Toxoplasma gondii is an intracellular protozoan parasite that causes a Th1 cellular immunity. Our previous study showed that T. gondii lysate antigen (TLA) treatment in S180 tumor-bearing mice resulted in tumor reduction by suppressing CD31 expression, a marker of angiogenesis. In the present study, to investigate tumor suppressive effect of TLA under the absence of T lymphocytes, athymic nude mice were compared with euthymic mice in the anti-tumorigenic effect triggered by TLA in CT26 tumors. According to the results, intratumorally injected TLA reduced tumor growth and TIMP-1 level, a metastatic marker, in both euthymic and athymic mice. TLA treatment led to a sharp increase in IL-12 expression in serum cytokine profiling of athymic mice, and increased MyD88 signals in macrophages derived from the bone marrow, implying the activation of innate immunity. The selective induction of IL-12 by TLA treatment had an anti-tumorigenic effect.
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The effects of zinc amino acid complex on biomarkers of gut integrity, inflammation, and metabolism in heat-stressed ruminants J. Opgenorth, M. Abuajamieh, E.A. Horst, S.K. Kvidera, J.S. Johnson, E.J. Mayorga, M.V. Sanz-Fernandez, M.A. Al-Qaisi, J.M. DeFrain, D.H. Kleinschmit, P.J. Gorden, L.H. Baumgard Journal of Dairy Science.2021; 104(2): 2410. CrossRef
Soluble total antigen derived from Toxoplasma gondii tachyzoites increased the expression levels of NLRP1, NLRP3, NLRC4, AIM2, and the release of mature form of IL1β, but downregulated the expression of IL1β and IL18 genes in THP-1cell line Hossein Pazoki, Hanieh Mohammad Rahimi, Hamed Mirjalali, Maryam Niyyati, Nariman Mosaffa, Seyed Javad Seyed Tabaei, Shabnam Shahrokh, Hamid Asadzadeh Aghdaei, Mohammad Reza Zali Microbial Pathogenesis.2021; 158: 105072. CrossRef
GSH-C4 Acts as Anti-inflammatory Drug in Different Models of Canonical and Cell Autonomous Inflammation Through NFκB Inhibition Dolores Limongi, Sara Baldelli, Paola Checconi, Maria Elena Marcocci, Giovanna De Chiara, Alessandra Fraternale, Mauro Magnani, Maria Rosa Ciriolo, Anna Teresa Palamara Frontiers in Immunology.2019;[Epub] CrossRef
Production of Inflammatory Cytokines and Nitric Oxide by Human Mast Cells Incubated with Toxoplasma gondii Lysate Eun-Ah Park, Ik-Hwan Han, Jung-Hyun Kim, Soon-Jung Park, Jae-Sook Ryu, Myoung-Hee Ahn The Korean Journal of Parasitology.2019; 57(2): 201. CrossRef
The GRA15 protein from Toxoplasma gondii enhances host defense responses by activating the interferon stimulator STING Peiyan Wang, Siji Li, Yingchi Zhao, Baohuan Zhang, Yunfei Li, Shengde Liu, Hongqiang Du, Lili Cao, Meiling Ou, Xiaohong Ye, Peng Li, Xiang Gao, Penghua Wang, Chunxia Jing, Feng Shao, Guang Yang, Fuping You Journal of Biological Chemistry.2019; 294(45): 16494. CrossRef
Secreted Toxoplasma gondii molecules interfere with expression of MHC-II in interferon gamma-activated macrophages Louis-Philippe Leroux, Dayal Dasanayake, Leah M. Rommereim, Barbara A. Fox, David J. Bzik, Armando Jardim, Florence S. Dzierszinski International Journal for Parasitology.2015; 45(5): 319. CrossRef
Possible role of TLR4 and TLR9 SNPs in protection against congenital toxoplasmosis W. Wujcicka, Z. Gaj, J. Wilczyński, D. Nowakowska European Journal of Clinical Microbiology & Infectious Diseases.2015; 34(10): 2121. CrossRef
TLR4 in Toxoplasmosis; friends or foe? Mohammad Zare-Bidaki, Hamid Hakimi, Seyyed Hossein Abdollahi, Nahid Zainodini, Mohammad Kazemi Arababadi, Derek Kennedy Microbial Pathogenesis.2014; 69-70: 28. CrossRef
Toxoplasma gondii antigens: Recovery analysis of tachyzoites cultivated in Vero cell maintained in serum free medium Thaís Alves da Costa-Silva, Cristina da Silva Meira, Neuza Frazzatti-Gallina, Vera Lucia Pereira-Chioccola Experimental Parasitology.2012; 130(4): 463. CrossRef
Suppressed CD31 Expression in Sarcoma-180 Tumors after Injection with Toxoplasma gondii Lysate Antigen in BALB/c Mice Kyoung-Ho Pyo, Bong-Kwang Jung, Jong-Yil Chai, Eun-Hee Shin The Korean Journal of Parasitology.2010; 48(2): 171. CrossRef
Suppression of CD4+T-Cells in the Spleen of Mice Infected withToxoplasma gondiiKI-1 Tachyzoites Won-Hee Kim, Eun-Hee Shin, Jae-Lip Kim, Seung-Young Yu, Bong-Kwang Jung, Jong-Yil Chai The Korean Journal of Parasitology.2010; 48(4): 325. CrossRef
Disparate Regulation of LPS-Induced MAPK Signaling and IL-12p40 Expression Between Different Myeloid Cell Types with and without HIV Infection Jonathan G. Boucher, Kelley A. Parato, Fiona Frappier, Peter Fairman, Aurelia Busca, Mansi Saxena, Maria A. Blahoianu, Wei Ma, Niranjala Gajanayaka, Robin J. Parks, Ashok Kumar, Jonathan B. Angel Viral Immunology.2010; 23(1): 17. CrossRef
Proinflammatory Cytokine and Nitric Oxide Production by Human Macrophages Stimulated with Trichomonas vaginalis Ik-Hwan Han, Sung Young Goo, Soon-Jung Park, Se-Jin Hwang, Yong-Seok Kim, Michael Sungwoo Yang, Myoung-Hee Ahn, Jae-Sook Ryu The Korean Journal of Parasitology.2009; 47(3): 205. CrossRef
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