Parasites, Hosts and Diseases

"salivary gland"

Original Articles

Changes in Protein Phosphorylation during Salivary Gland Degeneration in Haemaphysalis longicornis: Qi Xiao, Yuhong Hu, Xiaohong Yang, Jianna Tang, Xiaoshuang Wang, Xiaomin Xue, Mengxue Li, Minjing Wang, Yinan Zhao, Jingze Liu, Hui Wang; Korean J Parasitol 2020;58(2):161-171.
Published online April 30, 2020; DOI: https://doi.org/10.3347/kjp.2020.58.2.161

Abstract
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The ticks feed large amount of blood from their hosts and transmit pathogens to the victims. The salivary gland plays an important role in the blood feeding. When the female ticks are near engorgement, the salivary gland gradually loses its functions and begins to rapidly degenerate. In this study, data-independent acquisition quantitative proteomics was used to study changes in the phosphorylation modification of proteins during salivary gland degeneration in Haemaphysalis longicornis. In this quantitative study, 400 phosphorylated proteins and 850 phosphorylation modification sites were identified. Trough RNA interference experiments, we found that among the proteins with changes in phosphorylation, apoptosis-promoting Hippo protein played a role in salivary gland degeneration.

Citations

Citations to this article as recorded by

Transcriptome reveals the roles and potential mechanisms of CeRNA in the regulation of salivary gland development in the tick Rhipicephalus haemaphysaloides
Shanming Hu, Songqin Chen, Haotian Zhu, Yanan Wang, Yongzhi Zhou, Jie Cao, Houshuang Zhang, Jinlin Zhou
Frontiers in Cellular and Infection Microbiology.2025;[Epub] CrossRef
Quantitative proteomic analysis of salivary glands in female Ornithodoros lahorensis (syn. Alveonasus lahorensis) after blood feeding via DIA-coupled LC-MS/MS
Xiangfen Yuan, Xiaolin Xu, Huiyu Wang, Hongli Jing, Songyin Qiu, Yufang Kong, Yue Zhang, Jizhou Lv, Xun Suo, Shaoqiang Wu
Ticks and Tick-borne Diseases.2025; 16(6): 102575. CrossRef
Protein regulation mechanism of cold tolerance in Haemaphysalis longicornis
Ningmei Wang, Aimeng Ji, Abolfazl Masoudi, Shuang Li, Yuhong Hu, Yefei Zhang, Zhijun Yu, Han Wang, Hui Wang, Jingze Liu
Insect Science.2023; 30(3): 725. CrossRef
Effect of chlorpyrifos on the expression and regulation of salivary gland protein of Haemaphysalis longicornis
Xiaomin Xue, Ningmei Wang, Jingyi Ma, Aimeng Ji, Han Wang, Mengxue Li, Xiaohan Di, Jingze Liu, Hui Wang
International Journal of Acarology.2023; 49(2): 154. CrossRef
Phosphoproteomic Analysis of Haemaphysalis longicornis Saliva Reveals the Influential Contributions of Phosphoproteins to Blood-Feeding Success
Desmond O. Agwunobi, Ningmei Wang, Lei Huang, Yefei Zhang, Guomin Chang, Kuang Wang, Mengxue Li, Hui Wang, Jingze Liu
Frontiers in Cellular and Infection Microbiology.2022;[Epub] CrossRef

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Detection of Heparin in the Salivary Gland and Midgut of Aedes togoi: Young-Ran Ha, So-Ra Oh, Eun-Seok Seo, Bo-Heum Kim, Dong-Kyu Lee, Sang-Joon Lee; Korean J Parasitol 2014;52(2):183-188.
Published online April 18, 2014; DOI: https://doi.org/10.3347/kjp.2014.52.2.183

Abstract
PDF

Mosquitoes secrete saliva that contains biological substances, including anticoagulants that counteract a host's hemostatic response and prevent blood clotting during blood feeding. This study aimed to detect heparin, an anticoagulant in Aedes togoi using an immunohistochemical detection method, in the salivary canal, salivary gland, and midgut of male and female mosquitoes. Comparisons showed that female mosquitoes contained higher concentrations of heparin than male mosquitoes. On average, the level of heparin was higher in blood-fed female mosquitoes than in non-blood-fed female mosquitoes. Heparin concentrations were higher in the midgut than in the salivary gland. This indicates presence of heparin in tissues of A. togoi.

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