Toxoplasmosis, a neglected tropical disease caused by the protozoan parasite Toxoplasma gondii, occurs throughout the world. Human T. gondii infection is asymptomatic in 80% of the population; however, the infection is life-threatening and causes substantial neurologic damage in immunocompromised patients such as HIV-infected persons. The major purpose of this study was to investigate the seroprevalence of T. gondii infection in subjects infected with HIV/AIDS in eastern China. Our findings showed 9.7% prevalence of anti-T. gondii IgG antibody in HIV/AIDS patients, which was higher than in intravenous drug users (2.2%) and healthy controls (4.7%), while no significant difference was observed in the seroprevalence of anti-Toxoplasma IgM antibody among all participants (P>0.05). Among all HIV/AIDS patients, 15 men (7.7%) and 10 women (15.9%) were positive for anti-T. gondii IgG antibody; however, no significant difference was detected in the seroprevalence of anti-Toxoplasma IgG antibody between males and females. The frequency of anti-Toxoplasma IgG antibody was 8.0%, 13.2%, 5.5%, and 0% in patients with normal immune function (CD4+ T-lymphocyte count ≥500 cells/ml), immunocompromised patients (cell count ≥200 and <500 cells/ml), severely immunocompromised patients (cell count ≥50 and <200 cells/ml), and advanced AIDS patients, respectively (cell count <50 cells/ml), while only 3 immunocompromised patients were positive for anti-T. gondii IgM antibody. The results indicate a high seroprevalence of T. gondii infection in HIV/AIDS patients in eastern China, and a preventive therapy for toxoplasmosis may be given to HIV/AIDS patients based on CD4+ T lymphocyte count.
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The Global Prevalence of and Factors Associated with Parasitic Coinfection in People Living with Viruses: A Systematic Review and Meta-Analysis Yan Ge, Huaman Liu, Ningjun Ren, Abdul Qadeer, Ian Kim B. Tabios, Ian Kendrich C. Fontanilla, Lydia R. Leonardo, Banchob Sripa, Guofeng Cheng Pathogens.2025; 14(6): 534. CrossRef
Seroprevalence and Risk Factors for Toxoplasma gondii Infection in People Living with HIV: A Cross-Sectional Study from Maputo Central Hospital, Mozambique Leonardo Manuel, Isac Comia, Regina Miambo, Irina Sousa, Nelson Cuboia, Awa Carimo, Sara Massuanganhe, Titos Buene, Lucas Banze, Belmiro Paraque, Noémia Nhancupe, Robert Schooley, Gabriela Santos-Gomes, Emília Noormahomed, Constance Benson Research and Reports in Tropical Medicine.2025; Volume 16: 43. CrossRef
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Seroprevalencia y factores de riesgo de Toxoplasma gondii en Personas que Viven con VIH/SIDA (PVVS) en el departamento de Cochabamba, Bolivia Amilcar Alejandro Flores Leon, Bertha Alanoca, Tania Vargas Rivero, Gustavo Allende Larrain Gaceta Médica Boliviana.2023; 46(2): 63. CrossRef
Primary Toxoplasma gondii infection-associated with hemophagocytic syndrome in a man with HIV infection: a case report Ying Zhou, Yongfeng Liu, Ying Wen BMC Infectious Diseases.2022;[Epub] CrossRef
Seronegative Infection with Toxoplasma gondii in Asymptomatic Human Immunodeficiency Virus Type 1 (HIV-1)-Infected Patients and in Blood Donors Agnieszka Pawełczyk, Małgorzata Bednarska, Kamila Caraballo Cortés, Marianna Glamkowska-Sady, Justyna Kowalska, Beata Uszyńska-Kałuża, Marek Radkowski, Renata Welc-Falęciak Journal of Clinical Medicine.2022; 11(3): 638. CrossRef
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Anti-Toxoplasmic Immunoglobulin G Quantitation Correlates with Immunovirological Parameters of HIV-Infected Cameroonians Aude Christelle Ka’e, Samuel Martin Sosso, Joseph Fokam, Rachel Kamgaing Simo, Sara Riwom Essama, Alex Durand Nka, Bouba Yagai, Cédric Joël Ninsu Dzukou, Michel Carlos Tommo Tchouaket, Collins Chenwi, Aissatou Abba, Nadine Fainguem, Marie Krystel Nnomo Za Current HIV Research.2021; 19(1): 73. CrossRef
Seroprevalence and B1 gene Phylogeny of Toxoplasma gondii of Dogs and Cats in Republic of Korea Yeojin Park, Jinhyeong Noh, Hyun-Ji Seo, Keun-Ho Kim, Subin Min, Mi-Sun Yoo, Bo-Ram Yun, Jong-Ho Kim, Eun-Jin Choi, Doo-Sung Cheon, Sung-Jong Hong, Soon-Seek Yoon, Yun Sang Cho The Korean Journal of Parasitology.2020; 58(3): 257. CrossRef
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Evaluation of potential anti-toxoplasmosis efficiency of combined traditional herbs in a mouse model Xun-hui Zhuo, Hong-chao Sun, Bin Huang, Hai-jie Yu, Ying Shan, Ai-fang Du Journal of Zhejiang University-SCIENCE B.2017; 18(6): 453. CrossRef
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