Plasmodium vivax, a protozoan malaria parasite of humans, represents a major public health concern in the Republic of Korea (= South Korea). However, little is known about the genetic properties and population structures of the P. vivax isolates circulating in South Korea. This article reviews known polymorphic genetic markers in South Korean isolates of P. vivax and briefly summarizes the current issues surrounding the gene and population structures of this parasite. The critical genetic characteristics of major antigens of the parasite, such as circumsporozoite protein (CSP), merozoite surface protein 1 (MSP-1) and MSP-3, Duffy binding protein (DBP), apical membrane antigen 1 (AMA-1), and GAM-1, are also discussed.
Citations
Citations to this article as recorded by
Alternative Invasion Mechanisms and Host Immune Response to Plasmodium vivax Malaria: Trends and Future Directions Daniel Kepple, Kareen Pestana, Junya Tomida, Abnet Abebe, Lemu Golassa, Eugenia Lo Microorganisms.2020; 9(1): 15. CrossRef
Identification of an Immunogenic Broadly Inhibitory Surface Epitope of the Plasmodium vivax Duffy Binding Protein Ligand Domain Miriam T. George, Jesse L. Schloegel, Francis B. Ntumngia, Samantha J. Barnes, Christopher L. King, Joanne L. Casey, Michael Foley, John H. Adams, Photini Sinnis mSphere.2019;[Epub] CrossRef
Genetic Diversity of Plasmodium vivax Causing Epidemic Malaria in the Republic of Korea Young Yil Bahk, Jeonga Kim, Seong Kyu Ahn, Byoung-Kuk Na, Jong-Yil Chai, Tong-Soo Kim The Korean Journal of Parasitology.2018; 56(6): 545. CrossRef
Genetic diversity and effect of natural selection at apical membrane antigen-1 (AMA-1) among Iranian Plasmodium vivax isolates Ahmad Reza Esmaeili Rastaghi, Fatemeh Nedaei, Hossein Nahrevanian, Nazanin Hoseinkhan Folia Parasitologica.2014; 61(5): 385. CrossRef
The association of Duffy binding protein region II polymorphisms and its antigenicity in Plasmodium vivax isolates from Thailand Patchanee Chootong, Amy M. McHenry, Francis B. Ntumngia, Jetsumon Sattabongkot, John H. Adams Parasitology International.2014; 63(6): 858. CrossRef
First imported relapse case of Plasmodium vivax malaria and analysis of its origin by CSP sequencing in Henan Province, China Ying Liu, Hong-wei Zhang, Rui-min Zhou, Cheng-yun Yang, Dan Qian, Yu-ling Zhao, Bian-li Xu Malaria Journal.2014;[Epub] CrossRef
Microsatellite DNA Analysis Revealed a Drastic Genetic Change of Plasmodium vivax Population in the Republic of Korea During 2002 and 2003 Moritoshi Iwagami, Seung-Young Hwang, So-Hee Kim, So-Jung Park, Ga-Young Lee, Emilie Louise Akiko Matsumoto-Takahashi, Weon-Gyu Kho, Shigeyuki Kano, Shan Lv PLoS Neglected Tropical Diseases.2013; 7(10): e2522. CrossRef
Population Structure and Transmission Dynamics of Plasmodium vivax in the Republic of Korea Based on Microsatellite DNA Analysis Moritoshi Iwagami, Megumi Fukumoto, Seung-Young Hwang, So-Hee Kim, Weon-Gyu Kho, Shigeyuki Kano, Mehmet Ali Ozcel PLoS Neglected Tropical Diseases.2012; 6(4): e1592. CrossRef
Plasmodium vivax populations revisited: mitochondrial genomes of temperate strains in Asia suggest ancient population expansion Miao Miao, Zhaoqing Yang, Harland Patch, Yaming Huang, Ananias A Escalante, Liwang Cui BMC Evolutionary Biology.2012;[Epub] CrossRef
Geographical origin of Plasmodium vivax in the Republic of Korea: haplotype network analysis based on the parasite's mitochondrial genome Moritoshi Iwagami, Seung-Young Hwang, Megumi Fukumoto, Toshiyuki Hayakawa, Kazuyuki Tanabe, So-Hee Kim, Weon-Gyu Kho, Shigeyuki Kano Malaria Journal.2010;[Epub] CrossRef
A complete cDNA sequence encoding a pore-forming subunit (Kir6.2) of ATP-senstive potassium channel in the adult worm, Clonorchis sinensis, termed CsKir6.2, was isolated from an adult cDNA library. The cDNA contained a single open-reading frame of 333 amino acids, which has a structural motif (a GFG-motif) of the putative pore-forming loop of the Kir6.2. Peculiarly, the CsKir6.2 shows a lack-sequence structure, which deleted 57 amino acids were deleted from its N-terminus. The predicted amino acid sequence revealed a highly conserved sequence as other known other Kir6.2 subunits. The mRNA was weekly expressed in the adult worm.
Citations
Citations to this article as recorded by
Pipeline for the identification and classification of ion channels in parasitic flatworms Bahiyah Nor, Neil D. Young, Pasi K. Korhonen, Ross S. Hall, Patrick Tan, Andrew Lonie, Robin B. Gasser Parasites & Vectors.2016;[Epub] CrossRef
Progress on the transcriptomics of carcinogenic liver flukes of humans—Unique biological and biotechnological prospects Neil D. Young, Aaron R. Jex, Cinzia Cantacessi, Bronwyn E. Campbell, Thewarach Laha, Woon-Mok Sohn, Banchob Sripa, Alex Loukas, Paul J. Brindley, Robin B. Gasser Biotechnology Advances.2010; 28(6): 859. CrossRef
Functional Genes and Proteins of Clonorchis sinensis Tae Im Kim, Byoung-Kuk Na, Sung-Jong Hong The Korean Journal of Parasitology.2009; 47(Suppl): S59. CrossRef
Clonorchiasis: an update H.-J. Rim Journal of Helminthology.2005; 79(3): 269. CrossRef
First
Prev
