Anthelmintic efficacy of methyl-5-benzoylbenzimidazole-2-carbamate(Mebendazole) against multiple helminthic infections

, Seo, Byong Seol; , Cho, Seung Yull; , Kang, Shin Yong; , Chai, Jong Yil

doi:1977.15.1.11

Korean J Parasito > Volume 15(1):1977 > Article

Original Article


Korean J Parasitol. 1977 Jun;15(1):11-16. English. Published online Mar 20, 1994. http://dx.doi.org/10.3347/kjp.1977.15.1.11
Copyright © 1977 by The Korean Society for Parasitology


Anthelmintic efficacy of methyl-5-benzoylbenzimidazole-2-carbamate(Mebendazole) against multiple helminthic infections
Byong-Seol Seo,Seung-Yull Cho,Shin Yong Kang and Jong-Yil Chai
Department of Parasitology and Institute of Endemic Diseases, College of Medicine, Seoul National University, Korea.


Abstract
A clinical trial of Korean Patent mebendazole was undertaken upon some intestinal helminthic infections in 288 rural Koreans residing in Pochun and Jinyang Gun, from November to December, 1976. They were examined by the cellophane thick smear technique, Stoll's egg counting technique and/or Scotch-tape anal swab before and 3 weeks after the treatment. The administered dose of mebendazole was 600 mg, divided by 100 mg, twice daily for 3 consecutive days disregarding the body weight and the age of the cases. It was confirmed that mebendazole is very effective, broad-spectrum anthelmintic, especially against Ascaris, Ancylostoma, Trichostrongylus and Enterobius infections. Their negative conversion rate and egg reduction rate were respectively; 94.0 and 99.6 per cent in Ascaris, 71.4 and 97.3 per cent in Ancylostoma and 95.0 and 100 per cent in Trichostrongylus. The negative conversion rate in Enterobius was 92.3 per cent. The anthelmintic efficacy against T. trichiura infection was not satisfactory in spite of low worm burden (negative conversion rate, 27.3%, egg reduction rate, 65.5%).

Tables


	Table 1 The results of stool examination before treatment in Pochun and Jinyang Gun, revealed by cellophane thick smear technique


	Table 2 Analysis of multiple infections of helminths (No. examined: 218)


	Table 3 Cure rate of intestinal helminths in dose of 200mg/day for 3 days of mebendazole


	Table 4 Egg reduction rate of mebendazole against intestinal helminths

References


1.	Actor P, Anderson EL, DiCuollo CJ, Ferlauto RJ, Hoover JR, Pagano JF, Ravin LR, Scheidy SF, Stedman RJ, Theodorides VJ. New broad spectrum anthelmintic, methyl 5(6)-butyl-2-benzimidazolecarbamate. Nature 1967;215(5098):321–322.

2.	Banerjee D, Mandal A, Prakash O. Mebendazole (R-17,635): a new anthelmintic in the development of hookworms. Trans R Soc Trop Med Hyg 1971;65(5):685–686.

3.	Brugmans JP, Thienpont DC, van Wijngaarden I, Vanparijs OF, Schuermans VL, Lauwers HL. Mebendazole in enterobiasis. Radiochemical and pilot clinical study in 1,278 subjects. JAMA 1971;217(3):313–316.

4.	Islam N, et al. S.E. Asian J Trop Med Publ Hlth 1976;7:81–84.

5.	Kammerer WS, Judge DM. Chemotherapy of hydatid disease (Echinococcus granulosus) in mice with mebendazole and bithionol. Am J Trop Med Hyg 1976;25(5):714–717.

6.	Marsboom S. Toxicol & Appl Pharmacol 1973;24:371–377.

7.	Miller MJ, et al. J Am Med Assoc 1974;230:1412–1414.

8.	Nagalingam I, Lam LE, Robinson MJ, Dissanaike AS. Mebendazole in treatment of severe Trichuris trichiura infection in Malaysian children. Am J Trop Med Hyg 1976;25(4):568–572.

9.	Chavarria AP, Swartzwelder JC, Villarejos VM, Zeledon R. Mebendazole, an effective broad-spectrum anthelmintic. Am J Trop Med Hyg 1973;22(5):592–595.

*10.*	Sargent RG, Savory AM, Mina A, Lee PR. A clinical evaluation of mebendazole in the treatment of trichuriasis. Am J Trop Med Hyg 1974;23(3):375–377.

*11.*	Soh CT, et al. Yonsei Rept Trop Med 1974;5:148–152.

*12.*	Wagner ED, Chavarria AP. In vivo effects of a new anthelmintic, mebendazole (R-17,635) on the eggs of Trichuris trichiura and hookworm. Am J Trop Med Hyg 1974;23(2):151–153.

*13.*	Wagner ED, Chavarria AP. Morphologically altered eggs of Trichuris trichiura following treatment with mebendazole. Am J Trop Med Hyg 1974;23(2):154–157.

*14.*	Wolfe MS, Wershing JM. Mebendazole. Treatment of trichuriasis and ascariasis in Bahamian children. JAMA 1974;230(10):1408–1411.

*15.*	Yokogawa M, et al. Jpn J Parasit 1976;25 1 Suppl:16.