Host-parasite relationship in trematodes I. Susceptability and development of Clonorchis sinensis in rabbits

, Lee, Won Koo; , Lee, Kyu Myon; , Lee, Ok Ran; , Choi, Won Young

doi:1973.11.2.76

Korean J Parasito > Volume 11(2):1973 > Article

Original Article


Korean J Parasitol. 1973 Aug;11(2):76-82. English. Published online Mar 20, 1994. http://dx.doi.org/10.3347/kjp.1973.11.2.76
Copyright © 1973 by The Korean Society for Parasitology


Host-parasite relationship in trematodes I. Susceptability and development of Clonorchis sinensis in rabbits
W. K. Lee,K. M. Lee,O. R. Lee and W. Y. Choi
Department of Parasitology, Catholic Medical College, Seoul, Korea.


Abstract
In order to study host-parasite relationship in trematode, the susceptibility in rabbits of Clonorchis sinensis were examined. A certain number of metacercariae of C. sinensis were administered orally to rabbits, and rats and dogs were used to compare with rabbits. The results were summerized as follows: 1) The rabbits were successfully infected with metacercariae of C. sinensis in all case of the groups given 10 to 500 each. But the highest recovery rate of the worm was 33.0% in the case given 100 metacercariae. 2) In the early stage of infection, the worms were hardly found, but 10 days after the infection, the number of worms were detected easily. Three months after the infection, the recovery rate of worms was 31.3% in the rabbits given 300 metacercariae. 3) The recovery rates of the worms in two months after the infection were 27.4% in rabbits, 51.0% in rats and 54.6% in dogs. 4) Morphologically the body length and the body width markedly increased in the period until 10 days after the infection, and after that the genital organs began to get mature gradually while the growth of the body showed down. 5) The measurement of adult C. sinensis recovered from the animals two months after the infection was the largest in rabbits followed by rats and the worms from dogs showed the smallest measurement.

Figures


	Fig. 1 Development of body length and body width in rabbits at various periods of infections


	Explanation of Figures Fig. 1: Excysted metacercaria Fig. 2: 1 day old worm Fig. 3: 3 day old worm Fig. 4: 7 day old worm, anterior part Fig. 5: 10 day old worm, anterior part Fig. 6: 15 day old worm, middle part, showing eggs in uterus Fig. 7: 20 day old worm, middle part Fig. 8: 30 day worm, middle part

Tables


	Table 1 Recovery rates of the worms in rabbits fed with various number of metacercariae of C. sinensis during the period from one to three months after infection


	Table 2 Comparison of the recovery rates of C. sinensis in rabbits fed with 300 metacercariae from various periods after infection


	Table 3 Mean measurement of the worms obtained from various animals infected with C. sinensis two months after infection


	Table 4 Mean measurement of the worms in rabbits fed with 300 metacercariae of C. sinensis from various periods after infection Unit: mm


	Table 5 Mean measurement of the worms recovered from the rabbits infected with various of Clonorchis sinensis metacercaria

References


1.	Sheung-To C, Gibson JB. The histochemistry of biliary mucins and the changes caused by infestation with Clonorchis sinensis. J Pathol 1970;101(2):185–197.

2.	Faust EC, et al. Am J Hyg Monographic series 1927;8:1–207.

3.	Hsu HF, et al. Chin Med J 1938;2 Suppl:385–400.

4.	Komiya Y, et al. Jpn J Med Sci & Biol 1953;6:571–575.

5.	Seo BS. Seoul Univ J Nat Sci 1958;7:1–15.

6.	Wykoff DE. Studies on Clonorchis sinensis. III. The host-parasite relations in the rabbit and observations on the relative susceptibility of certain laboratory hosts. J Parasitol 1958;44(5):461–466.