Parasites, Hosts and Diseases

" egg"

Original Article

A novel kit for enrichment of fecal helminth eggs: Eunsol Lee, Seon-Ok Back, Young-Ju Lee, Jung-Won Ju, Hee-Il Lee, Myoung-Ro Lee; Parasites Hosts Dis 2024;62(3):323-329.
Published online August 26, 2024; DOI: https://doi.org/10.3347/PHD.24021

Abstract
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We developed a new concentration kit, called the ParaEgg (PE), for easy detection trematode eggs from fecal samples in endemic areas of clonorchiasis and metagonimiasis in Korea. To create a standard of detection efficiency, 120 fecal samples were examined using the water–ether concentration method (WECM). The PE kit and Mini ParaSep (PS) kit were used to compare the detection sensitivity of 100 egg-positive and 20 egg-negative samples in WECM. Additionally, stool samples, which were intentionally spiked with 10, 20, and 30 Clonorchis sinensis eggs, were evaluated to assess the sensitivity in lowinfection cases. The PE and PS kits showed detection rates of 100% and 92%, respectively, from 100 egg-positive samples in WECM. Meanwhile, eggs were detected in 3 (PE) and 2 (PS) out of 20 egg-negative samples in WECM. The PE kit detected the highest number of eggs per gram of feces (727 on average), followed by the WECM (524) and PS kit (432). In fecal samples that were intentionally spiked with 10, 20, and 30 C. sinensis eggs, PE only detected eggs 2 out of 5 samples in 10 eggs spiked (40%), and the detection rates were 80% and 100%, respectively. The PE kit enabled a more accurate identification of trematode eggs because of the clearance of small fecal debris in the microscopic field. In conclusion, the PE kit is obviously helpful to detect and identify trematode eggs in stool examinations especially in endemic areas of clonorchiasis and metagonimiasis.

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2024년 장내기생충 유행지역 감염 조사

Public Health Weekly Report.2025; 18(19): 707. CrossRef
Diagnostic performance evaluation of ParaEgg for identifying intestinal helminthiasis: A comparative study with conventional copromicroscopy
Tilak Chandra Nath, Heeil Lee, Md. Mahamudul Hasan, Tanmoy Roy Rudro, Dipta Das, Md. Taufiqur Rahman, Nandiny Saha Roy, Pritha Parial, Proloy Chakraborty Tusher, Tarek Siddiki
Parasite Epidemiology and Control.2025; 30: e00449. CrossRef
Detection of intestinal parasites in leopard cat fecal samples using shotgun metagenomics
Jun Ho Choi, Singeun Oh, Myung-hee Yi, Dongjun Kang, Du-Yeol Choi, Xavier Chavarria, Arwa Shatta, Yoon Hee Cho, Seongjun Choe, Seung-Hun Lee, Ju Yeong Kim
Parasites, Hosts and Diseases.2025; 63(4): 349. CrossRef

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Case Report

Helminth Eggs Detected in Soil Samples of a Possible Toilet Structure Found at the Capital Area of Ancient Baekje Kingdom of Korea: Chang Seok Oh, Sang-Yuck Shim, Yongjun Kim, Jong Ha Hong, Jong-Yil Chai, Hisashi Fujita, Min Seo, Dong Hoon Shin; Korean J Parasitol 2021;59(4):393-397.
Published online August 18, 2021; DOI: https://doi.org/10.3347/kjp.2021.59.4.393

Abstract
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Although research conducted in East Asia has uncovered parasite eggs from ancient toilets or cesspits, data accumulated to date needs to be supplemented by more archaeoparasitological studies. We examined a total of 21 soil samples from a toilet-like structure at the Hwajisan site, a Baekje-period royal villa, in present-day Korea. At least 4 species of helminth eggs, i.e., Trichuris trichiura, Ascaris lumbricoides, Clonorchis sinensis, and Trichuris sp. (or Trichuris vulpis) were detected in 3 sediment samples of the structure that was likely a toilet used by Baekje nobles. The eggs of T. trichiura were found in all 3 samples (no. 1, 4, and 5); and A. lumbricoides eggs were detected in 2 samples (no. 4 and 5). C. sinensis and T. vulpis-like eggs were found in no. 5 sample. From the findings of this study, we can suppose that the soil-transmitted helminths were prevalent in ancient Korean people, including the nobles of Baekje Kingdom during the 5th to 7th century.

