Abstract
A human Echinostoma hortense infection was diagnosed by gastroduodenoscopy. An 81-year-old Korean male, living in Yeongcheon-shi, Gyeongsangbuk-do and with epigastric discomfort of several days duration, was subjected to upper gastrointestinal endoscopy. He was in the habit of eating fresh water fish. Two live worms were found in the duodenal bulb area and were removed using an endoscopic forcep. Based on their morphological characteristics, the worms were identified as E. hortense. The patient was treated with praziquantel 10 mg/kg as a single dose. The source of the infection in this case remains unclear, but the fresh water fish consumed, including the loach, may have been the source. This is the second case of E. hortense infection diagnosed by endoscopy in Korea.
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Key words: Echinostomiasis, gastrointestinal endoscopy
Members of the family Echinostomatidae are zoonotic flukes, which infect birds and mammals including humans. Human infections by the echinostomatid flukes, i.e.
Echinostoma hortense,
E. cinetorchis,
Echinochasmus japonicus, and
Acanthoparyphium tyosenense, have been reported in Korea (
Seo et al., 1983;
Ryang et al., 1986;
Ahn and Ryang, 1986). Of the four species,
E. hortense is the most frequently reported to be a causative fluke (
Chai and Lee, 2002). Endemic foci of
E. hortense have been previously reported in Umsong-gun, Chungchongbuk-do (
We, 1987) and Chongsong-gun, Kyongsangbuk-do (
Lee et al., 1988).
An 81-year-old Korean male, living in Yeongcheon-shi, Gyeongsangbuk-do, was admitted to the outpatient's department of Internal Medicine, Kyungpook National University Hospital. The patient complained of epigastric discomfort of several days duration. No significant abnormality was detected by laboratory findings. He was in the habit of eating raw fresh water fish. Gastroduodenal endoscopy revealed two live worms in the duodenal bulb area; the mucosa of which showed mild erosion (
Fig. 1). The worms were picked out with an endoscopic biopsy forcep and transported to the Department of Parasitology, Kyungpook National University School of Medicine, where they were fixed in 70% ethanol and stained with Semichon's acetocarmine. They were very slender (7.92 × 1.33 mm), and had a characteristic head crown equipped with 27 collar spines around the subterminal oral sucker (
Fig. 2A and B). The ventral sucker (0.68 × 0.77 mm) was positioned at the anterior 1/3 of the body and was much larger than the oral sucker (0.25 × 0.26 mm). The uterus was distended and contained thin-shelled elliptical eggs. A spontaneously discharged egg (124.3 × 68.6 µm) had an operculum at the narrower end and a well-defined germ ball (
Fig. 2C). Two testes were distinct, slightly lobulated, and located in tandem at the equatorial portion. The worms were identified as
E. hortense by morphological characteristics and measurements.
The symptoms of echinostomiasis vary from none to abdominal pain, although a case in Korea showed duodenal ulceration (
Chai et al., 1994). Because of high incidence of stomach cancer and ulcer in Korea, many senior citizens with gastrointestinal symptoms are subjected to endoscopic examinations.
Echinostoma hortense can be easily demonstrated by gastroduodenoscopy due to its habitat in the upper small intestine and its relatively large size. The present case is the second Korean case of
E. hortense infection, which was diagnosed by gastroduodenoscopy (
Chai et al., 1994). Four cases diagnosed by endoscopy have been reported in Japan (
Hamamoto et al., 1997).
The source of the infection in this case is unclear. Many senior residents of inland areas of Gyeongsangbuk-do eat raw fresh water fish, including loaches, a known source of human infection. An epizootiological survey in the Yeongcheon area should be performed to determine the sources of human infection. The residence of this patient was Yeongcheon-shi neighboring Cheongsong-gun, which has been reported to be one of the endemic foci of
E. hortense. Yeongcheon-shi and Cheongsong-gun are inlands of Gyeongsangbuk-do and contain upper reaches of the Nakdong-gang (river). The geographic characteristics of both localities coincide well with the indications of Chai and Lee (
2002), namely, that
E. hortense is distributed inland along the upper reaches of large rivers. Therefore, to confirm Yeongcheon-shi as an endemic area of
E. hortense, an epidemiological survey of this fluke should be undertaken.
References
- 1. Ahn YK, Ryang YS. Experimental and epidemiological studies on the life cycle of Echinostoma hortense Asada, 1926 (Trematoda: Echinostomatidae). Korean J Parasitol 1986;24:121-136.
- 2. Chai JY, Lee SH. Food-borne intestinal trematode infections in the Republic of Korea. Parasitol Int 2002;51:129-154.
- 3. Chai JY, Hong ST, Lee SH, Lee GC, Min YI. A case of echinostomiasis with ulcerative lesions in the duodenum. Korean J Parasitol 1994;32:201-204.
