This is a case report of intestinal eosinophilic granuloma caused by Ascaris ova and worm which is supposed to be rare in Korea. Case: A 23 year old healthy female reached Pusan Sanitation Hospital with complaints of high fever and abdominal pain on December 3 in 1966. Examination: Her temperature was 99.6 F. Pulse 80. Abdominal palpation showed muscle rigidity and tenderness. On the right side of the abdomen diagnosis due to ruptured appendix was made, and a laparotomy was performed the same day. Operation: Intestinal perforation by a Ascaris worm in the caecum about 7 cm from the ileo-caecal junction was also found. The worm was liquefied already. The intestine was edematous . Numerous rice sized nodules were seen on the intestine. The omentum was markdly inflammed and was adhered with a fist size mass.
The mass and appendix were also resected in order to do a histological study. Pathology: Two kinds of tissues were examined : one a mesenteric mass, the other lymph node.
Microscopically, it showed intensive and entirely necrotic tissue in which numerous parasitic ova were surrounded by granulomatous inflammatory cells with eosinophiles . The parasitic ova were degenerative and partialy necrotic although they had three layers of egg shell which are identified with Ascaris ova.
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Intussusception as a Presentation of Anisakis Infestation in the Global Era of Raw Fish Consumption: A Case Report and Literature Review Satoshi Umemoto, Yasuhiko Fujita, Teruyoshi Amagai Cureus.2024;[Epub] CrossRef
This study was undertaken to find out the possibility of iron-deficiency anemia by the intestinal blood loss in massive infection cases of T. trichiurus. Among the children of a community in which the whipworm infections were highly prevalent, 7 cases were selected whose E.P.G. of whipworm ova were more than 1,000. The hematological findings and estimated blood loss using (51)Cr were undertaken. The results could be summarized as follows: The E.P.G. and E.P.D. of T. trichiurus ova in studied 7 cases were 10,500-37,200/gm of feces and 0.90-5.14 million/day respectively. Findings of hematological examination were in lower limit of normal in hemoglobin content and hematocrit.
And erythrocytes were neither microcytic nor hypochromic.
Differential count of leucocytes showed persistently low grade of eosinophilia. Serum iron content measured by modification of Barkan method showed subnormal value in 5 out of 7 cases. Erythrocyte radioactivity half disappearance time(T1/2) and intestinal blood loss were estimated using (51)Cr-tagging erythrocytes. And the results showed that T1/2 were shortened (13-19 days ) in all cases and the blood loss was 0.94-6.54 ml/day which were correlated with worm burden (E.P.D.) significantly. From the above results, it could be concluded that intestinal blood loss of T.
trichiurus heavy infection were actually occurred but the amount of losses were easily compensated.
Santonin-kainic acid complex was evaluated as a chemotherapeutic of the mass treatment of the Ascaris lumbricoides infection in Korea. The results could be summarized as follows: The negative conversion rate was 82.9% in average in 4 treated groups. Some variations of negative conversion rate among the treated groups were noticed. The egg reduciton rate was 97.7% in average and the results were rather uniform among the three evaluated groups. By the analysis of egg reduction, it seems that the lightly infected cases whose E.P.G. were under 5,000 were resistant to treatment with the less reduced egg output.
After the treatment with this complex, the number of egg discharged cases were reduced to 1.84% and the average number of discharge eggs per incompletely treated or untreated cases were reduced to 12.5% compared with the level of before-treatment egg output. The successive observations of the pattern of worm expulsion after drug intake was made. The worms were mostly expelled in the stool within 3 days, and 58.9% of total expelled worms were collected within 24-hour stool. The minimum length of the immature worms expelled was 7.6cm. Among the 659 Ascaris collected in the first-day stool from 91 rural people, 8.5% were in the range of 7.6-12.2 cm-long, immature worms. The sex ratio, male: female= 0.69: 1.
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Microorganism-mediated algal biomass processing for clean products manufacturing: Current status, challenges and future outlook Fady Abd El-Malek, Marian Rofeal, Hossain M. Zabed, Abdul-Sattar Nizami, Mohammad Rehan, Xianghui Qi Fuel.2022; 311: 122612. CrossRef
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Jonathan R. Chekan, Shaun M. K. McKinnie, Joseph P. Noel, Bradley S. Moore Proceedings of the National Academy of Sciences.2020; 117(23): 12799. CrossRef
Biosynthesis of marine toxins Jonathan R. Chekan, Timothy R. Fallon, Bradley S. Moore Current Opinion in Chemical Biology.2020; 59: 119. CrossRef
Scalable Biosynthesis of the Seaweed Neurochemical, Kainic Acid Jonathan R. Chekan, Shaun M. K. McKinnie, Malia L. Moore, Shane G. Poplawski, Todd P. Michael, Bradley S. Moore Angewandte Chemie International Edition.2019; 58(25): 8454. CrossRef
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Pyrantel embonate in mass treatment of ascariasis and comparison with piperazine adipate and santonin-kainic acid complex Han Jong Rim, Joung Hwan Ha, Joon Sang Lee, Il Hyun, Kwang Bon Uh The Korean Journal of Parasitology.1974; 12(2): 141. CrossRef
Adult Clonorchis sinensis were collected from the biliary passage of nine cases of medico-legal autopsies. The worms were washed repeatedly with tap water and rinsed twice with physiological saline. Incubation took place in Tyrode's medium in order to recover live worms. The number of worms surviving in the medium was determined. The rate of surviving worms showed an unexpectedly high percentage (22.8%) in those cases autopsied 2 days after death. The surviving worm burden dropped sharply to 6.3 and 9.2 percent for those samples taken 5 days after death.