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Clonorchis sinensis and Cholangiocarcinoma
Eun-Min Kim, Sung-Tae Hong
Journal of Korean Medical Science.2025;[Epub] CrossRef
Problems in Japanese archaeoparasitology: Analysis of paleo-parasitic eggs from Hachinohe Castle
Hisashi Fujita, Masako Funaba, Shiori O. Fujisawa
Parasites, Hosts and Diseases.2025; 63(3): 278. CrossRef
Paleoparasitology research on ancient helminth eggs and larvae in the Republic of Korea
Jong-Yil Chai, Min Seo, Dong Hoon Shin
Parasites, Hosts and Diseases.2023; 61(4): 345. CrossRef

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Original Article

Application of Autofluorescence for Confocal Microscopy to Aid in Archaeoparasitological Analyses: Johnica Jo Morrow, Christian Elowsky; Korean J Parasitol 2019;57(6):581-585.
Published online December 31, 2019; DOI: https://doi.org/10.3347/kjp.2019.57.6.581

Abstract
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Confocal laser scanning microscopy (CLSM) was used to examine archaeoparasitological specimens from coprolites associated with La Cueva de los Muertos Chiquitos (CMC) located near present-day Durango, Mexico. The eggs for 4 different types of parasites recovered from CMC coprolites were imaged using CLSM to assist with identification efforts. While some of the parasite eggs recovered from CMC coprolites were readily identified using standard light microscopy (LM), CLSM provided useful data for more challenging identifications by highlighting subtle morphological features and enhancing visualization of parasite egg anatomy. While other advanced microscopy techniques, such as scanning electron microscopy (SEM), may also detect cryptic identifying characters, CLSM is less destructive to the specimens. Utilizing CLSM allows for subsequent examinations, such as molecular analyses, that cannot be performed following SEM sample preparation and imaging. Furthermore, CLSM detects intrinsic autofluorescence molecules, making improved identification independent of resource and time-intensive protocols. These aspects of CLSM make it an excellent method for assisting in taxonomic identification and for acquiring more detailed images of archaeoparasitological specimens.

Citations

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Label-free spectral confocal reflectance microscopy for ex vivo neuroimaging and neural structure visualization
Reinher Pimentel-Domínguez, Rainald Pablo Ordaz, Abraham J. Cisneros-Mejorado, Rogelio O. Arellano, Remy Avila
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Noel Case, Nikki Johnston, Jay Nadeau
Astrobiology.2024; 24(3): 300. CrossRef
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Mina Magdy
Critical Reviews in Analytical Chemistry.2022; 52(6): 1171. CrossRef
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Riccardo Nodari, Michel Drancourt, Rémi Barbieri
Microbial Pathogenesis.2021; 157: 104972. CrossRef
Exploring confocal laser scanning microscopy (CLSM) and fluorescence staining as a tool for imaging and quantifying traces of marine microbioerosion and their trace‐making microendoliths
Philipp‐Konrad Schätzle, Max Wisshak, Andreas Bick, André Freiwald, Alexander Kieneke
Journal of Microscopy.2021; 284(2): 118. CrossRef

