Skip to main navigation Skip to main content
  • KSPTM
  • E-Submission

PHD : Parasites, Hosts and Diseases

OPEN ACCESS
ABOUT
BROWSE ARTICLES
FOR CONTRIBUTORS

Page Path

23
results for

"eosinophil"

Article category

Keywords

Publication year

Authors

Funded articles

"eosinophil"

Original Articles

Infectious Causes of Eosinophilic Meningitis in Korean Patients: A Single-Institution Retrospective Chart Review from 2004 to 2018
Sunghee Park, Jiwon Jung, Yong Pil Chong, Sung-Han Kim, Sang-Oh Lee, Sang-Ho Choi, Yang Soo Kim, Min Jae Kim
Korean J Parasitol 2021;59(3):227-233.
Published online June 21, 2021
DOI: https://doi.org/10.3347/kjp.2021.59.3.227
Eosinophilic meningitis is defined as the presence of more than 10 eosinophils per μl in the cerebrospinal fluid (CSF), or eosinophils accounting for more than 10% of CSF leukocytes in patients with acute meningitis. Parasites are the most common cause of eosinophilic meningitis worldwide, but there is limited research on patients in Korea. Patients diagnosed with eosinophilic meningitis between January 2004 and June 2018 at a tertiary hospital in Seoul, Korea were retrospectively reviewed. The etiology and clinical characteristics of each patient were identified. Of the 22 patients included in the study, 11 (50%) had parasitic causes, of whom 8 (36%) were diagnosed as neurocysticercosis and 3 (14%) as Toxocara meningitis. Four (18%) patients were diagnosed with fungal meningitis, and underlying immunodeficiency was found in 2 of these patients. The etiology of another 4 (18%) patients was suspected to be tuberculosis, which is endemic in Korea. Viral and bacterial meningitis were relatively rare causes of eosinophilic meningitis, accounting for 2 (9%) and 1 (5%) patients, respectively. One patient with neurocysticercosis and 1 patient with fungal meningitis died, and 5 (23%) had neurologic sequelae. Parasite infections, especially neurocysticercosis and toxocariasis, were the most common cause of eosinophilic meningitis in Korean patients. Fungal meningitis, while relatively rare, is often aggressive and must be considered when searching for the cause of eosinophilic meningitis.

Citations

Citations to this article as recorded by  Crossref logo
  • Severe angiostrongyliasis with neuropsychiatric symptoms in vulnerable adults: Early diagnosis via next-generation sequencing and successful treatment
    Xiaomiao Tang, Juanjuan Wu, Yefeng Yang, Yingqiong Wang, Chengji Jin, Chengzhi Xie, Mei Wang, Run Liu, Xiaozhi Wang, Fengyun Wang, Jing Wang
    Journal of Infection and Public Health.2025; 18(5): 102759.     CrossRef
  • Eosinophilic Meningitis: Eleven-Year Experience at Texas Children's Hospital
    Margaret G. Taylor, Alexander Ankar, Avner Meoded, Imad T. Jarjour, Sarah Risen, J. Chase McNeil
    The Journal of Pediatrics.2022; 251: 202.     CrossRef
  • 6,332 View
  • 147 Download
  • 2 Web of Science
  • Crossref
Prevalence of Toxocariasis and Its Risk Factors in Patients with Eosinophilia in Korea
Hyun Beom Song, Deokho Lee, Yan Jin, Jinwoo Kang, Shin-Hyeong Cho, Min Sun Park, Jin-Ho Park, Woo-Jung Song, Hye-Ryun Kang, Sang Hyub Lee, Sung-Tae Hong, Min-Ho Choi
Korean J Parasitol 2020;58(4):413-419.
Published online August 26, 2020
DOI: https://doi.org/10.3347/kjp.2020.58.4.413
Eosinophilia occurs commonly in many diseases including allergic diseases and helminthic infections. Toxocariasis has been suggested as one cause of eosinophilia. The present study was undertaken to examine the prevalence of toxocariasis in patients with eosinophilia and to identify the risk factors for toxocariasis. This prospective cohort study recruited a total of 81 patients with eosinophilia (34 males and 47 females) who visited the outpatient clinic at Seoul National University Hospital from January 2017 to February 2018 and agreed to participate in this study. The prevalence of toxocariasis was examined by T. canis-specific ELISA, and the various risk factors for toxocariasis were evaluated by a questionnaire survey. Among 81 patients with eosinophilia, 18 were positive for anti-T. canis antibodies (22.2%); 88.9% were male (16/18) and 11.1% were female (2/18). Multivariate statistical analysis revealed that males (OR 21.876, 95% CI: 1.667-287.144) with a history of consuming the raw meat or livers of animals (OR 5.899, 95% CI: 1.004-34.669) and a heavy alcohol-drinking habit (OR 8.767, 95% CI: 1.018-75.497) were at higher risk of toxocariasis in patients with eosinophilia. Toxocariasis should be considered a potential cause of eosinophilia when the patient has a history of eating the raw meat or livers of animals in Korea. A single course of albendazole is recommended to reduce the migration of Toxocara larvae in serologically positive cases with eosinophilia.

Citations

Citations to this article as recorded by  Crossref logo
  • Evaluation of a Multiplex Bead Assay for Strongyloides stercoralis diagnosis using the recombinant antigen rSs-NIE-1
    Joelma Nascimento de Souza, Wéslei Almeida Costa Araújo, Márcia Cristina Aquino Teixeira, Neci Matos Soares
    Diagnostic Microbiology and Infectious Disease.2026; 114(2): 117108.     CrossRef
  • High toxocariasis seroprevalence in a tri-border indigenous community (Brazil, Paraguay and Argentina): A One Health perspective
    Isabella Braghin Ferreira, Roberto Teixeira de Souza Filho, Susana Angélica Zevallos Lescano, Rogério Giuffrida, Daniele Rodrigues, Suelen Teixeira de Faria Resende, Fabiano Borges Figueiredo, Louise Bach Kmetiuk, Andrea Pires dos Santos, Alexander Welker
    One Health.2025; 21: 101106.     CrossRef
  • Human toxocariasis
    Susana Lopez-Alamillo, Pravallika Padyala, Megan Carey, Megan M. Duffey, Jill E. Weatherhead, Louisa A. Messenger, Bachir Medrouh, Marcelo U. Ferreira
    Clinical Microbiology Reviews.2025;[Epub]     CrossRef
  • First Report on the Seroprevalence and Risk Factors Associated with Toxocara Infection in Blood Donors from Romania
    Ana Alexandra Ardelean, Rodica Lighezan, Sorin Ursoniu, Sergiu Adrian Sprintar, Daniela Adriana Oatis, Alin Gabriel Mihu, Maria Alina Lupu, Tudor Rareș Olariu
    Pathogens.2025; 14(9): 857.     CrossRef
  • TỶ LỆ VÀ YẾU TỐ LIÊN QUAN NHIỄM TOXOCARA CANIS TẠI PHÒNG KHÁM BỆNH VIỆN ĐẠI HỌC Y DƯỢC 1 THÀNH PHỐ HỒ CHÍ MINH
    Nguyễn Ngọc Phi Anh Nguyễn Ngọc Phi Anh, Trần Thị Kim Dung Trần Thị Kim Dung, Huỳnh Thị Thu Thảo Huỳnh Thị Thu Thảo
    Tạp Chí Khoa Học Trường Đại Học Quốc Tế Hồng Bàng.2024; : 213.     CrossRef
  • Toxocariasis: potential association with bronchial asthma, and pneumonia among pediatric children
    Wegdan M. Abd El Wahab, Mona I. Ali, Shimaa S. Ibrahim, Yasmen A. Mohamed, Doaa A. Hamdy
    Journal of Parasitic Diseases.2023; 47(1): 93.     CrossRef
  • One health approach to toxocariasis in quilombola communities of southern Brazil
    Vamilton Alvares Santarém, Giovanni Kalempa Panazzolo, Louise Bach Kmetiuk, Orlei José Domingues, Isabella Braghin Ferreira, Roberto Teixeira de Souza Filho, João Henrique Farinhas, Fernando Rodrigo Doline, Susana Angélica Zevallos Lescano, Leandro Menegu
    Parasites & Vectors.2023;[Epub]     CrossRef
  • Seroprevalence of toxocariasis among allergic patients in Kuwait and its association with eosinophilia
    Mohammad Al-Awadhi, Wafaa Jamal
    Parasite Epidemiology and Control.2022; 18: e00260.     CrossRef
  • Green vegetable juice as a potential source of human fascioliasis in Korea
    Sungim Choi, Sunghee Park, Sooji Hong, Hyejoo Shin, Bong-Kwang Jung, Min Jae Kim
    One Health.2022; 15: 100441.     CrossRef
  • Serosurvey of anti-Toxocara canis antibodies in people experiencing homelessness and shelter workers from São Paulo, Brazil
    Vamilton Alvares Santarém, Anahi Chechia do Couto, Susana Zevallos Lescano, William Henry Roldán, Ruana Renostro Delai, Rogério Giuffrida, Louise Bach Kmetiuk, Alexander Welker Biondo, Sriveny Dangoudoubiyam, Andrea Pires dos Santos
    Parasites & Vectors.2022;[Epub]     CrossRef
  • Seroprevalence of Toxocariasis Among Hypereosinophilic Children: A Single Center Study, Tehran, Iran
    Meysam Sharifdini, Mehdi Zarean, Mehrzad Sadredinamin, Mitra Zare- Bavani, Sarah Sharifi-yazdi, Bahram Nikmanesh
    Archives of Pediatric Infectious Diseases.2022;[Epub]     CrossRef
  • The Role of Nile Tilapia (Oreochromis niloticus) in the Life Cycle of Toxocara spp.
    Everton André de Oliveira, Yslla Fernanda Fitz Balo Merigueti, Isabella Braghin Ferreira, Isabele Santos Garcia, Alini Soriano Pereira, Rosemeire de Souza Santos, Louise Bach Kmetiuk, Andrea Pires dos Santos, Alexander Welker Biondo, Rogerio Giuffrida, Va
    Frontiers in Veterinary Science.2021;[Epub]     CrossRef
  • 7,311 View
  • 185 Download
  • 11 Web of Science
  • Crossref
Dexamethasone Downregulates Expressions of 14-3-3β and γ-Isoforms in Mice with Eosinophilic Meningitis Caused by Angiostrongylus cantonensis Infection
Hung-Chin Tsai, Yu-Hsin Chen, Chuan-Min Yen, Li-Yu Chung, Shue-Ren Wann, Susan Shin-Jung Lee, Yao-Shen Chen
Korean J Parasitol 2019;57(3):249-256.
Published online June 30, 2019
DOI: https://doi.org/10.3347/kjp.2019.57.3.249
Steroids are commonly used in patients with eosinophilic meningitis caused by A. cantonensis infections. The mechanism steroids act on eosinophilic meningitis remains unclear. In this mouse experiments, expressions of 14-3-3 isoform β and γ proteins significantly increased in the CSF 2-3 weeks after the infection, but not increasedin the dexamethasone-treated group. Expression of 14-3-3 β, γ, ε, and θ isoforms increased in brain meninges over the 3-week period after infection and decreased due to dexamethasone treatment. In conclusion, administration of dexamethasone in mice with eosinophilic meningitis decreased expressions of 14-3-3 isoform proteins in the CSF and in brain meninges.

