Trichomoniasis is the most common curable sexually-transmitted infection. Most Trichomonas vaginalis-infected men are asymptomatic and can remain undiagnosed and untreated, and this has been thought to result in chronic persistent prostatic infection. Chronic inflammation is regarded as the major factor in the pathogenesis and progression of benign prostatic hyperplasia (BPH) and prostatic cancer (PCa). The aim of this study is to identify seropositivity to T. vaginalis in men with prostate tumors (BPH or PCa) visited to Hanyang University Hospital. A total of 183 men were enrolled between October 2013 and November 2014. They consisted of 139 with BPH (mean age: 64.0 ± 0.07) and 44 with prostate cancer (mean age: 73.3±0.18). We carried out ELISA to identify the seropositivity to T. vaginalis. Mixed lysate antigen extracted from 8 strains of T. vaginalis was used in the ELISA. Also 58 male outpatients visited to Health Promotion Center in Hanyang University Hospital were evaluated for comparing group. As a results, seropositivity to T. vaginalis in patients with prostatic diseases was 19.7% (BPH: 18.7%, PCa: 22.7%) and it was significantly higher than the 1.7% of the comparing healthy group (P = 0.001). Therefore, prostatic tumor showed higher seropositivity against T. vaginalis than normal men. As far as we know, this is the first report about seroprevalence in prostatic tumor in Korea.
Citations
Citations to this article as recorded by
The Past, Present, and Future in the Diagnosis of a Neglected Sexually Transmitted Infection: Trichomoniasis Alexandra Ibáñez-Escribano, Juan José Nogal-Ruiz Pathogens.2024; 13(2): 126. CrossRef
Prevalence and Genotype of Trichomonas vaginalis among Men in Xinxiang City, Henan Province, China Zhenchao Zhang, Yuhui Sang, Pucheng Wu, Yujia Shang, Lesong Li, Yujuan Duan, Linfei Zhao, Minghui Gao, Lihua Guo, Xiaowei Tian, Zhenke Yang, Shuai Wang, Lixia Hao, Xuefang Mei, Jianbing Mu Journal of Tropical Medicine.2023; 2023: 1. CrossRef
Inflammatory responses during trichomoniasis: The role of Toll‐like receptors and inflammasomes Abdollah Jafarzadeh, Maryam Nemati, Ehsan Salarkia, Sonal Yadav, Najmeh Aminizadeh, Sara Jafarzadeh, Manisha Yadav Parasite Immunology.2023;[Epub] CrossRef
No Association of Trichomonas vaginalis Seropositivity with Advanced Prostate Cancer Risk in the Multiethnic Cohort: A Nested Case-Control Study Michelle Nagata, Anne Tome, Kami White, Lynne R. Wilkens, Song-Yi Park, Loïc Le Marchand, Christopher Haiman, Brenda Y. Hernandez Cancers.2023; 15(21): 5194. CrossRef
Identification of Signature Genes and Construction of an Artificial Neural Network Model of Prostate Cancer Hongye Dong, Xu Wang, Kalidoss Rajakani Journal of Healthcare Engineering.2022; 2022: 1. CrossRef
Multiple pathogens and prostate cancer James S. Lawson, Wendy K. Glenn Infectious Agents and Cancer.2022;[Epub] CrossRef
Trichomonas vaginalis serostatus and prostate cancer risk in Egypt: a case-control study Nora E. Saleh, Samar M. Alhusseiny, Wafaa M. El-Zayady, Engy M. Aboelnaga, Wafaa N. El-beshbishi, Yasser M. Saleh, Hala S. Abou-ElWafa, Samar N. El-Beshbishi Parasitology Research.2021; 120(4): 1379. CrossRef