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Case Report

A Case of Ectopic Peritoneal Paragonimiasis Mimicking Diverticulitis or Abdominal Abscess: Min Jae Kim, Sung-Han Kim, Sang-Oh Lee, Sang-Ho Choi, Yang Soo Kim, Jun Hee Woo, Yong Sik Yoon, Kyung Won Kim, Jaeeun Cho, Jong-Yil Chai, Yong Pil Chong; Korean J Parasitol 2017;55(3):313-317.
Published online June 30, 2017; DOI: https://doi.org/10.3347/kjp.2017.55.3.313

Abstract
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Paragonimiasis is a parasitic disease caused by Paragnonimus species. The primary site of infection is the lung, and extrapulmonary involvement is also reported. When infected with Paragonimus westermani, which is the dominant species in Korea, the central nervous system is frequently involved along with the liver, intestine, peritoneal cavity, retroperitoneum, and abdominal wall. Ectopic paragonimiasis raises diagnostic challenge since it is uncommon and may be confused with malignancy or other inflammatory diseases. Here, we report an ectopic paragonimiasis case initially presented with recurrent abdominal pain. The patient developed abdominal pain 3 times for the previous 3 years and the computed tomography (CT) of the abdomen revealed fluid collection with wall enhancement. Recurrent diverticulitis was initially suspected and part of the ascending colon was resected. However, the specimen showed intact colon wall without evidence of diverticulitis and multiple parasite eggs and granulomas were found instead. The size of about 70 μm, the presence of an operculum and relatively thick egg shell suggested eggs of Paragonimus species. With appropriate exposure history and a positive antibody test, the definitive diagnosis was made as peritoneal paragonimiasis.

Citations

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A case report of Paragonimus infection diagnosed by medicine thoracoscopy
Xia Wu, Zhengfu Li, Dan Yang, Zhangli Peng, Nana Li, Yuanbo Lan, Ling Chen
Infection, Genetics and Evolution.2025; 134: 105791. CrossRef
Intra-abdominal paragonimiasis presenting as abscesses: A case report
Haidong Zhang, Mingchun Mu, Xin He, Yuan Yin
Asian Journal of Surgery.2023; 46(2): 1004. CrossRef
Crustaceans (shrimp, crab, and lobster): A comprehensive review of their potential health hazards and detection methods to assure their biosafety
Mohamed A. Farag, Somaia T. Mansour, Roua A. Nouh, Amira R. Khattab
Journal of Food Safety.2023;[Epub] CrossRef
Intra-abdominal paragonimiasis abscess: A note on rare recurrent acute abdomen disease
Pathum Sookaromdee, Viroj Wiwanitkit
Formosan Journal of Surgery.2023; 56(6): 200. CrossRef
A case of paragonimiasis inducing bilateral pneumothorax with lung and liver involvement
Ji Sung Ha, Jang Young Lee, Won Young Sung, Sang Won Seo, Won Suk Lee
Asian Cardiovascular and Thoracic Annals.2022; 30(3): 339. CrossRef
Ectopic peritoneal paragonimiasis mimicking tuberculous peritonitis: A care report
Jung Woo Choi, Chang Min Lee, Seong Je Kim, Se In Hah, Ji Yoon Kwak, Hyun Chin Cho, Chang Yoon Ha, Woon Tae Jung, Ok Jae Lee
World Journal of Clinical Cases.2022; 10(16): 5359. CrossRef
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Jong-Yil Chai, Bong-Kwang Jung
Parasitology.2022; 149(10): 1262. CrossRef
One delayed diagnosis of paragonimiasis case and literature review
Luxia Kong, Lijuan Hua, Qian Liu, Chen Bao, Jiannan Hu, Shuyun Xu
Respirology Case Reports.2021;[Epub] CrossRef
Laparoscopic excision for ectopic peritoneal paragonimiasis mimicking a gastric duplication cyst: A case report
Chul Kyu Roh, Min Jung Jung
Annals of Medicine and Surgery.2021; 69: 102754. CrossRef
A case of group infections with Paraginimus species in Henan, Central China
Wei-qi Chen, Yan Deng, Ya-lan Zhang, Lin Ai, Jia-xu Chen, Xi-meng Lin, Xiao-bo Du, Peng Li, Rui-min Zhou, Cheng-yun Yang, Ying Liu, Hong-wei Zhang, Bian-li Xu, Yu-ling Zhao
Acta Tropica.2020; 202: 105111. CrossRef
Paragonimus westermani infection manifesting as a pulmonary cavity and adrenal gland mass: A case report
Yong Shik Kwon, Hye Won Lee, Hyun Jung Kim
Journal of Infection and Chemotherapy.2019; 25(3): 200. CrossRef
A Paragonimiasis Mimicking Gastric Submucosal Tumor
Hyeri Seok, Tae Sung Sohn, Kyong Ran Peck
Journal of Korean Medical Science.2019;[Epub] CrossRef
Simultaneous Paragonimus infection involving the breast and lung: A case report
Moon Young Oh, Ajung Chu, Jeong Hwan Park, Jong Yoon Lee, Eun Youn Roh, Young Jun Chai, Ki-Tae Hwang
World Journal of Clinical Cases.2019; 7(24): 4292. CrossRef

