Parasites, Hosts and Diseases

"Fascioliasis"

Case Reports

A Case of Fascioliasis in A Wild Nutria, Myocastor coypus, in Republic of Korea: Hyo-Seok Kim, Joo-Yeon Kong, Jong-Hyun Kim, Seong-Chan Yeon, Il-Hwa Hong; Korean J Parasitol 2018;56(4):375-378.
Published online August 31, 2018; DOI: https://doi.org/10.3347/kjp.2018.56.4.375

Abstract
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A total of 44 adult or juvenile nutrias were necropsied for disease survey. A large nodule was found in the liver of a nutria. The histopathological specimen of the hepatic nodule was microscopically examined, and sectional worms were found in the bile duct. The worms showed a tegument with spines, highly branches of vitelline glands and intestine. Finally, we histopathologically confirmed fascioliasis in a wild nutria. In the present study, a case of fascioliasis in a wild nutria is first confirmed in Korea.

Citations

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The use of Glutathione-S-transferase levels as marker of hepatic damage in chronic fasciolosis in cattle
Al-Hassan Mohammed Mostafa, Gehan Mohammed Sayed, Ali Ali Hassan Al-Ezzi, Alaa Eldin Kamal
Veterinary Parasitology.2025; 339: 110577. CrossRef
Fasciola hepatica infection in Korean water deer (Hydropotes inermis argyropus)
Na-Hyeon Kim, Min-Gyeong Seo, Bumseok Kim, Yu Jeong Jeon, In Jung Jung, Il-Hwa Hong
Parasites, Hosts and Diseases.2025; 63(3): 243. CrossRef
Intestinal parasites of Myocastor coypus (Rodentia, Myocastoridae) on animal farms in Eastern Ukraine
N. V. Sumakova, A. P. Paliy, O. V. Pavlichenko, R. V. Petrov, B. S. Morozov, V. M. Plys, A. B. Mushynskyi
Regulatory Mechanisms in Biosystems.2025; 16(3): e25117. CrossRef
Prevalence and hepatic histopathological findings of fascioliasis in sheep slaughtered in Jeddah, Saudi Arabia
Safinaz J. Ashoor, Majed H. Wakid
Scientific Reports.2023;[Epub] CrossRef
Climate change induced habitat expansion of nutria (Myocastor coypus) in South Korea
Pradeep Adhikari, Baek-Jun Kim, Sun-Hee Hong, Do-Hun Lee
Scientific Reports.2022;[Epub] CrossRef
Genetic diversity and relationships of the liver fluke Fasciola hepatica (Trematoda) with native and introduced definitive and intermediate hosts
Antonio A. Vázquez, Emeline Sabourin, Pilar Alda, Clémentine Leroy, Carole Leray, Eric Carron, Stephen Mulero, Céline Caty, Sarah Hasfia, Michel Boisseau, Lucas Saugné, Olivier Pineau, Thomas Blanchon, Annia Alba, Dominique Faugère, Marion Vittecoq, Sylvi
Transboundary and Emerging Diseases.2021; 68(4): 2274. CrossRef
Preputial gland adenoma in a wild nutria (Myocastor coypus): a case report
Joo-Yeon Kong, Hyo-Seok Kim, Seong-Chan Yeon, Jin-Kyu Park, Kyu-Shik Jeong, Il-Hwa Hong
Journal of Veterinary Science.2020;[Epub] CrossRef
Preputial gland adenoma in a wild nutria (Myocastor coypus): a case report
Joo-Yeon Kong, Hyo-Seok Kim, Seong-Chan Yeon, Jin-Kyu Park, Kyu-Shik Jeong, Il-Hwa Hong
Journal of Veterinary Science.2019;[Epub] CrossRef

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Ectopic Human Fasciola hepatica Infection by an Adult Worm in the Mesocolon: Ah Jin Kim, Chang Hwan Choi, Sun Keun Choi, Yong Woon Shin, Yun-Kyu Park, Lucia Kim, Suk Jin Choi, Jee Young Han, Joon Mee Kim, Young Chae Chu, In Suh Park; Korean J Parasitol 2015;53(6):725-730.
Published online December 31, 2015; DOI: https://doi.org/10.3347/kjp.2015.53.6.725

