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"Jong-Soo Lee"

Original Article

Seasonal Prevalence of Mosquitoes, Including Vectors of Brugian Filariasis, in Southern Islands of the Republic of Korea
Hyeng-Il Cheun, Shin-Hyeong Cho, Hee-Il Lee, E-Hyun Shin, Jong-Soo Lee, Tong-Soo Kim, Won-Ja Lee
Korean J Parasitol 2011;49(1):59-64.
Published online March 18, 2011
DOI: https://doi.org/10.3347/kjp.2011.49.1.59

A survey of mosquitoes, including the vector status of Brugia malayi filariasis and their relative larval density, was conducted from 2002 to 2005 at several southern remote islands of Jeollanam-do (province), Gyeongsangnam-do, and Jeju-do, Korea, where filariasis was previously endemic. Overall, a total of 9 species belonging to 7 genera were collected. Ochlerotatus togoi (formerly known as Aedes togoi), Anopheles (Hyrcanus) group, and Culex pipiens were the predominant species captured at all areas. Oc. togoi larvae were most frequently collected at salinity levels <0.5% during June and July, with densities decreasing sharply during the rainy season in August. The most likely explanation for the eradication of filariasis in these areas is suggested to be an aggressive treatment program executed during the 1970s and the 1990s. However, high prevalence of the vector mosquitoes may constitute a potential risk for reemerging of brugian filariasis in these areas.

Citations

Citations to this article as recorded by  Crossref logo
  • Fauna associated with Malayan filariasis transmission in Banyuasin, South Sumatra, Indonesia
    Budi Mulyaningsih, Sitti Rahmah Umniyati, Suwarno Hadisusanto, Erwin Edyansyah
    Veterinary World.2021; : 1954.     CrossRef
  • A multiplex PCR assay for six Aedini species, including Aedes albopictus
    Woo Jun Bang, Min Hyeok Won, Seong Tae Cho, Jihun Ryu, Kwang Shik Choi
    Parasites & Vectors.2021;[Epub]     CrossRef
  • Modeling the Putative Ancient Distribution of Aedes togoi (Diptera: Culicidae)
    Daniel A H Peach, Benjamin J Matthews, Konrad Fiedler
    Journal of Insect Science.2020;[Epub]     CrossRef
  • Insecticide Coated Screen Models Reduce Insect-vector Population in a Pasture Area in Ngaoundere, Cameroon
    Sevidzem Silas Lendzele, Raymond Tchawe, Zinga-Koumba Roland, Mamoudou Abdoulmoum, Ndjonka Dieudonne, Mavoungou Jacques Francois
    Trends in Applied Sciences Research.2019; 14(2): 80.     CrossRef
  • Immune responses of Aedes togoi, Anopheles paraliae and Anopheles lesteri against nocturnally subperiodic Brugia malayi microfilariae during migration from the midgut to the site of development
    Watcharatip Dedkhad, Bruce M Christensen, Lyric C Bartholomay, Deepak Joshi, Chayanit Hempolchom, Atiporn Saeung
    Parasites & Vectors.2018;[Epub]     CrossRef
  • Co-occurrence of viruses and mosquitoes at the vectors’ optimal climate range: An underestimated risk to temperate regions?
    Marcus S. C. Blagrove, Cyril Caminade, Elisabeth Waldmann, Elizabeth R. Sutton, Maya Wardeh, Matthew Baylis, Christopher M. Barker
    PLOS Neglected Tropical Diseases.2017; 11(6): e0005604.     CrossRef
  • Peripheral Blood Smear Contamination with Helicosporium Fungi Resembling Microfilaria
    Kui-Hyun Yoon
    Annals of Laboratory Medicine.2015; 35(1): 169.     CrossRef
  • Sero-surveillance of Getah Virus among Thoroughbred Horses in Korea
    Hyun-Ye Jo, Dong-Kun Yang, Ha-Hyun Kim, Sung-Suk Choi, Kyung-Suk Kang, Sun-Ju Yang, Young-Jin Yang, In-Soo Cho
    Journal of Bacteriology and Virology.2015; 45(3): 235.     CrossRef
  • Phylogeography of the Coastal Mosquito Aedes togoi across Climatic Zones: Testing an Anthropogenic Dispersal Hypothesis
    Teiji Sota, Peter Belton, Michelle Tseng, Hoi Sen Yong, Motoyoshi Mogi, Igor Mokrousov
    PLOS ONE.2015; 10(6): e0131230.     CrossRef
  • Peritrophic matrix formation and Brugia malayi microfilaria invasion of the midgut of a susceptible vector, Ochlerotatus togoi (Diptera: Culicidae)
    Narissara Jariyapan, Atiporn Saeung, Nuchpicha Intakhan, Wetpisit Chanmol, Sriwatapron Sor-suwan, Benjarat Phattanawiboon, Kritsana Taai, Wej Choochote
    Parasitology Research.2013; 112(7): 2431.     CrossRef
  • Environmental Forcing Shapes Regional House Mosquito Synchrony in a Warming Temperate Island
    Luis Fernando Chaves, Yukiko Higa, Su Hyun Lee, Ji Yeon Jeong, Sang Taek Heo, Miok Kim, Noboru Minakawa, Keun Hwa Lee
    Environmental Entomology.2013; 42(4): 605.     CrossRef
  • Surveillance and Vector Control of Lymphatic Filariasis in the Republic of Korea
    Shin Hyeong Cho, Da Won Ma, Bo Ra Koo, Hee Eun Shin, Wook Kyo Lee, Byong Suk Jeong, Chaeshin Chu, Won Ja Lee, Hyeng Il Cheun
    Osong Public Health and Research Perspectives.2012; 3(3): 145.     CrossRef
  • 9,691 View
  • 66 Download
  • Crossref

