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"S.C. Lu"

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"S.C. Lu"

Original Article
Rodent model for long-term maintenance and development of the viable cysticerci of Taenia saginata asiatica
I.C. Wang, W.C. Chung, S.C. Lu, P.C. Fan
Korean J Parasitol 2000;38(4):237-244.
Published online December 31, 2000
DOI: https://doi.org/10.3347/kjp.2000.38.4.237

Although oncospheres of Taenia saginata asiatica can develop into cysticerci in immunodeficiency, immunosuppressed, and normal mice, no detailed information on the development features of these cysticerci from SCID mice is available. In the present study, the tumor-like cyst was found in the subcutaneous tissues of each of 10 SCID mice after 38-244 days inoculation with 39,000 oncospheres of T. s. asiatica. These cysts weighed 2.0-9.6 gm and were 1.5-4.3 cm in diameter. The number of cysticerci were collected from these cysts ranged from 125 to 1,794 and the cysticercus recovery rate from 0.3% to 4.6%. All cysticerci were viable with a diameter of 1-6 mm and 9 abnormal ones each with 2 evaginated protoscoleces were also found. The mean length and width of scolex, protoscolex, and bladder were 477 × 558, 756 × 727, and 1,586 × 1,615 ?m, respectively. The diameters of suckers and rostellum were 220 ?m and 70 ?m, respectively. All cysticerci had two rows of rostellar hooks. These findings suggest that the SCID mouse model can be employed as a tool for long-term maintenance of the biological materials for advanced studies of immunodiagnosis, vaccine development, and evaluation of cestocidal drugs which would be most benefit for the good health of the livestocks.

Citations

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  • Experimental animal models and their use in understanding cysticercosis: A systematic review
    Muloongo C. Sitali, Veronika Schmidt, Racheal Mwenda, Chummy S. Sikasunge, Kabemba E. Mwape, Martin C. Simuunza, Clarissa P. da Costa, Andrea S. Winkler, Isaac K. Phiri, Adler R. Dillman
    PLOS ONE.2022; 17(7): e0271232.     CrossRef
  • Taeniasis and cysticercosis in Asia: A review with emphasis on molecular approaches and local lifestyles
    Akira Ito, Tiaoying Li, Toni Wandra, Paron Dekumyoy, Tetsuya Yanagida, Munehiro Okamoto, Christine M Budke
    Acta Tropica.2019; 198: 105075.     CrossRef
  • Opinion of the Scientific Panel on biological hazards (BIOHAZ) on the suitability and details of freezing methods to allow human consumption of meat infected with Trichinella or Cysticerc

    EFSA Journal.2005; 3(1): 142.     CrossRef
  • Development of Taenia saginata asiatica metacestodes in SCID mice and its infectivity in human and alternative definitive hosts
    S. L. Chang, N. Nonaka, M. Kamiya, Y. Kanai, H. K. Ooi, W. C. Chung, Y. Oku
    Parasitology Research.2005; 96(2): 95.     CrossRef
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