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Original Article

Microarray Analysis of Differentially Expressed Genes between Cysts and Trophozoites of Acanthamoeba castellanii

Eun-Kyung Moon1, Ying-Hua Xuan2, Dong-Il Chung1, Yeonchul Hong1, Hyun-Hee Kong1
The Korean Journal of Parasitology 2011;49(4):341-347.
Published online: December 16, 2011

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Corresponding author (hhkong@mail.knu.ac.kr)
• Received: July 28, 2011   • Revised: September 6, 2011   • Accepted: September 9, 2011

© 2011, Korean Society for Parasitology

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Microarray Analysis of Differentially Expressed Genes between Cysts and Trophozoites of Acanthamoeba castellanii
Korean J Parasitol. 2011;49(4):341-347.   Published online December 16, 2011
DOI: https://doi.org/10.3347/kjp.2011.49.4.341
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Microarray Analysis of Differentially Expressed Genes between Cysts and Trophozoites of Acanthamoeba castellanii
Korean J Parasitol. 2011;49(4):341-347.   Published online December 16, 2011
DOI: https://doi.org/10.3347/kjp.2011.49.4.341
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Microarray Analysis of Differentially Expressed Genes between Cysts and Trophozoites of Acanthamoeba castellanii
Image
Fig. 1 Comparison of gene expression by microarray and KOG analysis. Cyst up-regulated genes showed higher percentages in A, D, T, W, U, O, and F articles. In J, C, and Z (cytoskeleton) articles, cyst genes were down-regulated.