Usually egg count technique has been employed to know the intensity of infestation of human intestinal helminths and to elucidate the effects of anthelmintics. Comparing the three egg count methods - Stoll's egg dilution method, Beaver's direct smear method and FHK counting board method - the authors reached the following results: As the result of application of the three methods to 75 Ascaris egg positives and 95 Trichocephalus egg positives, in the case of Ascaris eggs, the egg detection rate was 99 per cent by Stoll's method, 97 per cent by Beaver's method and was lowest by FHK method at 79 percent. Meanwhile, in Trichocephalus eggs, Stoll's method revealed 92 percent, Beaver's method 95 percent, and FHK method 95 percent, there being no noticeable differences. With regard to EPG, in counting Ascaris eggs, Stoll's method showed a value closest to the actual number of eggs, and the value revealed by FHK method was smaller than the actual number. As the result of comparing the coefficiencies of variation of the three egg counting methods, both in Ascaris eggs and Trichocephalus eggs, the FHK method showed the smallest, followed by Stoll's method and Beaver's method.
The author carried out a study on the effectiveness of the boric acid as a stomach poison for German cockroach control from July to September 1971. The test was performed by the feeding method under conditions of 20 C and 80 per cent relative humidity. The baits were composed of one control group and five different combination groups with boric acid and sugar as follows. 10 g sugar only(control group), 1 g powedered boric acid to 9 g sugar(1:9 poison baits), 2 g powdered boric acid to 8 g sugar(2:8 poison baits), 4 g powdered boric acid to 6 g sugar(4:6 poison baits), 5 g powdered boric acid to 5g sugar(5:5 poison baits), 10 g powdered boric acid only (10:0 poison baits). The insects were composed of 360 female adult German cockroaches collected by traps at the kitchens of restaurants and house holds in Seoul City. The results were as follows: The total mortality by poison baits in 72 hours after treatment were: 44.3 per cent by 1:9 poison baits , 79.4 per cent by 2: poison baits , 96.7 per cent by 4:6 poison baits(the most effective poison baits), 88.3 per cent by 5:5 poison baits, 91.1 per cent by 10:0 poison baits. The peak mortality by the treatment hours were: Up to 21 hours: 23.3 per cent by 5:5 poison baits, 20.0 per cent by 10:10 poison baits, From 24 to 48 hours: 71.1 per cent by 4:6 poison baits, 55.6 per cent by 10:0 poison baits, From 48 to 72 hours: 21.9 per cent by 2:8 poison baits, 19.6 per cent by 1:9 poison baits.
The most effective treatment hours was from 24 to 48 hours.
The authors examined 3,169 fecal specimens from inhabitants of seven localities such as City, Eups and Myons in Cheju Do on July 1970 with cellophane thick smear technique. The results were analysed and summarized as follows: The overall egg positive rate of helminths was 82.2% and it was attributed to high rates of soil-transmitted helminths as in case of other parts in Korea. The infection rates of each species were; A. lumbricoides 44.3%, T. trichiurus 65.6%, hookworm 1.5%, T. orientalis 0.8%, C. sinensis 0.2%, P.
westermani 0.4%, M. yokogawai 0.9%, Taenia sp. 12.7% and H.
nana 1.4%. The infection rates of soil-transmitted helminths were relatively lower than those of mainland Korea especially in case of hookworm and T. orientalis. The proportion of unfertilized ova passers among the Ascaris infected case was 22.1%. The ova of heterophyids, most probably Metagonimus yokogawai were detected in lower percentage but discovered throughout the localities surveyed and in all age groups. It is certainly presumed that Metagonimus infection is autochthonous. The most interesting results were obtained in Taenia sp. infection and the higher rates were shown in rural area than in urbanized areas. The positive rates were within 5% in childhood and adolescence but abruptly increased up to 36.4 % in adults.
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Human Taeniasis in the Republic of Korea: Hidden or Gone? Jong-Yil Chai The Korean Journal of Parasitology.2013; 51(1): 9. CrossRef
Review of Zoonotic Parasites in Medical and Veterinary Fields in the Republic of Korea Heejeong Youn The Korean Journal of Parasitology.2009; 47(Suppl): S133. CrossRef
A histopathological study on human cysticercosis Hyun Sook Chi, Je Geun Chi The Korean Journal of Parasitology.1978; 16(2): 123. CrossRef
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