The ticks feed large amount of blood from their hosts and transmit pathogens to the victims. The salivary gland plays an important role in the blood feeding. When the female ticks are near engorgement, the salivary gland gradually loses its functions and begins to rapidly degenerate. In this study, data-independent acquisition quantitative proteomics was used to study changes in the phosphorylation modification of proteins during salivary gland degeneration in Haemaphysalis longicornis. In this quantitative study, 400 phosphorylated proteins and 850 phosphorylation modification sites were identified. Trough RNA interference experiments, we found that among the proteins with changes in phosphorylation, apoptosis-promoting Hippo protein played a role in salivary gland degeneration.
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Quantitative proteomic analysis of salivary glands in female Ornithodoros lahorensis (syn. Alveonasus lahorensis) after blood feeding via DIA-coupled LC-MS/MS Xiangfen Yuan, Xiaolin Xu, Huiyu Wang, Hongli Jing, Songyin Qiu, Yufang Kong, Yue Zhang, Jizhou Lv, Xun Suo, Shaoqiang Wu Ticks and Tick-borne Diseases.2025; 16(6): 102575. CrossRef
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Phosphoproteomic Analysis of Haemaphysalis longicornis Saliva Reveals the Influential Contributions of Phosphoproteins to Blood-Feeding Success Desmond O. Agwunobi, Ningmei Wang, Lei Huang, Yefei Zhang, Guomin Chang, Kuang Wang, Mengxue Li, Hui Wang, Jingze Liu Frontiers in Cellular and Infection Microbiology.2022;[Epub] CrossRef
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