Abstract
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We report here an ectopic case of Fasciola hepatica infection confirmed by recovery of an adult worm in the mesocolon. A 56-year-old female was admitted to our hospital with discomfort and pain in the left lower quadrant of the abdomen. Abdominal CT showed 3 abscesses in the left upper quadrant, mesentery, and pelvic cavity. On surgical exploration, abscess pockets were found in the mesocolon of the sigmoid colon and transverse colon. A leaf-like worm found in the abscess pocket of the mesocolon of the left colon was diagnosed as an adult fluke of F. hepatica. Histologically, numerous eggs of F. hepatica were noted with acute and chronic granulomatous inflammations in the subserosa and pericolic adipose tissues. Conclusively, a rare case of ectopic fascioliasis has been confirmed in this study by the adult worm recovery of F. hepatica in the mesocolon.

Citations

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Molecular identification of Fasciola and Dicrocoelium species isolates in ruminants livestock from Kashan and Arak in center of Iran
Mohsen Arbabi, Hossein Hooshyar, Mahdi Delavari
Journal of Parasitic Diseases.2025; 49(2): 453. CrossRef
Hepatic and Extrahepatic Fascioliasis Mimicking Colon Cancer with Hepatic Metastasis
Youe Ree Kim, Young Hwan Lee, Kwon-Ha Yoon
Korean Journal of Abdominal Radiology.2022; 6(1): 51. CrossRef
Phylogenetic Characteristics of Fasciola hepatica Isolated from a Korean Patient
Mi Jin Jeong, Jae Kyun Park, Hak Sun Yu
The Korean Journal of Parasitology.2022; 60(5): 367. CrossRef
Prevalence of Schistosoma japonicum infection in water buffaloes in selected areas in Davao del Norte and Davao de Oro, the Philippines
Rohani C. Navarro, Aleyla E. de Cadiz, Jordan M. Fronda, Lynnell Alexie D. Ong, Vicente Y. Belizario Jr.
International Journal of One Health.2021; 7(1): 12. CrossRef
Ascariasis Presenting as Hematoma in the Sigmoid Mesocolon: A Case Report
Ji-Eun Kim, Kyung Eun Bae, Hyun-Jung Kim, Byung-Noe Bae, Ji Hae Lee, Mi-Jin Kang, Ji-Young Kim, Jae Hyung Kim
Journal of the Korean Society of Radiology.2020; 81(4): 1013. CrossRef
Parasitological monitoring of European bison (Bison bonasus) from three forests of north-eastern Poland between 2014 and 2016
Michał K. Krzysiak, Aleksander W. Demiaszkiewicz, Magdalena Larska, Jarosław Tomana, Krzysztof Anusz
Journal of Veterinary Research.2020; 64(1): 103. CrossRef
NumerousFasciolaplasminogen-binding proteins may underlie blood-brain barrier leakage and explain neurological disorder complexity and heterogeneity in the acute and chronic phases of human fascioliasis
J. González-Miguel, M. A. Valero, M. Reguera-Gomez, C. Mas-Bargues, M. D. Bargues, F. Simón, S. Mas-Coma
Parasitology.2019; 146(3): 284. CrossRef
Highlights of human ectopic fascioliasis: a systematic review
Ali Taghipour, Leila Zaki, Ali Rostami, Masoud Foroutan, Fatemeh Ghaffarifar, Atefeh Fathi, Amir Abdoli
Infectious Diseases.2019; 51(11-12): 785. CrossRef
A Case of Ectopic Peritoneal Paragonimiasis Mimicking Diverticulitis or Abdominal Abscess
Min Jae Kim, Sung-Han Kim, Sang-Oh Lee, Sang-Ho Choi, Yang Soo Kim, Jun Hee Woo, Yong Sik Yoon, Kyung Won Kim, Jaeeun Cho, Jong-Yil Chai, Yong Pil Chong
The Korean Journal of Parasitology.2017; 55(3): 313. CrossRef

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Original Articles

Experimental Murine Fascioliasis Derives Early Immune Suppression with Increased Levels of TGF-β and IL-4: Joon-Yong Chung, Young-An Bae, Doo-Hee Yun, Hyun-Jong Yang, Yoon Kong; Korean J Parasitol 2012;50(4):301-308.
Published online November 26, 2012; DOI: https://doi.org/10.3347/kjp.2012.50.4.301

