Sungim Choi, Heun Choi, Seong Yeon Park, Yee Gyung Kwak, Je Eun Song, So Youn Shin, Ji Hyeon Baek, Hyun-IL Shin, Hong Sang Oh, Yong Chan Kim, Joon-Sup Yeom, Jin-Hee Han, Min Jae Kim
Korean J Parasitol 2022;60(1):39-43. Published online February 23, 2022
Plasmodium vivax exhibits dormant liver-stage parasites, called hypnozoites, which can cause relapse of malaria. The only drug currently used for eliminating hypnozoites is primaquine. The antimalarial properties of primaquine are dependent on the production of oxidized metabolites by the cytochrome P450 isoenzyme 2D6 (CYP2D6). Reduced primaquine metabolism may be related to P. vivax relapses. We describe a case of 4 episodes of recurrence of vivax malaria in a patient with decreased CYP2D6 function. The patient was 52-year-old male with body weight of 52 kg. He received total gastrectomy and splenectomy 7 months before the first episode and was under chemotherapy for the gastric cancer. The first episode occurred in March 2019 and each episode had intervals of 34, 41, and 97 days, respectively. At the first and second episodes, primaquine was administered as 15 mg for 14 days. The primaquine dose was increased with 30 mg for 14 days at the third and fourth episodes. Seven gene sequences of P. vivax were analyzed and revealed totally identical for all the 4 samples. The CYP2D6 genotype was analyzed and intermediate metabolizer phenotype with decreased function was identified.
Citations
Citations to this article as recorded by
Ellagic Acid from Geranium thunbergii and Antimalarial Activity of Korean Medicinal Plants Hojong Jun, Joon-Hee Han, Min Hong, Fadhila Fitriana, Jadidan Hada Syahada, Wang-Jong Lee, Ernest Mazigo, Johnsy Mary Louis, Van-Truong Nguyen, Seok Ho Cha, Wanjoo Chun, Won Sun Park, Se Jin Lee, Sunghun Na, Soo-Ung Lee, Eun-Taek Han, Tae-Hyung Kwon, Jin- Molecules.2025; 30(2): 359. CrossRef
Characteristics of Plasmodium vivax apicomplexan amino acid transporter 8 (PvApiAT8) in the cationic amino acid transport Wang-Jong Lee, Ernest Mazigo, Jin-Hee Han, Seok Ho Cha Scientific Reports.2025;[Epub] CrossRef
Efficacy of Primaquine for the Radical Cure of Plasmodium vivax Malaria in Northeast Myanmar and the Impact of Cytochrome P450 2D6 Genotypes Weilin Zeng, Huaie Liu, Pallavi Malla, Yan Zhao, Lynette Menezes, Yaming Cao, Chengqi Wang, Zhaoqing Yang, Liwang Cui Clinical Infectious Diseases.2025; 81(2): 379. CrossRef
Evaluation of the antimalarial activity of SAM13-2HCl with morpholine amide (SKM13 derivative) against antimalarial drug-resistant Plasmodium falciparum and Plasmodium berghei infected ICR mice Hyelee Hong, Kwonmo Moon, Thuy-Tien Thi Trinh, Tae-Hui Eom, Hyun Park, Hak Sung Kim, Seon-Ju Yeo Parasites, Hosts and Diseases.2024; 62(1): 42. CrossRef
Identification of breeding habitats and kdr mutations in Anopheles spp. in South Korea Hyelee Hong, Tae-Hui Eom, Thuy-Tien Thi Trinh, Bao Duong Tuan, Hyun Park, Seon-Ju Yeo Malaria Journal.2023;[Epub] CrossRef
Cost-Benefit Analysis of Tafenoquine for Radical Cure of Plasmodium vivax Malaria in Korea Jiyeon Suh, Jung Ho Kim, Jong-Dae Kim, Changsoo Kim, Jun Yong Choi, Jeehyun Lee, Joon-Sup Yeom Journal of Korean Medical Science.2022;[Epub] CrossRef
Cytochrome P450 2D6 (CYP2D6) and glucose-6-phosphate dehydrogenase (G6PD) genetic variations in Thai vivax malaria patients: Implications for 8-aminoquinoline radical cure Kamonwan Chamchoy, Sirapapha Sudsumrit, Thanyapit Thita, Srivicha Krudsood, Rapatbhorn Patrapuvich, Usa Boonyuen, Paul O. Mireji PLOS Neglected Tropical Diseases.2022; 16(12): e0010986. CrossRef
Hyo-Ju Son, Min Jae Kim, Kyung Hwa Jung, Sungim Choi, Jiwon Jung, Yong Pil Chong, Sung-Han Kim, Sang-Oh Lee, Sang-Ho Choi, Yang Soo Kim, Jun Hee Woo, Bong-Kwang Jung, Hyemi Song, Jong-Yil Chai
Korean J Parasitol 2019;57(3):265-271. Published online June 30, 2019
The prevalence of human taeniasis has decreased in Korea. The stool egg positive proportion decreased from 1.9% in 1971 to 0% in 2004 in nationwide surveys. The neurocysticercosis (NCC) is also presumed to decrease. However, detailed information regarding the recent status of NCC in Korea is lacking. We retrospectively reviewed NCC cases from 1990 to 2016 at Asan Medical Center, a 2700-bed tertiary referral hospital in Korea. We identified patients based on clinical symptoms, brain imaging, pathology and serological assay. The cases were classified as parenchymal, extraparenchymal, and mixed NCC. Eighty-one patients were included in the analysis. The mean age was 54.5 years, and 79.0% were male. The number of NCC cases was highest from 1995 to 1999, and continuously decreased thereafter. Forty (49.4%) patients had parenchymal NCC, while 25 (30.9%) patients had extraparenchymal NCC, and 16 (19.8%) patients had mixed NCC. The seizure and headache were most common symptom of parenchymal NCC and extraparenchymal NCC respectively. Hydrocephalus was more common in extraparenchymal NCC, and patients with extraparenchymal NCC were more likely to require a ventriculoperitoneal shunt. Cases of NCC are decreasing accordingly with human taeniasis and lesion location was the most important determinant of clinical presentation and outcome of NCC in Korea.
