Steroids are commonly used in patients with eosinophilic meningitis caused by A. cantonensis infections. The mechanism steroids act on eosinophilic meningitis remains unclear. In this mouse experiments, expressions of 14-3-3 isoform β and γ proteins significantly increased in the CSF 2-3 weeks after the infection, but not increasedin the dexamethasone-treated group. Expression of 14-3-3 β, γ, ε, and θ isoforms increased in brain meninges over the 3-week period after infection and decreased due to dexamethasone treatment. In conclusion, administration of dexamethasone in mice with eosinophilic meningitis decreased expressions of 14-3-3 isoform proteins in the CSF and in brain meninges.
Citations
Citations to this article as recorded by
A Case Series of Eosinophilic Meningitis from Kerala Githin B George, Jose K Paul, Praveen Panicker, Dileep Ramachandran, B Srikumar, Thomas Iype Neurology India.2025; 73(4): 892. CrossRef
Impact of Systemic versus Intratympanic Dexamethasone Administration on the Perilymph Proteome Betsy Szeto, Chris Valentini, Aykut Aksit, Emily G. Werth, Shahar Goeta, Lewis M. Brown, Elizabeth S. Olson, Jeffrey W. Kysar, Anil K. Lalwani Journal of Proteome Research.2021; 20(8): 4001. CrossRef
Serum 14-3-3β protein: a new biomarker in asthmatic patients with acute exacerbation in an observational study Decai Wang, Lizong Rao, Yalan Cui, Guoting Tang, Haiming Huang, Ting Yuan, Biwen Mo Allergy, Asthma & Clinical Immunology.2021;[Epub] CrossRef
First
Prev