Abstract
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In fascioliasis, T-helper 2 (Th2) responses predominate, while little is known regarding early immune phenomenon. We herein analyzed early immunophenotype changes of BALB/c, C57BL/6, and C3H/He mice experimentally infected with 5 Fasciola hepatica metacercariae. A remarkable expansion of CD19⁺ B cells was observed as early as week 1 post-infection while CD4⁺/CD8⁺ T cells were down-regulated. Accumulation of Mac1⁺ cells with time after infection correlated well with splenomegaly of all mice strains tested. The expression of tumor necrosis factor (TNF)-α mRNA in splenocytes significantly decreased while that of IL-4 up-regulated. IL-1β expression was down-modulated in BALB/c and C57BL/6 mice, but not in C3H/He. Serum levels of transforming growth factor (TGF)-β were considerably elevated in all mice during 3 weeks of infection period. These collective results suggest that experimental murine fascioliasis might derive immune suppression with elevated levels of TGF-β and IL-4 during the early stages of infection.

Citations

Citations to this article as recorded by

Evaluation of Th1/Th2, regulatory cytokines and transcriptional factor FoxP3 in sheep immunized with a partially protective and non-protective vaccine and challenged with Fasciola hepatica
María Teresa Ruiz-Campillo, Isabel Lourdes Pacheco, Nieves Abril, María José Bautista, Álvaro Martínez-Moreno, Francisco Javier Martínez-Moreno, Leandro Buffoni, José Pérez, Verónica Molina-Hernández, Rafael Zafra
Veterinary Research.2024;[Epub] CrossRef
Fascioliasis: Image Findings, Diagnosis, and Treatment
Jae Seung Lee
Clinical Ultrasound.2024; 9(1): 18. CrossRef
Fasciolosis: pathogenesis, host-parasite interactions, and implication in vaccine development
Luis Miguel Flores-Velázquez, María Teresa Ruiz-Campillo, Guillem Herrera-Torres, Álvaro Martínez-Moreno, Francisco Javier Martínez-Moreno, Rafael Zafra, Leandro Buffoni, Pablo José Rufino-Moya, Verónica Molina-Hernández, José Pérez
Frontiers in Veterinary Science.2023;[Epub] CrossRef
The immunosuppression effects of deforolimus (ridaforolimus, AP23573) on allograft organ transplantation
Lumin Wang, Yanping Li, Dawei Yang, Jiazhao Fu, Bin Zhao, Yaguang Li, Yanrong Ye, Zhongquan Qi
Clinical and Translational Discovery.2023;[Epub] CrossRef
Immunization of Goats with Recombinant Protein 14-3-3 Isoform 2(rHcftt-2) Induced Moderate Protection against Haemonchus contortus Challenge
Yongqian Bu, Caiwen Jia, Xiaowei Tian, Kalibixiati Aimulajiang, Muhammad Ali Memon, Ruofeng Yan, Xiaokai Song, Lixin Xu, Xiangrui Li
Pathogens.2020; 9(1): 46. CrossRef
Characterization of dendritic cells and follicular dendritic cells in the hepatic lymph nodes and liver of sheep experimentally infected with Fasciola hepatica
María Teresa Ruiz-Campillo, Verónica Molina-Hernández, María José Bautista, Isabel L. Pacheco, Rafael Zafra, Leandro Buffoni, Francisco Javier Martínez-Moreno, Alvaro Martínez-Moreno, José Pérez
Veterinary Research.2020;[Epub] CrossRef
Helminth infection-induced carcinogenesis: spectrometric insights from the liver flukes, Opisthorchis and Fasciola
Maria João Gouveia, Maria Y. Pakharukova, Gabriel Rinaldi, Viatcheslav A. Mordvinov, Paul J. Brindley, Fátima Gärtner, Nuno Vale, Martin Michaelis
Experimental Results.2020;[Epub] CrossRef
Fasciola and fasciolosis in ruminants in Europe: Identifying research needs
N. J. Beesley, C. Caminade, J. Charlier, R. J. Flynn, J. E. Hodgkinson, A. Martinez-Moreno, M. Martinez-Valladares, J. Perez, L. Rinaldi, D. J. L. Williams
Transboundary and Emerging Diseases.2018; 65: 199. CrossRef
Fasciola hepatica induces Foxp3 T cell, proinflammatory and regulatory cytokine overexpression in liver from infected sheep during early stages of infection
Isabel L. Pacheco, Nieves Abril, Rafael Zafra, Verónica Molina-Hernández, Noelia Morales-Prieto, María J. Bautista, María T. Ruiz-Campillo, Raúl Pérez-Caballero, Alvaro Martínez-Moreno, José Pérez
Veterinary Research.2018;[Epub] CrossRef
Association of Fasciola hepatica Infection with Liver Fibrosis, Cirrhosis, and Cancer: A Systematic Review
Claudia Machicado, Jorge D. Machicado, Vicente Maco, Angelica Terashima, Luis A. Marcos, Hector H Garcia
PLOS Neglected Tropical Diseases.2016; 10(9): e0004962. CrossRef