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Mini Review

Detection Trend of Helminth Eggs in the Strata Soil Samples from Ancient Historic Places of Korea: Min Seo, Jong-Yil Chai, Myeung Ju Kim, Sang Yuk Shim, Ho Chul Ki, Dong Hoon Shin; Korean J Parasitol 2016;54(5):555-563.
Published online October 31, 2016; DOI: https://doi.org/10.3347/kjp.2016.54.5.555

Abstract
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For several years, we have conducted a series of studies on the patterns of ancient parasitism prevailing in the soil of rural and urban areas of past Kingdom of Korea. Actually, during our survey of paleoparasitology in archaeological sites of Korean peninsula, numerous ancient parasite eggs were discovered in the samples from the city districts of Hansung (Joseon) and Buyeo (Baikje), the palace moat at Gyeongju (Silla), shell-midden site at Bonghwang-dong (Silla to Joseon), and the reservoir found in Hwawangsansung fortress (Silla). By the paleoparasitological studies, with respect to parasitism in the high-density populations of ancient towns and cities, we have managed to catch glimpses of the patterns prevalent therein: a serious parasitic contamination of the soil in ancient urban areas, but not in rural areas of the past. Our historical research also proposed the plausible mechanism of parasite infection very serious indeed among urban populations in Korean history. Although city dwelling doubtless has accrued significant benefits for people and populations with agriculture, it can be equally supposed that living in such highly populated areas might have facilitated the spread of parasite infection.