The Role of Microbial Factors in Prostate Cancer Development—An Up-to-Date Review Karolina Garbas, Piotr Zapała, Łukasz Zapała, Piotr Radziszewski Journal of Clinical Medicine.2021; 10(20): 4772. CrossRef
Involvement of Macrophages in Proliferation of Prostate Cancer Cells Infected with Trichomonas vaginalis Kyu-Shik Kim, Hong-Sang Moon, Sang-Su Kim, Jae-Sook Ryu The Korean Journal of Parasitology.2021; 59(6): 557. CrossRef
Seroprevalence and risk factors of Trichomonas vaginalis among couples in Al-Hamza city-Iraq. Musafer H. Al-Ardi Al-Kufa University Journal for Biology.2021; 13(1): 26. CrossRef
Is Trichomonas vaginalis a Risk Factor for Prostate Cancer? A Systematic Review and Meta-analysis Gianpaolo Perletti, Vittorio Magri, Louise Beckers-Perletti, Alberto Trinchieri, Konstantinos Stamatiou Hellenic Urology.2021; 33(1): 12. CrossRef
IL-6 produced by prostate epithelial cells stimulated with Trichomonas vaginalis promotes proliferation of prostate cancer cells by inducing M2 polarization of THP-1-derived macrophages Ik-Hwan Han, Hyun-Ouk Song, Jae-Sook Ryu, Michael H. Hsieh PLOS Neglected Tropical Diseases.2020; 14(3): e0008126. CrossRef
Development of a convenient detection method for Trichomonas vaginalis based on loop-mediated isothermal amplification targeting adhesion protein 65 Yuhua Li, Shuai Wang, Haoran Li, Xiaoxiao Song, Hao Zhang, Yujuan Duan, Chengyang Luo, Bingli Wang, Sifan Ji, Qing Xie, Zhenchao Zhang BMC Infectious Diseases.2020;[Epub] CrossRef
The Crosstalk between Prostate Cancer and Microbiota Inflammation: Nutraceutical Products Are Useful to Balance This Interplay? Felice Crocetto, Mariarosaria Boccellino, Biagio Barone, Erika Di Zazzo, Antonella Sciarra, Giovanni Galasso, Giuliana Settembre, Lucio Quagliuolo, Ciro Imbimbo, Silvia Boffo, Italo Francesco Angelillo, Marina Di Domenico Nutrients.2020; 12(9): 2648. CrossRef
The present study aimed to investigate the possible association of Toxoplasma gondii and Toxocara spp. infections with cryptogenic epilepsy in children. The study was carried out between June 2014 and March 2015. T otal 90 children (40 with cryptogenic epilepsy, 30 with non-cryptogenic epilepsy, and 20 healthy control children) were evaluated to determine the anti-Toxocara and anti-T . gondii IgG seropositivity using ELISA kits. Epileptic cases were selected from those attending the pediatrics outpatient clinic of Benha University Hospital, Pediatrics Neurology Unit, and from Benha Specialized Hospital of children. The results showed that the level of anti-T . gondii IgG seropositivity was significantly higher among children with cryptogenic epilepsy (20%) than among children with non-cryptogenic children (0%). In healthy controls (10%), there was no association between toxocariasis seropositivity and cryptogenic epilepsy (only 5.7%; 4 out of 70 cases) among cases and 10% (2 out of 20) among controls. Among toxocariasis IgG positive cases, 3 (7.5%) were cryptogenic, and only 1 (3.3%) was non-cryptogenic. These statistically significant results support the association between T . gondii infection and cryptogenic epilepsy while deny this association with toxocariasis.