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Protective Role of Purified Cysteine Proteinases against Fasciola gigantica Infection in Experimental Animals: Eman EL-Ahwany, Ibrahim Rabia, Faten Nagy, Mona Zoheiry, Tarek Diab, Suher Zada; Korean J Parasitol 2012;50(1):45-51.
Published online March 6, 2012; DOI: https://doi.org/10.3347/kjp.2012.50.1.45

Abstract
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Fascioliasis is one of the public health problems in the world. Cysteine proteinases (CP) released by Fasciola gigantica play a key role in parasite feeding, migration through host tissues, and in immune evasion. There has been some evidence from several parasite systems that proteinases might have potential as protective antigens against parasitic infections. Cysteine proteinases were purified and tested in vaccine trials of sheep infected with the liver fluke. Multiple doses (2 mg of CP in Freund's adjuvant followed by 3 booster doses 1 mg each at 4 week intervals) were injected intramuscularly into sheep 1 week prior to infect orally with 300 F. gigantica metacercariae. All the sheep were humanely slaughtered 12 weeks after the first immunization. Changes in the worm burden, ova count, and humoral and cellular responses were evaluated. Significant reduction was observed in the worm burden (56.9%), bile egg count (70.7%), and fecel egg count (75.2%). Immunization with CP was also found to be associated with increases of total IgG, IgG₁, and IgG₂ (P<0.05). Data showed that the serum cytokine levels of pro-inflammatory cytokines, IL-12, IFN-γ, and TNF-α, revealed significant decreases (P<0.05). However, the anti-inflammatory cytokine levels, IL-10, TGF-β, and IL-6, showed significant increases (P<0.05). In conclusion, it has been found that CP released by F. gigantica are highly important candidates for a vaccine antigen because of their role in the fluke biology and host-parasite relationships.

Citations

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Genetic diversity and adaptability of native sheep breeds from different climatic zones
George Wanjala, Zoltán Bagi, Dinu Gavojdian, Bouabid Badaoui, Putri Kusuma Astuti, Alexandru Mizeranschi, Elena Ilisiu, Husein Ohran, Eva Pasic Juhas, Dimitrios Loukovitis, Aldona Kawęcka, Rūta Šveistienė, Zsolt Becskei, Péter Strausz, Nelly Kichamu, Szil
Scientific Reports.2025;[Epub] CrossRef
Serodiagnosis of Fasciola gigantica Infection in Buffaloes with Native Cathepsin-L Proteases and Recombinant Cathepsin L1-D
Andleeb Aftab, Rohit Lall, Savita Bisen, Arun Anandanarayanan, Ajayta Rialch, Jayanta K. Chamuah, Shobha Yadav, M. Silamparasan, O. K. Raina
Acta Parasitologica.2020; 65(2): 413. CrossRef
A Survey on the Adjuvant Role of Naloxone Alone or Combined with Alum in Vaccination Against Fasciolosis in BALB/c Mice
Hakim Azizi, Hadi Mirzaeei, Amin Bagheri, Ali Bazi, Ali Khamesipour, Hajar Yaghoobi, Aliyar Mirzapour, Mehrdad Khatami, Samira Elikaee
Acta Parasitologica.2019;[Epub] CrossRef
Oral delivery of Bacillus subtilis spores expressing cysteine protease of Clonorchis sinensis to grass carp ( Ctenopharyngodon idellus ): Induces immune responses and has no damage on liver and intestine function
Zeli Tang, Hengchang Sun, TingJin Chen, Zhipeng Lin, Hongye Jiang, Xinyi Zhou, Cunbin Shi, Houjun Pan, Ouqin Chang, Pengli Ren, Jinyun Yu, Xuerong Li, Jin Xu, Yan Huang, Xinbing Yu
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Comparative analysis of immune effects in mice model: Clonorchis sinensis cysteine protease generated from recombinant Escherichia coli and Bacillus subtilis spores
Zhanshuai Wu, Zeli Tang, Mei Shang, Lu Zhao, Lina Zhou, Xiangzhan Kong, Zhipeng Lin, Hengchang Sun, Tingjin Chen, Jin Xu, Xuerong Li, Yan Huang, Xinbing Yu
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The immunological characteristics and probiotic function of recombinant Bacillus subtilis spore expressing Clonorchis sinensis cysteine protease
Zeli Tang, Mei Shang, Tingjin Chen, Pengli Ren, Hengchang Sun, Hongling Qu, Zhipeng Lin, Lina Zhou, Jinyun Yu, Hongye Jiang, Xinyi Zhou, Xuerong Li, Yan Huang, Jin Xu, Xinbing Yu
Parasites & Vectors.2016;[Epub] CrossRef
Immunological features of LPS from Ochrobactrum intermedium on sheep experimentally infected with Fasciola hepatica
J.M. Martínez-Pérez, D. Robles-Pérez, F.A. Rojo-Vázquez, M. Martínez-Valladares
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Case Report