Mini Review

Successful Control of Lymphatic Filariasis in the Republic of Korea
Hyeng-Il Cheun, Yoon Kong, Shin-Hyeong Cho, Jong-Soo Lee, Jong-Yil Chai, Joo-Shil Lee, Jong-Koo Lee, Tong-Soo Kim
Korean J Parasitol 2009;47(4):323-335.
Published online December 1, 2009
DOI: https://doi.org/10.3347/kjp.2009.47.4.323

A successful experience of lymphatic filariasis control in the Republic of Korea is briefly reviewed. Filariasis in the Republic of Korea was exclusively caused by infection with Brugia malayi. Over the past several decades from the 1950s to 2006, many investigators exerted their efforts to detection, treatment, and follow-up of filariasis patients in endemic areas, and to control filariasis. Mass, combined with selective, treatments with diethylcarbamazine to microfilaria positive persons had been made them free from microfilaremia and contributed to significant decrease of the microfilarial density in previously endemic areas. Significant decrease of microfilaria positive cases in an area influenced eventually to the endemicity of filariasis in the relevant locality. Together with remarkable economic growth followed by improvement of environmental and personal hygiene and living standards, the factors stated above have contributed to blocking the transmission cycle of B. malayi and led to disappearance of this mosquito-borne ancient disease in the Republic of Korea.

