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Experimental infection of Paragonimus westermani in mice and rats
P C Fan,*H Lu and L H Lin
Department of Parasitology, National Yangming Medical College and Parasitology Laboratory, Department of Medical Research, Veterans General Hospital, Taipei, Taiwan, Republic of China.
Received December 21, 1992; Accepted March 15, 1993.
Abstract
To determine the infectivity and maturity of metacercariae of Paragonimus westermani after keeping at low temperature for a long period, 45 mice and 45 rats were each infected with 20 metacercariae which were kept at 4℃ for 8 to 234 days. The worm recovery in mice increased with age of worm and reached a peak of 32% at 41-50 days and then decreased with age. The rate in rats first decreased to a lowest point of 6% at 71-100 days and then increased with age. In 42 infected mice and 41 infected rats, 187 immature worms (183 tiny and 4 juvenile ones) and 190 worms (164 tiny, 19 juvenile and 7 mature ones) were recovered respectively. Two worm cysts with eggs only and 8 empty worm cysts were also found in the rats. In addition, the frozen metacercariae can still develop to mature worms in SD rats.
Figures
Fig. 1 A 123 days old adult worm of P. westermani in a lungcyst of the left upper lobe of a SD rat (Bar = 1 mm).
Tables
Table 1 Susceptibility and worm recovery of Paragonimus westermani in rodents
Table 2 Worm recovery rate of Paragonimus westermani in albino mice by age of worms
Table 3 Worm recovery rate of Paragonimus westermani in SD rats by age of worm
Table 4 Comparison of distribution pattern of Paragonimus westermani in albino mice and SD rats
Table 5 Comparison of size of Paragonimus westermani in albino mice and SD rats
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