Citations
Citations to this article as recorded by
Evaluation of Toxoplasma gondii in the Etiology of Cryptogenic Epilepsy: A Case-control Study Selahattin Aydemir, Milad Torkamanian Afshar, Özlem Sarı Torkamanian Afshar, Zeynep Taş Cengiz, Mustafa Kiraz, Caner Baydar, Hasan Yılmaz Archives Of Epilepsy.2024; : 39. CrossRef
Effects of diet and ovariectomy on Toxoplasma gondii brain infection: functional alterations and neuronal loss in rats Nene Ahidjo, Paul F Seke Etet, Leonard Ngarka, Frederic Maidawa Yaya, Ethel W Ndianteng, Aude L Eyenga Nna, Luc Yvan Meka’a Zang, Christelle Kemmo, Caroline N C Nwasike, Floriane G Yonkeu Tatchou, Wepnyu Y Njamnshi, Leonard N Nfor, Patrick V Tsouh Fokou, Brain Communications.2024;[Epub] CrossRef
Common infectious and parasitic diseases as a cause of seizures: geographic distribution and contribution to the burden of epilepsy Elza Márcia T. Yacubian, Angelina Kakooza‐Mwesige, Gagandeep Singh, Arturo Carpio, Nathália V. de Figueiredo, Ricardo Lutzky Saute, Tissiana Marques de Haes Epileptic Disorders.2022; 24(6): 994. CrossRef
Seroprevalence and Genetic Characterization of Toxoplasma gondii among Children with Neurodevelopmental Disorders in Egypt Sara M. Elzeky, Nairmen Nabih, Aida A. Abdel-Magied, Dina S. Abdelmagid, Aya E. Handoussa, Marwa M. Hamouda, Wei Wang Journal of Tropical Medicine.2022; 2022: 1. CrossRef
Exposure to Toxocara Canis is not Associated with New-Onset Epilepsy Vivek Rishi, Rajveer Singh, Manoj Kumar Goyal, Manish Modi, Vivek Garg, J. S. Thakur, R. K. Sehgal, N. Khandelwal, Gourav Jain, Amith S. Kumar, Aditya Choudhary, Sudesh Prabhakar, Vivek Lal Neurology India.2022; 70(6): 2383. CrossRef
Cerebral Toxocariasis as a Cause of Epilepsy: A Pediatric Case Grazia Bossi, Raffaele Bruno, Stefano Novati, Roberta Maserati, Georgia Mussati, Mariasole Prevedoni Gorone, Edoardo Vecchio Nepita, Corrado Regalbuto, Gioia Gola, Anna Maria Simoncelli, Antonella Bruno, Paola Musso, Edoardo Clerici, Gian Luigi Marseglia Neuropediatrics.2021; 52(02): 142. CrossRef
Case-Control Study to Assess the Association between Epilepsy and Toxocara Infection/Exposure Ali Alizadeh Khatir, Mahdi Sepidarkish, Mohammad Reza Rajabalizadeh, Solmaz Alizadeh Moghaddam, Saeed Aghapour, Saeed Mehravar, Peter J. Hotez, Robin B. Gasser, Ali Rostami Microorganisms.2021; 9(10): 2091. CrossRef
Neurological and Neurobehavioral Disorders Associated with Toxoplasma gondii Infection in Humans Maxwell A. Virus, Evie G. Ehrhorn, LeeAnna M. Lui, Paul H. Davis, Hassen Mamo Journal of Parasitology Research.2021; 2021: 1. CrossRef
Toxoplasma infection and risk of epilepsy: A case-control study of incident patients Ali Alizadeh Khatir, Solmaz Alizadeh Moghaddam, Mustafa Almukhtar, Hossein Ghorbani, Arefeh Babazadeh, Saeed Mehravar, Ali Rostami Microbial Pathogenesis.2021; 161: 105302. CrossRef
Frequency ofToxocara canisantibodies in Mexican paediatric patients with epilepsy M.d.L. Caballero-García, J. Simón-Salvador, J.C. Hernández-Aguilar, A. Reyes-Lopez, B. Nogueda-Torres, E. Jiménez-Cardoso Journal of Helminthology.2020;[Epub] CrossRef
A review on toxoplasmosis in humans and animals from Egypt I. E. Abbas, I. Villena, J. P. Dubey Parasitology.2020; 147(2): 135. CrossRef
Zoonotic and vector-borne parasites and epilepsy in low-income and middle-income countries Gagandeep Singh, Samuel A. Angwafor, Alfred K. Njamnshi, Henry Fraimow, Josemir W. Sander Nature Reviews Neurology.2020; 16(6): 333. CrossRef
Effects of Toxoplasma gondii infection and schizophrenia comorbidity on serum lipid profile: A population retrospective study from Eastern China Fei Xu, Xinyu Ma, Yuwei Zhu, Arjen Sutterland, Ruitang Cheng, Sunhan Miao, Jialu Chen, Liying Qiu, Yonghua Zhou Microbial Pathogenesis.2020; 149: 104587. CrossRef
