A total of 60 patients with Hymenolepis nana infection were treated with a single oral dose of praziquantel in two different dose levels. Twenty-nine cases treated with praziquantel in a single dose of 15 mg/kg body weight produced a 100% cure rate. On the otehr hand, 30 out of 31 patients who received a single dose of 25 mg/kg body weight cured completely, but only one case had counts of 200 EPG of feces in each tests on the 20th and 21st days after treatment. The cure rate was 96.8% and the mean egg reduction rate of 99.8 per cent was obtained. Side effects were mild and transitory. In a few cases, abdominal pain, vertigo, headache and diarrhea were complained in a few hours after medication. Clinial hematology, serum biochemistry and urinalysis were performed immediately before and the next day after treatment in all cases. There were no significant abnormalities detected in these tests.
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In Silico Chemogenomics Drug Repositioning Strategies for Neglected Tropical Diseases Carolina Horta Andrade, Bruno Junior Neves, Cleber Camilo Melo-Filho, Juliana Rodrigues, Diego Cabral Silva, Rodolpho Campos Braga, Pedro Vitor Lemos Cravo Current Medicinal Chemistry.2019; 26(23): 4355. CrossRef
Synthesis of leading chalcones with high antiparasitic, against Hymenolepis nana, and antioxidant activities José Tomás Díaz-Carrillo, Sylvia Páz Díaz-Camacho, Francisco Delgado-Vargas, Ignacio Alfredo Rivero, Gabriela López-Angulo, Juan Ignacio Sarmiento-Sánchez, Julio Montes-Avila Brazilian Journal of Pharmaceutical Sciences.2018;[Epub] CrossRef
Prevalence of Hymenolepis nana among primary school children in Burkina Faso Bagayan Mohamed, Zongo Dramane, Ou eacute da Adama, Savadogo Boubacar, Sorgho Hermann, Drabo Fran ccedil ois, Ou eacute draogo Amado, Bamba Issouf, Zhang Yaobi, Boureima Kabr eacute Gustave, No euml l Poda Jean International Journal of Medicine and Medical Sciences.2015; 7(10): 148. CrossRef
Praziquantel Treatment in Trematode and Cestode Infections: An Update Jong-Yil Chai Infection & Chemotherapy.2013; 45(1): 32. CrossRef
Efficacy and Safety of Tribendimidine Against Clonorchis sinensis Men-Bao Qian, Peiling Yap, Yi-Chao Yang, Hai Liang, Zhi-Hua Jiang, Wei Li, Yu-Guang Tan, Hui Zhou, Jürg Utzinger, Xiao-Nong Zhou, Jennifer Keiser Clinical Infectious Diseases.2013; 56(7): e76. CrossRef
Clinical study evaluating efficacy of praziquantel in clonorchiasis B G Yangco, C De Lerma, G H Lyman, D L Price Antimicrobial Agents and Chemotherapy.1987; 31(2): 135. CrossRef
Praziquantel Peter Andrews, Herbert Thomas, Rolf Pohlke, JÜRgen Seubert Medicinal Research Reviews.1983; 3(2): 147. CrossRef
Clinical evaluation of the therapeutic efficacy of praziquantel (Embay 8440) againstClonorchis sinensisinfection in man Han-Jong Rim, Kwang-Sa Lyu, Joon-Sang Lee, Kyoung-Hwan Joo Annals of Tropical Medicine & Parasitology.1981; 75(1): 27. CrossRef
Tentativa de controle de Hymenolepis nana através de tratamentos clínicos repetidos, com praziquantel, em uma comunidade fechada R. S. Rocha, Omar dos Santos Carvalho, José Soares dos Santos, Naftale Katz Revista de Saúde Pública.1981; 15(4): 364. CrossRef
Therapeutic effects of praziquantel (Embay 8440) against Taenia solium infection Han Jong Rim, Soo Bae Park, Joon Sang Lee, Kyoung Hwan Joo The Korean Journal of Parasitology.1979; 17(1): 67. CrossRef