Citations

Citations to this article as recorded by  Crossref logo
  • A Case Series of Eosinophilic Meningitis from Kerala
    Githin B George, Jose K Paul, Praveen Panicker, Dileep Ramachandran, B Srikumar, Thomas Iype
    Neurology India.2025; 73(4): 892.     CrossRef
  • Impact of Systemic versus Intratympanic Dexamethasone Administration on the Perilymph Proteome
    Betsy Szeto, Chris Valentini, Aykut Aksit, Emily G. Werth, Shahar Goeta, Lewis M. Brown, Elizabeth S. Olson, Jeffrey W. Kysar, Anil K. Lalwani
    Journal of Proteome Research.2021; 20(8): 4001.     CrossRef
  • Serum 14-3-3β protein: a new biomarker in asthmatic patients with acute exacerbation in an observational study
    Decai Wang, Lizong Rao, Yalan Cui, Guoting Tang, Haiming Huang, Ting Yuan, Biwen Mo
    Allergy, Asthma & Clinical Immunology.2021;[Epub]     CrossRef
  • 8,017 View
  • 108 Download
  • 3 Web of Science
  • Crossref
Neuronal Apoptosis: Pathological Basis of Behavioral Dysfunctions Induced by Angiostrongylus cantonensis in Rodents Model
Shiqi Luo, Lisi OuYang, Jie Wei, Feng Wu, Zhongdao Wu, Wanlong Lei, Dongjuan Yuan
Korean J Parasitol 2017;55(3):267-278.
Published online June 30, 2017
DOI: https://doi.org/10.3347/kjp.2017.55.3.267
Angiostrongylus cantonensis invades the central nervous system (CNS) of humans to induce eosinophilic meningitis and meningoencephalitis and leads to persistent headache, cognitive dysfunction, and ataxic gait. Infected mice (nonpermissive host), admittedly, suffer more serious pathological injuries than rats (permissive host). However, the pathological basis of these manifestations is incompletely elucidated. In this study, the behavioral test, histological and immunohistochemical techniques, and analysis of apoptotic gene expression, especially caspase-3, were conducted. The movement and motor coordination were investigated at week 2 post infection (PI) and week 3 PI in mice and rats, respectively. The cognitive impairs could be found in mice at week 2 PI but not in rats. The plaque-like lesion, perivascular cuffing of inflammatory cells, and dilated vessels within the cerebral cortex and hippocampus were more serious in mice than in rats at week 3 PI. Transcriptomic analysis showed activated extrinsic apoptotic pathway through increased expression of TNFR1 and caspase-8 in mice CNS. Immunohistochemical and double-labeling for NeuN and caspase-3 indicated the dramatically increased expression of caspase-3 in neuron of the cerebral cortex and hippocampus in mice but not in rats. Furthermore, western-blotting results showed high expression of cleaved caspase-3 proteins in mice but relatively low expression in rats. Thus, extrinsic apoptotic pathway participated in neuronal apoptosis might be the pathological basis of distinct behavioral dysfunctions in rodents with A. cantonensis infection. It provides the evidences of a primary molecular mechanism for the behavioral dysfunction and paves the ways to clinical diagnosis and therapy for A. cantonensis infection.

Citations

Citations to this article as recorded by  Crossref logo
  • Insights into the biology of the rat lungworm, Angiostrongylus cantonensis
    Chasen D. Griffin, Vanessa O. Ezenwa, Robert H. Cowie
    Parasites & Vectors.2025;[Epub]     CrossRef
  • Defective glycolysis in the cerebrum and cerebellum correlates with the pathology and neurological declines in mice with Angiostrongylus cantonensis infection
    Shih-Yi Peng, Ho Yin Pekkle Lam, Yu-Ting Huang
    Parasitology International.2024; 98: 102821.     CrossRef
  • Angiostrongylus cantonensis induces energy imbalance and dyskinesia in mice by reducing the expression of melanin-concentrating hormone
    Hui Huang, Zhongyuan Zhang, Mengdan Xing, Zihan Jin, Yue Hu, Minyu Zhou, Hang Wei, Yiwen Liang, Zhiyue Lv
    Parasites & Vectors.2024;[Epub]     CrossRef
  • IL-17A Mediates Demyelination by Activating A1 Astrocytes via SOCS3 During Angiostrongylus cantonensis Infection
    Zongpu Zhou, Tuo Lin, Zhen Liu, Qian Ding, Zhixuan Ma, Wanqi Li, Fukang Xie, Yue Lan, Ying Feng
    Frontiers in Immunology.2022;[Epub]     CrossRef
  • Mechanisms of the host immune response and helminth-induced pathology during Trichobilharzia regenti (Schistosomatidae) neuroinvasion in mice
    Tomáš Macháček, Roman Leontovyč, Barbora Šmídová, Martin Majer, Oldřich Vondráček, Iveta Vojtěchová, Tomáš Petrásek, Petr Horák, Elise O’Connell
    PLOS Pathogens.2022; 18(2): e1010302.     CrossRef
  • Improvements of cognitive functions in mice heavily infected by Angiostrongylus cantonensis after treatment with albendazole, dexamethasone, or co-therapy
    Kai-Yuan Jhan, Chien-Ju Cheng, Chih-Jen Chou, Shih-Ming Jung, Guan-Jhih Lai, Kuang-Yao Chen, Lian-Chen Wang
    Journal of Microbiology, Immunology and Infection.2022; 55(5): 935.     CrossRef
  • Necroptosis and Caspase-2-Mediated Apoptosis of Astrocytes and Neurons, but Not Microglia, of Rat Hippocampus and Parenchyma Caused by Angiostrongylus cantonensis Infection
    Hongli Zhou, Zhe Chen, Yanin Limpanont, Yue Hu, Yubin Ma, Ping Huang, Paron Dekumyoy, Minyu Zhou, Yixin Cheng, Zhiyue Lv
    Frontiers in Microbiology.2020;[Epub]     CrossRef
  • Severe CNS angiostrongyliasis in a young marine: a case report and literature review
    Liane McAuliffe, Shannon Fortin Ensign, Derek Larson, Mary Bavaro, Joseph Yetto, Michael Cathey, Mitsuru Mukaigawara, Masashi Narita, Kiyofumi Ohkusu, Timothy Quast, Charles Volk
    The Lancet Infectious Diseases.2019; 19(4): e132.     CrossRef
  • Regulatory effect of host miR-101b-3p on parasitism of nematode Angiostrongylus cantonensis via superoxide dismutase 3
    Dongjuan Yuan, Shiqi Luo, Lian Xu, Xingda Zeng, Zhongdao Wu
    Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms.2019; 1862(5): 557.     CrossRef
  • Trichostatin A, a Histone Deacetylase Inhibitor, Alleviates Eosinophilic Meningitis Induced by Angiostrongylus cantonensis Infection in Mice
    Yanhua Zhang, Hui Xie, Wenyan Tang, Xingda Zeng, Yu Lin, Lian Xu, Lihua Xiao, Jun Xu, Zhongdao Wu, Dongjuan Yuan
    Frontiers in Microbiology.2019;[Epub]     CrossRef
  • MicroRNA-125b mimic inhibits ischemia reperfusion-induced neuroinflammation and aberrant p53 apoptotic signalling activation through targeting TP53INP1
    Xiao-Qian Li, Qian Yu, Wen-Fei Tan, Zai-Li Zhang, Hong Ma
    Brain, Behavior, and Immunity.2018; 74: 154.     CrossRef
  • Apoptosis and necroptosis of mouse hippocampal and parenchymal astrocytes, microglia and neurons caused by Angiostrongylus cantonensis infection
    Zhang Mengying, Xu Yiyue, Pan Tong, Hu Yue, Yanin Limpanont, Huang Ping, Kamolnetr Okanurak, Wu Yanqi, Paron Dekumyoy, Zhou Hongli, Dorn Watthanakulpanich, Wu Zhongdao, Wang Zhi, Lv Zhiyue
    Parasites & Vectors.2017;[Epub]     CrossRef
  • 10,328 View
  • 151 Download
  • 13 Web of Science
  • Crossref
Immune Correlates of Resistance to Trichinella spiralis Reinfection in Mice
Ki-Back Chu, Sang-Soo Kim, Su-Hwa Lee, Dong-Hun Lee, Ah-Ra Kim, Fu-Shi Quan
Korean J Parasitol 2016;54(5):637-643.
Published online October 31, 2016
DOI: https://doi.org/10.3347/kjp.2016.54.5.637
The immune correlate of host resistance induced by reinfection of Trichinella spiralis remains unclear. In this study, we investigated immune correlates between the resistance and serum IgG antibody level, CD23+ IgM+ B cells, and eosinophil responses induced by T. spiralis reinfection. Mice were primarily infected with 10 or 100 T. spiralis larvae (10 TS, 100 TS), respectively, and after 4 weeks, they were challenge infected with 100 T. spiralis larvae (10-100 TS, 100-100 TS). Upon challenge infections, 10-100 TS mice induced significantly higher levels of T. spiralis-specific total IgG antibody responses in sera and antibody secreting cell responses in spleens compared to 100-100 TS mice, resulting in significantly reduced worm burdens in 10-100 TS mice (60% and 70% reductions for adult and larvae, respectively). Higher levels of eosinophils were found in mice primarily infected with 10 TS compared to those of 100 TS at week 8 upon challenge. CD23+ IgM+ B cells were found to be increased significantly in mice primarily infected with 10 TS. These results indicate that primary infection of 10 larvae of T. spiralis, rather than 100 larvae, induces significant resistance against reinfection which closely correlated with T. spiralis-specific IgG, eosinophil, and CD23+ IgM+ B cell responses.

Citations

Citations to this article as recorded by  Crossref logo
  • Virus-like particles expressing microneme-associated antigen of Plasmodium berghei confer better protection than those expressing apical membrane antigen 1
    Min-Ju Kim, Ki Back Chu, Keon-Woong Yoon, Hae-Ji Kang, Dong-Hun Lee, Eun-Kyung Moon, Fu-Shi Quan
    Parasites, Hosts and Diseases.2024; 62(2): 193.     CrossRef
  • Retrospective Survey of Human Trichinellosis in a Romanian Infectious Diseases Hospital over a Thirty-Year Interval—The Never-Ending Story
    Mihaela Lupșe, Angela Monica Ionică, Mirela Flonta, Mihai Aronel Rus, Violeta Briciu
    Pathogens.2023; 12(3): 369.     CrossRef
  • Real-time PCR versus traditional and Nano-based ELISA in early detection of murine trichinellosis
    S. M. Mohammad, L. A. Hegazy, R. S. Abdel Hady, M. A. Salama, S. K. Hammad, S. M. Ibrahim
    Journal of Helminthology.2023;[Epub]     CrossRef
  • Trichinella infectivity and antibody response in experimentally infected pigs
    Nan Wang, Xue Bai, Jing Ding, Jiaojiao Lin, Hongfei Zhu, Xuenong Luo, Zhiqiang Fu, Chuangang Zhu, Hong Jia, Mingyuan Liu, Xiaolei Liu
    Veterinary Parasitology.2021; 297: 109111.     CrossRef
  • Immunoprotective effects of invasive Lactobacillus plantarum delivered nucleic acid vaccine coexpressing Trichinella spiralis CPF1 and murine interleukin-4
    Ying Xue, Bo Zhang, Hai-Bin Huang, Jun-Yi Li, Tian-Xu Pan, Yue Tang, Chun-Wei Shi, Hong-Liang Chen, Nan Wang, Gui-Lian Yang, Chun-Feng Wang
    Veterinary Parasitology.2021; 298: 109556.     CrossRef
  • Immune responses induced by co-infection withCapillaria hepaticainClonorchis sinensis-infected rats
    E.-K. Moon, S.-H. Lee, T.W. Goo, F.-S. Quan
    Journal of Helminthology.2018; 92(4): 395.     CrossRef
  • Correlates of Immune Response in Trichinella spiralis Infection
    Eun-Kyung Moon, Su-Hwa Lee, Yunsoo Soh, Yuan-Ri Guo, Ying Piao, Fu-Shi Quan
    Immunological Investigations.2018; 47(6): 605.     CrossRef
  • 9,339 View
  • 149 Download
  • 7 Web of Science
  • Crossref

Case Reports

A Case of Ancylostoma ceylanicum Infection Occurring in an Australian Soldier Returned from Solomon Islands
Rick Speare, Richard Stewart Bradbury, John Croese
Korean J Parasitol 2016;54(4):533-536.
Published online August 31, 2016
DOI: https://doi.org/10.3347/kjp.2016.54.4.533
A 26-year-old male member of the Australian Defense Force presented with a history of central abdominal pain of 4 weeks duration and peripheral eosinophilia consistent with eosinophilic enteritis. Acute hookworm disease was diagnosed as the cause. Adult worms recovered from feces after therapy with albendazole were morphologically consistent with Ancylostoma ceylanicum. As the patient had been deployed with the Regional Assistance Mission to Solomon Islands for 6 months prior to this presentation, it is very likely that the A. ceylanicum was acquired in Solomon Islands. Until now, it has been assumed that any Ancylostoma spp. recovered from humans in Solomon Islands is A. duodenale. However, this case demonstrates that human hookworm infection acquired in the Solomon Islands could be caused by A. ceylanicum.