An updated meta-analysis of the association between Toxoplasma gondii infection and risk of epilepsy Maryam Sadeghi, Seyed Mohammad Riahi, Mona Mohammadi, Vafa Saber, Somayeh Aghamolaie, Solmaz Alizadeh Moghaddam, Shima Aghaei, Mostafa Javanian, H Ray Gamble, Ali Rostami Transactions of The Royal Society of Tropical Medicine and Hygiene.2019; 113(8): 453. CrossRef
Updated evidence of the association between toxocariasis and epilepsy: Systematic review and meta-analysis Jaime Luna, Calogero Edoardo Cicero, Guillaume Rateau, Graziella Quattrocchi, Benoit Marin, Elisa Bruno, François Dalmay, Michel Druet-Cabanac, Alessandra Nicoletti, Pierre-Marie Preux, Agnes Fleury PLOS Neglected Tropical Diseases.2018; 12(7): e0006665. CrossRef
Seroprevalence of Toxoplasma gondii infection in children with central nervous system disorders in Mansoura, Egypt: a case–control study Samar N El-Beshbishi, Nora L El-Tantawy, Sara M Elzeky, Khalid F Abdalaziz, Raefa A Atia Transactions of The Royal Society of Tropical Medicine and Hygiene.2018;[Epub] CrossRef
Toxocariasis in humans in Africa – A systematic review Felix Lötsch, Rieke Vingerling, Rene Spijker, Martin Peter Grobusch Travel Medicine and Infectious Disease.2017; 20: 15. CrossRef
Toxoplasmosis is considered as an important risk factor for bad obstetric history (BOH) and one of the major causes of congenitally acquired infections. The present study aimed to estimate the seropositivity of T. gondii infection and associated risk factors among the attendees of high risk pregnancy and low risk antenatal care clinic of Minia Maternity and Pediatric University Hospital, Minia, Egypt. The study was carried out from April 2013 to April 2014 through 2 phases, the first phase was case-control study, and the second phase was follow-up with intervention. A total of 120 high risk pregnant and 120 normal pregnant females were submitted to clinical examinations, serological screening for anti-Toxoplasma IgM and IgG antibodies by ELISA, and an interview questionnaire. Seropositive cases were subjected to spiramycin course treatment. The results showed that the seroprevalence of toxoplasmosis in high-risk pregnancy group was 50.8%, which was significantly different from that of normal pregnancy group (P < 0.05). Analysis of seropositive women in relation to BOH showed that abortion was the commonest form of the pregnancy wastage (56.5%). The high prevalence of T. gondii seropositive cases was observed in the age group of 21-30 years. Post-delivery adverse outcome was observed in 80.3% of high-risk pregnancy group compared to 20% of normal pregnancy group. There was a statistically significant relationship between seropositivity and living in rural area, low socioeconomic level, and undercooked meat consumption (P<0.05). Serological screening for anti-Toxoplasma antibodies should be routine tests especially among high-risk pregnant women.
Citations
Citations to this article as recorded by
Seroprevalence of Toxoplasma gondii Antibodies and Associated Risk Factors Among Women in Zakho City, Iraq Kalthom M Mustafa, Ahmed B Mohammed, Wijdan M.S. Mero Cureus.2024;[Epub] CrossRef
Interplay between cross sectional analysis of risk factors associated with Toxoplasma gondii infection in pregnant women and their domestic cats Eman A. A. Hassanen, Dennis N. Makau, Mohamed Afifi, Omar A. Al-Jabr, Mohammed Abdulrahman Alshahrani, Ahmed Saif, Reham G. A. Anter, Wafaa M. El-Neshwy, Doaa Ibrahim, Rasha M. M. Abou Elez Frontiers in Veterinary Science.2023;[Epub] CrossRef
Upregulation of IL-33, CCL2, and CXCL16 levels in Brazilian pregnant women infected by Toxoplasma gondii Priscilla Vilela dos Santos, Débora Nonato Miranda de Toledo, Nathalia Sernizon Guimarães, Luiza Oliveira Perucci, Valter Ferreira de Andrade-Neto, André Talvani Acta Tropica.2023; 243: 106931. CrossRef
