution Frequency of Pathogenic Bacteria Isolated from Cutaneus Leishmaniasis Lesions
Hengameh Ziaei, Giti Sadeghian, SH Hejazi
Korean J Parasitol 2008;46(3):191-193.
Published online September 20, 2008
DOI: https://doi.org/10.3347/kjp.2008.46.3.191

Cutaneous leishmaniasis (CL) is a parasitic disease characterized by single or multiple ulcerations. Secondary bacterial infections are one of the complications that can increase the tissue destruction and the resulting scar. To better determine the incidence of real secondary bacterial infections in CL, we designed the current study. This was a cross-sectional study performed in Skin Diseases and Leishmaniasis Research Centre, Isfahan, Iran. A total of 1,255 patients with confirmed CL enrolled in the study. Sterile swaps were achieved for ulcer exudates and scraping was used for non-ulcerated lesions. All samples were transferred to tryptic soy broth medium. After 24 hr of incubation at 37℃ they were transferred to eosin methylene blue agar (EMB) and blood agar. Laboratory tests were used to determine the species of bacteria. Among 1,255 confirmed CL patients, 274 (21.8%) had positive cultures for secondary bacterial infections. The bacteria isolated from the lesions were Staphylococcus aureus in 190 cases (69.3%), coagulase negative Staphylococcus in 63 cases (23.0%), E. coli in 10 cases (3.6%), Proteus sp. in 6 cases (2.2%), and Klebsiella sp. in 5 cases (1.9%). The results show that the overall incidence of secondary bacterial infections in the lesions of CL was 21.8%, considerably high. The incidence of secondary bacterial infections was significantly higher in ulcerated lesions compared with non-ulcerated lesions.

Citations

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  • The microbiological signature of human cutaneous leishmaniasis lesions exhibits restricted bacterial diversity compared to healthy skin
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Case Report
Successful Treatment of Lupoid Cutaneous Leishmaniasis with Glucantime and Topical Trichloroacetic Acid (A Case Report)
Mohamad Ali Nilforoushzadeh, Giti Sadeghian, Fariba Jaffary, Hengameh Ziaei, Liela Shirani-Bidabad, Parvin Mahzoni
Korean J Parasitol 2008;46(3):175-177.
Published online September 20, 2008
DOI: https://doi.org/10.3347/kjp.2008.46.3.175

Lupoid leishmaniasis is a unique form of cutaneous leishmaniasis characterized by unusual clinical features and a chronic relapsing course, mostly caused by infection with Leishmania tropica. In this clinical form, 1-2 yr after healing of the acute lesion, new papules and nodules appear at the margin of the remaining scar. Herein, we describe a case of this clinical form that was resistant to 2 courses of treatments: systemic glucantime and then a combination therapy with allopurinol and systemic glucantime. However, marked improvement was seen after a combination therapy with topical trichloroacetic acid solution (50%) and systemic glucantime, and there were no signs of recurrence after 1 yr of follow-up.

Citations

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  • Atypical Manifestations of Old World Cutaneous Leishmaniasis: A Systematic Review and Clinical Atlas of Unusual Clinical and Specific Anatomical Presentations
    Bahareh Abtahi‐Naeini, Seyed Naser Emadi, Zabihollah Shahmoradi, Mahsa Pourmahdi‐Boroujeni, Ali Saffaei, Fereshte Rastegarnasab
    Health Science Reports.2025;[Epub]     CrossRef
  • Old world cutaneous leishmaniasis in Iran: clinical variants and treatments
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    Journal of Dermatological Treatment.2021; 32(7): 673.     CrossRef
  • Novel Strategies and Pharmaceutical Agents for the Treatment of Leishmaniasis: A Review
    Mohammad A. Nilforoushzadeh, Maryam Heidari-Kharaji, Mehrak Zare, Elham Torkamaniha, Sima Rafati
    Anti-Infective Agents.2020; 18(2): 89.     CrossRef
  • Synergic Effect of Allopurinol in Combination with Nitroheterocyclic Compounds against Trypanosoma cruzi
    Ana Lia Mazzeti, Lívia de F. Diniz, Karolina R. Gonçalves, Ruan Schott WonDollinger, Tassiane Assíria, Isabela Ribeiro, Maria T. Bahia
    Antimicrobial Agents and Chemotherapy.2019;[Epub]     CrossRef
  • Comparison of Lesion Improvement in Lupoid Leishmaniasis Patients with Two Treatment Approaches
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    Journal of Cutaneous Medicine and Surgery.2015; 19(1): 35.     CrossRef
  • Comparison Between Intralesional Meglumine Antimoniate and Combination of Trichloroacetic Acid 50% and Intralesional Meglumine Antimoniate in the Treatment of Acute Cutaneous Leishmaniasis: A Randomized Clinical Trial
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    Journal of Skin and Stem Cell.2014;[Epub]     CrossRef
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    Dermatologic Therapy.2011; 24(3): 378.     CrossRef
  • Discoid chronic lupus erythematosus at the site of a previously healed cutaneous leishmaniasis: an example of isotopic response
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    Dermatologic Therapy.2010; 23: S44.     CrossRef
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