Citations

Citations to this article as recorded by  Crossref logo
  • Rare case of human Ancylostoma ceylanicum infection in Bangladesh
    Tilak Chandra Nath, Proloy Chakraborty Tusher, Tarek Siddiki, Jannatul Nyema, Tiluttom Bhattacharjee, Nilotpal Dey, Mandira Mukutmoni, Kazi Mehetazul Islam, Jamal Uddin Bhuiyan
    IJID Regions.2024; 11: 100376.     CrossRef
  • Global distribution of human hookworm species and differences in their morbidity effects: a systematic review
    Archie C A Clements, Kefyalew Addis Alene
    The Lancet Microbe.2022; 3(1): e72.     CrossRef
  • Neglected tropical diseases in Australia: a narrative review
    Johanna Kurcheid, Catherine A Gordon, Naomi E Clarke, Kinley Wangdi, Matthew Kelly, Aparna Lal, Polydor N Mutombo, Dongxu Wang, Mary L Mationg, Archie CA Clements, Stephen Muhi, Richard S Bradbury, Beverley‐Ann Biggs, Wendy Page, Gail Williams, Donald P M
    Medical Journal of Australia.2022; 216(10): 532.     CrossRef
  • Molecular identification of zoonotic hookworms in dogs from four counties of Kenya
    E. Mulinge, S.M. Njenga, D. Odongo, J. Magambo, E. Zeyhle, C. Mbae, D. Kagendo, H. Kanyi, R.J. Traub, M. Wassermann, P. Kern, T. Romig
    Journal of Helminthology.2020;[Epub]     CrossRef
  • Opportunistic Mapping of Strongyloides stercoralis and Hookworm in Dogs in Remote Australian Communities
    Meruyert Beknazarova, Harriet Whiley, Rebecca Traub, Kirstin Ross
    Pathogens.2020; 9(5): 398.     CrossRef
  • High-throughput multiplex qPCRs for the surveillance of zoonotic species of canine hookworms
    Luca Massetti, Vito Colella, Patsy A. Zendejas, Dinh Ng-Nguyen, Lana Harriott, Lara Marwedel, Anke Wiethoelter, Rebecca J. Traub, Cinzia Cantacessi
    PLOS Neglected Tropical Diseases.2020; 14(6): e0008392.     CrossRef
  • Zoonotic Ancylostomiasis: An Update of a Continually Neglected Zoonosis
    Katharina Stracke, Aaron R. Jex, Rebecca J. Traub
    The American Journal of Tropical Medicine and Hygiene.2020; 103(1): 64.     CrossRef
  • Ancylostoma ceylanicum, novel etiological agent for traveler’s diarrhea—report of four Japanese patients who returned from Southeast Asia and Papua New Guinea
    Masahide Yoshikawa, Yukiteru Ouji, Nobuyasu Hirai, Fukumi Nakamura-Uchiyama, Minoru Yamada, Naoki Arizono, Naoaki Akamatsu, Takaharu Yoh, Daisuke Kaya, Toshiya Nakatani, Eiryo Kikuchi, Yuichi Katanami, Kimitoshi Satoh, Ryosuke Maki, Yusuke Miyazato, Yuich
    Tropical Medicine and Health.2018;[Epub]     CrossRef
  • Comparative analysis of Ancylostoma ceylanicum mitochondrial genome with other Ancylostoma species
    Xianli Shi, Mingwei Wang, A.Y. Abdullahi, Yeqi Fu, Fang Yang, Xingang Yu, Weida Pan, Xinxin Yan, Jianxiong Hang, Pan Zhang, Guoqing Li
    Infection, Genetics and Evolution.2018; 62: 40.     CrossRef
  • Development and Evaluation of a Multiplex Quantitative Real-Time Polymerase Chain Reaction for Hookworm Species in Human Stool
    Sze Fui Hii, Dammika Senevirathna, Stacey Llewellyn, Tawin Inpankaew, Peter Odermatt, Virak Khieu, Sinoun Muth, James McCarthy, Rebecca J. Traub
    The American Journal of Tropical Medicine and Hygiene.2018; 99(5): 1186.     CrossRef
  • Ancylostoma ceylanicumHookworm in the Solomon Islands
    Richard S. Bradbury, Sze Fui Hii, Humpress Harrington, Richard Speare, Rebecca Traub
    Emerging Infectious Diseases.2017; 23(2): 252.     CrossRef
  • Soil-Transmitted Helminths in Tropical Australia and Asia
    Catherine Gordon, Johanna Kurscheid, Malcolm Jones, Darren Gray, Donald McManus
    Tropical Medicine and Infectious Disease.2017; 2(4): 56.     CrossRef
  • A Japanese Patient with Ancylostoma ceylanicum Infection on Returning from Papua New Guinea Diagnosed by Molecular Identification of the Parasite Eggs
    Yuichi KATANAMI, Fukumi NAKAMURA-UCHIYAMA, Masatoshi SATO, Yukiteru OUJI, Masahide YOSHIKAWA, Keiichi MIKASA
    Kansenshogaku Zasshi.2017; 91(5): 759.     CrossRef
  • 12,765 View
  • 238 Download
  • 12 Web of Science
  • Crossref
A Case of Ocular Angiostrongyliasis with Molecular Identification of the Species in Vietnam
Nguyen Van De, Le Van Duyet, Jong-Yil Chai
Korean J Parasitol 2015;53(6):713-717.
Published online December 31, 2015
DOI: https://doi.org/10.3347/kjp.2015.53.6.713
A 23-year-old female residing in a village of Cao Bang Province, North Vietnam, visited the Hospital of Hanoi Medical University in July 2013. She felt dim eyes and a bulge-sticking pain in her left eye for some days before visiting the hospital. In the hospital, a clinical examination, an eye endoscopy, and an operation were carried out. A nematode specimen was collected from the eye of this patient. The body of this worm was thin and long and measured 22.0×0.3 mm. It was morphologically suggested as an immature female worm of Angiostrongylus cantonensis. By a molecular method using 18S rRNA gene, this nematode was confirmed as A. cantonensis. This is the first molecular study for identification of A. cantonensis in Vietnam.

Citations

Citations to this article as recorded by  Crossref logo
  • Insights into the genetic diversity of Angiostrongylus spp. causing human angiostrongyliasis and implications for molecular identification and diagnosis
    Abigail Hui En Chan, Chanisara Kaenkaew, Wallop Pakdee, Urusa Thaenkham
    Food and Waterborne Parasitology.2024; 35: e00230.     CrossRef
  • Identification and genetic characterization of Angiostrongylus cantonensis isolated from the human eye
    Abdulhakam Dumidae, Kanin Luangsawang, Aunchalee Thanwisai, Apichat Vitta
    Parasitology Research.2023; 122(9): 2217.     CrossRef
  • Two Ocular Angiostrongyliasis Cases in Thailand with Molecular Identification of Causative Parasite Species
    Patcharaporn Boonroumkaew, Thuss Sanguansak, Siriraksa Visaetsilpanonta, Oranuch Sanpool, Lakkhana Sadaow, Pewpan M. Intapan, Wanchai Maleewong
    The American Journal of Tropical Medicine and Hygiene.2020; 102(6): 1399.     CrossRef
  • The metagenomic next-generation sequencing in diagnosing central nervous system angiostrongyliasis: a case report
    Li Feng, Aiwu Zhang, Jiali Que, Hongyan Zhou, Haiyan Wang, Yuanlin Guan, Cunzhou Shen, Xunsha Sun, Rong Lai, Fuhua Peng, Huiyu Feng, Ling Chen
    BMC Infectious Diseases.2020;[Epub]     CrossRef
  • Angiostrongylus cantonensis Is an Important Cause of Eosinophilic Meningitis in Southern Vietnam
    Angela McBride, Tran Thi Hong Chau, Nguyen Thi Thu Hong, Nguyen Thi Hoang Mai, Nguyen To Anh, Tran Tan Thanh, Tran Thi Hue Van, Le Thi Xuan, Tran Phu Manh Sieu, Le Hong Thai, Ly Van Chuong, Dinh Xuan Sinh, Nguyen Duy Phong, Nguyen Hoan Phu, Jeremy Day, Ho
    Clinical Infectious Diseases.2017; 64(12): 1784.     CrossRef
  • Development of Lateral Flow Immunoassay for Antigen Detection in Human Angiostrongylus cantonensis Infection
    Mu-Xin Chen, Jia-Xu Chen, Shao-Hong Chen, Da-Na Huang, Lin Ai, Ren-Li Zhang
    The Korean Journal of Parasitology.2016; 54(3): 375.     CrossRef
  • Angiostrongylus cantonensis and A. malaysiensis Broadly Overlap in Thailand, Lao PDR, Cambodia and Myanmar: A Molecular Survey of Larvae in Land Snails
    Rutchanee Rodpai, Pewpan M. Intapan, Tongjit Thanchomnang, Oranuch Sanpool, Lakkhana Sadaow, Sakhone Laymanivong, Win Papa Aung, Issarapong Phosuk, Porntip Laummaunwai, Wanchai Maleewong, Donald James Colgan
    PLOS ONE.2016; 11(8): e0161128.     CrossRef
  • 10,475 View
  • 91 Download
  • 9 Web of Science
  • Crossref
Strongyloidiasis in a Diabetic Patient Accompanied by Gastrointestinal Stromal Tumor: Cause of Eosinophilia Unresponsive to Steroid Therapy
Eun Jeong Won, Jin Jeon, Young-Il Koh, Dong Wook Ryang
Korean J Parasitol 2015;53(2):223-226.
Published online April 22, 2015
DOI: https://doi.org/10.3347/kjp.2015.53.2.223
We report here a case of strongyloidiasis in a 72-year-old diabetic patient (woman) accompanied by gastrointestinal stromal tumor receiving imatinib therapy, first diagnosed as hypereosinophilic syndrome and treated with steroids for uncontrolled eosinophilia. She suffered from lower back pain and intermittent abdominal discomfort with nausea and diagnosed with gastrointestinal stromal tumor. After post-operative imatinib treatment eosinophilia persisted, so that steroid therapy was started under an impression of hypereosinophilic syndrome. In spite of 6 months steroid therapy, eosinophilia persisted. Stool examination was performed to rule out intestinal helminth infections. Rhabditoid larvae of Strongyloides stercoralis were detected and the patient was diagnosed as strongyloidiasis. This diagnosis was confirmed again by PCR. The patient was treated with albendazole for 14 days and her abdominal pain and diarrhea improved. This case highlights the need for thorough investigation, including molecular approaches, to test for strongyloidiasis before and during steroid therapies.

Citations

Citations to this article as recorded by  Crossref logo
  • Global prevalence and correlation of intestinal parasitic infections in patients with colorectal cancer: a systematic review and meta-analysis
    Maryam Hataminejad, Bahareh Basirpour, Melika Baharlou, Masoumeh Gholami Koohestan, Hajar Ziaei Hezarjaribi, Bahman Rahimi Esboei, Shirzad Gholami, Seyed Abdollah Hosseini, Reza Saberi
    BMC Gastroenterology.2025;[Epub]     CrossRef
  • A case of disseminated strongyloidiasis diagnosed by worms in the urinary sediment
    Young-Ha Lee
    Parasites, Hosts and Diseases.2024; 62(2): 238.     CrossRef
  • From past to present: opportunities and trends in the molecular detection and diagnosis of Strongyloides stercoralis
    Abigail Hui En Chan, Urusa Thaenkham
    Parasites & Vectors.2023;[Epub]     CrossRef
  • Seropositivity Rates of Strongyloides stercoralis Antibody in the Southeastern Region of Republic of Korea: A Single-Center Retrospective Study
    Taehwa Kim, Seungjin Lim
    The Korean Journal of Parasitology.2022; 60(3): 181.     CrossRef
  • Importance of detection of Strongyloides stercoralis DNA in fecal samples from patients with type 2 diabetes mellitus
    Márcia Carolina Mazzaro, Émelin Alves dos Santos, Gessica Baptista de Melo, Priscila Duarte Marques, Laura Vilela Souza, Jefferson Elias-Oliveira, Bruna Campos da Silva, Ronaldo César Borges Gryschek, Fabiana Martins de Paula, Rosângela Maria Rodrigues
    Clinics.2022; 77: 100060.     CrossRef
  • Phylogenetic Positioning of a Strongyloides stercoralis Isolate Recovered from a Korean Patient and Comparison with Other Asian Isolates
    Jaeho Bae, Mi Jin Jeong, Dong hoon Shin, Hyun Woo Kim, Sung Ho Ahn, Jun Ho Choi, Hak Sun Yu
    The Korean Journal of Parasitology.2020; 58(6): 689.     CrossRef
  • Report of the Korean Association of External Quality Assessment Service on Clinical Parasitology (2018–2019)
    Suhak Jeon, Eun Jeong Won, Yu Jeong Lee, Moon-Ju Kim, Myung Geun Shin, Jong Hee Shin
    Journal of Laboratory Medicine and Quality Assurance.2020; 42(4): 177.     CrossRef
  • Strongyloides stercoralis infection in a patient with rheumatoid arthritis and type 2 diabetes mellitus: a case-based review
    Alireza Ashiri, Molouk Beiromvand, Abdollah Khanzadeh
    Clinical Rheumatology.2019; 38(11): 3093.     CrossRef
  • Strongyloidiasis Current Status with Emphasis in Diagnosis and Drug Research
    Tiago Mendes, Karen Minori, Marlene Ueta, Danilo Ciccone Miguel, Silmara Marques Allegretti
    Journal of Parasitology Research.2017; 2017: 1.     CrossRef
  • 10,277 View
  • 113 Download
  • 9 Web of Science
  • Crossref
Eosinophilic Pleuritis due to Sparganum: A Case Report
Youngmin Oh, Jeong-Tae Kim, Mi-Kyeong Kim, You-Jin Chang, Keeseon Eom, Jung-Gi Park, Ki-Man Lee, Kang-Hyeon Choe, Jin-Young An
Korean J Parasitol 2014;52(5):541-543.
Published online October 22, 2014
DOI: https://doi.org/10.3347/kjp.2014.52.5.541

Sparganosis is a rare parasitic disease caused by migrating plerocercoid tapeworm larva of the genus Spirometra. Infection in humans is mainly caused by the ingestion of raw or inadequately cooked flesh of infected frogs, snakes, and chickens. Here, we report a rare case of a 45-year-old man who was admitted to our hospital with left lower chest pain. The chest radiograph and computed tomography (CT) scan revealed localized pleural effusion in the left lower lobe; further, peripheral blood eosinophilia and eosinophilic pleural effusion were present. Percutaneous catheter drainage was performed, which revealed long worm-shaped material that was identified as a sparganum by DNA sequencing. The patient showed clinical improvement after drainage of the sparganum. This study demonstrates the importance of considering parasitic diseases in the differential diagnosis of eosinophilic pleural effusion.