Latent Toxoplasmosis is Associated with Depression and Suicidal Behavior Ahmed M. Kamal, Amany M. Kamal, Aliaa S. Abd El-Fatah, Mina M. Rizk, Eptesam E. Hassan Archives of Suicide Research.2022; 26(2): 819. CrossRef
Detection of toxoplasmosis in aborted women in Alexandria, Egypt using ELISA and PCR Mona Hassan El-Sayad, Aziza Ibrahim Salem, Hisham Fazary, Haneen Nawaf Alzainny, Naglaa Fathi Abd El-Latif Journal of Parasitic Diseases.2021; 45(2): 539. CrossRef
Seroprevalence of Neospora caninum and Toxoplasma gondii IgG and IgM antibodies among buffaloes and cattle from Menoufia Province, Egypt Hany M. Ibrahim, Adel A. H. Abdel-Rahman, Nora M. Bishr Journal of Parasitic Diseases.2021; 45(4): 952. CrossRef
Distribution of integrons and phylogenetic groups among Escherichia coli causing community-acquired urinary tract infection in Upper Egypt Eman M. Farahat, Noha A. Hassuna, Adel M. Hammad, Medhat Abdel Fattah, Ahmed S. Khairalla Canadian Journal of Microbiology.2021; 67(6): 451. CrossRef
Evaluation of soluble CD279 (sCD279) and CD274 (sCD274) in Iraqi patients with Acute Myeloid Leukemia (AML) with Toxoplasmosis Ali A. Issa, Ali N. Yaseen, Muhammed A. H. Aldabagh IOP Conference Series: Earth and Environmental Science.2021; 790(1): 012065. CrossRef
Toxoplasma gondii infection and spontaneous abortion: A systematic review and meta-analysis Narges Kalantari, Tahmineh Gorgani-Firouzjaee, Zahra Moulana, Mohammad Chehrazi, Salman Ghaffari Microbial Pathogenesis.2021; 158: 105070. CrossRef
Toxoplasmosis in immunocompetent Saudi women: Correlation with vitamin D Zafar Rasheed, Ali Shariq, Ghaida B AlQefari, Ghayda S Alwahbi, Amal I Aljuaythin, Fidaa S Alsuhaibani, Daliyah F Alotaibi, Shahad S Aljohani, Ruqiah Alghasham, Thamir Alsaeed, Nada A Alharbi, Osamah Al Rugaie, Waleed Al Abdulmonem, Osama F Sharaf Women's Health.2021;[Epub] CrossRef
Toxoplasma gondii seropositivity and the associated risk factors in sheep and pregnant women in El-Minya Governorate, Egypt Abdelbaset E. Abdelbaset, Maha I. Hamed, Mostafa F. N. Abushahba, Mohamed S. Rawy, Amal S. M. Sayed, Jeffrey J. Adamovicz Veterinary World.2020; 13(1): 54. CrossRef
A review on toxoplasmosis in humans and animals from Egypt I. E. Abbas, I. Villena, J. P. Dubey Parasitology.2020; 147(2): 135. CrossRef
The global seroprevalence of anti-Toxoplasma gondii antibodies in women who had spontaneous abortion: A systematic review and meta-analysis Tooran Nayeri, Shahabeddin Sarvi, Mahmood Moosazadeh, Afsaneh Amouei, Zahra Hosseininejad, Ahmad Daryani, Maria Angeles Gómez-Morales PLOS Neglected Tropical Diseases.2020; 14(3): e0008103. CrossRef
Risk factors associated with seropositivity for Toxoplasma gondii in population-based studies among immunocompromised patients (pregnant women, HIV patients and children) in West African countries, Cameroon and Gabon: a meta-analysis Paul Olalekan Odeniran, Kehinde Foluke Omolabi, Isaiah Oluwafemi Ademola Acta Tropica.2020; 209: 105544. CrossRef
Serological prevalence of toxoplasmosis in pregnant women in Luanda (Angola): Geospatial distribution and its association with socio-demographic and clinical-obstetric determinants Amélia Nkutxi Vueba, Clarissa Perez Faria, Ricardo Almendra, Paula Santana, Maria do Céu Sousa, Adriana Calderaro PLOS ONE.2020; 15(11): e0241908. CrossRef
Clinico-epidemiological and sociodemographic profile of HIV/AIDS patients who are co-infected with Toxoplasma gondii in the border region of Brazil JANIELLE C. MORO, NEIDE M. MOREIRA Anais da Academia Brasileira de Ciências.2020;[Epub] CrossRef
