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Original Article

Neuronal Apoptosis: Pathological Basis of Behavioral Dysfunctions Induced by Angiostrongylus cantonensis in Rodents Model

Shiqi Luo1,2,3, Lisi OuYang4,*, Jie Wei5, Feng Wu6, Zhongdao Wu1,2,3, Wanlong Lei4, Dongjuan Yuan1,2,3,*
The Korean Journal of Parasitology 2017;55(3):267-278.
Published online: June 30, 2017

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4Department of Anatomy, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, 510080, China

5Department of Clinical Laboratory, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510260, China

6Department of Clinical Laboratory, the Sixth Affiliated Hospital, Sun Yat-sen University, Guangdong, Guangzhou 510655, China

*Corresponding authors (409728693@qq.com; dongjuanyuan@foxmail.com)
• Received: May 6, 2017   • Revised: May 24, 2017   • Accepted: May 25, 2017

Copyright © 2017 by The Korean Society for Parasitology and Tropical Medicine

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Neuronal Apoptosis: Pathological Basis of Behavioral Dysfunctions Induced by Angiostrongylus cantonensis in Rodents Model
Korean J Parasitol. 2017;55(3):267-278.   Published online June 30, 2017
DOI: https://doi.org/10.3347/kjp.2017.55.3.267
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Neuronal Apoptosis: Pathological Basis of Behavioral Dysfunctions Induced by Angiostrongylus cantonensis in Rodents Model
Korean J Parasitol. 2017;55(3):267-278.   Published online June 30, 2017
DOI: https://doi.org/10.3347/kjp.2017.55.3.267
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Neuronal Apoptosis: Pathological Basis of Behavioral Dysfunctions Induced by Angiostrongylus cantonensis in Rodents Model
Image Image Image Image Image Image
Fig. 1 Comparison of balance beam, foot slip, and grip strength for the infected rats and mice in balance-beam tasks. (A) Comparative analysis of completion time for balance-beam task of infected rats and mice. (B) Comparative analysis of foot slip for experimental rats and mice on completing the balance-beam task. (C) Comparative analysis of hang time for grip strength task of infected rats and mice. *: comparison between infection groups and control group, P<0.05. ★: comparison among the different infectious stages, P<0.05.▲: comparison between rats and mice, P<0.05.
Fig. 2 MWMT of rats and mice at different time points. (A-A″, B-B″) The tracks of spatial learning in MWMT for rats and mice, respectively. (C-C″, D-D″) The tracks of probe trail for rats and mice in MWMT, respectively. Bar-graphs B* and D* show the comparative analysis of the MWMT, from which the significant declines of spatial learning and memory abilities in infected mice are shown compared with the controls. *: comparison between the infectious groups and the control group, P<0.05.★: comparison among the different infectious stages, P<0.05.
Fig. 3 HE and immunohistochemical staining of the cerebral cortex and hippocampus of infected rats and mice. (A, B) HE staining of the cerebral cortex showing the plaque-like lesion and infiltration of inflammatory cells (white star), perivascular cuffing of inflammatory cells. (C, D) HE staining of the hippocampus showing the dilated vessels (black arrowheads), plaque-like lesion, and infiltration of inflammatory cells (white star). (A′, B′) Immunohistochemical staining for NeuN in the cerebral cortex showing loss of neurons (black star). (C′, D′) Immunohistochemical staining for NeuN in the hippocampus showing the blebbing in neurons, nucleus condensing, and cell shrinkage (black arrowheads) compared with normal neuron (white arrowheads). The magnification of the images saw the scale at their right bottom. Ctx: cortex; Hip: hippocampus.
Fig. 4 Transcriptomic analysis of expression pattern of the apoptotic pathways in infected mouse brain in different time points. Key genes of interest corresponding to the apoptosis profiling are divided into intrinsic and extrinsic pathways. Different time points of transcriptomic expression pattern in infected mouse brain are shown in the gradient heat map from blue (−10 fold) to red (5 fold) with baseline from 10–1 to 103.
Fig. 5 Immunohistochemistry for caspase-3 and double-labeling for NeuN and caspase-3 in cerebral cortex and hippocampus of the infected rats and mice. (A-A′, B-B′) Caspase-3 positive cells (black arrowheads) shown in the cerebral cortex and hippocampus of rats (A and B) and mice (A′ and B′) (star means the plaque-like lesions). (C-C″ to F-F″) The double-labeling for NeuN and caspase-3 in the hippocampus and cerebral cortex of rats and mice (white arrowhead means neurons labeled by caspase-3). Ctx: cortex; Hip: hippocampus.
Fig. 6 Protein expression levels of caspase-3 and cleaved-caspase-3 in the cerebral cortex and hippocampus of the infected rats and mice. Relative density shows the caspase-3 expression level in rats and mice with A. cantonensis. β-actin acted as the control. *P<0.05.

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Neuronal Apoptosis: Pathological Basis of Behavioral Dysfunctions Induced by Angiostrongylus cantonensis in Rodents Model
PHD : Parasites, Hosts and Diseases

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