Parasites, Hosts and Diseases

"Min Ki Lee"

Original Article

A 24 kDa Excretory-Secretory Protein of Anisakis simplex Larvae Could Elicit Allergic Airway Inflammation in Mice: Hye-Kyung Park, Min Kyoung Cho, Mi Kyung Park, Shin Ae Kang, Yun Seong Kim, Ki Uk Kim, Min Ki Lee, Mee Sun Ock, Hee Jae Cha, Hak Sun Yu; Korean J Parasitol 2011;49(4):373-380.
Published online December 16, 2011; DOI: https://doi.org/10.3347/kjp.2011.49.4.373

Abstract
PDF

We have reported that a 24 kDa protein (22U homologous; As22U) of Anisakis simplex larvae could elicit several Th2-related chemokine gene expressions in the intestinal epithelial cell line which means that As22U may play a role as an allergen. In order to determine the contribution of As22U to allergic reactions, we treated mice with 6 times intra-nasal application of recombinant As22U (rAs22U). In the group challenged with rAs22U and ovalbumin (OVA), the number of eosinophils in the bronchial alveolar lavage fluid (BALF) was significantly increased, as compared to the group receiving only OVA. In addition, mice treated with rAs22U and OVA showed significantly increased airway hyperresponsiveness. Thus, severe inflammation around the airway and immune cell recruitment was observed in mice treated with rAs22U plus OVA. The levels of IL-4, IL-5, and IL-13 cytokines in the BALF increased significantly after treatment with rAs22U and OVA. Similarly, the levels of anti-OVA specific IgE and IgG1 increased in mice treated with rAs22U and OVA, compared to those treated only with OVA. The Gro-α (CXCL1) gene expression in mouse lung epithelial cells increased instantly after treatment with rAs22U, and allergy-specific chemokines eotaxin (CCL11) and thymus-and-activation-regulated-chemokine (CCL17) gene expressions significantly increased at 6 hr after treatment. In conclusion, rAs22U may induce airway allergic inflammation, as the result of enhanced Th2 and Th17 responses.

Citations

Citations to this article as recorded by

Anisakis pegreffii Extract Induces Airway Inflammation with Airway Remodeling in a Murine Model System
Jun Ho Choi, Ju Yeong Kim, Myung-hee Yi, Myungjun Kim, Tai-Soon Yong, Kalman Imre
BioMed Research International.2021;[Epub] CrossRef
Allergen-like Molecules from Parasites
Ju Yeong Kim, Myung-Hee Yi, Tai-Soon Yong
Current Protein & Peptide Science.2020; 21(2): 186. CrossRef
Research Note. Prevalence, protein analysis and possible preventive measures against zoonotic anisakid larvae isolated from marine Atherina fish
M. Samir, M. A. Amin, A. O. Hassan, A. M. Merwad, M. A. I. Awadallah
Helminthologia.2015; 52(4): 375. CrossRef
Allergenicity of two Anisakis simplex allergens evaluated in vivo using an experimental mouse model
Min Kyoung Cho, Mi Kyung Park, Shin Ae Kang, Maria Luisa Caballero, Teresa Perez-Pinar, Rosa Rodriguez-Perez, Mee Sun Ock, Hee Jae Cha, Yeon Chul Hong, Hak Sun Yu
Experimental Parasitology.2014; 146: 71. CrossRef
Alteration of Cytokine Production during Visceral Larva Migrans by Toxascaris leonina in Mice
Shin Ae Kang, Mi-Kyung Park, Min Kyoung Cho, Hak Sun Yu
The Korean Journal of Parasitology.2013; 51(5): 583. CrossRef

9,533 View
76 Download
Crossref

Case Report

A Pulmonary Paragonimiasis Case Mimicking Metastatic Pulmonary Tumor: Ki Uk Kim, Kwangha Lee, Hye-Kyung Park, Yeon Joo Jeong, Hak Sun Yu, Min Ki Lee; Korean J Parasitol 2011;49(1):69-72.
Published online March 18, 2011; DOI: https://doi.org/10.3347/kjp.2011.49.1.69

Abstract
PDF

Pulmonary paragonimiasis is a relatively rare cause of lung disease revealing a wide variety of radiologic findings, such as air-space consolidation, nodules, and cysts. We describe here a case of pulmonary paragonimiasis in a 27-year-old woman who presented with a 2-month history of cough and sputum. Based on chest computed tomography (CT) scans and fluorodeoxyglucose positron emission tomography (FDG-PET) findings, the patient was suspected to have a metastatic lung tumor. However, she was diagnosed as having Paragonimus westermani infection by an immunoserological examination using ELISA. Follow-up chest X-ray and CT scans after chemotherapy with praziquantel showed an obvious improvement. There have been several reported cases of pulmonary paragonimiasis mimicking lung tumors on FDG-PET. However, all of them were suspected as primary lung tumors. To our knowledge, this patient represents the first case of paragonimiasis mimicking metastatic lung disease on FDG-PET CT imaging.

