Parasites, Hosts and Diseases

"Kazumi Norose"

Original Article

Breast-Feeding Protects Infantile Diarrhea Caused by Intestinal Protozoan Infections: Ekhlas Hamed Abdel-Hafeez, Usama Salah Belal, Manal Zaki Mohamed Abdellatif, Koji Naoi, Kazumi Norose; Korean J Parasitol 2013;51(5):519-524.
Published online October 31, 2013; DOI: https://doi.org/10.3347/kjp.2013.51.5.519

Abstract
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This study investigated the effect of breast-feeding in protection against protozoan infection in infants with persistent diarrhea. Infants were classified into 2 groups; 161 breast-fed infants and the same number of non-breast-fed infants. Microscopic examinations of stool were done for detection of parasites and measuring the intensity of infection. Moreover, serum levels of IgE and TNF-α were measured by ELISA. Cryptosporidium spp., Entamoeba histolytica/Entamoeba dispar, Giardia lamblia, and Blastocystis sp. were demonstrated in infants with persistent diarrhea. The percentage of protozoan infections was significantly lower in breast-fed infants than that in the non-breast-fed infants. The levels of IgE and TNF-α were significantly lower in the breast-fed group than in the non-breast-fed group. There were significant positive associations between the serum levels of IgE and TNF-α and the intensity of parasite infection in the breast-fed group. It is suggested that breast-feeding has an attenuating effect on the rate and intensity of parasite infection.

Citations

Citations to this article as recorded by

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Brief Communication

A role of carboxy-terminal region of Toxoplasma gondii-heat shock protein 70 in enhancement of T. gondii infection in mice: Hye-Seong Mun, Kazumi Norose, Fumie Aosai, Mei Chen, Akihiko Yano; Korean J Parasitol 2000;38(2):107-110.
Published online June 30, 2000; DOI: https://doi.org/10.3347/kjp.2000.38.2.107

Abstract
PDF

We investigated the role of recombinant Toxoplasma gondii heat shock protein (rT.g.HSP) 70-full length, rT.g.HSP70-NH2-terminal region, or rT.g.HSP70-carboxy-terminal region in prophylactic immunity in C57BL/6 mice perorally infected with Fukaya cysts of T. gondii. At 3, 4, 5, and 6 weeks after infection, the number of T. gondii in the brain tissue of each mouse was measured by quantitative competitive-polymerase chain reaction (QC-PCR) targeting the surface antigen (SAG) 1 gene. Immunization with rT.g.HSP70-full length or rT.g.HSP70-carboxy-terminal region increased the number of T.gondii in the brain tissue after T. gondii infection, whereas immunization with rT.g.HSP70-NH₂-terminal region did not. These results suggest that T.g.HSP70-carboxy-terminal region as well as T.g.HSP70-full length may induce deleterious effects on the protective immunity of mice infected with a cyst-forming T. gondii strain, Fukaya.

Citations

Citations to this article as recorded by

Recombinant TgHSP70 Immunization Protects against Toxoplasma gondii Brain Cyst Formation by Enhancing Inducible Nitric Oxide Expression
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Frontiers in Cellular and Infection Microbiology.2017;[Epub] CrossRef
Toxoplasma gondii: Proteomic analysis of antigenicity of soluble tachyzoite antigen
Guang-Yuan Ma, Jian-Zhong Zhang, Guo-Rong Yin, Jian-Hong Zhang, Xiao-Li Meng, Fei Zhao
Experimental Parasitology.2009; 122(1): 41. CrossRef
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Joseph Prandota
International Journal of Neuroscience.2009; 119(10): 1655. CrossRef
Toll-Like Receptor 4 Mediates Tolerance in Macrophages Stimulated withToxoplasma gondii-Derived Heat Shock Protein 70
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Infection and Immunity.2005; 73(8): 4634. CrossRef
Identification and characterization of cross-reactive antigens from Neospora caninum and Toxoplasma gondii
M. LIAO, X. XUAN, X. HUANG, H. SHIRAFUJI, S. FUKUMOTO, H. HIRATA, H. SUZUKI, K. FUJISAKI
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Pathogenicity of Toxoplasma gondii through B‐2 Cell‐Mediated Downregulation of Host Defense Responses
Hye‐Seong Mun, Fumie Aosai, Mei Chen, Lian‐Xun Piao, Kazumi Norose, Yoichiro Iwakura, Akihiko Yano
Microbiology and Immunology.2003; 47(7): 533. CrossRef