Citations

Citations to this article as recorded by  Crossref logo
  • Current Status and a Perspective of Mosquito-Borne Diseases in the Republic of Korea
    Jae Hyoung Im, Tong-Soo Kim, Moon-Hyun Chung, Ji Hyeon Baek, Hea Yoon Kwon, Jin-Soo Lee
    Vector-Borne and Zoonotic Diseases.2021; 21(2): 69.     CrossRef
  • Lymphatic filariasis in Asia: a systematic review and meta-analysis
    Negar Bizhani, Saeideh Hashemi Hafshejani, Neda Mohammadi, Mehdi Rezaei, Mohammad Bagher Rokni
    Parasitology Research.2021; 120(2): 411.     CrossRef
  • The global distribution of lymphatic filariasis, 2000–18: a geospatial analysis
    Elizabeth A Cromwell, Chris A Schmidt, Kevin T Kwong, David M Pigott, Denise Mupfasoni, Gautam Biswas, Shreya Shirude, Elex Hill, Katie M Donkers, Amir Abdoli, Michael R M Abrigo, Victor Adekanmbi, Olatunji O Adetokunboh Sr., Srividya Adinarayanan, Ehsan
    The Lancet Global Health.2020; 8(9): e1186.     CrossRef
  • Progress in the elimination of lymphatic filariasis in the Western Pacific Region: successes and challenges
    Aya Yajima, Kazuyo Ichimori
    International Health.2020; 13(Supplement): S10.     CrossRef
  • Prevention and Control Strategies for Parasitic Infections in the Korea Centers for Disease Control and Prevention
    Young Yil Bahk, Eun-Hee Shin, Shin-Hyeong Cho, Jung-Won Ju, Jong-Yil Chai, Tong-Soo Kim
    The Korean Journal of Parasitology.2018; 56(5): 401.     CrossRef
  • Short-Course, High-Dose Rifampicin Achieves Wolbachia Depletion Predictive of Curative Outcomes in Preclinical Models of Lymphatic Filariasis and Onchocerciasis
    Ghaith Aljayyoussi, Hayley E. Tyrer, Louise Ford, Hanna Sjoberg, Nicolas Pionnier, David Waterhouse, Jill Davies, Joanne Gamble, Haelly Metuge, Darren A. N. Cook, Andrew Steven, Raman Sharma, Ana F. Guimaraes, Rachel H. Clare, Andrew Cassidy, Kelly L. Joh
    Scientific Reports.2017;[Epub]     CrossRef
  • Follow-up Study of Patients Previously Diagnosed with Lymphatic Filariasis in Korea
    Hyeng Il Cheun, Hee Eun Shin, Da Won Ma, Sung Hee Hong, Tae Yun Kim, Sang Eun Lee, JungWon Ju, Yun-Kyu Park, Tong-Soo Kim, Shin Hyeong Cho
    Osong Public Health and Research Perspectives.2017; 8(6): 421.     CrossRef
  • Impact of vectorborne parasitic neglected tropical diseases on child health
    Meagan A Barry, Kristy O Murray, Peter J Hotez, Kathryn M Jones
    Archives of Disease in Childhood.2016; 101(7): 640.     CrossRef
  • Peripheral Blood Smear Contamination with Helicosporium Fungi Resembling Microfilaria
    Kui-Hyun Yoon
    Annals of Laboratory Medicine.2015; 35(1): 169.     CrossRef
  • Seroepidemiology of Toxocariasis and Its Clinical Implications in Gwangju and Jeonnam-province, Korea
    Eun Jeong Won, Jin Kim, Myung-Geun Shin, Jong Hee Shin, Soon Pal Suh, Dong Wook Ryang
    Annals of Laboratory Medicine.2015; 35(4): 449.     CrossRef
  • Elimination of Lymphatic Filariasis
    EISAKU KIMURA
    Juntendo Medical Journal.2015; 61(4): 378.     CrossRef
  • Human Taeniasis in the Republic of Korea: Hidden or Gone?
    Jong-Yil Chai
    The Korean Journal of Parasitology.2013; 51(1): 9.     CrossRef
  • Surveillance and Vector Control of Lymphatic Filariasis in the Republic of Korea
    Shin Hyeong Cho, Da Won Ma, Bo Ra Koo, Hee Eun Shin, Wook Kyo Lee, Byong Suk Jeong, Chaeshin Chu, Won Ja Lee, Hyeng Il Cheun
    Osong Public Health and Research Perspectives.2012; 3(3): 145.     CrossRef
  • A Research Agenda for Helminth Diseases of Humans: The Problem of Helminthiases
    Sara Lustigman, Roger K. Prichard, Andrea Gazzinelli, Warwick N. Grant, Boakye A. Boatin, James S. McCarthy, María-Gloria Basáñez, Charles D. Mackenzie
    PLoS Neglected Tropical Diseases.2012; 6(4): e1582.     CrossRef
  • Recent Advances in the Use of Anthelmintics for Treating Nematode Infections
    Jong-Yil Chai
    Infection and Chemotherapy.2011; 43(1): 26.     CrossRef
  • Changing Patterns of Human Parasitic Infection in Korea
    Myoung-Hee Ahn
    Hanyang Medical Reviews.2010; 30(3): 149.     CrossRef
  • Control of neglected tropical diseases needs a long-term commitment
    Yaobi Zhang, Chad MacArthur, Likezo Mubila, Shawn Baker
    BMC Medicine.2010;[Epub]     CrossRef
  • 12,553 View
  • 111 Download
  • Crossref