Potential risk factors associated with seropositivity for Toxoplasma gondii among pregnant women and HIV infected individuals in Ethiopia: A systematic review and meta-analysis Zewdu Seyoum Tarekegn, Haileyesus Dejene, Agerie Addisu, Shimelis Dagnachew, Olaf Horstick PLOS Neglected Tropical Diseases.2020; 14(12): e0008944. CrossRef
Toxoplasma gondii infection and toxoplasmosis in North Africa: a review Mariem Rouatbi, Safa Amairia, Yosra Amdouni, Mohamed Anis Boussaadoun, Ouarda Ayadi, Amira Adel Taha Al-Hosary, Mourad Rekik, Rym Ben Abdallah, Karim Aoun, Mohamed Aziz Darghouth, Barbara Wieland, Mohamed Gharbi Parasite.2019; 26: 6. CrossRef
BCG scar, socioeconomic and nutritional status: a study of newborns in urban area of Makassar, Indonesia Aldian Irma Amaruddin, Sitti Wahyuni, Firdaus Hamid, Maisuri T. Chalid, Maria Yazdanbakhsh, Erliyani Sartono Tropical Medicine & International Health.2019; 24(6): 736. CrossRef
Conhecimento e comportamento preventivo de gestantes sobre Toxoplasmose no município de Imperatriz, Maranhão, Brasil Ivone Pereira da Silva Moura, Ilma Pastana Ferreira, Altem Nascimento Pontes, Cléa Nazaré Carneiro Bichara Ciência & Saúde Coletiva.2019; 24(10): 3933. CrossRef
Performance of Zika Assays in the Context of Toxoplasma gondii, Parvovirus B19, Rubella Virus, and Cytomegalovirus (TORCH) Diagnostic Assays Bettie Voordouw, Barry Rockx, Thomas Jaenisch, Pieter Fraaij, Philippe Mayaud, Ann Vossen, Marion Koopmans Clinical Microbiology Reviews.2019;[Epub] CrossRef
Seroprevalence of Toxoplasma gondii among pregnant women attending antenatal clinics at Hawassa University comprehensive specialized and Yirgalem General Hospitals, in Southern Ethiopia Demissie Assegu Fenta BMC Infectious Diseases.2019;[Epub] CrossRef
Toxoplasma gondii seroprevalence among pregnant women attending antenatal clinic in Northern Tanzania Eliakimu Paul, Ireen Kiwelu, Blandina Mmbaga, Rebeka Nazareth, Elias Sabuni, Athanasia Maro, Arnold Ndaro, Jo E. B. Halliday, Jaffu Chilongola Tropical Medicine and Health.2018;[Epub] CrossRef
Seroprevalence and associated risk factors of Toxoplasma gondii among Manchu pregnant women in northeastern China Ruo-Lan Jiang, Ling-Hui Ma, Zhen-Rong Ma, Guangyu Hou, Quan Zhao, Xiang Wu Microbial Pathogenesis.2018; 123: 398. CrossRef
Seroprevalence and potential risk factors of T. gondii infection in pregnant women attending antenatal care at Bonga Hospital, Southwestern Ethiopia Jalel Negero, Moti Yohannes, Kifle Woldemichael, Dechassa Tegegne International Journal of Infectious Diseases.2017; 57: 44. CrossRef
Comparative and analytical study on active toxoplasmosis to assess the IgG avidity in correlation to serological profile in a cohort of Egyptian patients Al Shaimaa M. R. Hamed, Shadia H. Omar, Maha M. A. Basyoni, Abeer S. El Antably, Engy El Khateeb, Abdulla Y. El Kateb Comparative Clinical Pathology.2017; 26(5): 1157. CrossRef
Molecular and serological prevalence of Toxoplasma gondii in pregnant women and sheep in Egypt Hany M. Ibrahim, Azza H. Mohamed, Ahmed A. El-Sharaawy, Hend E. El-Shqanqery Asian Pacific Journal of Tropical Medicine.2017; 10(10): 996. CrossRef
Seroprevalence of Anti-Toxoplasma gondiiAntibodies Among Lebanese Pregnant Women Hasan Nahouli, Nour El Arnaout, Elias Chalhoub, Elie Anastadiadis, Hiba El Hajj Vector-Borne and Zoonotic Diseases.2017; 17(12): 785. CrossRef
Comparison of Placenta PCR and Maternal Serology of Aborted Women for Detection of Toxoplasma gondii in Ardabil, Iran Somaie Matin, Gholamreza Shahbazi, Shervin Tabrizian Namin, Rouhallah Moradpour, Farideh Feizi, Hadi Piri-dogahe The Korean Journal of Parasitology.2017; 55(6): 607. CrossRef
Is Toxoplasma Gondii Infection a Risk Factor for Leukemia? An Evidence-Based Meta-Analysis Yi Huang, Yu Huang, Aoshuang Chang, Jishi Wang, Xiaoqing Zeng, Jiahong Wu Medical Science Monitor.2016; 22: 1547. CrossRef
