Parasites, Hosts and Diseases

"metacestode"

Case Report

Clinical and Pathological Characteristics of Intraocular Cysticercosis: Juan-Juan Li, Li-Wei Zhang, Hua Li, Zhu-Lin Hu; Korean J Parasitol 2013;51(2):223-229.
Published online April 25, 2013; DOI: https://doi.org/10.3347/kjp.2013.51.2.223

Abstract
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This study aimed to explore the clinical, radiological, and pathological characteristics of intraocular cysticercosis due to Taenia solium metacestode infection. Total 8 patients diagnosed with intraocular cysticercosis at the Red Cross Hospital of Yunnan Province, China were examined retrospectively. Patients with clear dioptic media had undergone fundus chromophotography. All patients underwent B ultrasonography of the ocular region (CT) successive scanning of the orbit and cerebral tissues. Parasites were extracted surgically and then examined pathologically. The fundus chromophotography showed a white and condensing scolex package in the vesicle. The B ultrasonic examination showed a vesicle-like echogenic mass in the vitreous chamber, in which the high-level echo spot was the cysticercus scolex. The pathological examinations showed that the vesicle wall exhibited hyaline degeneration, inflammatory cell infiltration, neuroglial fiber, and glial cell proliferation layers from the inside to the outside. The scolex is round and is composed of the outer tissue (the body wall) and the inner furrow tissue; these tissues migrated together. Primordially differentiated sucking discs were found in one case, but no hooklets were found. The inner scolex tissue was folded like a paper flower. The severity of intraocular disease is closely correlated with the pathophysiological processes of the cysticercus worm. Pathological examination of the intraocular lesions can help to evaluate the course of the disease as well as to provide a scientific basis for effective antiparasitic medication.

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Toxic granulomatous anterior uveitis in live intracameral cysticercosis masquerading as leukocoria
Brijesh Takkar, Parijat Chandra, Kiran Kumar, Murugesan Vanathi
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Brijesh Takkar, Manzoor U Mehdi, Nasreen R Ahmed, Parijat Chandra, Murugesan Vanathi
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Brief Communication

Partial characterization of a 29 kDa cysteine protease purified from Taenia solium metacestodes: Ji-Young Kim, Hyun-Jong Yang, Kwang-Sig Kim, Young-Bae Chung; Korean J Parasitol 2005;43(4):157-160.
Published online December 20, 2005; DOI: https://doi.org/10.3347/kjp.2005.43.4.157

Abstract
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A 29 kDa cysteine protease of Taenia solium metacestodes was purified by Mono Q anion-exchanger and Superose 6 HR gel filtration chromatography. The enzyme was effectively inhibited by cysteine protease inhibitors, such as iodoacetic acid (IAA) and trans-epoxy-succinyl-L-leucyl-amido (4-guanidino) butane (E-64) while inhibitors acting on serine- or metallo-proteases did not affect the enzyme activity. The purified enzyme degraded human immunoglobulin G (IgG), collagen and bovine serum albumin (BSA), but human IgG was more susceptible for proteolysis by the enzyme. To define the precise biological roles of the enzyme, more detailed biochemical and functional studies would be required.

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Molecular characterization of EcCLP1, a new putative cathepsin L protease from Echinococcus canadensis
Ariel Naidich, Ariana M. Gutierrez, Federico Camicia
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Cloning and characterization of a cathepsin L-like cysteine protease from Taenia pisiformis
Qiuxia Wang, Shaohua Zhang, Xuenong Luo, Junling Hou, Xueliang Zhu, Xuepeng Cai
Veterinary Parasitology.2013; 194(1): 26. CrossRef
Partial Purification and Characterization of a Cysteine Protease Inhibitor from the Plerocercoid of Spirometra erinacei
Young-Bae Chung, Hyun-Jong Yang
The Korean Journal of Parasitology.2008; 46(3): 183. CrossRef
Cloning and characterization of cathepsin L-like peptidases of Echinococcus multilocularis metacestodes
Yasuhito Sako, Hiroshi Yamasaki, Kazuhiro Nakaya, Minoru Nakao, Akira Ito
Molecular and Biochemical Parasitology.2007; 154(2): 181. CrossRef
Identification and characterization of a cathepsin L-like cysteine protease from Taenia solium metacestode
Ai Hua Li, Sung-Ung Moon, Yun-Kyu Park, Byoung-Kuk Na, Myung-Gi Hwang, Chang-Mi Oh, Shin-Hyeong Cho, Yoon Kong, Tong-Soo Kim, Pyung-Rim Chung
Veterinary Parasitology.2006; 141(3-4): 251. CrossRef

