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Brief Communication

Effects of Mannose on Pathogenesis of Acanthamoeba castellanii

Kyung-Tae Yoo1, Suk-Yul Jung2
The Korean Journal of Parasitology 2012;50(4):365-369.
Published online: November 26, 2012

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Corresponding author (syjung@nsu.ac.kr)
• Received: March 3, 2012   • Revised: May 30, 2012   • Accepted: July 5, 2012

© 2012, Korean Society for Parasitology and Tropical Medicine

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Effects of Mannose on Pathogenesis of Acanthamoeba castellanii
Korean J Parasitol. 2012;50(4):365-369.   Published online November 26, 2012
DOI: https://doi.org/10.3347/kjp.2012.50.4.365
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Effects of Mannose on Pathogenesis of Acanthamoeba castellanii
Korean J Parasitol. 2012;50(4):365-369.   Published online November 26, 2012
DOI: https://doi.org/10.3347/kjp.2012.50.4.365
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Effects of Mannose on Pathogenesis of Acanthamoeba castellanii
Image Image Image
Fig. 1 Morphologic changes of A. castellanii trophozoites by adding mannose. Mannose was added to the amoebae for 24 hr, resulting in 1 cycle. At the end of 20 cycles, the following resultant amoebae were obtained. (A) control group, (B) glucose-treated amoebae, and (C) mannose-treated amoebae. Arrows indicates larger vacuoles in cytoplasm of mannose-selected amoebae. ×250.
Fig. 2 Adhesion and cytotoxicity assay of mannose-selected A. castellanii trophozoites to CHO cells. After mannose-selected amoebae (MS) were incubated with CHO cells for 1 hr at 37℃, adhesion assays were performed (A). Also, they were pre-incubated with exogenous saccharides for 1 hr and then added to CHO cells for 1 hr as mentioned in materials and methods. Cytotoxicity was measured post co-incubation of 24 hr (B). Results are representative of 3 independent experiments performed in triplicate. Asterisks indicate a significant difference, i.e., P<0.05, using the paired t-test, one-tail distribution.
Fig. 3 Phagocytosis of mannose-selected A. castellanii trophozoites using non-invasive E. coli K12. To determine the role of a mannose-binding protein in mannose-selected amoebae (MS), phagocytosis assays were performed. (A) represents bacterial association with amoebae and (B) represents ratio of bacteria per amoeba. Results are representative of 3 independent experiments performed in triplicate. Asterisks indicate a significant difference, i.e., P<0.05, using the paired t-test, one-tail distribution.

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Effects of Mannose on Pathogenesis of Acanthamoeba castellanii
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