Citations

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Ancient parasite analysis: Exploring infectious diseases in past societies
Piers D. Mitchell
Journal of Archaeological Science.2024; 170: 106067. CrossRef
A parasitological study on the possible toilet ruins of the Japanese colonial period in Korea
Jieun Kim, Min Seo, Hisashi Fujita, Jong Yil Chai, Jin Woo Park, Jun Won Jang, In Soo Jang, Dong Hoon Shin
Parasites, Hosts and Diseases.2023; 61(2): 198. CrossRef
トイレ考古学と考古寄生虫学
尚藤田, 宗河洪, 東勳申
Anthropological Science (Japanese Series).2023; 131(1): 9. CrossRef
Paleoparasitology research on ancient helminth eggs and larvae in the Republic of Korea
Jong-Yil Chai, Min Seo, Dong Hoon Shin
Parasites, Hosts and Diseases.2023; 61(4): 345. CrossRef
Presence of Parasite Remains in Historical Contexts in the City of Córdoba, Argentina, in the Nineteenth Century
Darío Alejandro Ramirez, Henrik Bernhard Lindskoug, Rodrigo Nores
Latin American Antiquity.2022; 33(2): 395. CrossRef
Ancient Echinostome Eggs Discovered in Archaeological Strata Specimens from a Baekje Capital Ruins of South Korea
Min Seo, Sang-Yuck Shim, Hwa Young Lee, Yongjun Kim, Jong Ha Hong, Ji Eun Kim, Jong-Yil Chai, Dong Hoon Shin
Journal of Parasitology.2020; 106(1): 184. CrossRef
Beyond diversity loss and climate change: Impacts of Amazon deforestation on infectious diseases and public health
JOEL HENRIQUE ELLWANGER, BRUNA KULMANN-LEAL, VALÉRIA L. KAMINSKI, JACQUELINE MARÍA VALVERDE-VILLEGAS, ANA BEATRIZ G. DA VEIGA, FERNANDO R. SPILKI, PHILIP M. FEARNSIDE, LÍLIAN CAESAR, LEANDRO LUIZ GIATTI, GABRIEL L. WALLAU, SABRINA E.M. ALMEIDA, MAURO R. B
Anais da Academia Brasileira de Ciências.2020;[Epub] CrossRef
Review of Successful Control of Parasitic Infections in Korea
Sung-Tae Hong, Tai-Soon Yong
Infection & Chemotherapy.2020; 52(3): 427. CrossRef
Ancient Soil-Transmitted Parasite Eggs Detected from the Sixth Century Three Kingdom Period Silla Tomb
Min Seo, Chang Seok Oh, Jong Ha Hong, Jong-Yil Chai, Jin Og Ju, Dong Hoon Shin
Journal of Korean Medical Science.2018;[Epub] CrossRef
Archaeoparasitological Strategy Based on the Microscopic Examinations of Prehistoric Samples and the Recent Report on the Difference in the Prevalence of Soil Transmitted Helminthic Infections in the Indian Subcontinent
Dong Hoon Shin, Yong Jun Kim, Ravindra Singh Bisht, Vivek Dangi, Prabodh Shirvalkar, Nilesh Jadhav, Chang Seok Oh, Jong Ha Hong, Jong Yil Chai, Min Seo, Vasant Shinde
Ancient Asia.2018;[Epub] CrossRef
Discovery of Parasite Eggs in Archeological Residence during the 15th Century in Seoul, Korea
Pyo Yeon Cho, Jung-Min Park, Myeong-Ki Hwang, Seo Hye Park, Yun-Kyu Park, Bo-Young Jeon, Tong-Soo Kim, Hyeong-Woo Lee
The Korean Journal of Parasitology.2017; 55(3): 357. CrossRef
Historical Details about the Meat Consumption and Taeniases in Joseon Period of Korea
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The Korean Journal of Parasitology.2017; 55(4): 457. CrossRef

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Brief Communication

V-shaped Pits in Regions of Ancient Baekje Kingdom Paleoparasitologically Confirmed as Likely Human-Waste Reservoirs: Dong Hoon Shin, Sang-Yuck Shim, Myeung Ju Kim, Chang Seok Oh, Mi-Hyun Lee, Suk Bae Jung, Geon Il Lee, Jong-Yil Chai, Min Seo; Korean J Parasitol 2014;52(5):569-573.
Published online October 22, 2014; DOI: https://doi.org/10.3347/kjp.2014.52.5.569

Abstract
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In a paleo-parasitological analysis of soil samples obtained from V-shaped pits dating to the ancient Baekje period in Korean history, we discovered Ascaris lumbricoides, Trichuris trichiura, and Clonorchis sinensis eggs. In light of the samples' seriously contaminated state, the V-shaped pits might have served as toilets, cesspits, or dung heaps. For a long period of time, researchers scouring archaeological sites in Korea have had difficulties locating such structures. In this context then, the present report is unique because similar kind of the ancient ruins must become an ideal resource for successful sampling in our forthcoming paleoparasitological studies.