A Case of Biliary Fascioliasis by Fasciola gigantica in Turkey: Vedat Goral, Senem Senturk, Omer Mete, Mutallib Cicek, Berat Ebik, Be?ir Kaya; Korean J Parasitol 2011;49(1):65-68.
Published online March 18, 2011; DOI: https://doi.org/10.3347/kjp.2011.49.1.65

Abstract
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A case of Fasciola gigantica-induced biliary obstruction and cholestasis is reported in Turkey. The patient was a 37- year-old woman, and suffered from icterus, ascites, and pain in her right upper abdominal region. A total of 7 living adult flukes were recovered during endoscopic retrograde cholangiopancreatography (ERCP). A single dose of triclabendazole was administered to treat possible remaining worms. She was living in a village of southeast of Anatolia region and had sheeps and cows. She had the history of eating lettuce, mallow, dill, and parsley without washing. This is the first case of fascioliasis which was treated via endoscopic biliary extraction during ERCP in Turkey.

Citations

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Human and Animal Fascioliasis: Origins and Worldwide Evolving Scenario
Santiago Mas-Coma, M. Adela Valero, M. Dolores Bargues
Clinical Microbiology Reviews.2022;[Epub] CrossRef
Foodborne Parasites and Their Complex Life Cycles Challenging Food Safety in Different Food Chains
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Triclabendazole in the treatment of human fascioliasis: a review
Preetam Gandhi, Esther K Schmitt, Chien-Wei Chen, Sanjay Samantray, Vinay Kumar Venishetty, David Hughes
Transactions of The Royal Society of Tropical Medicine and Hygiene.2019; 113(12): 797. CrossRef
Fasciola hepatica in the common bile duct: spyglass visualization and endoscopic extraction
Edson Guzmán Calderón, Augusto Vera Calderón, Ramiro Díaz Ríos, Ronald Arcana López, Edgar Alva Alva
Revista Española de Enfermedades Digestivas.2018;[Epub] CrossRef
Human fascioliasis by Fasciola hepatica: the first case report in Nepal
Ranjit Sah, Shusila Khadka, Mohan Khadka, Dipesh Gurubacharya, Jeevan Bahadur Sherchand, Keshab Parajuli, Niranjan Prasad Shah, Hari Prasad Kattel, Bharat Mani Pokharel, Basista Rijal
BMC Research Notes.2017;[Epub] CrossRef
Biliary Fasciola gigantica infestation in a nonendemic area — An intraoperative surprise
Prema Menon, Amit Kumar Sinha, Katragadda Lakshmi Narasimha Rao, Sumeeta Khurana, Sadhana Lal, Babu Ram Thapa
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Molecular identification ofFasciolaspp. (Digenea: Platyhelminthes) in cattle from Vietnam
S. Nguyen, S. Amer, M. Ichikawa, T. Itagaki, Y. Fukuda, Y. Nakai
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