This study describes an evaluation of the sonographic, cholangiographic, pathological, and immunological findings, and the protective effect shown by rats reinfected with Clonorchis sinensis. Eight experimental rat groups were, namely, a normal control, a primary infection control, a reinfection I (reinfection 7 week after treatment following 3-week infection), a reinfection II (reinfection 2 week after treatment following 8-week infection), a reinfection III (exploration of the intrahepatic bile ducts 1 week after reinfection 4 week after treatment following 4-week infection), a superinfection, a secondary infection control, and an infection following immunization group. Sonographic and cholangiographic findings showed moderate or marked dilatation of the bile duct confluence in the primary infection control, reinfection II, and secondary infection control groups. Juvenile worms survived in the intrahepatic bile ducts 1 week after reinfection following treatment in the reinfection III group. It was concluded that reinfecting juvenile worms found during the first week following reinfection failed to survive or grow further. Anatomical, pathophysiological, or immunological changes may induce protection from reinfection in rats.
Perturbations of Metabolomic Profiling of Spleen From Rats Infected With Clonorchis sinensis Determined by LC-MS/MS Method Xiaoli Zhang, Xinyi Hu, Rui Chen, Beibei Sun, Yannan Gao, Shanshan Duan, Liyan Liu, Su Han Frontiers in Molecular Biosciences.2020;[Epub] CrossRef
The Role of Stroma in Cholangiocarcinoma: The Intriguing Interplay between Fibroblastic Component, Immune Cell Subsets and Tumor Epithelium Alessandra Gentilini, Mirella Pastore, Fabio Marra, Chiara Raggi International Journal of Molecular Sciences.2018; 19(10): 2885. CrossRef
In-vivo monitoring of development of cholangiocarcinoma induced with C. sinensis and N-nitrosodimethylamine in Syrian golen hamsters using ultrasonography and magnetic resonance imaging: a preliminary study Hyunsik Woo, Joon Koo Han, Jung Hoon Kim, Sung-Tae Hong, Md. Hafiz Uddin, Ja-June Jang European Radiology.2017; 27(4): 1740. CrossRef
Oxidative stress-mediated mouse liver lesions caused by Clonorchis sinensis infection Sejung Maeng, Hye Won Lee, Qudsia Bashir, Tae Im Kim, Sung-Jong Hong, Tae Jin Lee, Woon-Mok Sohn, Byoung-Kuk Na, Tong-Soo Kim, Jhang Ho Pak International Journal for Parasitology.2016; 46(3): 195. CrossRef
Cell Death and Proliferation after Treatment and Reinfection of Clonorchis sinensis in the Sprague-Dawley Rat Bile Duct Byoung-Hoon Min, Ka-Young Ahn, Haeng-Sook Lee, Soo-Jin Kim, Kyoung-Hwan Joo Applied Microscopy.2015; 45(2): 80. CrossRef
Recent Advances in Serodiagnosis for Clonorchiasis Tae Im Kim, Sung-Jong Hong Hanyang Medical Reviews.2010; 30(3): 232. CrossRef
Fas/FasL-dependent apoptosis of hepatocytes induced in rat and patients with Clonorchis sinensis infection Xiaoli Zhang, Zhanfeng Jin, Rong Da, Yunxia Dong, Wuqi Song, Xiaobei Chen, Qi Huang, Hong Ling, Yang Che, Yihong Li, Fengmin Zhang Parasitology Research.2008; 103(2): 393. CrossRef
Changing Patterns of Serum and Bile Antibodies in Re-infected Rats with Clonorchis sinensis Hongman Zhang, Byung-Suk Chung, Shunyu Li, Min-Ho Choi, Sung-Tae Hong The Korean Journal of Parasitology.2008; 46(1): 17. CrossRef
Factors in the resistance of rats to re-infection and super-infection by Clonorchis sinensis Hongman Zhang, Byung-Suk Chung, Shunyu Li, Min-Ho Choi, Sung-Tae Hong Parasitology Research.2008; 102(6): 1111. CrossRef
Molecular cloning and phylogenetic analysis of Clonorchis sinensis elongation factor-1α Tae Yun Kim, Pyo Yun Cho, Jong Won Na, Sung-Jong Hong Parasitology Research.2007; 101(6): 1557. CrossRef
Clonorchis sinensis: molecular cloning and localization of myosin regulatory light chain Yeong-Deok Kwon, Pyo Yun Cho, Sung-Jong Hong Parasitology Research.2005; 97(1): 21. CrossRef
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