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"Interleukin-10"

Brief Communication

Elevated interleukin-10 levels in patients with ocular toxoplasmosis
Gee-Hyun Kim, Jae Hyuck Kwak, Young-Hoon Park
Parasites Hosts Dis 2023;61(3):310-316.
Published online August 21, 2023
DOI: https://doi.org/10.3347/PHD.22172
In elderly patients, ocular toxoplasmosis is one of the most common etiologies of uveitis, which should be differentially diagnosed from ocular lymphoma, another common pathology of uveitis in older adults. The high level of interleukin (IL)-10 and an IL-10/IL-6 ratio higher than 1 (>1.0) are helpful parameters to diagnose ocular lymphoma. In this study, we used aqueous humor samples to detect 4 cases of ocular toxoplasmosis in patients with high levels of IL-10 and an IL-10/IL-6 ratio higher than 1. Our results show that ocular toxoplasmosis may be associated with increased cytokine levels in aqueous humor.

Citations

Citations to this article as recorded by  Crossref logo
  • Toxoplasma gondii IST suppresses inflammatory and apoptotic responses by inhibiting STAT1-mediated signaling in IFN-γ/TNF-α-stimulated hepatocytes
    Seung-Hwan Seo, Ji-Eun Lee, Do-Won Ham, Eun-Hee Shin
    Parasites, Hosts and Diseases.2024; 62(1): 30.     CrossRef
  • Factors related to central nervous system involvement of primary vitreoretinal lymphoma
    Joo Young Kim, Jae Jung Kim, Rae Young Kim, Mirinae Kim, Young Gun Park, Young-Hoon Park
    Graefe's Archive for Clinical and Experimental Ophthalmology.2024; 262(8): 2421.     CrossRef
  • 7,946 View
  • 101 Download
  • 2 Web of Science
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Original Article
Trichomonas vaginalis α-Actinin 2 Modulates Host Immune Responses by Inducing Tolerogenic Dendritic Cells via IL-10 Production from Regulatory T Cells
Hye-Yeon Lee, Juri Kim, Jae-Sook Ryu, Soon-Jung Park
Korean J Parasitol 2017;55(4):375-384.
Published online August 31, 2017
DOI: https://doi.org/10.3347/kjp.2017.55.4.375
Trichomonas vaginalis is a pathogen that triggers severe immune responses in hosts. T. vaginalis α-actinin 2, Tvα-actinin 2, has been used to diagnose trichomoniasis. This study was undertaken to examine the role of Tvα-actinin 2 as an antigenic molecule to induce immune responses from humans. Western blot analysis using anti-Tvα-actinin 2 antibodies indicated its presence in the secreted proteins of T. vaginalis. ELISA was employed to measure cytokine production by vaginal epithelial cells, prostate cells, mouse dendritic cells (DCs), or T cells stimulated with T. vaginalis or Tvα-actinin 2 protein. Both T. vaginalis and rTvα-actinin 2 induced cytokine production from epithelial cell lines, including IL-10. Moreover, CD4+CD25- regulatory T cells (Treg cells) incubated with rTvα-actinin 2-treated DCs produced high levels of IL-10. These data indicate that Tvα-actinin 2 modulates immune responses via IL-10 production by Treg cells.

Citations

Citations to this article as recorded by  Crossref logo
  • Identification and Characterization of α-Actinin 1 of Histomonas meleagridis and Its Potential Vaccine Candidates against Histomonosis
    Dandan Liu, Chen Chen, Qiaoguang Chen, Shuang Wang, Zaifan Li, Jie Rong, Yuming Zhang, Zhaofeng Hou, Jianping Tao, Jinjun Xu
    Animals.2023; 13(14): 2330.     CrossRef
  • Surface‐enhanced Raman scattering of secretory proteins for the cytotoxicity analysis of low‐dose doxorubicin
    Mengmeng Zheng, Siqi Gao, Yamin Lin, Yating Lin, Zufang Huang, Shusen Xie, Yun Yu, Juqiang Lin
    Journal of Raman Spectroscopy.2020; 51(11): 2217.     CrossRef
  • Vasoactive intestinal peptide is required in the maintenance of immune regulatory competency of immune regulatory monocytes
    L Guan, D Yu, G-H Wu, H-J Ning, S-D He, S-S Li, T-Y Hu, G Yang, Z-Q Liu, H-Q Yu, X-Z Sun, Z-G Liu, P-C Yang
    Clinical and Experimental Immunology.2019; 196(2): 276.     CrossRef
  • 8,931 View
  • 175 Download
  • 4 Web of Science
  • Crossref