Citations

Citations to this article as recorded by  Crossref logo
  • Pleural effusion caused by Trichinella spiralis infection: two case reports
    Zhen-zhen Pan, Miao-juan Zhu, Yu-qiong Rong, Jiong Yang
    BMC Infectious Diseases.2023;[Epub]     CrossRef
  • Epidemiology, Diagnosis, and Prevention of Sparganosis in Asia
    Wei Liu, Tengfang Gong, Shuyu Chen, Quan Liu, Haoying Zhou, Junlin He, Yong Wu, Fen Li, Yisong Liu
    Animals.2022; 12(12): 1578.     CrossRef
  • Incidence, aetiology and clinical features of eosinophilic pleural effusion: a retrospective study
    Minfang Li, Yunxiang Zeng, Yaqing Li, Dan Jia, Sheng Chen, Jinlin Wang
    BMC Pulmonary Medicine.2021;[Epub]     CrossRef
  • Recurrent eosinophilic pleuritis caused by sparganum infection
    Liangjie Fang, Yuehong Wang, Qiqi Gao, Bing Yan, Jianying Zhou
    Medicine.2020; 99(22): e20226.     CrossRef
  • Retrospective study of pleural parasitic infestations: a practical diagnostic approach
    Jinlin Wang, Weizhan Luo, Panxiao Shen, Jianxing He, Yunxiang Zeng
    BMC Infectious Diseases.2019;[Epub]     CrossRef
  • Eosinophilia in Pleural Effusions: a Speculative Negative Predictor for Malignancy
    Fang-Yeh Chu, Ching-Biau Liou, Jen-Tang Sun, Chia-Hao Bei, Tse-Hsuan Liou, N-Chi Tan, Yun-Chieh Yu, Chih-Chun Chang, Tzung-Hai Yen, Ming-Jang Su
    Asian Pacific Journal of Cancer Prevention.2016; 17(3): 1411.     CrossRef
  • Clinical Features of Pulmonary Sparganosis
    Ning Li, Yi Xiang, Yun Feng, Min Li, Bei Li Gao, Qing Yun Li
    The American Journal of the Medical Sciences.2015; 350(6): 436.     CrossRef
  • 9,491 View
  • 83 Download
  • 6 Web of Science
  • Crossref
Pulmonary Toxocariasis Mimicking Invasive Aspergillosis in a Patient with Ulcerative Colitis
Eun Jin Park, Joon Young Song, Min Ju Choi, Ji Ho Jeon, Jah-yeon Choi, Tae Un Yang, Kyung Wook Hong, Ji Yun Noh, Hee Jin Cheong, Woo Joo Kim
Korean J Parasitol 2014;52(4):425-428.
Published online August 29, 2014
DOI: https://doi.org/10.3347/kjp.2014.52.4.425

A 45-year-old-male who had underlying ulcerative colitis and presented with fever and dry cough. Initially, the patient was considered to have invasive aspergillosis due to a positive galactomannan assay. He was treated with amphotericin B followed by voriconazole. Nevertheless, the patient deteriorated clinically and radiographically. The lung biopsy revealed eosinophilic pneumonia, and ELISA for Toxocara antigen was positive, leading to a diagnosis of pulmonary toxocariasis. After a 10-day treatment course with albendazole and adjunctive steroids, the patient recovered completely without any sequelae. Pulmonary toxocariasis may be considered in patients with subacute or chronic pneumonia unresponsive to antibiotic agents, particularly in cases with eosinophilia.

  • 11,706 View
  • 121 Download
Clinical Manifestations of Eosinophilic Meningitis Due to Infection with Angiostrongylus cantonensis in Children
Kittisak Sawanyawisuth, Jarin Chindaprasirt, Vichai Senthong, Panita Limpawattana, Narong Auvichayapat, Sompon Tassniyom, Verajit Chotmongkol, Wanchai Maleewong, Pewpan M. Intapan
Korean J Parasitol 2013;51(6):735-738.
Published online December 31, 2013
DOI: https://doi.org/10.3347/kjp.2013.51.6.735

Eosinophilic meningitis, caused by the nematode Angiostrongylus cantonensis, is prevalent in northeastern Thailand, most commonly in adults. Data regarding clinical manifestations of this condition in children is limited and may be different those in adults. A chart review was done on 19 eosinophilic meningitis patients aged less than 15 years in Srinagarind Hospital, Faculty of Medicine, Khon Kaen University, Thailand. Clinical manifestations and outcomes were reported using descriptive statistics. All patients had presented with severe headache. Most patients were males, had fever, nausea or vomiting, stiffness of the neck, and a history of snail ingestion. Six patients had papilledema or cranial nerve palsies. It was shown that the clinical manifestations of eosinophilic meningitis due to A. cantonensis in children are different from those in adult patients. Fever, nausea, vomiting, hepatomegaly, neck stiffness, and cranial nerve palsies were all more common in children than in adults.

Citations

Citations to this article as recorded by  Crossref logo
  • Neuroangiostrongyliasis: Updated Provisional Guidelines for Diagnosis and Case Definitions
    Carlos Graeff-Teixeira, Kittisak Sawanyawisuth, Shan Lv, William Sears, Zhaily González Rodríguez, Hilda Hernández Álvarez, Pedro Casanova Arias, Leticia Karolini Walger Schultz, Alicia Rojas, John Jacob, Susan Jarvi, Kenton Kramer
    Pathogens.2023; 12(4): 624.     CrossRef
  • Clinical Characteristics and Treatment Outcome of Eosinophilic Meningoencephalitis in South Indian Children: Experience From a Prospective Registry
    Kollencheri Puthenveettil Vinayan, Sai Chandar Dudipala, Arun Grace Roy, Vaishakh Anand
    Pediatric Neurology.2023; 147: 9.     CrossRef
  • Clinical Efficacy and Safety of Albendazole and Other Benzimidazole Anthelmintics for Rat Lungworm Disease (Neuroangiostrongyliasis): A Systematic Analysis of Clinical Reports and Animal Studies
    John Jacob, Argon Steel, Zhain Lin, Fiona Berger, Katrin Zöeller, Susan Jarvi
    Clinical Infectious Diseases.2022; 74(7): 1293.     CrossRef
  • A Rare Etiology for Ascending Paralysis in an Infant
    Keisuke Abe, Chanel Casamina, Natascha Ching, Keith K Abe, Marian Melish, Karen S Thompson, Asim A Ahmed, Prashant J Purohit
    Journal of the Pediatric Infectious Diseases Society.2022; 11(10): 448.     CrossRef
  • Paratenic hosts of Angiostrongylus cantonensis and their relation to human neuroangiostrongyliasis globally
    Helena C. Turck, Mark T. Fox, Robert H. Cowie
    One Health.2022; 15: 100426.     CrossRef
  • The application of metagenomic next-generation sequencing for Angiostrongylus eosinophilic meningitis in a pediatric patient: A case report
    Jing Liu, Jinhao Tao, Weiming Chen, Tingting Wang, Xin Chen, Meili Shen, Qiuxiang Ou, Yunjian Zhang, Yifeng Ding, Jufang Wu, Xunjia Cheng, Guoping Lu, Gangfeng Yan
    Frontiers in Public Health.2022;[Epub]     CrossRef
  • Eosinophilic meningitis epidemiological data from a national database in Thailand’s Department of Disease Control: a pragmatic, retrospective analytical study
    Sittichai Khamsai, Verajit Chotmongkol, Somsak Tiamkao, Wanchai Maleewong, Panita Limpawattana, Watchara Boonsawat, Bundit Sawunyavisuth, Noppadol Aekphachaisawat, Kittisak Sawanyawisuth
    Orphanet Journal of Rare Diseases.2022;[Epub]     CrossRef
  • Gross, microscopic, radiologic, echocardiographic and haematological findings in rats experimentally infected withAngiostrongylus cantonensis
    Matthew K. Wun, Sarah Davies, Derek Spielman, Rogan Lee, Doug Hayward, Richard Malik
    Parasitology.2021; 148(2): 159.     CrossRef
  • Guidelines for the diagnosis and treatment of neuroangiostrongyliasis: updated recommendations
    Vernon Ansdell, Kenton J. Kramer, Jourdan K. McMillan, William L. Gosnell, Gerald S. Murphy, B C Meyer, Elizabeth U. Blalock, Johnnie Yates, Louis Lteif, Olivia A. Smith, Marian Melish
    Parasitology.2021; 148(2): 227.     CrossRef
  • Tetraventricular Hydrocephalus Following Eosinophilic Meningitis due to Angiostrongylus cantonensis in a 14-Month-Old Boy From Mayotte: A Case Report
    Chiara Cattaneo, Marion Hoarau, Sophie Valois, Abdourahim Chamouine, Yacouba Dembele, Luis Collet, Raphaëlle Sarton
    Open Forum Infectious Diseases.2021;[Epub]     CrossRef
  • Eosinophilic Meningitis due to Angiostrongylus cantonensis in Children
    Hai Thanh Phan, Kiem Hao Tran, Huu Son Nguyen
    Case Reports in Neurology.2021; 13(1): 184.     CrossRef
  • Next-generation sequencing specifies Angiostrongylus eosinophilic meningoencephalitis in infants
    Mei Xie, Zhen Zhou, Suhua Guo, Zengqing Li, Hui Zhao, Jiusheng Deng
    Medicine.2019; 98(35): e16985.     CrossRef
  • Magnetic resonance imaging findings and clinical manifestations in cerebral angiostrongyliasis from Dali, China
    Bin Yang, Ling Yang, Yili Chen, Guangming Lu
    Brain and Behavior.2019;[Epub]     CrossRef
  • Geographic distribution of Angiostrongylus cantonensis in wild rats (Rattus rattus) and terrestrial snails in Florida, USA
    Heather D. Stockdale Walden, John D. Slapcinsky, Shannon Roff, Jorge Mendieta Calle, Zakia Diaz Goodwin, Jere Stern, Rachel Corlett, Julia Conway, Antoinette McIntosh, Heike Lutermann
    PLOS ONE.2017; 12(5): e0177910.     CrossRef
  • Case 1: Fever and Ataxia in a Toddler with Pica
    Megan H. Tucker, Jonathan Holmes, Susan Harley, Maria Roca Garcia, Haidee Custodio
    Pediatrics In Review.2017; 38(9): 435.     CrossRef
  • Angiostrongylus cantonensis: a review of its distribution, molecular biology and clinical significance as a human pathogen
    JOEL BARRATT, DOUGLAS CHAN, INDY SANDARADURA, RICHARD MALIK, DEREK SPIELMAN, ROGAN LEE, DEBORAH MARRIOTT, JOHN HARKNESS, JOHN ELLIS, DAMIEN STARK
    Parasitology.2016; 143(9): 1087.     CrossRef
  • L’angiostrongylose humaine : une maladie tropicale négligée
    Loïc Epelboin, Louis Collet, Maxime Raz, Nicolas Villemant, Denis Malvy, Renaud Blondé
    Revue Francophone des Laboratoires.2016; 2016(483): 45.     CrossRef
  • Development of Lateral Flow Immunoassay for Antigen Detection in Human Angiostrongylus cantonensis Infection
    Mu-Xin Chen, Jia-Xu Chen, Shao-Hong Chen, Da-Na Huang, Lin Ai, Ren-Li Zhang
    The Korean Journal of Parasitology.2016; 54(3): 375.     CrossRef
  • Angiostrongylus cantonensisInfection: A Cause of Fever of Unknown Origin in Pediatric Patients
    Catherine E. Foster, Erin G. Nicholson, Angela C. Chun, Maya Gharfeh, Sara Anvari, Filiz O. Seeborg, Michael A. Lopez, Judith R. Campbell, Lucila Marquez, Jeffrey R. Starke, Debra L. Palazzi
    Clinical Infectious Diseases.2016; 63(11): 1475.     CrossRef
  • Angiostrongylus cantonensis Infection on Mayotte Island, Indian Ocean, 2007-2012
    Loïc Epelboin, Renaud Blondé, Abdourahim Chamouine, Alexandra Chrisment, Laure Diancourt, Nicolas Villemant, Agnès Atale, Claire Cadix, Valérie Caro, Denis Malvy, Louis Collet, Malcolm Jones
    PLOS Neglected Tropical Diseases.2016; 10(5): e0004635.     CrossRef
  • Feline lungworms unlock a novel mode of parasite transmission
    Vito Colella, Alessio Giannelli, Emanuele Brianti, Rafael Antonio Nascimento Ramos, Cinzia Cantacessi, Filipe Dantas-Torres, Domenico Otranto
    Scientific Reports.2015;[Epub]     CrossRef
  • 10,331 View
  • 103 Download
  • Crossref

Brief Communication

A Seroepidemiological Survey of Toxocariasis among Eosinophilia Patients in Chungcheongnam-do
Min Seo, Sung Chul Yoon
Korean J Parasitol 2012;50(3):249-251.
Published online August 13, 2012
DOI: https://doi.org/10.3347/kjp.2012.50.3.249

There have been several reports on the relationship between toxocariasis and eosinophilia, but all have been limited to the areas of Seoul or Gangwon-do. In the present study, we investigated the seroprevalence of toxocariasis among eosinophilia patients in Chungcheongnam-do, the central district of Korea. Among the 101 patients tested, 51 (50.5%) were identified as positive by Toxocara ELISA, and 46 (45.5%) were confidently diagnosed with toxocariasis because of absence of any other cause of eosinophilia. Whereas 22 of 42 seropositive patients (52.3%) had a recent history of consuming raw livers, especially the cow liver, only 1 of 25 seronegative patients (4%) had done so (P<0.01). From these results, we could confirm that toxocariasis is related to eosinophilia, and infer that ingestion of raw cow liver plays a vital role in the transmission of toxocariasis in Chungcheongnam-do.

