In malaria, splenic rupture is a serious complication potentially leading to death. Subcapsular hemorrhage of spleen is thought to be an impending sign of splenic rupture; however, the characteristics of subcapsular hemorrhage are not well known. We report 3 cases of subcapsular hemorrhage of the spleen in vivax malaria, with varying degrees of severity. Case 1 showed subcapsular hemorrhage without splenic rupture, was treated by antimalarial drug without any procedure. The healing process of the patient's spleen was monitored through 6 computed tomography follow-up examinations, over 118 days. Case 2 presented subcapsular hemorrhage with splenic rupture, treated only with an antimalarial drug. Case 3 showed subcapsular hemorrhage with splenic rupture and hypotension, treated using splenic artery embolization. They all recovered from subcapsular hemorrhage without any other complications. These 3 cases reveal the process of subcapsular hemorrhage leading to rupture and a potentially fatal outcome. The treatment plan of subcapsular hemorrhage should be determined carefully considering the vital signs, changes in hemoglobin, and bleeding tendency.
Babesiosis, caused by Babesia microti and B. divergens, is transmitted by Ixodid ticks. Symptoms of babesiosis vary from a mild flu-like illness to acute, severe, and sometimes fatal and fulminant disease. In Korea, 7 imported babesiosis cases and 1 endemic case have been reported. We report 2 cases of severe babesiosis initially mistaken as malaria. The first patient was complicated by shock and splenic infarction, the other co-infected with Lyme disease. As the population traveling abroad increases every year, physicians should be aware of babesiosis which mimics malaria, co-infection with other diseases, and its complications.
Citations
Citations to this article as recorded by
Imported parasitic diseases in the Republic of Korea: status and issues Jong-Yil Chai Journal of the Korean Medical Association.2025; 68(1): 52. CrossRef
Splenic Infarction in Babesiosis: A Case Series Kaetlyn Arant, Ty Agaisse, Athanasios Vassilopoulos, Sassine Ghanem, Michael Santos Journal of Brown Hospital Medicine.2025;[Epub] CrossRef
Detection of US and Kobe‐type Babesia microti in ticks collected from small mammals of the Republic of Korea Tae Yun Kim, Seong Yoon Kim, Jiye Seo, Hee IL Lee, Wook‐Gyo Lee, Hyunwoo Kim Entomological Research.2024;[Epub] CrossRef
Current Status of Trypanosoma grosi and Babesia microti in Small Mammals in the Republic of Korea Hyun Jung Kim, BoGyeong Han, Hee-Il Lee, Jung-Won Ju, Hyun-Il Shin Animals.2024; 14(7): 989. CrossRef
Imported human babesiosis in the Republic of Korea, 2019: two case reports Hyun Jung Kim, Min Jae Kim, Hyun-Il Shin, Jung-Won Ju, Hee-Il Lee Parasites, Hosts and Diseases.2023; 61(1): 72. CrossRef
iSeq 100 for metagenomic pathogen screening in ticks Ju Yeong Kim, Myung-hee Yi, Alghurabi Areej Sabri Mahdi, Tai-Soon Yong Parasites & Vectors.2021;[Epub] CrossRef
Molecular evidence of zoonotic Babesia species, other than B. microti, in ixodid ticks collected from small mammals in the Republic of Korea Tae Yun Kim, Seong Yoon Kim, Tae‐Kyu Kim, Hee IL Lee, Shin‐Hyeong Cho, Wook‐Gyo Lee, Hyunwoo Kim Veterinary Medicine and Science.2021; 7(6): 2427. CrossRef
Interactions between Babesia microti merozoites and rat kidney cells in a short-term in vitro culture and animal model Marta Albertyńska, Hubert Okła, Krzysztof Jasik, Danuta Urbańska-Jasik, Przemysław Pol Scientific Reports.2021;[Epub] CrossRef
A Review of Zoonotic Babesiosis as an Emerging Public Health Threat in Asia Sabir Hussain, Abrar Hussain, Muhammad Umair Aziz, Baolin Song, Jehan Zeb, David George, Jun Li, Olivier Sparagano Pathogens.2021; 11(1): 23. CrossRef
Splenic Complications ofBabesia microtiInfection in Humans: A Systematic Review Igor Dumic, Cristian Madrid, Libardo Rueda Prada, Charles W. Nordstrom, Pahnwat Tonya Taweesedt, Poornima Ramanan Canadian Journal of Infectious Diseases and Medical Microbiology.2020; 2020: 1. CrossRef
A Practical Approach to the Diagnosis of Lyme Borreliosis: From Clinical Heterogeneity to Laboratory Methods Giusto Trevisan, Serena Bonin, Maurizio Ruscio Frontiers in Medicine.2020;[Epub] CrossRef