Brief Communication

A survey of Brugia malayi infection on the Heugsan Islands, Korea
Jong-Yil Chai, Soon-Hyung Lee, Sung-Yil Choi, Jong-Soo Lee, Tai-Soon Yong, Kyun-Jong Park, Kyeong-Ae Yang, Keon-Hoon Lee, Mi-Jeng Park, Hyung-Ran Park, Mi-Ja Kim, Han-Jong Rim
Korean J Parasitol 2003;41(1):69-73.
Published online March 20, 2003
DOI: https://doi.org/10.3347/kjp.2003.41.1.69

Lymphatic filariasis due to Brugia malayi infection was endemic in several areas of South Korea. The infection was controlled, or disappeared, in most areas, with the exception of the remote southwestern islands of Jeonranam-do, including the Heugsan Islands. To discover its current situation, a small-scale survey was performed on the Heugsan Islands in September 2000. A total of 378 people, 151 male and 227 female, living in 8 villages (6 on Daeheugsan-do, 1 on Daejang-do, and 1 on Yeongsan-do) were subjected to a night blood survey for microfilaremia, and physical examination for elephantiasis on the extremities. There were 6 (1.6%) microfilaria positive cases, all in females aged 57-72 years, and from only two villages of the Daeheugsan-do area. There were 4 patients with lower leg elephantiasis, but they showed no microfilaremia. The results show that a low-grade endemicity of filariasis remains on the Daeheugsan-do.

Citations

Citations to this article as recorded by  Crossref logo
  • Prevention and Control Strategies for Parasitic Infections in the Korea Centers for Disease Control and Prevention
    Young Yil Bahk, Eun-Hee Shin, Shin-Hyeong Cho, Jung-Won Ju, Jong-Yil Chai, Tong-Soo Kim
    The Korean Journal of Parasitology.2018; 56(5): 401.     CrossRef
  • Follow-up Study of Patients Previously Diagnosed with Lymphatic Filariasis in Korea
    Hyeng Il Cheun, Hee Eun Shin, Da Won Ma, Sung Hee Hong, Tae Yun Kim, Sang Eun Lee, JungWon Ju, Yun-Kyu Park, Tong-Soo Kim, Shin Hyeong Cho
    Osong Public Health and Research Perspectives.2017; 8(6): 421.     CrossRef
  • Surveillance and Vector Control of Lymphatic Filariasis in the Republic of Korea
    Shin Hyeong Cho, Da Won Ma, Bo Ra Koo, Hee Eun Shin, Wook Kyo Lee, Byong Suk Jeong, Chaeshin Chu, Won Ja Lee, Hyeng Il Cheun
    Osong Public Health and Research Perspectives.2012; 3(3): 145.     CrossRef
  • Seasonal Prevalence of Mosquitoes, Including Vectors of Brugian Filariasis, in Southern Islands of the Republic of Korea
    Hyeng-Il Cheun, Shin-Hyeong Cho, Hee-Il Lee, E-Hyun Shin, Jong-Soo Lee, Tong-Soo Kim, Won-Ja Lee
    The Korean Journal of Parasitology.2011; 49(1): 59.     CrossRef
  • Elimination of lymphatic filariasis in the Republic of Korea: an epidemiological survey of formerly endemic areas, 2002–2006
    Hyeong‐Il Cheun, Jong‐Soo Lee, Shin‐Hyeong Cho, Yoon Kong, Tong‐Soo Kim
    Tropical Medicine & International Health.2009; 14(4): 445.     CrossRef
  • Review of Zoonotic Parasites in Medical and Veterinary Fields in the Republic of Korea
    Heejeong Youn
    The Korean Journal of Parasitology.2009; 47(Suppl): S133.     CrossRef
  • Successful Control of Lymphatic Filariasis in the Republic of Korea
    Hyeng-Il Cheun, Yoon Kong, Shin-Hyeong Cho, Jong-Soo Lee, Jong-Yil Chai, Joo-Shil Lee, Jong-Koo Lee, Tong-Soo Kim
    The Korean Journal of Parasitology.2009; 47(4): 323.     CrossRef
  • Trends in parasitic diseases in the Republic of Korea
    Eun-Hee Shin, Sang-Mee Guk, Hyo-Jin Kim, Soon-Hyung Lee, Jong-Yil Chai
    Trends in Parasitology.2008; 24(3): 143.     CrossRef
  • 10,794 View
  • 88 Download
  • Crossref
Original Articles
A mark-release-recapture experiment with Anopheles sinensis in the northern part of Gyeonggi-do, Korea
Shin-Hyeong Cho, Hyeong-Woo Lee, E-Hyun Shin, Hee-Il Lee, Wook-Gyo Lee, Chong-Han Kim, Jong-Taek Kim, Jong-Soo Lee, Won-Ja Lee, Gi-Gon Jung, Tong-Soo Kim
Korean J Parasitol 2002;40(3):139-148.
Published online September 30, 2002
DOI: https://doi.org/10.3347/kjp.2002.40.3.139