Citations

Citations to this article as recorded by  Crossref logo
  • Seroprevalence of Toxocara spp. infection and its associated factors among children in Vietnam: A cross-sectional study
    Giao Huynh, Dung Quoc Phan, Tien Minh Tran, Thai Duy Nguyen, Hau Viet Nguyen, Han Thi Ngoc Nguyen, Ly Trieu Vo
    Medicine.2025; 104(47): e46235.     CrossRef
  • Toxocariasis and Strongyloidiasis as Triggering Factors for Wells’ Syndrome
    Hendra Gunawan, Zulfan Zulfan
    Clinical, Cosmetic and Investigational Dermatology.2024; Volume 17: 1687.     CrossRef
  • Evidence of helminthic infestation and efficacy of anthelminthic treatment in children investigated for eosinophilia
    Predrag Rodic, Marija Cazic, Dejan Skoric, Jelena Lazic, Goran Milosevic, Srdja Jankovic, Nada Krstovski
    Vojnosanitetski pregled.2024; 81(9): 555.     CrossRef
  • Dog and Cat Contact as Risk Factor for Human Toxocariasis: Systematic Review and Meta-Analysis
    Yslla Fernanda Fitz Balo Merigueti, Rogerio Giuffrida, Rodrigo Costa da Silva, Louise Bach Kmetiuk, Andrea Pires Dos Santos, Alexander Welker Biondo, Vamilton Alvares Santarém
    Frontiers in Public Health.2022;[Epub]     CrossRef
  • Seroprevalence of Toxocariasis Among Hypereosinophilic Children: A Single Center Study, Tehran, Iran
    Meysam Sharifdini, Mehdi Zarean, Mehrzad Sadredinamin, Mitra Zare- Bavani, Sarah Sharifi-yazdi, Bahram Nikmanesh
    Archives of Pediatric Infectious Diseases.2022;[Epub]     CrossRef
  • Ocular Toxocariasis: Beyond Typical Patterns through the New Imaging Technologies
    I Hernanz, A Moll-Udina, Belles V. Llorenç, Civera A. Adan
    Ocular Immunology and Inflammation.2021; 29(7-8): 1252.     CrossRef
  • Keys to Unlock the Enigma of Ocular Toxocariasis: A Systematic Review and Meta-analysis
    Milad Badri, Aida Vafae Eslahi, Meysam Olfatifar, Sahar Dalvand, Elham Houshmand, Amir Abdoli, Hamidreza Majidiani, Ali Eslami, Mohammad Zibaei, Morteza Ghanbari Johkool, Ali Taghipour, Sima Hashemipour
    Ocular Immunology and Inflammation.2021; 29(7-8): 1265.     CrossRef
  • Prevalence of Toxocariasis and Its Risk Factors in Patients with Eosinophilia in Korea
    Hyun Beom Song, Deokho Lee, Yan Jin, Jinwoo Kang, Shin-Hyeong Cho, Min Sun Park, Jin-Ho Park, Woo-Jung Song, Hye-Ryun Kang, Sang Hyub Lee, Sung-Tae Hong, Min-Ho Choi
    The Korean Journal of Parasitology.2020; 58(4): 413.     CrossRef
  • Latent and AsymptomaticToxocaraInfection among Young Population in Northwest Iran: The Necessity of Informing People as a Potential Health Risk
    Tina Momeni, Mahmoud Mahami-Oskouei, Esmaeil Fallah, Abdolrasoul Safaiyan, Leyla Mahami-Oskouei
    Scientifica.2016; 2016: 1.     CrossRef
  • Evaluating correlation between serum liver enzymes and toxocariasis: a case control study
    Hosein Miladi, Mojtaba Didehdar, Reza Hajihossein, Fatemeh Rafiei, Zahra Eslamirad
    Asian Pacific Journal of Tropical Disease.2016; 6(6): 460.     CrossRef
  • Clinical characteristics and progression of liver abscess caused by toxocara
    Kyung Ho Ha, Jung Eun Song, Byung Seok Kim, Chang Hyeong Lee
    World Journal of Hepatology.2016; 8(18): 757.     CrossRef
  • Clinical Features of Ocular Toxocariasis in Adult Korean Patients
    Donghyun Jee, Kyu Seop Kim, Won Ki Lee, Wungjae Kim, Sohee Jeon
    Ocular Immunology and Inflammation.2015; : 1.     CrossRef
  • Cross-reactivity of Toxocariasis with Crude Antigen ofToxascaris leoninaLarvae by ELISA
    Yan Jin, Chenghua Shen, Sun Huh, Min-Ho Choi, Sung-Tae Hong
    Journal of Korean Medical Science.2015; 30(5): 549.     CrossRef
  • Seroepidemiology of Toxocariasis and Its Clinical Implications in Gwangju and Jeonnam-province, Korea
    Eun Jeong Won, Jin Kim, Myung-Geun Shin, Jong Hee Shin, Soon Pal Suh, Dong Wook Ryang
    Annals of Laboratory Medicine.2015; 35(4): 449.     CrossRef
  • The Prevalence of Toxocariasis and Diagnostic Value of Serologic Tests in Asymptomatic Korean Adults
    Jin-Young Lee, Moon Hee Yang, Jung-Hae Hwang, Mira Kang, Jae-Won Paeng, Sehyo Yune, Byung-Jae Lee, Dong-Chull Choi
    Allergy, Asthma & Immunology Research.2015; 7(5): 467.     CrossRef
  • Eosinophilic Meningitis Associated with Toxocariasis
    Jin Kyo Choi, Jin Woo Lee, Yong Hui Park, Seo Hyun Kim
    Journal of Neurocritical Care.2015; 8(2): 115.     CrossRef
  • Ocular toxocariasis: clinical features, diagnosis, treatment, and prevention
    Seong Joon Ahn, Na-Kyung Ryoo, Se Joon Woo
    Asia Pacific Allergy.2014; 4(3): 134.     CrossRef
  • Significance of Serum Antibody Test for Toxocariasis in Healthy Healthcare Examinees with Eosinophilia in Seoul and Gyeongsangnam-do, Korea
    Hong Seok Kim, Yan Jin, Min-Ho Choi, Jae-Hwan Kim, Young Ha Lee, Cheong Ha Yoon, Eui-Hyuk Hwang, Hun Kang, Sang-Yong Ahn, Gi Jin Kim, Sung-Tae Hong
    Journal of Korean Medical Science.2014; 29(12): 1618.     CrossRef
  • Chest CT findings of toxocariasis: Correlation with laboratory results
    J.H. Hur, I.J. Lee, J.-H. Kim, D.-G. Kim, H.J. Hwang, S.H. Koh, K. Lee
    Clinical Radiology.2014; 69(6): e285.     CrossRef
  • A Comparative Seroprevalence Study of Toxocariasis in Hypereosinophilic and Apparently Healthy Individuals
    Bahador Sarkari, Malihe Lari, Reza Shafiei, Seyed Mahmoud Sadjjadi
    Archives of Pediatric Infectious Diseases.2014;[Epub]     CrossRef
  • Anti-Toxocara spp. antibodies in an adult healthy population: serosurvey and risk factors in Southeast Brazil
    Elaine Cristina Negri, Vamilton Alvares Santarém, Guita Rubinsky-Elefant, Rogério Giuffrida
    Asian Pacific Journal of Tropical Biomedicine.2013; 3(3): 211.     CrossRef
  • Serodiagnosis of Toxocariasis by ELISA Using Crude Antigen of Toxocara canis Larvae
    Yan Jin, Chenghua Shen, Sun Huh, Woon-Mok Sohn, Min-Ho Choi, Sung-Tae Hong
    The Korean Journal of Parasitology.2013; 51(4): 433.     CrossRef
  • Chemotherapeutic drugs for common parasitic diseases in Korea
    Sun Huh
    Journal of the Korean Medical Association.2013; 56(6): 513.     CrossRef
  • 9,051 View
  • 88 Download
  • Crossref

Mini Review

Eosinophil-Mediated Tissue Inflammatory Responses in Helminth Infection
Myeong Heon Shin, Young Ah Lee, Duk-Young Min
Korean J Parasitol 2009;47(Suppl):S125.
Published online October 26, 2009
DOI: https://doi.org/10.3347/kjp.2009.47.S.S125

Eosinophilic leukocytes function in host protection against parasitic worms. In turn, helminthic parasites harbor specific molecules to evade or paralyze eosinophil-associated host immune responses; these molecules facilitate the migration and survival of parasitic helminths in vivo. This competition between eosinophil and worm leads to stable equilibria between them. An understanding of such dynamic host-eosinophil interactions will help us to uncover mechanisms of cross talk between host and parasite in helminth infection. In this review, we examine recent findings regarding the innate immune responses of eosinophils to helminthic parasites, and discuss the implications of these findings in terms of eosinophil-mediated tissue inflammation in helminth infection.

