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Original Article

Effect of Diclazuril on the Bursa of Fabricius Morphology and SIgA Expression in Chickens Infected with Eimeria tenella

Bian-hua Zhou1,*, Li-li Liu1, Jeffrey Liu2, Fu-wei Yuan1, Er-jie Tian1, Hong-wei Wang1
The Korean Journal of Parasitology 2015;53(6):675-682.
Published online: December 31, 2015

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*Corresponding author (haustzbh@163.com)
• Received: April 25, 2015   • Revised: October 7, 2015   • Accepted: October 17, 2015

© 2015, Korean Society for Parasitology and Tropical Medicine

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Effect of Diclazuril on the Bursa of Fabricius Morphology and SIgA Expression in Chickens Infected with Eimeria tenella
Korean J Parasitol. 2015;53(6):675-682.   Published online December 31, 2015
DOI: https://doi.org/10.3347/kjp.2015.53.6.675
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Effect of Diclazuril on the Bursa of Fabricius Morphology and SIgA Expression in Chickens Infected with Eimeria tenella
Korean J Parasitol. 2015;53(6):675-682.   Published online December 31, 2015
DOI: https://doi.org/10.3347/kjp.2015.53.6.675
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Effect of Diclazuril on the Bursa of Fabricius Morphology and SIgA Expression in Chickens Infected with Eimeria tenella
Image Image Image Image
Fig. 1. Morphological changes in BF tissue analyzed by HE. The normal control group (A, 100× and B, 400×); the diclazuril group (C, 100× and D, 400×); the infected and untreated group (E, 100× and F, 400×); and the infected and treated group (G, 100× and H, 400×).
Fig. 2. TEM observation of BF. The circumscriptions among ordered cells were clear. The BF cells have an ovoid or sometimes irregular nucleus with nucleoli occupying a central position in the normal control group (A). There are no any obvious changes in the diclazuril group (B). Compared with the normal control group, the BF cells became smaller in volume and even irregularly arranged in the infected and untreated group (C). With the administration of diclazuril, the injury of cells was lessened and partially injured cell-membranes became visible in the infected and treated group (D). Nu, nucleus; NM, nuclear membrane; Ch, chromosome; IS, intercellular space.
Fig. 3. SIgA expression analysis by immunohistochemistry. In the normal control group (A, 100× and B, 400×) and the diclazuril group (C, 100× and D, 400×), only a few SIgA positive cells were distributed in the lymphoid follicular cortex. In the infected and untreated group, SIgA positive cells were present in the epithelium mucosae and the cortex and medulla of lymphoid follicles (E, 100× and F, 400×). Relatively fewer positive SIgA cells were seen in the epithelium and the cortex in the infected and treated group (G, 100× and H, 400×). Arrows indicate the SIgA positive cells.
Fig. 4. SIgA relative expression in BF. aP<0.01: compared to the normal control group, the positive cells that secrete SIgA were increased significantly by 350.4% in the infected and untreated group. bP<0.01: With the treatment of diclazuril, SIgA expression was significantly decreased by 46.7% compared with the infected and untreated group.

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Fig. 3.

Fig. 4.

Effect of Diclazuril on the Bursa of Fabricius Morphology and SIgA Expression in Chickens Infected with Eimeria tenella
PHD : Parasites, Hosts and Diseases

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