Citations

Citations to this article as recorded by

Paleoparasitology research on ancient helminth eggs and larvae in the Republic of Korea
Jong-Yil Chai, Min Seo, Dong Hoon Shin
Parasites, Hosts and Diseases.2023; 61(4): 345. CrossRef
Helminth Eggs Detected in Soil Samples of a Possible Toilet Structure Found at the Capital Area of Ancient Baekje Kingdom of Korea
Chang Seok Oh, Sang-Yuck Shim, Yongjun Kim, Jong Ha Hong, Jong-Yil Chai, Hisashi Fujita, Min Seo, Dong Hoon Shin
The Korean Journal of Parasitology.2021; 59(4): 393. CrossRef
Clonorchis sinensis and clonorchiasis
Byoung-Kuk Na, Jhang Ho Pak, Sung-Jong Hong
Acta Tropica.2020; 203: 105309. CrossRef
Metagenomics and microscope revealed T. trichiura and other intestinal parasites in a cesspit of an Italian nineteenth century aristocratic palace
Daniela Chessa, Manuela Murgia, Emanuela Sias, Massimo Deligios, Vittorio Mazzarello, Maura Fiamma, Daniela Rovina, Gabriele Carenti, Giulia Ganau, Elisabetta Pintore, Mauro Fiori, Gemma L. Kay, Alessandro Ponzeletti, Piero Cappuccinelli, David J. Kelvin,
Scientific Reports.2020;[Epub] CrossRef
Archaeoparasitological Strategy Based on the Microscopic Examinations of Prehistoric Samples and the Recent Report on the Difference in the Prevalence of Soil Transmitted Helminthic Infections in the Indian Subcontinent
Dong Hoon Shin, Yong Jun Kim, Ravindra Singh Bisht, Vivek Dangi, Prabodh Shirvalkar, Nilesh Jadhav, Chang Seok Oh, Jong Ha Hong, Jong Yil Chai, Min Seo, Vasant Shinde
Ancient Asia.2018;[Epub] CrossRef
Estimation of parasite infection prevalence of Joseon people by paleoparasitological data updates from the ancient feces of pre-modern Korean mummies
MIN SEO, CHANG SEOK OH, JONG HA HONG, JONG-YIL CHAI, SOON CHUL CHA, YURI BANG, IN GUK CHA, YANG GUN WI, JUNG MIN PARK, DONG HOON SHIN
Anthropological Science.2017; 125(1): 9. CrossRef
Discovery of Parasite Eggs in Archeological Residence during the 15th Century in Seoul, Korea
Pyo Yeon Cho, Jung-Min Park, Myeong-Ki Hwang, Seo Hye Park, Yun-Kyu Park, Bo-Young Jeon, Tong-Soo Kim, Hyeong-Woo Lee
The Korean Journal of Parasitology.2017; 55(3): 357. CrossRef

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Original Articles

T Regulatory Cell Responses to Immunization with a Soluble Egg Antigen in Schistosoma mansoni-Infected Mice: Eman El-Ahwany, Ibrahim Rabia Bauiomy, Faten Nagy, Rabab Zalat, Ola Mahmoud, Suher Zada; Korean J Parasitol 2012;50(1):29-35.
Published online March 6, 2012; DOI: https://doi.org/10.3347/kjp.2012.50.1.29

