Matheus D. Baldissera, Carine de F. Souza, Cl?udia M. Bertoncheli, Karine L. da Silveira, Thirssa H. Grando, Bianca C. Z. Porto, Daniela B. R. Leal, Aleksandro S. Da Silva, Ricardo E. Mendes, Lenita M. Stefani, Silvia G. Monteiro
Korean J Parasitol 2016;54(3):247-252. Published online June 30, 2016
This study was conducted to investigate the occurrence of oxidative stress in the heart tissue of rats infected with Trypanosoma evansi. Rats were divided into 2 groups (A and B) with 12 animals each, and further subdivided into 4 subgroups (A1 and A2, 6 animals/each; and B1 and B2, 6 animals/each). Animals in the groups B1 and B2 were subcutaneously inoculated with T. evansi. Thiobarbituric acid reactive substances (TBARS), superoxide dismutase activity (SOD), glutathione S-transferase activity (GST), reduced glutathione activity (GSH), and non-protein thiols (NPSH) in the heart tissue were evaluated. At day 5 and 15 post-infection (PI), an increase in the TBARS levels and a decrease in the SOD activity (P<0.05) were observed. GSH and GST activities were decreased in infected animals at day 15 PI (P<0.05). Considering the proper functioning of the heart, it is possible that the changes in the activity of these enzymes involved in the oxidative stress may be related, at least in part, in the pathophysiology of rats infected with T. evansi.
Citations
Citations to this article as recorded by
Novel insights into antioxidant status, gene expression, and immunohistochemistry in an animal model infected with camel-derived Trypanosoma evansi and Theileria annulata Reem M. Ramadan, Alaa F. Bakr, Esraa Fouad, Faten F. Mohammed, Azza M. Abdel-Wahab, Sahar Z. Abdel-Maogood, Mohamed M. El-Bahy, Mai A. Salem Parasites & Vectors.2024;[Epub] CrossRef
Molecular and phylogenetic analysis of a type K1 strain Trypanosoma evansi isolate from Nigerian cattle: An evaluation of the therapeutic effects of compounds from Brassica oleracea on the histopathology of infected wister rats Kingsley Onyekachi Moh, Sodangi Abdulkarim Luka, Iliya Shehu Ndams, Idris Alao Lawal, Dahiru Sani, Sylvester Sunday Obeta, Gbenga Peter Oderinde, Emeka John Dingwoke, Fatima Amin Adamude, Abraham Ehinomhen Ubhenin, Saifullahi Umar Biochemistry and Biophysics Reports.2023; 33: 101424. CrossRef
The disturbance of antioxidant/oxidant balance in fish experimentally infected by Aeromonas caviae: Relationship with disease pathophysiology Matheus D. Baldissera, Carine F. Souza, Belisa Parmeggiani, Guilhian Leipnitz, Camila Marina Verdi, RobertoC.V. Santos, Lenita M. Stefani, Bernardo Baldisserotto Microbial Pathogenesis.2018; 122: 53. CrossRef
Relationship between antioxidant defense in Acanthamoeba spp. infected lungs and host immunological status N. Łanocha-Arendarczyk, I. Baranowska-Bosiacka, I. Gutowska, K. Kot, E. Metryka, D.I. Kosik-Bogacka Experimental Parasitology.2018; 193: 58. CrossRef
Achyrocline satureioides essential oil loaded in nanocapsules ameliorate the antioxidant/oxidant status in heart of rats infected with Trypanosoma evansi Carine F. Souza, Matheus D. Baldissera, Luciana F. Cossetin, Daiane F. Dalla Lana, Silvia G. Monteiro Microbial Pathogenesis.2017; 105: 30. CrossRef
Matheus D. Baldissera, Camila B. Oliveira, Carine E. P. Zimmermann, Aline A. Boligon, Margareth Linde Athayde, Leandro P. Bolzan, Rodrigo de A. Vaucher, Janio M. Santurio, Michele R. Sagrillo, Aleksandro Schafer da Silva, Silvia G. Monteiro
Korean J Parasitol 2014;52(3):311-315. Published online June 26, 2014
The aim of this study was to verify the trypanocidal effectiveness of aqueous, methanolic, and ethanolic extracts of Achyrocline satureioides against Trypanosoma evansi in vitro. A. satureioides extracts, known as macela, were used on trypomastigotes at different concentrations (1, 5, 10, 50, 100, 500, and 1,000 ?g/ml) and exposure times (0, 1, 3, 6, and 9 hr). A dose-dependent effect was observed when the 3 extracts were tested. The concentrations of 1, 5, and 10 ?g/ml were not able to kill trypomastigotes until 3 hr after exposure, and the highest concentrations (500 and 1,000 ?g/ml) were able to kill all trypomastigotes after 1 hr. When the time of exposure was increased up to 9 hr, the concentrations at 50 and 100 ?g/ml were 100% effective to 3 extracts. The chemical analysis of the extracts revealed the presence of flavonoids, a trypanocidal compound already described. Based on the results, we can conclude that the A. satureioides extracts exhibit trypanocidal effects.
