Efficacy of praziquantel (CesocideCesocide® injection) in treatment of cestode infections in domestic and laboratory animals

, Eom, Kee Seon; , Kim, Seung Ho; , Rim, Han Jong

doi:1988.26.2.121

Korean J Parasito > Volume 26(2):1988 > Article

Original Article


Korean J Parasitol. 1988 Jun;26(2):121-126. English. Published online Mar 20, 1994. http://dx.doi.org/10.3347/kjp.1988.26.2.121
Copyright © 1988 by The Korean Society for Parasitology


Efficacy of praziquantel (CesocideCesocide® injection) in treatment of cestode infections in domestic and laboratory animals
Kee Seon Eom,Seung Ho Kim,^* and Han Jong Rim^**
Department of Parasitology,College of Medicine, Chungbuk National University, Cheonju 360-763, Korea.
^*Department of Animal Husbandry, College of Agriculture, Cheju University, Cheju 690-121, Korea.
^**Department of Parasitology, College of Medicine, Korea University, Seoul 110-522, Korea.


Abstract
Efficacy of praziquantel (Cesocide injection) by intramuscular (I.M.) route against cestode infections was evaluated. Total 93 domestic or laboratory animals such as dogs, cats, rats, mice, goats, deers and chickens were used. Animals were infected with Dipylidium caninum, Spirometra sp., Taenia pisiformis, Taenia taeniaeformis, Hymenolepis nana, Moniezia expansa, Moniezia sp. or Raillietina sp. A single dose of praziquantel, 6 mg/kg of body weight, was highly effective (97.9%) against cestodes of various kinds disregarding the host species or their intensity of infection. At high dose above 6 mg/kg, the cure rate was 100%. All the cestodes treated were expelled from the host within 48 hours. The discharged proglottids were damaged severely except Hymenolepis nana and Moniezia expansa. Intramuscular injection of this drug evoked a brief pain response in a dog, but no other side reactions were observed.

Tables


	Table 1 Efficacy of praziquantel injection for treatment of cestode infections in animals


	Table 2 Expulsion of proglottides after injection of praziquantel

References


1.	Andrews P, Thomas H, Pohlke R, Seubert J. Praziquantel. Med Res Rev 1983;3(2):147–200.

2.	Becker B, Mehlhorn H, Andrews P, Thomas H. Ultrastructural investigations on the effect of praziquantel on the tegument of five species of cestodes. Z Parasitenkd 1981;64(3):257–269.

3.	Botero D. Paromomycin as effective treatment of Taenia infections. Am J Trop Med Hyg 1970;19(2):234–237.

4.	Burrows RB, et al. Am J Vet Res 1966;27:1381–1384.

5.	Eslami A, et al. Vet Med Rev 1986;21:97–99.

6.	Gönnert R, Andrews P. Praziquantel, a new board-spectrum antischistosomal agent. Z Parasitenkd 1977;52(2):129–150.

7.	Nagahana M, Yoshida Y, Matsuno K, Kondo K. Treatment of Taenia saginata and Diphyllobothrium latum infections with bithionol. Am J Trop Med Hyg 1966;15(3):351–354.

8.	Poole JB, Dooley KL, Rollins LD. Efficacy of niclosamide for the removal of tapeworms (Dipylidium caninum and Taenia pisiformis) from dogs. J Am Vet Med Assoc 1971;159(1):78–80.

9.	Rim HJ, Lyu KS, Lee JS, Joo KH. Clinical evaluation of the therapeutic efficacy of praziquantel (Embay 8440) against Clonorchis sinensis infection in man. Ann Trop Med Parasitol 1981;75(1):27–33.

*10.*	Sakamoto T. Vet Med Rev 1977;1:64–74.

*11.*	Salem HH, el-Allaf G. Treatment of Taenia saginata and Hymenolepis nana infections with paromomycin. Trans R Soc Trop Med Hyg 1969;63(6):833–836.

*12.*	Seaton DR. Lancet 1956;2870:808.

*14.*	Thomas H, Gönnert R. The efficacy of praziquantel against cestodes in animals. Z Parasitenkd 1977;52(2):117–127.

*15.*	Thomas H, Gönnert R. The efficacy of praziquantel against cestodes in cats, dogs and sheep. Res Vet Sci 1978;24(1):20–25.

*16.*	Wescott RB. Efficacy of niclosamide in the treatment of Taenia taeniaeformis infections in cats. Am J Vet Res 1967;28(126):1475–1477.

*17.*	Yokogawa M, Yoshimura H, Okura T, Saito M. Effect of bithionol on Taenia saginata, especially with reference to the detection of eggs with fecal examination and the perianal cellophane tape method. J Chiba Med Soc 1962;37:455–462.