- 4. Hamamoto T, Kawasaki H, Maejima J, Hirai K. A case of Echinostoma hortense infection diagnosed by the upper gastrointestinal endoscopy. Nippon Shokakibyo Gakkai Zasshi 1997;94:487-491.
- 5. Lee SK, Chung NS, Ko IH, et al. An epidemiological survey of Echinostoma hortense infectin in Chongsong-gun, Kyongbuk Province. Korean J Parasitol 1988;26:199-206.
- 6. Ryang YS, Ahn YK, Kim WT, Shin KC, Lee KW, Kim TS. Two cases of human infection by Echinostoma cinetorchis. Korean J Parasitol 1986;24:71-76.
- 7. Seo BS, Hong ST, Chai JY, Lee SH. Studies on intestinal trematodes in Korea VIII. A human case of Echinostoma hortense infection. Korean J Parasitol 1983;21:219-223.
- 8. We JS. Prevalence of intestinal helminthiasies in some residents at Umsong-gun, Chungchongbuk-do, and detection of metacercariae from fresh water fish. 1987, Seoul National University; Dissertation for Master of Science (MSc) in Medicine.
Fig. 1Endoscopic images of two live parasitic worms in the patient's duodenal bulb.
Fig. 2Ventral view of an adult Echinostoma hortense stained with Semichon's acetocarmine (A), drawing of the head collar spines (B), and an egg (C).
Citations
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Frontiers in Medicine.2025;[Epub] CrossRef - Parasitic Diseases of Upper Gastrointestinal Tract
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Parasitology International.2019; 69: 39. CrossRef - Human echinostomiasis: a case report
Ranjit Sah, Shusila Khadka, Rabin Hamal, Sagar Poudyal
BMC Research Notes.2018;[Epub] CrossRef - Infection Status of Isthmiophora hortensis Metacercariae in Dark Sleepers, Odontobutis Species, from Some Water Systems of the Republic of Korea
Woon-Mok Sohn, Byoung-Kuk Na, Shin-Hyeong Cho, Jung-Won Ju
The Korean Journal of Parasitology.2018; 56(6): 633. CrossRef - New Definitive Hosts and Differential Body Indices of Isthmiophora hortensis (Digenea: Echinostomatidae)
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Parasitology Research.2016; 115(1): 51. CrossRef - Epidemiological analysis of human fascioliasis in northeastern Punjab, Pakistan
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Acta Tropica.2016; 156: 157. CrossRef - An update on human echinostomiasis
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Transactions of The Royal Society of Tropical Medicine and Hygiene.2016; 110(1): 37. CrossRef - Animal Models for Echinostoma malayanum Infection: Worm Recovery and Some Pathology
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The Korean Journal of Parasitology.2016; 54(1): 47. CrossRef - Complete Mitochondrial Genome of Echinostoma hortense (Digenea: Echinostomatidae)
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The Korean Journal of Parasitology.2016; 54(2): 173. CrossRef - A Case of Echinostoma cinetorchis (Trematoda: Echinostomatidae) Infection Diagnosed by Colonoscopy
Woon Tae Jung, Kyeong Ju Lee, Hong Jun Kim, Tae Hyo Kim, Byoung-Kuk Na, Woon-Mok Sohn
The Korean Journal of Parasitology.2014; 52(3): 287. CrossRef - Echinostoma hortense Infection with Enteritis Diagnosed by Upper Gastrointestinal Endoscopy in a Dog
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Journal of Veterinary Medical Science.2013; 75(7): 991. CrossRef - Evaluation of the role of rats as reservoir hosts for fishborne zoonotic trematodes in two endemic northern Vietnam fish farms
Nguyen Lan Anh Thi, Henry Madsen, Dao Thanh Ha, Eric Hoberg, Anders Dalsgaard, K. Darwin Murrell
Parasitology Research.2012; 111(3): 1045. CrossRef - Echinostoma hortense and Heterophyid Metacercariae Encysted in Yellowfin Goby, Acanthogobius flavimanus, from Shinan-gun and Muan-gun (Jeollanam-do), Korea
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The Korean Journal of Parasitology.2009; 47(3): 307. CrossRef - Foodborne Intestinal Flukes in Southeast Asia
Jong-Yil Chai, Eun-Hee Shin, Soon-Hyung Lee, Han-Jong Rim
The Korean Journal of Parasitology.2009; 47(Suppl): S69. CrossRef - ECHINOSTOMA HORTENSE ASADA INFECTION IN THE DUODENUM: INCIDENTAL FINDINGS DURING ROUTINE GASTROINTESTINAL ENDOSCOPY
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Digestive Endoscopy.2008; 20(2): 87. CrossRef - Eosinophilia: Causes and pathobiology in persons with prior exposures in tropical areas with an emphasis on parasitic infections
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Current Infectious Disease Reports.2006; 8(1): 43. CrossRef - A human infection of Echinostoma hortense in duodenal bulb diagnosed by endoscopy
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The Korean Journal of Parasitology.2005; 43(2): 57. CrossRef