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Original Article

A seroepidemiological survey of Taenia solium cysticercosis in Nabo, Guangxi Zhuang Autonomous Region, China: Joon-Yong Chung, Keeseon S. Eom, Yichao Yang, Xenming Li, Zheng Feng, Han-Jong Rim, Seung-Yull Cho, Yoon Kong; Korean J Parasitol 2005;43(4):135-139.
Published online December 20, 2005; DOI: https://doi.org/10.3347/kjp.2005.43.4.135

Abstract
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We have observed the seropositive rate of Taenia solium cysticercosis in residents at Nabo Village, Tiandong County, Guangxi Zhuang Autonomous Region, China by enzyme linked immunosorbent assay. The village had been found to be a relatively high endemic area of porcine cysticercosis among roaming pigs. Of 202 persons examined four males aged 15, 25, 35 and 41 year-old exhibited absorbance (abs) at 0.18, 0.20, 0.35 and 0.55, respectively. In addition, two females whose ages were 35 and 39 years revealed specific antibody levels of abs 0.26 and 0.41 in their sera. Overall positive rate among the people was 2.97%. All of these persons agreed that they had ingested the pork infected with T. solium metacestode (TsM), while history of proglottid discharge was not noticed from all of them. Three males and one female complained of intermittent headache. Our findings reinforced not only that the prevalence of cysticercosis might be related with roaming pigs infected with TsM but also that behavioral and environmental practices in local community constituted risk factors for transmission of the infection.

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A Marked Decline in Taenia solium Taeniasis and Cysticercosis Infections in China: Possible Reasons from the Ecological Determinants Perspective
Junqiang Li, Feifei Xu, Yuancai Chen, Md Robiul Karim, Yilin Wang, Kaihui Zhang, Xiaoying Li, Pitambar Dhakal, Rongjun Wang, Longxian Zhang
Zoonoses.2023;[Epub] CrossRef
The burden of T. solium cysticercosis and selected neuropsychiatric disorders in Mocuba district, Zambézia province, Mozambique
Irene Langa, Fernando Padama, Noémia Nhancupe, Alberto Pondja, Delfina Hlashwayo, Lidia Gouveia, Dominik Stelzle, Clarissa Prazeres da Costa, Veronika Schmidt, Andrea S. Winkler, Emília Virgínia Noormahomed, Eduardo Torres
PLOS Neglected Tropical Diseases.2022; 16(7): e0010606. CrossRef
Taeniasis and cysticercosis in Asia: A review with emphasis on molecular approaches and local lifestyles
Akira Ito, Tiaoying Li, Toni Wandra, Paron Dekumyoy, Tetsuya Yanagida, Munehiro Okamoto, Christine M Budke
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Young-Il Lee, Min Seo, Suk-Bae Kim
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Gloria Mwanjali, Charles Kihamia, Deodatus Vitalis Conatus Kakoko, Faustin Lekule, Helena Ngowi, Maria Vang Johansen, Stig Milan Thamsborg, Arve Lee Willingham, Malcolm K. Jones
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Serodiagnostic reliability of single-step enriched low-molecular weight proteins of Taenia solium metacestode of American and Asian isolates
E.-G. Lee, Y.-A. Bae, S.-H. Kim, S.P. Díaz-Camacho, Y. Nawa, Y. Kong
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V. Prabhakaran, M. Venkata Raghava, V. Rajshekhar, J. Muliyil, A. Oommen
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Amit Prasad, Rakesh K. Gupta, Sunil Pradhan, Mukesh Tripathi, Chandra M. Pandey, Kashi N. Prasad
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Brief Communications

Immunoblot findings of calcareous corpuscles binding proteins in cyst fluid of Taenia solium metacestodes: Hyun-Jong Yang; Korean J Parasitol 2004;42(3):141-143.
Published online September 20, 2004; DOI: https://doi.org/10.3347/kjp.2004.42.3.141

Abstract
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After collecting calcareous corpuscles from plerocercoid of Spirometra mansoni (sparganum), we evaluated the antigenic values of calcareous corpuscles binding proteins obtained from the cyst fluid of Taenia solium metacestodes. Immunoblot analysis revealed that cysticercosis patient sera strongly recognized 10 and 95 kDa calcareous corpuscles binding proteins. This result demonstrated that calcareous corpuscles are bound with major secretory antigenic proteins, which is possibly involved in the secretory pathways of the 10 and 95 kDa proteins presenting in the cyst fluid of T. solium metacestodes.