Citations

Citations to this article as recorded by  Crossref logo
  • Immunomodulatory and antioxidant responses of African catfish (Clarias gariepinus) to cestode infections: implications for intestinal health and aquaculture management
    Mahmoud Radwan, Jamila S. Al Malki, Amaal Mohammadein, Mohamed Fares
    Veterinary Research Communications.2025;[Epub]     CrossRef
  • Eosinophils in inflammatory bowel disease pathogenesis: an ROS-centric view
    Toshihiro Tomii, Gen Kano
    Frontiers in Allergy.2025;[Epub]     CrossRef
  • Eosinophils, Eosinophilic Gastrointestinal Diseases, and Inflammatory Bowel Disease: A Critical Review
    Giulia Migliorisi, Elisabetta Mastrorocco, Arianna Dal Buono, Roberto Gabbiadini, Gaia Pellegatta, Paola Spaggiari, Francesca Racca, Enrico Heffler, Edoardo Vincenzo Savarino, Cristina Bezzio, Alessandro Repici, Alessandro Armuzzi
    Journal of Clinical Medicine.2024; 13(14): 4119.     CrossRef
  • Evaluation of Azadirachta indica leaf extracts efficacy against gill flukes parasites with a focus on oxidative stress, pathological changes, and immune gene response in infected Nile tilapia
    Mahmoud Radwan, Mahmoud Mahrous M. Abbas, Mohamed Fares, Moussa Attia Moussa, Amaal Mohammadein, Jamila S. Al Malki, Alsayed E. Mekky, Shahd Yassir, Zeinab Aboezz, Said M. A. Elraey
    Aquaculture International.2024; 32(7): 10029.     CrossRef
  • Disruption of the C5a/C5aR1 axis confers protection against hookworm infection in lung
    Sarah Walachowski, Lucien Garo, Arjun Sharma, Archana Jayaraman, Jason Noon, Christoph Reinhardt, Markus Bosmann
    Frontiers in Immunology.2024;[Epub]     CrossRef
  • Cymbopogon citratus showing nematicidal activity against Heligmosomoides polygyrus bakeri
    Viviane Souza Campos, Letícia Oliveira da Rocha, Hassan Jerdy Leandro, Teresa Pontes, Fábio Conceição de Oliveira, Eulógio Carlos Queiroz de Carvalho, Leonardo Siqueira Glória, Clóvis de Paula Santos
    Revista Brasileira de Parasitologia Veterinária.2024;[Epub]     CrossRef
  • Antibody response and abomasal histopathology of lambs with haemonchosis during supplementation with medicinal plants and organic selenium
    Dominika Batťányi, Daniel Petrič, Michal Babják, Emília Dvorožňáková, Anna Łukomska, Adam Cieslak, Marián Várady, Zora Váradyová
    Veterinary and Animal Science.2023; 19: 100290.     CrossRef
  • Endoparasites in dogs diagnosed at the Veterinary Teaching Hospital (VTH)-University of Bologna, combined with clinicopathological results. A long-term retrospective secondary data study
    Benedetto Morandi, Maria Chiara Sabetti, Maira Napoleoni, Ilaria Pascucci, Gionata Orlandi, Marco Pietra, John A. VanLeeuwen, Spencer J. Greenwood, Giovanni Poglayen, Roberta Galuppi, Joshua Kamani
    PLOS ONE.2023; 18(10): e0293330.     CrossRef
  • Diagnostic Test of Blood Eosinophil Level as a Marker of Ascaris lumbricoides Infection
    Said Munazar Rahmat, Teuku Romi Imansyah Putra, Merina Panggabean, Aman Agustinus Depari, Dhiatama Endalif
    Indonesian Journal of Tropical and Infectious Disease.2023;[Epub]     CrossRef
  • Helicobacter pylori infection manifesting as Hypereosinophilic syndrome and immune thrombocytopenia complicated by portal vein thrombosis and ischemic colitis
    Awni Alshurafa, Mustafa Sied, Maab Elkhdier, Ahmed M. Abdalhadi, Mohamed A. Yassin
    IDCases.2022; 27: e01451.     CrossRef
  • Assessing the role of eosinophil‐mediated immune response markers in detecting hookworm infection: A case‐control study in Kintampo, Ghana
    Samuel A. Sakyi, Benjamin Amoani, Stephen Opoku, Lawrence Dzata, Wilfred Aniagyei, Ebenezer Senu, Kwabena Dankwa, Michael D. Wilson
    Health Science Reports.2022;[Epub]     CrossRef
  • Outcomes of pars plana vitrectomy in three cases of ophthalmomyiasis interna
    Lukpan Orazbekov, Elmira Kanafyanova, Kairat Ruslanuly
    American Journal of Ophthalmology Case Reports.2022; 28: 101697.     CrossRef
  • Schistosomiasis Mansoni-Recruited Eosinophils: An Overview in the Granuloma Context
    Kássia K. Malta, Cinthia Palazzi, Vitor H. Neves, Yasmin Aguiar, Thiago P. Silva, Rossana C. N. Melo
    Microorganisms.2022; 10(10): 2022.     CrossRef
  • Plasma cytokines during acute human fascioliasis
    Catalina Aron-Said, Martin Montes, A. Clinton White, Miguel M. Cabada
    Parasitology Research.2021; 120(8): 2965.     CrossRef
  • Eosinophils and Bacteria, the Beginning of a Story
    Edna Ondari, Esther Calvino-Sanles, Nicholas J. First, Monica C. Gestal
    International Journal of Molecular Sciences.2021; 22(15): 8004.     CrossRef
  • Heavy metals, parasitologic and oxidative stress biomarker investigations in Heterotis niloticus from Lekki Lagoon, Lagos, Nigeria
    Bamidele Akinsanya, Isaac O. Ayanda, Adeola O. Fadipe, Benson Onwuka, Joseph K. Saliu
    Toxicology Reports.2020; 7: 1075.     CrossRef
  • Influence of parasite load on the diagnosis and occurrence of eosinophilia in alcoholic patients infected withStrongyloides stercoralis
    M.L.S. Silva, E.J. Inês, J.N. Souza, A.B.S. Souza, V.M.S. Dias, L.N. Oliveira, C.M. Guimarães, E.R. Menezes, L.G. Barbosa, M.C.M. Alves, M.C.A. Teixeira, N.M. Soares
    Journal of Helminthology.2019; 93(1): 21.     CrossRef
  • Eosinophils in Inflammatory Bowel Disease
    Rhiannon T Filippone, Lauren Sahakian, Vasso Apostolopoulos, Kulmira Nurgali
    Inflammatory Bowel Diseases.2019; 25(7): 1140.     CrossRef
  • Differences in immune responses to Haemonchus contortus infection in the susceptible Ile de France and the resistant Santa Ines sheep under different anthelmintic treatments regimens
    Ana Cláudia A. Albuquerque, Cesar Cristiano Bassetto, Fabiana A. Almeida, Katie A. Hildersley, Tom N. McNeilly, Collette Britton, Alessandro F. T. Amarante
    Veterinary Research.2019;[Epub]     CrossRef
  • An outbreak of toxoplasmosis in squirrel monkeys (Saimiri sciureus) in South Korea
    Hanseul Oh, Kyung‐Yeon Eo, Sanjeev Gumber, Jung Joo Hong, C‐Yoon Kim, Hyun‐Ho Lee, Young‐Mok Jung, Jin Kim, Gyu‐Whan Whang, Ji‐Min Lee, Yong‐Gu Yeo, Bokyeong Ryu, Ji‐Sook Ryu, Seul‐Kee Lee, Ukjin Kim, Sin‐Geun Kang, Jae‐Hak Park
    Journal of Medical Primatology.2018; 47(4): 238.     CrossRef
  • Differences in RANTES and IL-6 levels among chronic rhinosinusitis patients with predominant gram-negative and gram-positive infection
    Almoaidbellah Rammal, Marc Tewfik, Simon Rousseau
    Journal of Otolaryngology - Head & Neck Surgery.2017;[Epub]     CrossRef
  • Branchial Pathomorphology of Southern Bluefin Tuna Thunnus maccoyii (Castelnau, 1872) Infected by Helminth and Copepodan Parasites
    Mark B. Adams, Craig J. Hayward, Barbara F. Nowak
    Frontiers in Physiology.2017;[Epub]     CrossRef
  • An unusual abdominal wall mass in a child
    Amalia Maria do Espirito Santo Souza, Tomas Marzagão Barbuto, Flávia Alessandra Freitas, Nathalia Fernandes Vianna, Carla Maria Costa Zanchetta, Silvana Forsait, Claudio Borba, Alessandra Milani Prandini de Azambuja, Lilian Maria Cristofani, Vicente Odone
    Revista do Instituto de Medicina Tropical de São Paulo.2017;[Epub]     CrossRef
  • Recent evolution of extreme cestode growth suppression by a vertebrate host
    Jesse N. Weber, Natalie C. Steinel, Kum Chuan Shim, Daniel I. Bolnick
    Proceedings of the National Academy of Sciences.2017; 114(25): 6575.     CrossRef
  • Gene Expression Contributes to the Recent Evolution of Host Resistance in a Model Host Parasite System
    Brian K. Lohman, Natalie C. Steinel, Jesse N. Weber, Daniel I. Bolnick
    Frontiers in Immunology.2017;[Epub]     CrossRef
  • Histological assessment of granulomas in natural and experimental Schistosoma mansoni infections using whole slide imaging
    Kátia B. Amaral, Thiago P. Silva, Felipe F. Dias, Kássia K. Malta, Florence M. Rosa, Sócrates F. Costa-Neto, Rosana Gentile, Rossana C. N. Melo, Paulo Lee Ho
    PLOS ONE.2017; 12(9): e0184696.     CrossRef
  • Cell Type-Specific Immunomodulation Induced by Helminthes: Effect on Metainflammation, Insulin Resistance and Type-2 Diabetes
    Vivekanandhan Aravindhan, Gowrishankar Anand
    The American Journal of Tropical Medicine and Hygiene.2017; 97(6): 1650.     CrossRef
  • The Role and Immunobiology of Eosinophils in the Respiratory System: a Comprehensive Review
    Stephanie S. Eng, Magee L. DeFelice
    Clinical Reviews in Allergy & Immunology.2016; 50(2): 140.     CrossRef
  • Leukocytosis and Leukemia
    Page Widick, Eric S. Winer
    Primary Care: Clinics in Office Practice.2016; 43(4): 575.     CrossRef
  • Strongyloides stercoralisInfection in Alcoholic Patients
    Marcia C. A. Teixeira, Flavia T. F. Pacheco, Joelma N. Souza, Mônica L. S. Silva, Elizabete J. Inês, Neci M. Soares
    BioMed Research International.2016; 2016: 1.     CrossRef
  • Correlation between eosinophil count and soil-transmitted helminth infection in children
    Syilvia Jiero, Muhammad Ali, Syahril Pasaribu, Ayodhia Pitaloka Pasaribu
    Asian Pacific Journal of Tropical Disease.2015; 5(10): 813.     CrossRef
  • Human Blood-Circulating Basophils Capture HIV-1 and Mediate Viraltrans-Infection of CD4+T Cells
    Ai-Ping Jiang, Jin-Feng Jiang, Ming-Gao Guo, Yong-Mei Jin, Yu-Ye Li, Jian-Hua Wang, S. R. Ross
    Journal of Virology.2015; 89(15): 8050.     CrossRef
  • CCR2 deficiency leads to increased eosinophils, alternative macrophage activation, and type 2 cytokine expression in adipose tissue
    W Reid Bolus, Dario A Gutierrez, Arion J Kennedy, Emily K Anderson-Baucum, Alyssa H Hasty
    Journal of Leukocyte Biology.2015; 98(4): 467.     CrossRef
  • Eosinophil chemotactic chemokine profilings of the brain from permissive and non-permissive hosts infected with Angiostrongylus cantonenis
    Shuting Li, Fan Yang, Pengyu Ji, Xin Zeng, Xiaoying Wu, Jie Wei, Lisi Ouyang, Jinyi Liang, Huanqin Zheng, Zhongdao Wu, Zhiyue Lv
    Parasitology Research.2014; 113(2): 517.     CrossRef
  • Cellular and chemokine-mediated regulation in schistosome-induced hepatic pathology
    Candy Chuah, Malcolm K. Jones, Melissa L. Burke, Donald P. McManus, Geoffrey N. Gobert
    Trends in Parasitology.2014; 30(3): 141.     CrossRef
  • 5-Lipoxygenase-Dependent Recruitment of Neutrophils and Macrophages by Eotaxin-Stimulated Murine Eosinophils
    Ricardo Alves Luz, Pedro Xavier-Elsas, Bianca de Luca, Daniela Masid-de-Brito, Priscila Soares Cauduro, Luiz Carlos Gondar Arcanjo, Ana Carolina Cordeiro Faria dos Santos, Ivi Cristina Maria de Oliveira, Maria Ignez Capella Gaspar-Elsas
    Mediators of Inflammation.2014; 2014: 1.     CrossRef
  • Bronchoalveolar lavage as a tool for evaluation of cellular alteration during Aelurostrongylus abstrusus infection in cats
    Vitor M. Ribeiro, Joziana M.P. Barçante, Déborah Negrão-Correa, Thales A. Barçante, André Klein, Walter S. Lima
    Pesquisa Veterinária Brasileira.2014; 34(10): 990.     CrossRef
  • Prednisolone and cyclosporine A: Effects on an experimental model of ancylostomiasis
    Sílvia Regina Costa Dias, Ana Flávia Dias Vieira da Costa, Pedro Henrique Gazzinelli-Guimarães, Bruno Mendes Roatt, Kátia da Silva Fonseca, Nívia Carolina Nogueira de Paiva, Rodolfo Cordeiro Giunchetti, Cláudia Martins Carneiro, Ricardo Toshio Fujiwara, É
    Experimental Parasitology.2013; 133(1): 80.     CrossRef
  • HOOKWORM AND THREADWORM INFECTIONS AND THEIR ASSOCIATION WITH HEMOGLOBIN AND EOSINOPHIL CONCENTRATIONS IN RESIDENTS OF SALVADOR-BAHIA, BRAZIL
    Fred Luciano Neves Santos, Alina Maria Gonzaga Carlos de Souza, Neci Matos Soares
    Revista do Instituto de Medicina Tropical de São Paulo.2013; 55(4): 233.     CrossRef
  • Ocular toxoplasmosis I: parasitology, epidemiology and public health
    João M Furtado, Kevin L Winthrop, Nicholas J Butler, Justine R Smith
    Clinical & Experimental Ophthalmology.2013; 41(1): 82.     CrossRef
  • Therapeutic Strategies for Harnessing Human Eosinophils in Allergic Inflammation, Hypereosinophilic Disorders, and Cancer
    Zhaleh J. Amini-Vaughan, Margarita Martinez-Moczygemba, David P. Huston
    Current Allergy and Asthma Reports.2012; 12(5): 402.     CrossRef
  • 12,797 View
  • 125 Download
  • Crossref

Case Report

Three Cases of Paragonimiasis in a Family
Byeong Seok Sohn, Yun-Jeong Bae, You Sook Cho, Hee-Bom Moon, Tae-Bum Kim
Korean J Parasitol 2009;47(3):281-285.
Published online August 28, 2009
DOI: https://doi.org/10.3347/kjp.2009.47.3.281

Paragonimiasis typically results from the consumption of raw or improperly cooked crustacea, especially crabs and crayfish. Although previously endemic in Korea, the prevalence of this disease decreased in the early 1970s because of educational campaigns and fewer intermediate hosts as a result of ecological changes. Recently, we were presented with a family where all members were infected with Paragonimus after ingestion of Kejang (= drunken crab). The mother was hospitalized for general myalgia and weakness first, followed by the father, who was hospitalized for dyspnea 2 month later. After the parents were diagnosed with paragonimiasis, we recommended their daughter to visit our hospital for a checkup, because they all had eaten freshwater crabs soaked in soybean sauce. She complained of generalized myalgia, fever, and pleuritic pain, and was also diagnosed with paragonimiasis. Peripheral blood of the 3 patients revealed hypereosinophilia, and computed tomography (CT) scans of their chests showed pleural effusion. The results of antibody tests by ELISA were positive for paragonimiasis. We report here the case series of familial paragonimiasis in a modern urban city, rather than in a typical endemic area.

