Expermental chemotherapeutic effects of niclofolan (Bayer 9015, Bilevon) on the animals infected with <i>Paragonimus westermani</i> or <i>P. iloktsuenensis</i>

, Rim, Han Jong; , Kim, Myung Se; , Ha, Joung Hwan; , Chang, Dong Shik

doi:1976.14.2.140

Korean J Parasito > Volume 14(2):1976 > Article

Original Article


Korean J Parasitol. 1976 Dec;14(2):140-146. English. Published online Mar 20, 1994. http://dx.doi.org/10.3347/kjp.1976.14.2.140
Copyright © 1976 by The Korean Society for Parasitology


Expermental chemotherapeutic effects of niclofolan (Bayer 9015, Bilevon) on the animals infected with Paragonimus westermani or P. iloktsuenensis
Han-Jong Rim,Myung-Se Kim,Joung-Hwan Ha and Dong-Shik Chang
Department of Parasitology and Institute for Tropical Endemic Diseases, College of Medicine, Korea University, Seoul, Korea.


Abstract
The new drug niclofolan (bayer 9015, Bilevon), 5,5'-dichloro-2,2'-dihydroxy-3, 3'-dinitrobiphenyl, has been used in the treatment of Paragonimus westermani in dogs and cats and P. iloktsuenensis in rats. It was proved that administration of daily dose of 1.0 mg/kg body weight for 3 days or in 2 doses of 2.0 mg/kg body weight by alternate days were evidently effective for the infected dogs, cats and rats with the lung flukes, and toxic manifestations were not found.

Tables


	Table 1 Results of treatment with niclofolan on 4 dogs experimentally infected with Paragonimus westermani


	Table 2 Result of treatment with niclofolan on 5 cats experimentally infected with Paragonimus westermani


	Table 3 Result of treatment with niclofolan on rats experimentally infected with Paragonimus westermani

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