Pyrantel embonate and bephenium hydroxynaphthoate in the treatment of hookworm infection

, Lim, Jung Kyoo

doi:1975.13.1.19

Korean J Parasito > Volume 13(1):1975 > Article

Original Article


Korean J Parasitol. 1975 Jun;13(1):19-30. English. Published online Mar 20, 1994. http://dx.doi.org/10.3347/kjp.1975.13.1.19
Copyright © 1975 by The Korean Society for Parasitology


Pyrantel embonate and bephenium hydroxynaphthoate in the treatment of hookworm infection
Jung-Kyoo Lim,Kwang-Sa Lyu,Il Hyun,Sun-Dae Song and Han-Jong Rim
Department of Pharmacology, College of Medicine, Seoul National University, Korea.
Department of Parasitology and Institute for Tropical Endemic Diseases, College of Medicine, Korea University, Seoul, Korea.


Abstract
A total of 100 hookworm infested patients were divided into two groups. One group of 49 received pyrantel embonate in a single oral dose of 10 mg as the base per kg body weight and the other group of 51 a single oral dose of 5.0 gm bephenium hydroxynaphthoate for a comparison of efficacy on hookworm infestation and other intestinal helminths. Forty-two(85.7%) cases of hookworm treated with pyrantel embonate were cured and there was a 99.9 per cent mean reduction in fecal egg count. Of the 51 patients who received bephenium hydroxynaphthoate complete cure occurred in 76.5 per cent and the mean reduction in fecal egg count was 91.8 per cent. These results plus the lower incidence of side effects recorded in the pyrnatel group suggest that pyrantel embonate is the more desirable trestment. Pyrantel embonate was highly effective against Ascaris lumbricoides, Trichostrongylus orientalis and both drugs were moderately effective against Trichuris trichiura. During the course of the study measurements of hematology, biochemistry and examinations of urine specimens were carried out. All values were normal throughout the study and no significant difference was observed between pyrantel embonate and bephenium hydroxynaphthoate treated subjects. Side effects were more common in the bephenium hydroxynaphthoate treated group.

Tables


	Table 1 Hookworm patients detail by age and sex in the treatment with pyrantel embonate and bephenium hydroxynaphthoate


	Table 2 Incidence of polyparasitic infestation in the 100 cases of hookworm treated with pyrantel embonate and bephenium bephenium hydroxynaphthoate


	Table 3 Results of fecal egg counts, incidence and identification of the hookworm and its larvae treated with pyrantel embonate


	Table 4 Results of fecal egg counts, of incidence and identification of the hookworm and its larvae in cases treated with bephenium hydroxynaphthoate


	Table 5 The effects of treatment with a single dose of pyrantel embonate and bephenium hydroxynaphthoate against hookworm


	Table 6 Efficacy of treatment of various helminths with pyrantel embonate and bephenium hydroxynaphthoate


	Table 7 Incidence of side effects

References


1.	Ahmad N, Rasool G. Bephenium hydroxynaphthoate against hookworm in West Pakistan. J Trop Med Hyg 1959;62:284–285.

2.	Bell WJ, Gould GC. Preliminary report on pyrantel pamoate in the treatment of human hookworm infection. East Afr Med J 1971;48(4):143–151.

3.	Bumbalo TS, Fugazzotto DJ, Wyczalek JV. Treatment of enterobiasis with pyrantel pamoate. Am J Trop Med Hyg 1969;18(1):50–52.

4.	Desowitz RS, Bell T, Williams J, Cardines R, Tamarua M. Anthelmintic activity of pyrantel pamoate. Am J Trop Med Hyg 1970;19(5):775–778.

5.	Goodwin LG, Jayewardene LG, Standen OD. Clinical trials with bephenium hydroxynaphthoate against hookworm in Ceylon. Br Med J 1958;2(5112):1572–1576.

6.	Shim SH, Hyung YK, Young SH. The anthelmintic effect of bephenium hydroxynaphthoate on intestinal helminths. J Trop Med Hyg 1960;63:180–184.

7.	Hsieh HC, Brown HW, Fite M, Chow LP, Cheng CS, Hsu CC. The treatment of hookworm, Ascaris and Trichuris infections with bephenium hydroxynaphthoate. Am J Trop Med Hyg 1960;9:496–499.

8.	Hsieh HC, et al. Chinese J Microbiology 1970;3:126–131.

9.	Hsieh HC, Chen ER. Treatment of A, lumbricoides with a small dose of pyrantel pamoate (combantrin). Southeast Asian J Trop Med Public Health 1971;2(3):362–364.

*10.*	Ishizaki T, et al. Jpn J Parasit 1971;20:164–169.

*11.*	Jung RC, McCroan JE. Efficacy of bephenium and tetrachloroethylene in mass treatment of hookworm infection. Am J Trop Med Hyg 1960;9:492–495.

*12.*	Kobayashi A, et al. Jpn J Parasit 1970;19:296–300.

*13.*	Kobayashi A, et al. Jpn J Parasit 1971;20:52–57.

*14.*	Nagaty HF, Rifaat MA. Clinical trials with bephenium hydroxynaphthoate against Ancylostoma duodenale and other helminthic infestations. J Trop Med Hyg 1959;62:255–258.

*15.*	Rim HJ, Lim JK. Treatment of enterobiasis and ascariasis with Combantrin (pyrantel pamoate). Trans R Soc Trop Med Hyg 1972;66(1):170–175.

*16.*	Rim HJ, et al. Asian J of Med 1973;9:393–396.

*17.*	Rim HJ, Ha JH, Lee JS, Hyun I, Uh KB. Pyrantel embonate in mass treatment of ascariasis and comparison with piperazine adipate and santonin-kainic acid complex. Korean J Parasitol 1974;12(2):141–146.

*18.*	Sato A, et al. Jpn J Parasit 1973;22:331–337.

*19.*	Tsuji M, et al. Shindan to Shinyaku 1971;8:543–551.

*20.*	Yokogawa M, et al. Jpn J Parasit 1970;19:301–306.

*21.*	Young MD, Jeffery GM, Freed JE, Morehouse WG. Bephenium, a new drug active against human hookworm. J Parasitol 1958;44(6):611–612.

*22.*	Young MD, Jeffery GM, Morehouse WG, Freed JE, Johnson RS. The comparative efficacy of bephenium hydroxynaphthoate and tetrachloroethylene against hook-worm and other parasites of man. Am J Trop Med Hyg 1960;9:488–491.