Citations

Citations to this article as recorded by  Crossref logo
  • A Cluster of Paragonimiasis with Delayed Diagnosis Due to Difficulty Distinguishing Symptoms from Post-COVID-19 Respiratory Symptoms: A Report of Five Cases
    Jun Sasaki, Masanobu Matsuoka, Takashi Kinoshita, Takayuki Horii, Shingo Tsuneyoshi, Daiki Murata, Reiko Takaki, Masaki Tominaga, Mio Tanaka, Haruhiko Maruyama, Tomotaka Kawayama, Tomoaki Hoshino
    Medicina.2023; 59(1): 137.     CrossRef
  • Analysis of COI and ITS2 regions of DNA obtained from Paragonimus westermani eggs in ancient coprolites on Joseon dynasty mummies
    Jong Ha Hong, Chang Seok Oh, Min Seo, Dong Hoon Shin
    Memórias do Instituto Oswaldo Cruz.2019;[Epub]     CrossRef
  • Paragonimus and paragonimiasis in Asia: An update
    Ayako Yoshida, Pham Ngoc Doanh, Haruhiko Maruyama
    Acta Tropica.2019; 199: 105074.     CrossRef
  • Inactivation of Paragonimus westermani metacercariae in soy sauce-marinated and frozen freshwater crabs
    Tae Im Kim, Se-Ra Oh, Fuhong Dai, Hyun-Jong Yang, Sang-Do Ha, Sung-Jong Hong
    Parasitology Research.2017; 116(3): 1003.     CrossRef
  • Paragonimiasis in Children in Southwest China
    Zongrong Gong, Ruixue Miao, Min Shu, Yu Zhu, Yang Wen, Qin Guo, Qiong Liao, Chaomin Wan
    Medicine.2017; 96(25): e7265.     CrossRef
  • Recent Incidence of Paragonimus westermani Metacercariae in Freshwater Crayfish, Cambaroides similis, from Two Enzootic Sites in Jeollanam-do, Korea
    Jin-Ho Song, Fuhong Dai, Xuelian Bai, Tae-Im Kim, Hyun-Jong Yang, Tong-Soo Kim, Shin-Hyung Cho, Sung-Jong Hong
    The Korean Journal of Parasitology.2017; 55(3): 347.     CrossRef
  • A Case of Ectopic Paragonimiasis in a 17th Century Korean Mummy
    D. H. Shin, Y.-S. Kim, D. S. Yoo, M. J. Kim, C. S. Oh, J. H. Hong, E. Lee, J. Y. Chai, M. Seo
    Journal of Parasitology.2017; 103(4): 399.     CrossRef
  • Clinical Update on Parasitic Diseases
    Min Seo
    Korean Journal of Medicine.2013; 85(5): 469.     CrossRef
  • Ectopic paragonimiasis from 400-year-old female mummy of Korea
    Dong Hoon Shin, Chang Seok Oh, Sang Jun Lee, Eun-Joo Lee, Se Gwon Yim, Myeung Ju Kim, Yi-Suk Kim, Soong Deok Lee, Yong Seok Lee, Hye Jung Lee, Min Seo
    Journal of Archaeological Science.2012; 39(4): 1103.     CrossRef
  • Consecutive extrapulmonary paragonimiasis involving liver and colon
    Chang Wook PARK, Woo Jin CHUNG, Young Lan KWON, Yong Jin KIM, Eun Soo KIM, Byung Kuk JANG, Kyung Sik PARK, Kwang Bum CHO, Jae Seok HWANG, Jung Hyuk KWON
    Journal of Digestive Diseases.2012; 13(3): 186.     CrossRef
  • Characterization of MicroRNAs in Paragonimus westermani by Solexa Deep Sequencing and Bioinformatics Analysis
    L. Ai, M.X. Chen, S.H. Chen, Y.N. Zhang, H. Li, Y.C. Cai, Y. Lu, L.G. Tian, X.N. Zhou, J.X. Chen
    Journal of Animal and Veterinary Advances.2012; 11(18): 3469.     CrossRef
  • Sensitive and rapid detection of Paragonimus westermani infection in humans and animals by loop-mediated isothermal amplification (LAMP)
    M. X. Chen, L. Ai, R. L. Zhang, J. J. Xia, K. Wang, S. H. Chen, Y. N. Zhang, M. J. Xu, X. Li, X. Q. Zhu, J. X. Chen
    Parasitology Research.2011; 108(5): 1193.     CrossRef
  • A Case of Pulmonary Paragonimiasis with Involvement of the Abdominal Muscle in a 9-Year-Old Girl
    Ah-Rum Cho, Hae-Ran Lee, Kwan-Sub Lee, Sang-Eun Lee, So-Yeon Lee
    The Korean Journal of Parasitology.2011; 49(4): 409.     CrossRef
  • Prevalence of Paragonimus and Angiostrongylus cantonensis Infections in Snails in Southeastern China
    Y.Z. Cheng, J. Hou, X.H. He, Z.K. Hong, L.S. Li, G.H. Lin, M.X. Chen, S.H. Chen
    Journal of Animal and Veterinary Advances.2011; 10(19): 2599.     CrossRef
  • A fluke occurrence of paramount significance
    D Gude, DP Bansal
    Journal of Postgraduate Medicine.2011; 57(3): 255.     CrossRef
  • 12,841 View
  • 102 Download
  • Crossref

Original Article

Toxocariasis and Ingestion of Raw Cow Liver in Patients with Eosinophilia
Dongil Choi, Jae Hoon Lim, Dong-Chull Choi, Seung Woon Paik, Sun-Hee Kim, Sun Huh
Korean J Parasitol 2008;46(3):139-143.
Published online September 20, 2008
DOI: https://doi.org/10.3347/kjp.2008.46.3.139

Ingestion of raw animal liver has been suggested as a possible mode of infection of human toxocariasis. We evaluated the relationship between toxocariasis and the ingestion of raw meat in patients with eosinophilia of unknown etiology. The study population consisted of 120 patients presenting with peripheral blood eosinophilia (> 500 cells/?l or > 10% of the white blood cell count). They were divided into 2 groups: 104 seropositive patients based on a Toxocara excretory-secretory IgG ELISA and 16 seronegative patients. While 25.0% of seronegative patients had a recent history of eating raw cow liver, 87.5% of seropositive patients had this history. Multivariate statistical analysis showed that a recent history of eating raw cow liver was related to an increased risk of toxocariasis. Collectively, it is proposed that raw cow liver is a significant infection source of toxocariasis in the patients with eosinophilia of unknown etiology.

