Parasites, Hosts and Diseases

"Hyun Jong Yang"

Brief Communications

Comparison of carbohydrate moieties of sparganum proteins of the snake, mouse and those of adult worm: Hyun Jong Yang; Korean J Parasitol 2003;41(2):135-137.
Published online June 20, 2003; DOI: https://doi.org/10.3347/kjp.2003.41.2.135

Abstract
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The carbohydrate moieties of larval sparganum proteins in two different species, the snakes, Elaphe rufodorsata, the Balb/c mouse and those of the adult worm, Spirometra erinacei, were compared using five different lectins including GNA, SNA, MAA, PNA and DSA. The GNA positive 53 kDa molecule, which is excretory-secretory protease in the sparganum from the snake showed a stage specific and developmental regulation. We also suggested that sparganum glycosylation may be involved in immune evasion and differentiation into an adult worm.

Citations

Citations to this article as recorded by

Functional changes in regulatory T cells during an experimental infection with sparganum (plerocercofid of Spirometra mansoni)
Hyung‐Ran Kim, Su‐Min Lee, Jong‐Wha Won, Woosung Lim, Byung‐In Moon, Hyun‐Jong Yang, Ju‐Young Seoh
Immunology.2013; 138(1): 57. CrossRef
Using community surveillance data to differentiate between emerging and endemic amphibian diseases
S Young, LF Skerratt, D Mendez, R Speare, L Berger, M Steele
Diseases of Aquatic Organisms.2012; 98(1): 1. CrossRef

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Usefulness of 8 kDa protein of Fasciola hepatica in diagnosis of fascioliasis: Kwangsig Kim, Hyun Jong Yang, Young-Bae Chung; Korean J Parasitol 2003;41(2):121-123.
Published online June 20, 2003; DOI: https://doi.org/10.3347/kjp.2003.41.2.121

Abstract
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This study was designed to detect and evaluate an antigenicity of low molecular weight proteins of Fasciola hepatica in fascioliasis. Low molecular weight protein of F. hepatica was purified by ammonium sulfate precipitation and Sephacryl S-100 HR gel filtration. The protein obtained was estimated to be 8 kDa on 7.5-15% gradient sodium dodecyl sulfate gel electrophoresis. Immunoblotting studies showed that the 8 kDa protein reacted with human fascioliasis sera, but not other trematodiasis sera. This result suggests that the 8 kDa protein of F. hepatica is one of diagnostic antigens in human fascioliasis without cross-reaction with other human trematodiasis.

Citations

Citations to this article as recorded by

Paramphistomum cervi: Antigenic profile of adults as recognized by infected cattle sera
Panat Anuracpreeda, Chaitip Wanichanon, Prasert Sobhon
Experimental Parasitology.2008; 118(2): 203. CrossRef
Humoral immune responses during experimental infection with Fascioloides magna and Fasciola hepatica in goats and comparison of their excretory/secretory products
Adam Novobilský, Martin Kašný, Libor Mikeš, Kamil Kovařčík, Břetislav Koudela
Parasitology Research.2007; 101(2): 357. CrossRef
Preliminary antigenic characterisation of an adult worm vomit preparation of Fasciola hepatica by infected human sera
María Alejandra De Almeida, María Benardetti Ferreira, Sandra Planchart, Angélica Terashima, Vicente Maco, Luis Marcos, Eduardo Gotuzzo, Elizabeth Sánchez, César Náquira, José Vicente Scorza, Renzo Nino Incani
Revista do Instituto de Medicina Tropical de São Paulo.2007; 49(1): 31. CrossRef
Fas2-ELISA in the detection of human infection by Fasciola hepatica
J.R. Espinoza, O. Timoteo, P. Herrera-Velit
Journal of Helminthology.2005; 79(3): 235. CrossRef

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Original Article

IgG antibody responses in early experimental sparganosis and IgG subclass responses in human sparganosis: Young Bae Chung, Yoon Kong, Hyun Jong Yang, Seung-Yull Cho; Korean J Parasitol 2000;38(3):145-150.
Published online September 30, 2000; DOI: https://doi.org/10.3347/kjp.2000.38.3.145

Abstract
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Antigenic components in the crude extracts of Spirometra mansoni plerocercoid were analyzed in early experimental infections and in IgG subclass observed in clinical sparganosis. By IgG immunoblot, sera obtained serially from experimental mice, fed 5 spargana each, were reacted with the crude extracts. Protein bands at 36-26 kDa and 103 kDa showed positive reactions since two weeks after infection. In a differential immunoblot, in which a monospecific antibody against sparganum chymase at 36 kDa was pre-treated, the reactions at 36-26 kDa disappeared, indicating that the sparganum chymase and its degradation products invoked IgG antibody reactions. When 69 patients sera of human sparganosis were examined for their IgG subclass responses, IgG4 levels showed the highest reaction which was followed by IgG1. The IgG4 antibody also reacted mainly with 36-31 kDa protease. These results indicate that 36 kDa chymase of S. mansoni plerocercoid is the main antigenic component inducing IgG antibody response in early stage of experimental sparganosis and for specific IgG subclass reactions in human sparganosis.

Citations

Citations to this article as recorded by

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Journal of Veterinary Internal Medicine.2019; 33(6): 2732. CrossRef
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Yun Ku Kim, Myung Hwan Kim, Han Seoung Park, Ji Woong Jang, Yil Sik Hyun, Ji Hun Kim
Korean Journal of Medicine.2012; 82(3): 331. CrossRef
Suppression of IP-10/CXCL10 gene expression in LPS- and/or IFN-γ-stimulated macrophages by parasite-secreted products
Soji Fukumoto, Miki Hiroi, Paramasari Dirgahayu, Kazutoyo Miura, Sayuri Tademoto, Hitoshi Otsuki, Yoshihiro Ohmori
Cellular Immunology.2012; 276(1-2): 101. CrossRef
A Protein Microarray for the Rapid Screening of Patients Suspected of Infection with Various Food-Borne Helminthiases
Jia-Xu Chen, Mu-Xin Chen, Lin Ai, Jun-Hu Chen, Shao-Hong Chen, Yong-Nian Zhang, Yu-Chun Cai, Xing-Quan Zhu, Xiao-Nong Zhou, Patrick J. Lammie
PLoS Neglected Tropical Diseases.2012; 6(11): e1899. CrossRef
Two-dimensional immunoblot analysis of antigenic proteins of Spirometra plerocercoid recognized by human patient sera
Moizur Rahman, Eung-Goo Lee, Young-An Bae
Parasitology International.2011; 60(2): 139. CrossRef
Production of Polyclonal Antibodies against the Tegument of Sparganum (Plerocercoid of Spirometra mansoni) and Its Immunolocalization
Hyun-Jong Yang
The Korean Journal of Parasitology.2010; 48(2): 183. CrossRef
Diagnostic values of IgG4 in human gnathostomiasis
Malinee T. Anantaphruti, S. Nuamtanong, P. Dekumyoy
Tropical Medicine & International Health.2005; 10(10): 1013. CrossRef