In order to study the range of flight and feeding activity of Anopheles sinensis, the dispersal experiment was conducted in Paju city, located in the northern part of Gyeonggi-do, Republic of Korea, during the period of 7th to 28th September 1998. Unfed females An. sinensis were collected in cowshed and released after being marked with fluorescent dye at 23:00 hours on the same day. Released female mosquitoes were recaptured everyday during 21 days using light traps, which were set at 10 sites in the cowsheds located 1, 3, 6, 9 and 12 km north-northwest and north-northeast and at 3 sites located 1, 6 and 9 km toward south-west from the release point. In addition, to study the longest flight distance in one night, we set the light traps at 16 and 20 km toward north-northeast from the release site. All the collected mosquitoes were placed on filter papers and observed on UV transilluminator after treatment with one drop of 100% ethanol. Out of 12,773 females of An. sinensis released, 194 marked females mosquitoes were recaptured, giving 1.52% recapture rate. Of 194, 72 mosquitoes (37.1%) were recaptured in light traps from three places set at 1 km from the release point, 57 mosquitoes (29.4%) from two places at 1-3 km, 41 mosquitoes (21.1%) from three places at 3-6 km, 20 mosquitoes (10.3%) from three places at 6-9 km, and 4 mosquitoes (2.1%) from two places at 9-12 km. Since 170 female mosquitoes (87.6%) out of 194 marked mosquitoes were captured within 6 km from the release point, this flight radius represents the main activity area. An. sinensis was found to be able to fly at least 12 km during one night.