Citations
Citations to this article as recorded by
Navigating a Rare Neurological Conundrum: Quadriparesis in Neurocysticercosis With Hydrocephalus Mudamanchu Vamsi Krishna, Pubali Biswas, C. A. Jayashankar, V. H. Ganaraja, Amey Joshi Clinical Case Reports.2025;[Epub] CrossRef
Disseminated Neurocysticercosis With Intraventricular and Cisternal Extension Without Hydrocephalus: A Case Report Bibek Shrestha, Priyesh Shrestha, Bikram Prasad Gajurel, Grishma Kandel, Laxmi Shah Clinical Case Reports.2025;[Epub] CrossRef
Intraventricular Neurocysticercosis: Comparative Analysis of Different Localizations. Clinical Course and Treatment: A Systematic Review Zoran Milenković, Stefan Momčilović, Aleksandra Ignjatović, Aleksandra Aracki-Trenkić, Tanja Džopalić, Nataša Vidović, Zorica Jović, Suzana Tasić-Otašević Journal of Neurological Surgery Part A: Central European Neurosurgery.2025; 86(05): 467. CrossRef
Neurocysticercosis Presenting as Status Epilepticus Vaaragie Subramaniam, Jessica Houck DO Cureus.2025;[Epub] CrossRef
Subarachnoid Neurocysticercosis Manifesting Cognitive Impairment and Gait Disturbance Minsung Kang, Ho-Won Lee Journal of the Korean Neurological Association.2025; 43(3): 169. CrossRef
Massive neurocysticercosis in a ten-year-old girl: a case report Guoguang Xiao, Min Shu BMC Pediatrics.2024;[Epub] CrossRef
Giant Neurocysticercosis: A Rare Medical Condition Jorge Zumaeta, Camilo Contreras, Paola Tapia, Diego Morales, Noe Santiago Rea, Jose Valerio Cureus.2024;[Epub] CrossRef
Knowledge and misconceptions about epilepsy among people with epilepsy and their caregivers attending mental health clinics: A qualitative study in Taenia solium endemic pig‐keeping communities in Tanzania Charles E Makasi, Andrew M Kilale, Bernard J Ngowi, Yakobo Lema, Victor Katiti, Michael J Mahande, Elizabeth F. Msoka, Dominik Stelzle, Andrea S Winkler, Blandina T. Mmbaga Epilepsia Open.2023; 8(2): 487. CrossRef
Infectious Causes of Eosinophilic Meningitis in Korean Patients: A Single-Institution Retrospective Chart Review from 2004 to 2018 Sunghee Park, Jiwon Jung, Yong Pil Chong, Sung-Han Kim, Sang-Oh Lee, Sang-Ho Choi, Yang Soo Kim, Min Jae Kim The Korean Journal of Parasitology.2021; 59(3): 227. CrossRef
Could Differences in Infection Pressure Be Involved in Cysticercosis Heterogeneity? Pedro T. Hamamoto Filho, Gagandeep Singh, Andrea S. Winkler, Arturo Carpio, Agnès Fleury Trends in Parasitology.2020; 36(10): 826. CrossRef
Neurocysticercosis Presenting as Homonymous Hemianopia Hye Jin Lee Journal of the Korean Ophthalmological Society.2020; 61(9): 1115. CrossRef
Parasitic infections and medical expenses according to Health Insurance Review Assessment claims data in South Korea, 2011–2018 Ju Yeong Kim, Myung-hee Yi, Tai-Soon Yong, Guilherme L. Werneck PLOS ONE.2019; 14(11): e0225508. CrossRef
First
Prev