Fig. 1

Microarray Analysis of Differentially Expressed Genes between Cysts and Trophozoites of Acanthamoeba castellanii
KOG category No. of genes (%)
Cyst-high Troph-high Information storage and processing  J Translation, ribosomal structure and biogenesis 28 (3.99) 135 (15.72)  A RNA processing and modification 27 (3.85) 22 (2.56)  K Transcription 10 (1.43) 11 (1.28)  L Replication, recombination and repair 1 (0.14) 4 (0.47)  B Chromatin structure and dynamics 3 (0.43) 9 (1.05) Metabolism  C Energy production and conversion 14 (2.00) 67 (7.80)  G Carbohydrate transport and metabolism 12 (1.71) 26 (3.03)  E Amino acid transport and metabolism 9 (1.28) 25 (2.91)  F Nucleotide transport and metabolism 17 (1.40) 13 (1.51)  H Coenzyme transport and metabolism 0 (0.00) 11 (1.28)  I Lipid transport and metabolism 12 (1.71) 23 (2.68)  P Inorganic ion transport and metabolism 7 (1.00) 5 (0.28)  Q Secondary metabolites biosynthesis, transport and metabolism 5 (0.71) 12 (1.40) Cellular process and signaling  D Cell cycle control, cell division, chromosome partitioning 7 (1.00) 5 (0.58)  Y Nuclear structure 0 (0.00) 1 (0.12)  V Defense mechanisms 3 (0.43) 2 (0.23)  T Signal transduction mechanisms 36 (5.14) 23 (2.68)  M Cell wall/membrane/envelope biogenesis 3 (0.43) 0 (0.00)  N Cell motility 0 (0.00) 0 (0.00)  Z Cytoskeleton 6 (0.86) 39 (4.54)  W Extracellular structures 16 (2.28) 12 (1.40)  U Intracellular trafficking, secretion, and vesicular transport 25 (3.57) 15 (1.75)  O Posttranslational modification, protein turnover, chaperones 39 (5.56) 30 (3.49) Poorly characterized  R General function prediction only 33 (4.71) 37 (4.31)  S Function unknown 7 (1.00) 13 (1.51) Not classified 381 (54.35) 319 (37.14) Total 701 (100.00) 859 (100.00) ID Probe comment Fold difference
Primer sequence Microarray Real-time PCR NC0115-T3 Cysteine proteinase; ACCP2 282.38 1,384 F: 5´-AAC AGC ACG CTC GTT TCC CTC T-3´ R: 5´-GTA GTT GGC CTC CGT CAT GAG CTT-3´ ACL00008706 Catalase related cluster 56.30 11.0 F: 5´-ATC GCA CAC ACA CCA CAC TTT C-3´ R: 5´-CAA CGG AGC ACA AGA GAA CAA A-3´ NC0392-T3 Proteophosphoglycan ppg4 31.21 137.19 F: 5´-TCA TCA TCA CCT CGC TAC ACC A-3´ R: 5´-TAG TTG CAG GTG CGT TCG AGA-3´ NC0903-T3 Arginase II 9.27 20.25 F: 5´-CTC AAG GAG CTA GAC GGT GGA A-3´ R: 5´-TAG GTG TCG AGA AGG CCA GAG A-3´ AC-T0782-T3 Cyst specific protein CSP21 5.19 24.95 F: 5´-GAG AAG TAC GGC AAC GTG GAG A-3´ R: 5´-GCA TAG AGC AGG CGT TCA ACA-3´ ACL00008536 Dipeptidyl peptidase IV cluster 4.64 4.06 F: 5´-ACT GGC GAC ACA CCG TCT ATC T-3´ R: 5´-TGC GCG AGG AAT CAA CAA A-3´ NC0224 Protein serine/threonine kinase 3.85 8.17 F: 5´-CCA CAT CAA CCA AAT CAC CGA-3´ R: 5´-CGC ATA ACC GAA CAT CAT CCA-3´ ACL00001979 Ubiquitin 3.69 13.27 F: 5´-ACA CAC AAG CCA GCA ATG CA-3´ R: 5´-AAG TGG TGG AGG AAA CAC GCT-3´ AC-C0063 Heat shock protein 2.8 3.41 F: 5´-GAC CGA CGG CAA TAA ACT CGT-3´ R: 5´-TCG CTG CAC CAA CAG ATT CTC-3´ ID Probe comment KOG Fold (Cyst/troph) NC0115-T3 Cysteine proteinase; ACCP2 O 282.38 NC0961-T3 Cysteine proteinase; ACCP2 O 273.54 AC-T0581-T3 Similar to elaC homology R 80.82 ACE00000784 - - 73.39 ACL00003940 Herpes_BLLF1 multi-domain protein - 60.94 ACL00008706 Catalase related cluster AR 56.30 NC0692-T3 Extracellular endoglucanase WV 54.94 NC0680-T3 - - 53.32 ACL00002157 - - 48.23 NC0642-T3 - - 41.34 NC0757-T3 - - 38.91 ACL00003760 - - 36.86 ACL00009010 - - 36.09 ACL00004491 - - 33.26 NC0678-T3 - - 31.73 NC0457-T3 - - 31.72 NC0392-T3 Proteophosphoglycan ppg4 - 31.21 AC-C0617-T3 SJCHGC01975 protein O 29.79 ACL00008637 Novel protein related cluster U 27.80 NC0271-T3 Salivary gland secretion 1 CG3047-PA - 27.04 NC0289-T3 - - 26.25 NC0423-T3 Proteophosphoglycan 5 - 23.32 ACL00004246 - - 23.31 NC0956-T3 Similar to serine/arginine repetitive matrix 1 - 22.54 NC0802-T3 Proteophosphoglycan 5 WV 21.72 ACL00002714 Dynamin B precursor related cluster UR 21.23 NC0276-T3 Similar to conserved hypothetical protein T 20.90 ACE00001346 Similar to molecular chaperone (HSP90 family) O 20.34 NC0283-T3 Proteophosphoglycan ppg4 - 19.68 ACL00008639 Herpes_gp2 multi-domain protein - 19.22 NC0994-T3 Proteophosphoglycan 5 - 19.13 NC0807-T3 Antifreeze glycoprotein - 18.43 NC0791-T3 Hypothetical protein Kpol_1072p54 DO 17.66 ACL00002613 - - 17.13 NC1140-T3 Proteophosphoglycan ppg4 - 16.94 NC0582-T3 - - 16.92 ACL00002232 - - 16.50 ACL00002108 Transcription factor TFIIF K 15.49 NC0747-T3 Pseudogene - 15.27 NC0325-T3 Proteophosphoglycan ppg4 - 15.07 NC1103-T3 Proteophosphoglycan ppg4 - 14.95 AC-T0529-T3 - - 14.77 ACL00002483 - - 14.58 AC-T0879-T3 Iron-sulfur cluster assembly fam... CU 14.54 NC0896-T3 Proteophosphoglycan ppg4 - 14.53 ACL00001119 trEST Trithorax protein related cluster R 13.83 NC0987-T3 Palmitoyl-protein thioesterase 3 IO 13.77 NC0591-T3 Similar to scavenger receptor class F, member 2, partial WV 13.70 NC0780-T3 Hemerythrin HHE cation binding domain-containing protein - 13.63 ACL00008833 Extensin_2 multi-domain protein T 12.98 ACL00008542 - - 12.47 ACL00009103 - - 12.34 ACL00009220 - - 11.76 NC0721-T3 LigA - 11.57 NC0626-T3 Proteophosphoglycan 5 A 11.57 ACL00000192 Ubiquitin OR 11.03 NC1049-T3 Antifreeze glycoprotein - 10.89 ACL00008353 Tymo_45kd_70kd multi-domain protein WV 10.73 NC0528-T3 BTB/POZ domain-containing protein - 10.62 ACL00002099 Putative 5-3 exoribonuclease related cluster LA 10.47 ACL00008536 Dipeptidyl peptidase IV related cluster O 10.46 ACL00003598 trEST Herpes_UL56 multi-domain protein - 10.35 ACL00004676 - - 10.27 AC-T0408-T3 Histone H3 B 10.16 NC0574-T3 Hypothetical protein MGG_00576 - 10.10 ACL00000775 Unknown (eubacterial similarity) - 10.05
Table 1. KOG analysis of cyst and trophozoite genes up-regulated more than 2 folds
Table 2. Real-time PCR analysis of selected genes based on the microarray results
Table 3. The list of genes that showed high expression changes more than 10 fold in cysts

Table 1.

Table 2.

Table 3.

PHD : Parasites, Hosts and Diseases

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