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    Pesticide Biochemistry and Physiology.2023; 194: 105520.     CrossRef
  • Is outdoor-resting behaviour in malaria vectors consistent? Short report from northern Ghana
    Majidah Hamid-Adiamoh, Davis Nwakanma, Isaac Sraku, Alfred Amambua-Ngwa, Yaw A. Afrane
    Open Research Africa.2022; 4: 53.     CrossRef
  • Is outdoor-resting behaviour in malaria vectors consistent? Short report from northern Ghana
    Majidah Hamid-Adiamoh, Davis Nwakanma, Isaac Sraku, Alfred Amambua-Ngwa, Yaw A. Afrane
    AAS Open Research.2021; 4: 53.     CrossRef
  • Laboratory Evaluation of Flight Capacities ofAedes japonicus(Diptera: Culicidae) Using a Flight Mill Device
    Eva Krupa, Alexa-Lou Gréhal, Jérémy Esnault, Christelle Bender, Bruno Mathieu, Kris Godfrey
    Journal of Insect Science.2021;[Epub]     CrossRef
  • A standardised method of marking male mosquitoes with fluorescent dust
    Nicole J. Culbert, Maria Kaiser, Nelius Venter, Marc J. B. Vreysen, Jeremie R. L. Gilles, Jérémy Bouyer
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    Journal of Korean Medical Science.2019;[Epub]     CrossRef
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Late season commercial mosquito trap and host seeking activity evaluation against mosquitoes in a malarious area of the Republic of Korea
Douglas A. Burkett, Won-Ja Lee, Kwan-Woo Lee, Heung-Chul Kim, Hee-Il Lee, Jong-Soo Lee, E-Hyun Shin, Robert A. Wirtz, Hae-Wol Cho, David M. Claborn, Russel E. Coleman, Wan Y Kim, Terry A. Klein
Korean J Parasitol 2002;40(1):45-54.
Published online March 31, 2002
DOI: https://doi.org/10.3347/kjp.2002.40.1.45

Field trials evaluating selected commercially available mosquito traps variously baited with light, carbon dioxide, and/or octenol were conducted from 18-27 September 2000 in a malarious area near Paekyeon-ri (Tongil-Chon ) and Camp Greaves in Paju County, Kyonggi Province, Republic of Korea. The host-seeking activity for common mosquito species, including the primary vector of Japanese encephalitis, Culex tritaeniorhynchus Giles, was determined using hourly aspirator collections from a human and propane lantern-baited Shannon trap during hours when temperatures exceeded 15℃. The total number of mosquitoes and number of each species captured during the test was compared using a block design. Significant differences were observed for the total number of mosquitoes collected, such that, the Mosquito MagnetTM with octenol > Shannon trap > ABC light trap with light and dry ice > Miniature Black Light trap (manufactured by John W. Hock) ≥ New Jersey Trap > ABC light trap with light only. Significant differences in numbers collected among traps were noted for several species including: Aedes vexans (Meigen), Anopheles lesteri Baisas and Hu, An. sinensis Weidemann, An. sineroides Yamada, An. yatsushiroensis Miyazaki, Culex pipiens pallens Coquillett L., Cx. orientalis Edwards and Cx. tritaeniorhynchus. Host-seeking activity for most common species showed a similar bimodal pattern. Results from these field trap evaluations can significantly enhance current vector and disease surveillance efforts especially for the primary vector of Japanese encephalitis, Cx. tritaeniorhynchus.

Citations

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  • The Comparative Field Evaluation of Four Different Traps for Mosquito Surveillance in the Republic of Korea
    Hak Seon Lee, Byung-Eon Noh, Seong Yoon Kim, Hyunwoo Kim, Hee Il Lee
    Insects.2024; 15(7): 531.     CrossRef
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Vector competence of Anopheles lesteri Baisas and Hu (Diptera: Culicidae) to Plasmodium vivax in Korea
E-Hyun Shin, Tong-Soo Kim, Hyeong-Woo Lee, Jong-Soo Lee, Won-Ja Lee
Korean J Parasitol 2002;40(1):41-44.
Published online March 31, 2002
DOI: https://doi.org/10.3347/kjp.2002.40.1.41

Three anopheline mosquitoes in Korea were studied for their abilities as vectors for Plasmodium vivax. The female mosquitoes of Anopheles lesteri, An. pullus and An. sinensis were allowed to suck malaria patient blood until fully fed, and they were then bred for 2 weeks to develop from malaria parasites to sporozoites. The result from the above confirmed the sporozoites in one An. lesteri of one individual and five An. sinensis of six individuals. We also confirmed that An. sinensis was the main vector to transmit malaria and An. lesteri as well as An. sinensis were able to carry Korean malaria parasites. Therefore, we propose that diversified study is needed to manage malaria projects.