The relationship between anti-Plasmodium vivax circumsporozoite protein (CSP) antibody levels and the prevalence of malaria in epidemic areas of South Korea was evaluated. Blood samples were collected from inhabitants of Gimpo-si (city), Paju-si, and Yeoncheon-gun (county) in Gyeonggi-do (province), as well as Cheorwon-gun in Gangwon-do from November to December 2004. Microscopic examinations were used to identify malaria parasites. ELISA was used to quantitate anti-circumsporozoite protein (CSP) antibodies against P. vivax. A total of 1,774 blood samples were collected. The overall CSP-ELISA-positive rate was 7.7% (n=139). The annual parasite incidences (APIs) in these areas gradually decreased from 2004 to 2005 (1.09 and 0.80, respectively). The positive rate in Gimpo (10.4%, 44/425) was the highest identified by CSP-ELISA. The highest API was found in Yeoncheon, followed by Cheorwon, Paju, and Gimpo in both years. The positive rates of CSP-ELISA were closely related to the APIs in the study areas. These results suggest that seroepidemiological studies based on CSP may be helpful in estimating the malaria prevalence in certain areas. In addition, this assay can be used to establish and evaluate malaria control and eradication programs in affected areas.
Citations
Citations to this article as recorded by
Updated global distribution of Plasmodium vivax circumsporozoite protein variants and their correlation with vector susceptibility: A systematic review and meta-analysis Marrara P. Sampaio, Marcelo Cerilo-Filho, Yasmin de A․G․do Amaral, Maria Naely G. Almeida, Rayanne I. Correa, Dulce J.V. Fernando, Nathália F. Reis, Leonardo A. Miceli, José R.S. Silva, Luciane M. Storti-Melo, Andréa R.S. Baptista, Ricardo L.D. Machado Acta Tropica.2025; 261: 107508. CrossRef
Using Serological Markers for the Surveillance of Plasmodium vivax Malaria: A Scoping Review Lejla Kartal, Ivo Mueller, Rhea J. Longley Pathogens.2023; 12(6): 791. CrossRef
Plasmodium vivax reemerged in the Republic of Korea (ROK) in 1993, and is likely to continue to affect public health. The purpose of this study was to measure levels of anti-P. vivax antibodies using indirect fluorescent antibody test (IFAT) in border areas of ROK, to determine the seroprevalence of malaria (2003-2005) and to plan effective control strategies. Blood samples of the inhabitants in Gimpo-si, Paju-si, and Yeoncheon-gun (Gyeonggi-do), and Cheorwon-gun (Gangwon-do) were collected and kept in Korea Centers for Disease Control and Prevention (KCDC). Out of a total of 1,774 serum samples tested, the overall seropositivity was 0.94% (n=17). The seropositivity was the highest in Paju-si (1.9%, 7/372), followed by Gimpo-si (1.4%, 6/425), Yeoncheon-gun (0.67%, 3/451), and Cheorwon-gun (0.19%, 1/526). The annual parasite incidence (API) in these areas gradually decreased from 2003 to 2005 (1.69, 1.09, and 0.80 in 2003, 2004, and 2005, respectively). The highest API was found in Yeoncheon-gun, followed by Cheorwon-gun, Paju-si, and Gimpo-si. The API ranking in these areas did not change over the 3 years. The seropositivity of Gimpo-si showed a strong linear relationship with the API of 2005 (r=0.9983, P=0.036). Seropositivity data obtained using IFAT may be useful for understanding malaria prevalence of relevant years, predicting future transmission of malaria, and for establishing and evaluating malaria control programs in affected areas.
Citations
Citations to this article as recorded by
Using Serological Markers for the Surveillance of Plasmodium vivax Malaria: A Scoping Review Lejla Kartal, Ivo Mueller, Rhea J. Longley Pathogens.2023; 12(6): 791. CrossRef
First
Prev
