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Activities of scavenging enzymes of oxygen radicals in early maturation stages of Paragonimus westermani
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Brief Communication
Korean J Parasitol. 1992 Dec;30(4):355-358. English.
Published online Mar 20, 1994.  http://dx.doi.org/10.3347/kjp.1992.30.4.355
Copyright © 1992 by The Korean Society for Parasitology
Activities of scavenging enzymes of oxygen radicals in early maturation stages of Paragonimus westermani
Y B Chung,H S Lee,*C Y Song,** and S Y Cho
Department of Parasitology, College of Medicine, Chung-Ang University, Seoul 156-756, Korea.
*Department of Biochemistry, College of Medicine, Chung-Ang University, Seoul 156-756, Korea.
**Department of Biology, College of Medicine, Chung-Ang University, Seoul 156-756, Korea.
Abstract

In early maturation stages of Paragonimus westermani (metacercariae, 4-, 8-, 12-week old worms), activities of antioxidant enzymes, such as superoxide dismutase, catalase, peroxidase and glutathione peroxidase, were examined. Specific activity of catalase was the highest in metacercariae and decreasing with age. That of superoxide dismutase was higher in metacercariae and 4-week worms. Specific activity of peroxidase was at its peak in 4-week worms while that of glutathione peroxidase was in 8-week worms. Specific activities of all these antioxidant enzymes were decreased to their lowest in 12-week old adults.

Tables


Table 1
Activities of superoxide dismutase in early maturation stages of P. westermani


Table 2
Activities of catalase in early maturation stages of P. westermani


Table 3
Activities of peroxideas in early maturation stages of P. westermani


Table 4
Activities of glutathione peroxidase in early maturation stages of P. westermani

References
1. Barrett J. Peroxide metabolism in the liver fluke, Fasciola hepatica. J Parasitol 1980;66(4):697.
  
2. Brawn MK, et al. J Biol Chem 1985;260:79–110.
3. Callahan HL, Crouch RK, James ER. Helminth anti-oxidant enzymes: a protective mechanism against host oxidants?. Parasitol Today 1988;4(8):218–225.
  
4. Chung YB, Song CY, Lee HS, Kong Y, Cho SY. Purification and characterization of a Cu, Zn-superoxide dismutase from adult Paragonimus westermani. Korean J Parasitol 1991;29(3):259–266.
 
5. Davies KJ, Delsignore ME, Lin SW. Protein damage and degradation by oxygen radicals II Modification of amino acids. J Biol Chem 1987;262(20):9902–9907.
 
6. Fridovich I. Ann Rev Biochem 1975;44:147–159.
  
7. Kellogg EW 3rd, Fridovich I. Superoxide, hydrogen peroxide, and singlet oxygen in lipid peroxidation by a xanthine oxidase system. J Biol Chem 1975;250(22):8812–8817.
 
8. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. Protein measurement with the Folin phenol reagent. J Biol Chem 1951;193(1):265–275.
 
9. McCord JM, Fridovich I. Superoxide dismutase. An enzymic function for erythrocuprein (hemocuprein). J Biol Chem 1969;244(22):6049–6055.
 
10. McKerrow JH. Parasite proteases. Exp Parasitol 1989;68(1):111–115.
  
11. Mkoji GM, Smith JM, Prichard RK. Antioxidant systems in Schistosoma mansoni: correlation between susceptibility to oxidant killing and the levels of scavengers of hydrogen peroxide and oxygen free radicals. Int J Parasitol 1988;18(5):661–666.
  
12. Mkoji GM, Smith JM, Prichard RK. Antioxidant systems in Schistosoma mansoni: evidence for their role in protection of the adult worms against oxidant killing. Int J Parasitol 1988;18(5):667–673.
  
13. Murray HW. Interaction of Leishmania with a macrophage cell line. Correlation between intracellular killing and the generation of oxygen intermediates. J Exp Med 1981;153(6):1690–1695.
  
14. Murray HW, Juangbhanich CW, Nathan CF, Cohn ZA. Macrophage oxygen-dependent antimicrobial activity. II. The role of oxygen intermediates. J Exp Med 1979;150(4):950–964.
  
15. Thomas LE, et al. J Infect Dis 1988;10:S450–S456.
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