Abstract
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The aim of the study is to characterize the phenotypes of CD4⁺ CD25⁺ T regulatory cells within the liver granulomas and association with both Foxp-3 gene expression and splenic cytokines. Na?ve C57BL/6 mice were intravenously injected with multiple doses of the soluble egg antigen (SEA) 7 days before cercarial infection. The immunized and infected control groups were sacrificed 8 and 16 weeks post-infection (PI). Histopathology, parasitological parameters, splenic phenotypes for T regulatory cells, the FOXP-3 expression in hepatic granuloma using real-time PCR, and the associated splenic cytokines were studied. Histopathological examination of the liver revealed remarkable increase in degenerated ova within hepatic granuloma which decreased in diameter at weeks 8 and 16 PI (P<0.01). The percentage of T regulatory cells (CD4⁺ CD25⁺) increased significantly (P<0.01) in the immunized group compared to the infected control at weeks 8 and 16 PI. The FOXP-3 expression in hepatic granulomas increased from 10 at week 8 to 30 fold at week 16 PI in the infected control group. However, its expression in the immunized group showed an increase from 30 at week 8 to 70 fold at week 16 PI. The splenic cytokine levels of pro-inflammatory cytokines, IFN-γ, IL-4, and TNF-α, showed significant decreases (P<0.05) compared to the infected control group. In conclusion, the magnitude and phenotype of the egg-induced effects on T helper responses were found to be controlled by a parallel response within the T regulatory population which provides protection in worm parasite-induced immunopathology.

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Micromorphological Changes in the Parenchymatous Organs of Muskrats Infected with Quinqueserialis quinqueserialis (Trematoda: Notocotilidae)
O. E. Mazur, A. S. Fomina
Biology Bulletin.2024; 51(2): 371. CrossRef
Micromorphological changes in the parenchymatous organs of the muskrat infected with Quinqueserialis quinqueserialis (Trematoda: Notocotilidae)
O. E. Mazur, A. S. Fomina
Известия Российской академии наук. Серия биологическая.2024;[Epub] CrossRef
Evaluation of schistosomula lung antigen preparation and soluble egg antigen vaccines on experimental schistosomiasis mansoni
Nagwa S. M. Aly, Hye-Sook Kim, Maysa A. Eraky, Asmaa A. El Kholy, Basma T. Ali, Shin-ichi Miyoshi, Rabab E. Omar
Parasites, Hosts and Diseases.2023; 61(3): 251. CrossRef
Protective effect and mechanism of Schistosoma japonicum soluble egg antigen against type 1 diabetes in NOD mice
Li-xia Wang, Yan-ru Gao, Qun Pan, Chun-lian Tang, Rong-hui Zhang, Yan-hong Li, Chun-lan Zheng
International Journal of Diabetes in Developing Countries.2022; 42(2): 363. CrossRef
Schistosoma japonicum Infection in Treg-Specific USP21 Knockout Mice
Youxiang Zhang, De-Hui Xiong, Yangyang Li, Guina Xu, Baoxin Zhang, Yang Liu, Shan Zhang, Qing Huang, Simin Chen, Fansheng Zeng, Jingyi Guo, Bin Li, Zhiqiang Qin, Zuping Zhang, Luiz Felipe Domingues Passero
Journal of Immunology Research.2021; 2021: 1. CrossRef
Role of regulatory T cells in Schistosoma-mediated protection against type 1 diabetes
Chun-lian Tang, Yan-ru Gao, Li-xia Wang, Ya-wen Zhu, Qun Pan, Rong-hui Zhang, Ying Xiong
Molecular and Cellular Endocrinology.2019; 491: 110434. CrossRef
Schistosoma japonicum Soluble Egg Antigen Protects Against Type 2 Diabetes in Leprdb/db Mice by Enhancing Regulatory T Cells and Th2 Cytokines
Chun-lian Tang, Xiao-hong Yu, Yan Li, Rong-hui Zhang, Jun Xie, Zhi-ming Liu
Frontiers in Immunology.2019;[Epub] CrossRef
Maternal schistosomiasis: IL-2, IL-10 and regulatory T lymphocytes to unrelated antigen in adult offspring mice
Erica de Souza Fernandes, Virgínia Maria de Barros Lorena, Iana Rafaela Fernandes Sales, Mônica Camelo Pessoa de Azevedo Albuquerque, Yara de Miranda Gomes, Vlaudia Maria Assis Costa, Valdênia Maria Oliveira de Souza
Revista da Sociedade Brasileira de Medicina Tropical.2018; 51(4): 546. CrossRef
Heat Shock Protein 60 in Eggs Specifically Induces Tregs and Reduces Liver Immunopathology in Mice with Schistosomiasis Japonica
Sha Zhou, Xin Jin, Xiaojun Chen, Jifeng Zhu, Zhipeng Xu, Xuefeng Wang, Feng Liu, Wei Hu, Liang Zhou, Chuan Su, Susmit Suvas
PLOS ONE.2015; 10(9): e0139133. CrossRef
Morphological features of cellular responses to different rates of trematode Quinqueserialis quinqueserialis (Trematoda: Notocotilidae) invasion in muskrat (Ondatra zibethicus)
O. E. Mazur, A. S. Fomina
Biology Bulletin.2014; 41(5): 444. CrossRef