Citations

Citations to this article as recorded by

Relationship between parasites and lung cancer: Unveiling the link
Mariam T. El Khadrawe, Nahla El Skhawy, Maha M. Eissa
Tropical Medicine & International Health.2025; 30(7): 613. CrossRef
Pulmonary paragonimiasis presenting as massive empyema requiring decortication in an adolescent: a case report
Kyo Jin Jo, Su Eun Park, Jong Myung Park, Joo-Young Na, Sungsu Jung
Journal of Medical Case Reports.2025;[Epub] CrossRef
Dynamic Computed Tomography for detecting pulmonary cysts in canine Paragonimiasis: a case report
Shinya MIZUTANI, Yuko MIZUTANI, Yoshimichi GODA, Hiroyuki SATOH, Taketoshi ASANUMA, Ayako YOSHIDA, Shidow TORISU
Journal of Veterinary Medical Science.2025; 87(9): 986. CrossRef
A clinical mimicry of malignancies in patients diagnosed with paragonimiasis
David E. Elem, Stella T. Chukwuma, Ikechukwu F. Agwu, Ukam E. Edadi, Okoi A. Ojah, Walter O. Egbara, Aje N. Ogar, Love E. Okafor, Bassey E. Ekeng
Journal of Clinical and Scientific Research.2025; 14(2): 121. CrossRef
Simple Pulmonary Eosinophilia Mimicking Lung Metastases on 18F-FDG PET/CT
Lan Yang, Ziqian Dong, Lingge Wei, Feilong Chen, Peng Xie
Clinical Nuclear Medicine.2024; 49(9): 884. CrossRef
Pulmonary, liver and cerebral paragonimiasis: An unusual clinical case in Colombia
Angel O. Donato-R., Jhon C. Donato-R.
Travel Medicine and Infectious Disease.2022; 46: 102253. CrossRef
What Findings on Chest CTs Can Delay Diagnosis of Pleuropulmonary Paragonimiasis?
Kai Ke Li, Gong Yong Jin, Keun Sang Kwon
Tomography.2022; 8(3): 1493. CrossRef
One delayed diagnosis of paragonimiasis case and literature review
Luxia Kong, Lijuan Hua, Qian Liu, Chen Bao, Jiannan Hu, Shuyun Xu
Respirology Case Reports.2021;[Epub] CrossRef
Pulmonary larval paragonimiasis mimicking lung cancer
V. V. Ermilov, A. V. Smirnov, G. L. Snigur, R. S. Dudin, S. S. Popov
Arkhiv patologii.2018; 80(2): 60. CrossRef
Electromagnetic Navigational Bronchoscopy Spares a Drunken Crab From the Surgeon’s Knife
Mihir S. Parikh, Eric Seeley, Ganesh Krishna
Journal of Bronchology & Interventional Pulmonology.2017; 24(3): 241. CrossRef
Recent Incidence of Paragonimus westermani Metacercariae in Freshwater Crayfish, Cambaroides similis, from Two Enzootic Sites in Jeollanam-do, Korea
Jin-Ho Song, Fuhong Dai, Xuelian Bai, Tae-Im Kim, Hyun-Jong Yang, Tong-Soo Kim, Shin-Hyung Cho, Sung-Jong Hong
The Korean Journal of Parasitology.2017; 55(3): 347. CrossRef
A 15-Year Old Burmese Girl With Hemoptysis: A Case Report
Charlie McLeod, Daniel Yeoh, Cameron Truarn, Christopher C Blyth, Asha C Bowen, Tom L Snelling, Ushma Wadia, Briony Hazelton, Michelle Porter
Open Forum Infectious Diseases.2017;[Epub] CrossRef
Pulmonary Paragonimiasis Misdiagnosed with Pulmonary Tuberculosis
Su Eun Park, Bokyung Song, Jae-Yeon Hwang
Pediatric Infection and Vaccine.2017; 24(3): 178. CrossRef
Imaging findings of Paragonimus westermani
Shambhu Kumar Sah, Silin Du, Yi Liu, Ping Yin, Oormila Ganganah, Manu Chiniah, Pranesh Kumar Yadav, You You Guo, Yongmei Li
Radiology of Infectious Diseases.2016; 3(2): 66. CrossRef
A Case of Intra-abdominal Paragonimiasis Mimicking Metastasis of Lung Cancer Diagnosed by Endoscopic Ultrasound-guided Fine Needle Aspiration
Cho Rong Oh, Mi-Jin Kim, Kwang Hyuck Lee
The Korean Journal of Gastroenterology.2015; 66(1): 41. CrossRef
A Case of Delayed Diagnosis of Pulmonary Paragonimiasis due to Improvement after Anti-tuberculosis Therapy
Suhyeon Lee, Yeonsil Yu, Jinyoung An, Jeongmin Lee, Jin-Sung Son, Young Kyung Lee, Sookhee Song, Hyeok Kim, Suhyun Kim
Tuberculosis and Respiratory Diseases.2014; 77(4): 178. CrossRef
Answer to February 2014 Photo Quiz
Yan Chen, Haidong Huang, Daoyin Zhou, Yanghua Qin, P. Bourbeau
Journal of Clinical Microbiology.2014; 52(2): 710. CrossRef
A Case of Ovarian Paragonimiasis Mimicking Ovarian Carcinoma
Charuwan Tantipalakorn, Surapan Khunamornpong, Theera Tongsong
Gynecologic and Obstetric Investigation.2014; 77(4): 261. CrossRef
A Case of Pulmonary Paragonimiasis Mimicking Lung Cancer Diagnosed by EBUS-TBNA
Jae June Lee, Chang Min Choi, Hwuk Hee Kwon, Min Soo Kim, Joon-Seok Kim, So Young Park, Hee Sang Hwang
Korean Journal of Medicine.2013; 84(3): 423. CrossRef
Clinical Update on Parasitic Diseases
Min Seo
Korean Journal of Medicine.2013; 85(5): 469. CrossRef
Chest CT Features of North American Paragonimiasis
Travis S. Henry, Michael A. Lane, Gary J. Weil, Thomas C. Bailey, Sanjeev Bhalla
American Journal of Roentgenology.2012; 198(5): 1076. CrossRef