A series of 250 patients with filariasis due to periodic type of Brugia malayi was selected for the mass treatment with diethylcarbamazine from two areas in Cheju-Do. Two types of dosage schedules have been employed: the one was the conventional dosage schedule (uninterrupted dose of 6 mg/kg once daily 6 times repeated with an interval of one or two month totaling 72 mg/kg), and the other was the low dosage schedule (uninterrupted dose of 0.5, 1, 2, 4, 6 mg/kg body weight given once a day with an additional 6 mg/kg once daily totaling the maximum 37.5 mg/kg). The relative effectiveness of those two schedules was evaluated under the basis of the effects on microfilaria counts and the results of analysis of side-reactions observed. The results obtained in this experiment are summarized as it follows. In the conventional dosage treatment, 118 out of 141 microfilaria positives treated (83.7%) became negative and microfilaria reduction rate was about 99%. However, in the low dosage treatment, 35 out of 43 positives treated (85.4%) became negative and reduction rate of microfilaria, 99.5% in average. Total dose and duration of treatment were 72 mg/kg and about 60 days in the former schedule but it were maximum 37.5 mg/kg and 10 days in the latter. The recurrence of filariasis after treatment in both conventional and low dosage was negligible. Comparative analyses regarding the resulting side-reactions between the two schedules were made on their frequency, severity, onset and duration and relationship with microfilaria density. The febrile reaction was most frequently observed in 80.5% in the conventional, 43.9% in the low dosage schedule. The main side-reactions usually appeared within 6 to 10 hours and lasted 48 to 72 hours in the former threament, however they occurred in 7 to 8 hours and lasted 24 to 43 hours in the latter dosage schedule. It is assumed that the side-reactions are not directly related with the microfilaria count. However, the febrile reaction seems to be correlated with microfilaria density if it is above a certain limit. The presence of adult worm in a lymphnode involved with local reaction was ascertained from the biopsy specimens performed and local reactions such as lymphangitis and lymphadenitis after drug administrations were assessed from clinical and pathological point of view. It was conclusively indicated that the chemotherapeutic response to low dosage schedule within shorter length of treatment was equal to that of larger doses in long term medication from the point of the reduction in microfilaria, and particularly the resulting side-reactions were also reduced in the low dosage schedule.
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In order to study host-parasite relationship in trematode, the susceptibility in rabbits of Clonorchis sinensis were examined. A certain number of metacercariae of C. sinensis were administered orally to rabbits, and rats and dogs were used to compare with rabbits. the results were summerized as follows: The rabbits were successfully infected with metacercariae of C. sinensis in all case of the groups given 10 to 500 each. But the highest recovery rate of the worm was 33.0 percent in the case given 100 metacercariae. In the early stage of infection, the worms were hardly found, but 10 days after the infection, the number of worms were detected easily. Three months after the infection, the recovery rate of worms was 31.3 percent in the rabbits given 300 metacercariae. The recovery rates of the worms in two months after the infection were 27.4 percent in rabbits, 51.0 percent in rats and 54.6 percent in dogs.
Morphologically the body length and the body width markedly increased in the period until 10 days after the infection, and after that the genital organs began to get mature gradually while the growth of the body showed down. The measurement of adult C. sinensis recovered from the animals two months after the infection was the largest in rabbits followed by rats and the worms from dogs showed the smallest measurement.
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Following is the result of a survey hold over a two year period(1971-1972), on the appearence and disappearence of ticks on cattle in Cheju. Number of Haemaphysalis longicornis. Larvae: From the beginning of July to mid September larvae abounded reaching their peak during July and August. In 1971 their period was from July to September.
In 1972 their period was from May to October. In both years their number reached their highest point in July and August(Table 1.2) Nymph: Ticks were found from February to October(1971) and January to December (1972), and they were especially plentiful during the periods of may (1971)(Table 1.2). Adult : Ticks were in evidence from April to October(1971) and January to December(1972). They were especially plentiful during the periods of July and August(1971) and August(1972). However, in 1972 they were also quite plentiful in June and July(1972)(Table 1.2).
Percentage of Haemaphysalis longicornis. 1971(Fig. 1): February-May: nymph 94.1 percent, adult female 5.9 percent ; July-August: larvae 54.8 percent, 1972(Fig. 2) : January-May: larvae 18.2 percent, nymph 18.2 percent, adult female 3.8 percent; July-August: larvae 48.2 percent, nymph 11.6 percent, adult female 40.2 percent. Number of Boophilus microplus: larvae; Ticks were in evidence from April to October(1971) and January to December(1972). They were especially plentiful during the periods of June adn July(1971) and July to August(1972). However, in 1972 they were also quite plentiful in May. Nymph: Ticks were in evidence from January to December 1971 and 1972. They were especially plentiful during the periods of June and August(1971) and May to September(1972). However, in 1972 they were also quite plentiful in October and November.
Adult: Ticks were in evidence from January to December 1971 and 1972. They were especially plentiful during the periods of July to September(1971) and July (1972). However, in 1972 they were also quite plentiful in May to August. Percentage of Boophilus microplus. 1971(Fig. 3): January-May: larvae 40.3 percent, nymph 32.3 percent, adult female 27.1 percent, July-August: larvae 31.2 percent , nymph 35.7 percent, adult female 33.5 percent. 1972(Fig. 4): January-May: larvae 32.8 percent , nymph 42.1 percent, adult female 25.1 percent, July-August: larvae 44.2 percent, nymph 26.4 percent, adult female 29.4 percent.
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