Citations
Citations to this article as recorded by
Achyrocline satureioides infusion, popularly prepared and consumed, has an in vitro protective effect on human neural cells exposed to rotenone Ivana Beatrice Mânica da Cruz, Maria Eduarda Chelotti, Barbara Osmarin Turra, Nathália Cardoso de Afonso Bonotto, Débora Felipetto Pulcinelli, Ana Laura Kerkhoff Escher, Caroline Klein, Paola de Azevedo Mello, Gustavo Rossato Bitencourt, Fernanda Barbisan Journal of Ethnopharmacology.2024; 332: 118350. CrossRef
Achyrocline satureioides review: From the pharmacochemical diversity to the technological development of products Sara Elis Bianchi, Gabriela de Carvalho Meirelles, Victorya Benes Raabe, Kellen Cristhinia Borges de Souza, Valquiria Linck Bassani Fitoterapia.2023; 168: 105537. CrossRef
Acaricidal and anthelmintic action of ethanolic extract and essential oil of Achyrocline satureioides Rafaela Regina Fantatto, Ana Carolina de Souza Chagas, Yousmel Alemán Gainza, Flávio Augusto Sanches Politi, Leonardo Mendes de Souza Mesquita, Wagner Vilegas, Humberto Ribeiro Bizzo, Ílio Montanari Junior, Rosemeire Cristina Linhari Rodrigues Pietro Experimental Parasitology.2022; 236-237: 108252. CrossRef
Trypanocidal Essential Oils: A Review Mayara Castro de Morais, Jucieudo Virgulino de Souza, Carlos da Silva Maia Bezerra Filho, Silvio Santana Dolabella, Damião Pergentino de Sousa Molecules.2020; 25(19): 4568. CrossRef
Untargeted LC–MS metabolomic studies of Asteraceae species to discover inhibitors of Leishmania major dihydroorotate dehydrogenase Lucas A. Chibli, Annylory L. Rosa, Maria Cristina Nonato, Fernando B. Da Costa Metabolomics.2019;[Epub] CrossRef
Purification, structural elucidation, antioxidant capacity and neuroprotective potential of the main polyphenolic compounds contained in Achyrocline satureioides (Lam) D.C. (Compositae) Marcela Martínez-Busi, Florencia Arredondo, David González, Carolina Echeverry, Mauricio A. Vega-Teijido, Diego Carvalho, Alejandra Rodríguez-Haralambides, Felicia Rivera, Federico Dajas, Juan A. Abin-Carriquiry Bioorganic & Medicinal Chemistry.2019; 27(12): 2579. CrossRef
Anticancer activity of flavonoids isolated from Achyrocline satureioides in gliomas cell lines Priscila Oliveira de Souza, Sara Elis Bianchi, Fabrício Figueiró, Luana Heimfarth, Karla Suzana Moresco, Rosângela Mayer Gonçalves, Juliana Bender Hoppe, Caroline Peres Klein, Christianne Gazzana Salbego, Daniel Pens Gelain, Valquíria Linck Bassani, Alfeu Toxicology in Vitro.2018; 51: 23. CrossRef
Insight into trypanosomosis (Surra) of Indian livestock: Recent updates VEER SINGH, BISWA RANJAN MAHARANA The Indian Journal of Animal Sciences.2018; 88(10): 1101. CrossRef
Achyrocline satureioides essential oil-loaded in nanocapsules reduces cytotoxic damage in liver of rats infected by Trypanosoma evansi Camila S. Ritter, Matheus D. Baldissera, Thirssa H. Grando, Carine F. Souza, Michele R. Sagrillo, Ana Paula T. da Silva, Rafael N. Moresco, Naiara S. Guarda, Aleksandro S. da Silva, Lenita M. Stefani, Silvia G. Monteiro Microbial Pathogenesis.2017; 103: 149. CrossRef
