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Original Article

Anti-Apoptotic Effects of SERPIN B3 and B4 via STAT6 Activation in Macrophages after Infection with Toxoplasma gondii

Kyoung Ju Song1,†,‡, Hye-Jin Ahn1,2,†, Ho-Woo Nam1,2
The Korean Journal of Parasitology 2012;50(1):1-6.
Published online: March 6, 2012

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Corresponding author (howoo@catholic.ac.kr)

†Kyoung Ju Song and Hye-Jin Ahn equally contributed as the first author.


‡Present Address: Department of Environmental Medical Biology, Institute of Tropical Medicine, Yonsei University College of Medicine, Seoul 120-752, Korea.

• Received: October 31, 2011   • Revised: December 13, 2011   • Accepted: December 19, 2011

© 2012, Korean Society for Parasitology

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Anti-Apoptotic Effects of SERPIN B3 and B4 via STAT6 Activation in Macrophages after Infection with Toxoplasma gondii
Korean J Parasitol. 2012;50(1):1-6.   Published online March 6, 2012
DOI: https://doi.org/10.3347/kjp.2012.50.1.1
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Anti-Apoptotic Effects of SERPIN B3 and B4 via STAT6 Activation in Macrophages after Infection with Toxoplasma gondii
Korean J Parasitol. 2012;50(1):1-6.   Published online March 6, 2012
DOI: https://doi.org/10.3347/kjp.2012.50.1.1
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Anti-Apoptotic Effects of SERPIN B3 and B4 via STAT6 Activation in Macrophages after Infection with Toxoplasma gondii
Image Image Image Image
Fig. 1 Expression of SERPIN B3 and B4 in various host cells. Expression of mRNA of SERPIN B4 and B4 in T. gondii infected or uninfected host cells (A). HeLa (cervix adenocarcinoma, epithelial), A549 (lung carcinoma, epithelial), Jurkat T (acute T cell lymphoma, T lymphocyte, lymphoblast), U937 (histiocytic lymphoma, histocyte, monocyte), THP-1 (peripheral blood, acute monocytic leukemia or macrophage) were tested. RT-PCR (B) and western blot (C) of induced SERPIN B3 and B4 in macrophage-differentiated THP-1 cells by time course. SCCA1/2 indicates SERIPN B3/B4 detectable antibody.
Fig. 2 Inhibitory relationship between SERPIN B3 or B4 and STAT6. Inhibitory effects of various si-SERPIN B3 or B4 RNAs or si-STAT6 in transcriptional level of SERPIN B 3 and B4 genes (A). Inhibitory effects of si-STAT6 and si-SERPIN B3/B4 mix in m-RNA level (B) and protein level of SERPIN B3 and B4 (C). Blank bar indicates control host cells, black bar by T. gondii infection only, dark grey bar with siSTAT6 under T. gondii infection, and bright grey bar with siSERPIN B3/B4 under T. gondii infection, respectively.
Fig. 3 Anti-apoptotic effects of SERPIN B3/B4 and T. gondii infection in macrophages after induction of apoptosis by staurosporine. The transcriptional level of SERPIN B3 and B4 was affected by the concentration of staurosporine (A). DNA fragmentation (B), activation of caspase-3 and cleavage of PARP (B) were measured in macrophages. SCCA1/2 indicates SERIPN B3/B4 detectable antibody and β-actin was used as control.
Fig. 4 Effects of anti-apoptosis in HeLa cells by expression of SERPIN B3 and B4. Over-expression of SERPIN B3 or B4 in macrophages was confirmed in fluorescent photographs (A) of which RH(+) indicates T. gondii infection. Activation of caspase-3, cleavage of PARP, and SCCA1/2 expression in untransfected HeLa cells (B) and in transfected HeLa cells (C). pDsSERPIN B3/4 indicates pDsRed-SERPIN B3 and pDsRed-SERPIN B4 co-transfected HeLa cells.

Fig. 1

Fig. 2

Fig. 3

Fig. 4

Anti-Apoptotic Effects of SERPIN B3 and B4 via STAT6 Activation in Macrophages after Infection with Toxoplasma gondii
SERPINB3-1 (RNA) -AUA UCC ACC AUU CCC AUG GUU CUC A (RNA) -UGA GAA CCA UGG GAA UGG UGG AUA A SERPINB3-2 (RNA) -UUA UUA AAU UUC UUC UCC CAC UGC C (RNA) -GGC AGU GGG AGA AGA AAU UUA AUA A SERPINB3-3 (RNA) -UGG ACU UGU AUG UAU UCU UGU UUG G (RNA) -CCA AAC AAG AAU ACA UAC AAG UCC A SERPINB4-1 (RNA) -AAA UUU AUU CUC CCA CUG CCC UUU G (RNA) -CAA AGG GCA GUG GGA GAA UAA AUU U SERPINB4-2 (RNA) -AGA UUU GUA UGU AUU CUU GUU UGG C (RNA) -GCC AAA CAA GAA UAC AUA CAA AUC U SERPINB4-3 (RNA) -AUC GAC ACA UGU CUC UCU CAU AUU C (RNA) -GAA UAG GAG AGA GAC AUG UGU CGA U
Table 1. The si-RNAs designed and tested for inhibition of SERPIN B3 and B4

Table 1.

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