Clinical trial of Tinidazole (Fasigyn) in acute and chronic intestinal amoebiasis

, Lim, Jung Kyoo

doi:1974.12.2.135

Korean J Parasito > Volume 12(2):1974 > Article

Original Article


Korean J Parasitol. 1974 Dec;12(2):135-140. English. Published online Mar 20, 1994. http://dx.doi.org/10.3347/kjp.1974.12.2.135
Copyright © 1974 by The Korean Society for Parasitology


Clinical trial of Tinidazole (Fasigyn) in acute and chronic intestinal amoebiasis
Jung-Kyoo Lim
Department of Pharmacology, College of Medicine, Seoul National University, Korea.



Abstract
Tinidazole (Fasigyn), a new drug which is active in vitro and in vivo against Entamoeba histolytica, was used in 30 Korean patients with acute and chronic intestinal amoebiasis. In aute amoebic dysentry eight of ten patients given tinidazole 150 mg q.i.d. for 10 days were cured clinically and parasitologically. In chronic intestinal amoebiasis, the parasitological cure was obtained 6 out of 10 patients given150 mg q.i.d. for 10 days and 8 out of 10 in patients given 300 mg q.i.d. for 7 days. Tinidazole is well tolerated and is free from serious toxicity. There was no significant alteration in blood count, liver function tests and urine analysis of any of the patients treated with tinidazole.

Tables


	Table 1 Incidence of intestinal protozoa on a group of 370 rural inhabitants in Korea.


	Table 2 Results of treatment with tinidazole.

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