Effect of the treatment with Achyrocline satureioides (free and nanocapsules essential oil) and diminazene aceturate on hematological and biochemical parameters in rats infected by Trypanosoma evansi Guilherme M. Do Carmo, Matheus D. Baldissera, Rodrigo A. Vaucher, Virginia Cielo Rech, Camila B. Oliveira, Michele Rorato Sagrillo, Aline A. Boligon, Margareth L. Athayde, Marta P. Alves, Raqueli T. França, Sonia T.A. Lopes, Claiton I. Schwertz, Ricardo E Experimental Parasitology.2015; 149: 39. CrossRef
Aleksandro S. Da Silva, Vinicius R. Fanfa, Mateus A. Otto, Lucas T. Gressler, Kaio C.S. Tavares, C?cera R. Lazzarotto, Alexandre A. Tonin, Luiz C. Miletti, Marta M.M.F. Duarte, Silvia G. Monteiro
Korean J Parasitol 2011;49(4):427-430. Published online December 16, 2011
The aim of this study was to test the susceptibility of mice to Trypanosoma evansi treated with human plasma containing different concentrations of apolipoprotein L-1 (APOL1). For this experiment, a strain of T. evansi and human plasma (plasmas 1, 2, and 3) from 3 adult males clinically healthy were used. In vivo test used 50 mice divided in 5 groups (A to E) with 10 animals in each group. Animals of groups B to E were infected, and then treated with 0.2 ml of human plasma in the following outline: negative control (A), positive control (B), treatment with plasma 1 (C), treatment with plasma 2 (D), and treatment with plasma 3 (E). Mice treated with human plasma showed an increase in longevity of 40.9±0.3 (C), 20±9.0 (D) and 35.6±9.3 (E) days compared to the control group (B) which was 4.3±0.5 days. The number of surviving mice and free of the parasite (blood smear and PCR negative) at the end of the experiment was 90%, 0%, and 60% for groups C, D, and E, respectively. The quantification of APOL1 was performed due to the large difference in the treatments that differed in the source plasma. In plasmas 1, 2, and 3 was detected the concentration of 194, 99, and 115 mg/dl of APOL1, respectively. However, we believe that this difference in the treatment efficiency is related to the level of APOL1 in plasmas.
Citations
Citations to this article as recorded by
The effect of normal human serum on the mouse trypanosome Trypanosoma musculi in vitro and in vivo Xuan Zhang, Xiao-Kun Hong, Su-Jin Li, De-Hua Lai, Geoff Hide, Zhao-Rong Lun, Yan-Zi Wen Experimental Parasitology.2018; 184: 115. CrossRef
Pre-treatment with curcumin modulates acetylcholinesterase activity and proinflammatory cytokines in rats infected with Trypanosoma evansi Patrícia Wolkmer, Cássia B. da Silva, Francine C. Paim, Marta M.M.F. Duarte, Verônica Castro, Heloisa E. Palma, Raqueli T. França, Diandra V. Felin, Lucas C. Siqueira, Sonia T.A. Lopes, Maria Rosa C. Schetinger, Silvia G. Monteiro, Cinthia M. Mazzanti Parasitology International.2013; 62(2): 144. CrossRef
First
Prev