Citations

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Fasciclin-calcareous corpuscle binary complex mediated protein-protein interactions in Taenia solium metacestode
Chun-Seob Ahn, Jeong-Geun Kim, Young-An Bae, Seon-Hee Kim, Joo-Ho Shin, Yichao Yang, Insug Kang, Yoon Kong
Parasites & Vectors.2017;[Epub] CrossRef
Morphometric characteristics of the metacestode Echinococcus vogeli Rausch & Bernstein, 1972 in human infections from the northern region of Brazil
F. Almeida, F. Oliveira, R. Neves, N. Siqueira, R. Rodrigues-Silva, D. Daipert-Garcia, J.R. Machado-Silva
Journal of Helminthology.2015; 89(4): 480. CrossRef
Identification and functional characterization of alpha-enolase from Taenia pisiformis metacestode
Shaohua Zhang, Aijiang Guo, Xueliang Zhu, Yanan You, Junling Hou, Qiuxia Wang, Xuenong Luo, Xuepeng Cai
Acta Tropica.2015; 144: 31. CrossRef
In vitro excystation of Echinostoma paraensei (Digenea: Echinostomatidae) metacercariae assessed by light microscopy, morphometry and confocal laser scanning microscopy
Joyce Souza, Juberlan Garcia, Renata H. Neves, José Roberto Machado-Silva, Arnaldo Maldonado
Experimental Parasitology.2013; 135(4): 701. CrossRef

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Immunolocalization of the 150 kDa protein in cyst fluid of Taenia solium metacestodes: Hyun-Jong Yang, Young-Bae Chung; Korean J Parasitol 2004;42(2):81-84.
Published online June 20, 2004; DOI: https://doi.org/10.3347/kjp.2004.42.2.81

Abstract
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The 150 kDa protein of cyst fluid (CF) of Taenia solium metacestodes was purified by ammonium sulfate fractionation and Superose 6 HR gel filtration chromatography. The purified protein consisted of three subunits (15, 10 and 7 kDa proteins), which were analyzed with the use of a 7.5-15% gradient sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE). Immunofluorescence study was carried out by using immunize specific polyclonal antibody. Positive reactions were noticed at bladder walls, calcareous corpuscles, granules of cyst fluid and some host tissue surrounding the bladder wall of the metacestodes. These results suggest that the 150 kDa protein was secreted into host tissues, inducing immune responses in the host, and it may play important roles in the cellular physiology of the parasites.

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Taenia saginata: Production and characterization of monoclonal antibodies against Taenia saginata metacestode antigens
Josy Campanhã Vicentini-Oliveira, Marjorie A. Golim, Silvana de Cássia Paulan, Germano Francisco Biondi, Rosana Rossi-Ferreira, Elenice Deffune, Cáris Maroni Nunes
Experimental Parasitology.2010; 126(4): 621. CrossRef

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The 10 kDa protein of Taenia solium metacestodes shows genus specific antigenicity: Seung-Kyu Park, Doo-Hee Yun, Joon-Yong Chung, Yoon Kong, Seung-Yull Cho; Korean J Parasitol 2000;38(3):191-194.
Published online September 30, 2000; DOI: https://doi.org/10.3347/kjp.2000.38.3.191

Abstract
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Genus specific antigenicity of the 10 kDa protein in cyst fluid (CF) of Taenia solium metacestodes was demonstrated by comparative immunoblot analysis. When CFs from taeniid metacestodes of T. saginata, T. solium, T. taeniaeformis and T. crassiceps were probed with specific monoclonal antibody (mAb) raised against 150 kDa protein of T. solium metacestodes, specific antibody reactions were observed in 7 and 10 kDa proteins of T. solium and in 7/8 kDa of T. saginata, T. taeniaeformis and T. crassiceps. The mAb did not react with any protein in hydatid fluid of Echinococcus granulosus and E. multilocularis. This result revealed that the 10 kDa peptide of T. solium metacestodes and its equivalent proteins of different Taenia metacestodes are genus specific antigens that are shared among different Taenia species.

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Valeria Silva-Álvarez, Ana Maite Folle, Ana Lía Ramos, Fernando Zamarreño, Marcelo D. Costabel, Eduardo García-Zepeda, Gustavo Salinas, Betina Córsico, Ana María Ferreira
Prostaglandins, Leukotrienes and Essential Fatty Acids.2015; 93: 17. CrossRef
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Edda Sciutto, Gladis Fragoso, Marisela Hernández, Gabriela Rosas, José J. Martínez, Agnès Fleury, Jacquelynne Cervantes, Aline Aluja, Carlos Larralde
Journal of Parasitology.2013; 99(4): 693. CrossRef