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    Desmond H. Foley, Terry A. Klein, Heung Chul Kim, Myung-Soon Kim, Richard C. Wilkerson, Cong Li, Genelle Harrison, Leopoldo M. Rueda
    Journal of Vector Ecology.2017; 42(2): 335.     CrossRef
  • Knockdown resistance of Anopheles sinensis in Henan province, China
    Hong-wei Zhang, Ying Liu, Tao Hu, Rui-min Zhou, Jian-she Chen, Dan Qian, Cheng-yun Yang, Yu-ling Zhao, Su-hua Li, Jing Cui, Zhong-quan Wang, Zhanchun Feng, Bian-li Xu
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  • Distribution of overwintering mosquitoes (Diptera: Culicidae) in grassy fields in the Republic of Korea, 2007–2008
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    Won-Ja Lee, Terry A. Klein, Heung-Chul Kim, Young-Mi Choi, Seok-Hyun Yoon, Kyu-Sik Chang, Sung-Tae Chong, In-Yong Lee, James W. Jones, Jolanta S. Jacobs, Jetsumon Sattabongkot, Jae-Sun Park
    Journal of Medical Entomology.2007; 44(6): 1086.     CrossRef
  • Anopheles kleini,Anopheles pullus, andAnopheles sinensis: Potential Vectors ofPlasmodium vivaxin the Republic of Korea
    Won-Ja Lee, Terry A. Klein, Heung-Chul Kim, Young-Mi Choi, Seok-Hyun Yoon, Kyu-Sik Chang, Sung-Tae Chong, In-Yong Lee, James W. Jones, Jolanta S. Jacobs, Jetsumon Sattabongkot, Jae-Sun Park
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Malaria transmission potential by Anopheles sinensis in the Republic of Korea
Hee-IL Lee, Jong-Soo Lee, E-Hyun Shin, Won-Ja Lee, Yoon-Young Kim, Kyung-Ro Lee
Korean J Parasitol 2001;39(2):185-192.
Published online June 30, 2001
DOI: https://doi.org/10.3347/kjp.2001.39.2.185

To evaluate the factors that determine the transmission level of vivax malaria using vectorial capacity, entomological surveys were conducted from June to August, 2000. From 6 nights of human-bait collection in Paju, the human biting rate (ma) was counted as 87.5 bites/man/night. The parity of Anopheles sinensis from human baiting collections fluctuated from 41% to 71% (average 48.8%) of which the rate gradually increased as time passed on: 35.2% in Jun.; 55.0% in July; 66.2% in Aug. From this proportion of parous, we could estimate the probability of daily survival rate of An. sinensis to be 0.79 assumed with 3 days gonotrophic cycle and the expectancy of infective life through 11 days could be defined as 0.073. Blood meal analysis was performed using ELISA to determine the blood meal source. Only 0.8% of blood meals were from human hosts. We could conclude that An. sinensis is highly zoophilic (cow 61.8%). Malaria is highly unstable (stability index < 0.5) in this area. From these data, vectorial capacity (VC) was determined to be 0.081. In spite of a high human biting rate (ma), malaria transmission potential is very low due to a low human blood index. Therefore, we could conclude that malaria transmission by An. sinensis is resulted by high population density, not by high transmission potential. For this reason, we need more effort to decrease vector population and vector-human contact to eradicate malaria in Korea.

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Two new genotypes of Plasmodium vivax circumsporozoite protein found in the Republic of Korea
Weon-Gyu Kho, Yeong-Hong Park, Joon-Yong Chung, Jong-Pil Kim, Sung-Tae Hong, Won-Ja Lee, Tong-Soo Kim, Jong-Soo Lee
Korean J Parasitol 1999;37(4):265-270.
Published online December 31, 1999
DOI: https://doi.org/10.3347/kjp.1999.37.4.265