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Growth and development of Gymnophalloides seoi in immunocompetent and immunosuppressed C3H/HeN mice: Jong-Yil Chai, Won-Jae Chung, Jina Kook, Min Seo, Yun-Kyu Park, Sang-Mee Guk, Min-Ho Choi, Soon-Hyung Lee; Korean J Parasitol 1999;37(1):21-26.
Published online March 31, 1999; DOI: https://doi.org/10.3347/kjp.1999.37.1.21

Abstract
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The growth and development of Gymnophalloides seoi were studied in C3H/HeN mice and effects of immunosuppression of the host on the worm development were observed. Two hundred metacercariae of G. seoi were orally administered to each mouse, and worms were recovered on days 1, 3, 5, 7, 14 and 21 post-infection (PI). The worm recovery rate was significantly higher in immunosuppressed (ImSP) mice than in immunocompetent (ImCT) mice except on days 1 and 3 PI. The worms attained sexual maturity by day 3 PI with eggs in the uterus, and worm dimensions and the number of uterine eggs continuously increased until day 14 PI in ImSP mice. Worms recovered from ImSP mice were significantly larger in size than those from ImCT mice on days 1 and 3 PI, and the number of uterine eggs was significantly larger in ImSP mice on days 5 and 7 PI. Genital organs such as the ovary, testes, and vitellaria, that were already developed in the metacercarial stage, grew a little in size until day 14 PI. The results show that the C3H/HeN mouse is, though not excellent, a suitable laboratory host for G. seoi.

Citations

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Increased Intestinal Epithelial Cell Turnover and Intestinal Motility in Gymnophalloides seoi-Infected C57BL/6 Mice
Sang Hyub Lee, Bong-Kwang Jung, Jae-Hwan Park, Eun-Hee Shin, Jong-Yil Chai
The Korean Journal of Parasitology.2014; 52(3): 273. CrossRef
Foodborne Intestinal Flukes in Southeast Asia
Jong-Yil Chai, Eun-Hee Shin, Soon-Hyung Lee, Han-Jong Rim
The Korean Journal of Parasitology.2009; 47(Suppl): S69. CrossRef
Gymnophalloides seoi: a new human intestinal trematode
Jong-Yil Chai, Min-Ho Choi, Jae-Ran Yu, Soon-Hyung Lee
Trends in Parasitology.2003; 19(3): 109. CrossRef
Food-borne intestinal trematode infections in the Republic of Korea
Jong-Yil Chai, Soon-Hyung Lee
Parasitology International.2002; 51(2): 129. CrossRef
A review of Gymnophalloides seoi (Digenea: Gymnophallidae) and human infections in the Republic of Korea
Soon-Hyung Lee, Jong-Yil Chai
The Korean Journal of Parasitology.2001; 39(2): 85. CrossRef
Intestinal histopathology and in situ postures of Gymnophalloides seoi in experimentally infected mice
Jong-Yil Chai, Hong-Soon Lee, Sung-Jong Hong, Jae Hyung Yoo, Sang-Mee Guk, Min Seo, Min-Ho Choi, Soon-Hyung Lee
The Korean Journal of Parasitology.2001; 39(1): 31. CrossRef