The gene encoding Plasmodium vivax circumsporozoite protein (PvCSP) exhibits polymorphism in many geographical isolates. The present study was designed to investigate polymorphism in PvCSP gene of P. vivax isolates in Korea. Thirty isolates, obtained from indigenous cases in Yonchon-gun, Kyonggi-do in 1997, were subjected for sequencing and RFLP analysis of the repeat and post-repeat regions of PvCSP gene and two genotypes (SK-A and SK-B) were identified. The genotype of 19 isolates was SK-A and that of 11 isolates was SK-B. Although the number of 12-base repeats present in SK-A was three while two were found in a Chinese strain CH-5, the repeat sequence of SK-A was identical to that of CH-5 except for one base substitution. Compared with known data there was no identical isolates with SK-B, but the sequence of SK-B was similar to that of a North Korean (NK) isolate. These results indicate that two genotypes of PvCSP coexist in the present epidemic area of Korea and the present parasite may originate from East Asia. RFLP would be useful to classify genotypes of P. vivax population instead of gene sequencing.

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  • Population genetics structure of Plasmodium vivax circumsporozoite protein during the elimination process in low and unstable malaria transmission areas, southeast of Iran
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Border malaria characters of reemerging vivax malaria in the Republic of Korea
Weon-Gyu Kho, Ji-Yeon Jang, Sung-Tae Hong, Hyong-Woo Lee, Won-Ja Lee, Jong-Soo Lee
Korean J Parasitol 1999;37(2):71-76.
Published online June 30, 1999
DOI: https://doi.org/10.3347/kjp.1999.37.2.71

Since 1993, the number of vivax malaria cases has increased every year in the northern part of the Republic of Korea (ROK). This study was designed to characterize factors related to the reemergence of malaria in the ROK. A total of 21 cases diagnosed in 1993 and 1994 distributed sporadically in the narrow zone along the demilitarized zone (DMZ). Of total 317 civilian inhabitant cases reported in 1994-1997, 287 cases were studied and 80.8% of them resided within 10 km from the southern border of the DMZ. The frequency distribution of anti-Plasmodium vivax antibody titers using indirect fluorescent antibody test was compared in three villages in relation with distance from the DMZ. The number of inhabitants with high antibody titers was larger in the village nearest to the border than that in more distant villages. The present results highly suggested that the reemerging vivax malaria start in the border area, most possibly caused by infected mosquitoes which flew across the border. This pattern of transmission repeated year after year.

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Current status of vivax malaria among civilians in Korea
Jong-Soo Lee, Weon-Gyu Kho, Hyeong-Woo Lee, Min Seo, Won-Ja Lee
Korean J Parasitol 1998;36(4):241-248.
Published online December 20, 1998
DOI: https://doi.org/10.3347/kjp.1998.36.4.241

A result of national malaria surveillance in Korean civilians was described. Since a case of indigenous vivax malaria was detected in 1993, a total of 2,198 cases was confirmed by blood smear up to 1997. Of them, 1,548 cases were soldiers serving in the demilitarized zone (DMZ), while 650 cases were civilians. Number of civilian cases was 3 in 1994, 19 in 1995, 71 in 1996, and 557 in 1997. Of them, 239 were ex-soldiers who discharged after military service in the prevalent areas such as Paju, Yonchon, Kimpo, Kangwha, Tongduchon in Kyonggi-do and Chorwon in Kangwon-do while 308 patients were civilian residents in the prevalent areas. Seventy-two patients, living nationwide, had a history of visiting the prevalent areas during transmission season. Only 32 civilian patients denied any relation with the prevalent areas. As a whole, a half of the civilian cases was diagnosed when living in non-prevalent areas. Male patients in their twenties was the highest in number. Annual parasite index is steadily elevated in residents living in the prevalent areas. Monthly incidence showed an unimodal distribution, forming a peak in August. Ex-soldiers exhibited a delayed incubation ranging from 153 to 452 days (279 ± 41 days). The time required for diagnosis was shortened from 23.6 days in 1995 to 13.7 days in 1997. Although the current epidemic of vivax malaria started as a border malaria, it seems highly probable that vivax malaria is established in the local areas and responsible for at least a part of transmission.

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