Citations

Citations to this article as recorded by  Crossref logo
  • Knowledge and risky behaviors of Kabul city butchers regarding Crimean-Congo hemorrhagic fever
    Assadullah Samadi, Mohammad Asif Safi
    CABI One Health.2024;[Epub]     CrossRef
  • State-of-the-art of portable (bio)sensors based on smartphone, lateral flow and microfluidics systems in protozoan parasites monitoring: A review
    Raed H. Althomali, Ebraheem Abdu Musad Saleh, Jitendra Gupta, Aiman Mohammed Baqir Al-Dhalimy, Ahmed Hjazi, Beneen M. Hussien, Amran M. AL-Erjan, Abduladheem Turki Jalil, Rosario Mireya Romero-Parra, Luis Andres Barboza-Arenas
    Microchemical Journal.2023; 191: 108804.     CrossRef
  • Incidentally Detected Löffler’s Syndrome on Abdomen Magnetic Resonance Imaging: Case Report
    Yedaun Lee
    Investigative Magnetic Resonance Imaging.2023; 27(3): 158.     CrossRef
  • Who Let the Dogs Out? Unmasking the Neglected: A Semi-Systematic Review on the Enduring Impact of Toxocariasis, a Prevalent Zoonotic Infection
    Katrin Henke, Sotirios Ntovas, Eleni Xourgia, Aristomenis K. Exadaktylos, Jolanta Klukowska-Rötzler, Mairi Ziaka
    International Journal of Environmental Research and Public Health.2023; 20(21): 6972.     CrossRef
  • Therapy and Prevention for Human Toxocariasis
    Jean-François Magnaval, Emilie Bouhsira, Judith Fillaux
    Microorganisms.2022; 10(2): 241.     CrossRef
  • TOXOCARA CANİS VE VİSCERAL LARVA MİGRANS
    Selma KOCADEMİR, Kader YILDIZ
    Veteriner Farmakoloji ve Toksikoloji Derneği Bülteni.2022; 13(1): 47.     CrossRef
  • Dog and Cat Contact as Risk Factor for Human Toxocariasis: Systematic Review and Meta-Analysis
    Yslla Fernanda Fitz Balo Merigueti, Rogerio Giuffrida, Rodrigo Costa da Silva, Louise Bach Kmetiuk, Andrea Pires Dos Santos, Alexander Welker Biondo, Vamilton Alvares Santarém
    Frontiers in Public Health.2022;[Epub]     CrossRef
  • Isolation and Production of Human Monoclonal Antibody Proteins Against a Toxocara Canis Excretory-Secretory Recombinant Antigen
    Anizah Rahumatullah, Zamrina Baharudeen, Rahmah Noordin, Lim Theam Soon, Dinesh Balachandra, Nor Suhada Anuar, Fatin Hamimi Mustafa
    SSRN Electronic Journal .2022;[Epub]     CrossRef
  • Ocular Toxocariasis: Beyond Typical Patterns through the New Imaging Technologies
    I Hernanz, A Moll-Udina, Belles V. Llorenç, Civera A. Adan
    Ocular Immunology and Inflammation.2021; 29(7-8): 1252.     CrossRef
  • Role of cats in human toxocarosis
    Pablo David Jimenez Castro, Sarah GH Sapp
    Companion Animal.2021; 26(3): 6.     CrossRef
  • Infectious Causes of Eosinophilic Meningitis in Korean Patients: A Single-Institution Retrospective Chart Review from 2004 to 2018
    Sunghee Park, Jiwon Jung, Yong Pil Chong, Sung-Han Kim, Sang-Oh Lee, Sang-Ho Choi, Yang Soo Kim, Min Jae Kim
    The Korean Journal of Parasitology.2021; 59(3): 227.     CrossRef
  • Electrochemical microfluidic immunosensor based on TES-AuNPs@Fe3O4 and CMK-8 for IgG anti-Toxocara canis determination
    Claudio F. Jofre, Matías Regiart, Martin A. Fernández-Baldo, Mauro Bertotti, Julio Raba, Germán A. Messina
    Analytica Chimica Acta.2020; 1096: 120.     CrossRef
  • Saccharomyces boulardii reduces the mean intensity of infection in mice caused by the consumption of liver contaminated by Toxocara canis
    Paula Dutra Cardoso, Débora Liliane Walcher, Priscila da Silva Cadore, Ana Carolina Beheregaray, Luis Augusto Xavier Cruz, Gabriel Baracy Klafke, Lourdes Helena Rodrigues Martins, João Luis Rheingantz Scaini, Luciana Farias da Costa de Avila, Fabricio Roc
    Parasitology Research.2020; 119(3): 1161.     CrossRef
  • Excretory/Secretory Metabolome of the Zoonotic Roundworm Parasite Toxocara canis
    Phurpa Wangchuk, Owen Lavers, David S. Wishart, Alex Loukas
    Biomolecules.2020; 10(8): 1157.     CrossRef
  • Prevalence of Toxocariasis and Its Risk Factors in Patients with Eosinophilia in Korea
    Hyun Beom Song, Deokho Lee, Yan Jin, Jinwoo Kang, Shin-Hyeong Cho, Min Sun Park, Jin-Ho Park, Woo-Jung Song, Hye-Ryun Kang, Sang Hyub Lee, Sung-Tae Hong, Min-Ho Choi
    The Korean Journal of Parasitology.2020; 58(4): 413.     CrossRef
  • Role of cats in human toxocarosis
    Pablo David Jimenez Castro, Sarah GH Sapp
    The Veterinary Nurse.2020; 11(9): 400.     CrossRef
  • Seroprevalence of <italic>Toxocara</italic> in Children from Urban and Rural Areas of Ilam Province, West Iran
    Sahar Shokouhi, Jahangir Abdi
    Osong Public Health and Research Perspectives.2018; 9(3): 101.     CrossRef
  • Clinical course and treatment outcomes of toxocariasis-related eosinophilic disorder
    Sun-Young Yoon, Seunghee Baek, So Y. Park, Bomi Shin, Hyouk-Soo Kwon, You S. Cho, Hee-Bom Moon, Tae-Bum Kim
    Medicine.2018; 97(37): e12361.     CrossRef
  • Fluorescent immunosensor using AP-SNs and QDs for quantitation of IgG anti-Toxocara canis
    Victoria Medawar, Germán A. Messina, Martin Fernández-Baldo, Julio Raba, Sirley V. Pereira
    Microchemical Journal.2017; 130: 436.     CrossRef
  • Clinical usefulness of Western blotting and ELISA avidity for the diagnosis of human toxocariasis
    M. Rudzińska, B. Kowalewska, K. Sikorska
    Parasite Immunology.2017;[Epub]     CrossRef
  • A Systematic Review of Toxocariasis: A Neglected But High-Prevalence Disease in Brazil
    Carlos Roberto Silveira Corrêa, Paula Mayara Matos Fialho
    The American Journal of Tropical Medicine and Hygiene.2016; 94(6): 1193.     CrossRef
  • Human Toxocariasis: Prevalence and Factors Associated with Biosafety in Research Laboratories
    Gabriela Torres Mattos, Paula Costa dos Santos, Paula de Lima Telmo, Maria Elisabeth Aires Berne, Carlos James Scaini
    The American Journal of Tropical Medicine and Hygiene.2016; 95(6): 1428.     CrossRef
  • Clinical characteristics and progression of liver abscess caused by toxocara
    Kyung Ho Ha, Jung Eun Song, Byung Seok Kim, Chang Hyeong Lee
    World Journal of Hepatology.2016; 8(18): 757.     CrossRef
  • Seroepidemiology of Toxocariasis and Its Clinical Implications in Gwangju and Jeonnam-province, Korea
    Eun Jeong Won, Jin Kim, Myung-Geun Shin, Jong Hee Shin, Soon Pal Suh, Dong Wook Ryang
    Annals of Laboratory Medicine.2015; 35(4): 449.     CrossRef
  • Molecular mechanism of serine/threonine protein phosphatase 1 (PP1cα–PP1r7) in spermatogenesis of Toxocara canis
    Guang Xu Ma, Rong Qiong Zhou, Zhen Hui Song, Hong Hong Zhu, Zuo Yong Zhou, Yuan Qin Zeng
    Acta Tropica.2015; 149: 148.     CrossRef
  • Presence of anti-Toxocara canis antibodies and risk factors in children from the Amecameca and Chalco regions of México
    Nadyeli Nava Cortés, Camilo Romero Núñez, Bautista Gómez Linda Guiliana, Pedro Abel Hernández García, Rafael Heredia Cárdenas
    BMC Pediatrics.2015;[Epub]     CrossRef
  • The Prevalence of Toxocariasis and Diagnostic Value of Serologic Tests in Asymptomatic Korean Adults
    Jin-Young Lee, Moon Hee Yang, Jung-Hae Hwang, Mira Kang, Jae-Won Paeng, Sehyo Yune, Byung-Jae Lee, Dong-Chull Choi
    Allergy, Asthma & Immunology Research.2015; 7(5): 467.     CrossRef
  • The Seropositivity of Toxocara spp. Antibodies in Pregnant Women Attented at the University Hospital in Southern Brazil and the Factors Associated with Infection
    Paula Costa Santos, Lis Maurente Lehmann, Carolina Lorenzi, Carolina Hirsch, Paula Lima Telmo, Gabriela Torres Mattos, Priscila Silva Cadore, Gabriel Baracy Klafke, Maria Elisabeth Aires Berne, Carla Vitola Gonçalves, Carlos James Scaini, Henk D. F. H. Sc
    PLOS ONE.2015; 10(7): e0131058.     CrossRef
  • Significance of Serum Antibody Test for Toxocariasis in Healthy Healthcare Examinees with Eosinophilia in Seoul and Gyeongsangnam-do, Korea
    Hong Seok Kim, Yan Jin, Min-Ho Choi, Jae-Hwan Kim, Young Ha Lee, Cheong Ha Yoon, Eui-Hyuk Hwang, Hun Kang, Sang-Yong Ahn, Gi Jin Kim, Sung-Tae Hong
    Journal of Korean Medical Science.2014; 29(12): 1618.     CrossRef
  • A Case of Ocular Toxocariasis Successfully Treated with Albendazole and Triamcinolon
    San Seong, Daruchi Moon, Dong Kyu Lee, Hyung Eun Kim, Hyun Sup Oh, Soon Hyun Kim, Oh Woong Kwon, Yong Sung You
    The Korean Journal of Parasitology.2014; 52(5): 537.     CrossRef
  • Ocular toxocariasis: clinical features, diagnosis, treatment, and prevention
    Seong Joon Ahn, Na-Kyung Ryoo, Se Joon Woo
    Asia Pacific Allergy.2014; 4(3): 134.     CrossRef
  • Chest CT findings of toxocariasis: Correlation with laboratory results
    J.H. Hur, I.J. Lee, J.-H. Kim, D.-G. Kim, H.J. Hwang, S.H. Koh, K. Lee
    Clinical Radiology.2014; 69(6): e285.     CrossRef
  • Human toxocariasis: current advances in diagnostics, treatment, and interventions
    Gustavo Marçal Schmidt Garcia Moreira, Paula de Lima Telmo, Marcelo Mendonça, Ângela Nunes Moreira, Alan John Alexander McBride, Carlos James Scaini, Fabricio Rochedo Conceição
    Trends in Parasitology.2014; 30(9): 456.     CrossRef
  • Clinical Features and Course of Ocular Toxocariasis in Adults
    Seong Joon Ahn, Se Joon Woo, Yan Jin, Yoon-Seok Chang, Tae Wan Kim, Jeeyun Ahn, Jang Won Heo, Hyeong Gon Yu, Hum Chung, Kyu Hyung Park, Sung Tae Hong, Calum N. L. Macpherson
    PLoS Neglected Tropical Diseases.2014; 8(6): e2938.     CrossRef
  • Anti-Toxocara spp. antibodies in an adult healthy population: serosurvey and risk factors in Southeast Brazil
    Elaine Cristina Negri, Vamilton Alvares Santarém, Guita Rubinsky-Elefant, Rogério Giuffrida
    Asian Pacific Journal of Tropical Biomedicine.2013; 3(3): 211.     CrossRef
  • Evaluation of the initial and chronic phases of toxocariasis after consumption of liver treated by freezing or cooling
    Gisele Ferreira Dutra, Nitza Souto França Pinto, Luciana Farias da Costa de Avila, Paula de Lima Telmo, Vanusa Pousada da Hora, Lourdes Helena Rodrigues Martins, Maria Elisabeth Aires Berne, Carlos James Scaini
    Parasitology Research.2013; 112(6): 2171.     CrossRef
  • Serodiagnosis of Toxocariasis by ELISA Using Crude Antigen of Toxocara canis Larvae
    Yan Jin, Chenghua Shen, Sun Huh, Woon-Mok Sohn, Min-Ho Choi, Sung-Tae Hong
    The Korean Journal of Parasitology.2013; 51(4): 433.     CrossRef
  • Laboratory diagnosis of human toxocariasis
    J. Fillaux, J.-F. Magnaval
    Veterinary Parasitology.2013; 193(4): 327.     CrossRef
  • Clinical and Serological Findings in Patients with Toxocariasis in the Pohang Region: The Features of Toxocariasis in Pohang
    Byung Han Ryu, Jun Seok Park, Yeo Jin Jung, Soo Kyoung Kang, Seung Hee Lee, Sung Jin Choi
    Korean Journal of Medicine.2013; 84(2): 203.     CrossRef
  • Toxocara spp. seroprevalence in sheep from southern Brazil
    Gabriela Lopes Rassier, Sibele Borsuk, Felipe Pappen, Carlos Jaime Scaini, Tiago Gallina, Marcos Marreiro Villela, Nara Amélia da Rosa Farias, Magda Vieira Benavides, Maria Elisabeth Aires Berne
    Parasitology Research.2013; 112(9): 3181.     CrossRef
  • Clinical Update on Parasitic Diseases
    Min Seo
    Korean Journal of Medicine.2013; 85(5): 469.     CrossRef
  • Manifestaciones cardiovasculares de la toxocariasis humana
    Adrián Bolívar-Mejía, Alfonso J. Rodríguez-Morales, Alberto E. Paniz-Mondolfi, Olinda Delgado
    Archivos de Cardiología de México.2013; 83(2): 120.     CrossRef
  • Prevalence and Risk Factors Associated with Toxocara canis Infection in Children
    Camilo Romero Núñez, Germán David Mendoza Martínez, Selene Yañez Arteaga, Martha Ponce Macotela, Patricia Bustamante Montes, Ninfa Ramírez Durán, Gabriella Cancrini, Edward L. Jarroll
    The Scientific World Journal.2013;[Epub]     CrossRef
  • Transmission of Toxocara canis via Ingestion of Raw Cow Liver: A Cross-Sectional Study in Healthy Adults
    Dongil Choi, Jae Hoon Lim, Dong-Chull Choi, Kyung Soo Lee, Seung Woon Paik, Sun-Hee Kim, Yoon-Ho Choi, Sun Huh
    The Korean Journal of Parasitology.2012; 50(1): 23.     CrossRef
  • Meningitis byToxocara canisafter Ingestion of Raw Ostrich Liver
    Young Noh, Sung-Tae Hong, Ji Young Yun, Hong-Kyun Park, Jung-Hwan Oh, Young Eun Kim, Beom S. Jeon
    Journal of Korean Medical Science.2012; 27(9): 1105.     CrossRef
  • A Seroepidemiological Survey of Toxocariasis among Eosinophilia Patients in Chungcheongnam-do
    Min Seo, Sung Chul Yoon
    The Korean Journal of Parasitology.2012; 50(3): 249.     CrossRef
  • Anti-Toxocara spp. antibodies in sheep from southeastern Brazil
    Vamilton Alvares Santarém, Paula Andreia Fabris Chesine, Beatriz Esther Leme Lamers, Guita Rubinsky-Elefant, Rogério Giuffrida
    Veterinary Parasitology.2011; 179(1-3): 283.     CrossRef
  • Survey of gastrointestinal parasitic infections of beef cattle in regions under Mediterranean weather in Greece
    Georgios Theodoropoulos, Panayiota Peristeropoulou, Marc K. Kouam, Vaia Kantzoura, Helen Theodoropoulou
    Parasitology International.2010; 59(4): 556.     CrossRef
  • A Case of Recurrent Toxocariasis Presenting With Urticaria
    Min-Hye Kim, Jae-Woo Jung, Jae-Woo Kwon, Tae-Whan Kim, Sae-Hoon Kim, Sang-Heon Cho, Kyung-Up Min, You-Young Kim, Yoon-Seok Chang
    Allergy, Asthma and Immunology Research.2010; 2(4): 267.     CrossRef
  • Ultrastructural Localization of Toxocara canis Larval Antigen Reacted with a Seropositive Human Serum
    Soo-Ung Lee, Jae-Ran Yu, Sun Huh
    The Korean Journal of Parasitology.2009; 47(1): 65.     CrossRef
  • 10,550 View
  • 99 Download
  • Crossref

Brief Communication

Eosinophil degranulation plays a crucial role in tissue inflammatory reactions associated with helminth parasitic infections and allergic diseases. Paragonimus westermani, a lung fluke causing human paragonimiasis, secretes a large amount of cysteine proteases, which are involved in nutrient uptake, tissue invasion, and modulation of hos's immune responses. There is, however, limited information about the response of eosinophils to direct stimulation by cysteine proteases (CP) secreted by P. westermani. In the present study, we tested whether degranulation and superoxide production from human eosinophils can be induced by stimulation of the 2 CP (27 kDa and 28 kDa) purified from excretory-secretory products (ESP) of P. westermani newly excysted metacercariae (PwNEM). A large quantity of eosinophil-derived neurotoxin (EDN) was detected in the culture supernatant when human eosinophils isolated from the peripheral blood were incubated with the purified 27 kDa CP. Furthermore, the 27 kDa CP induced superoxide anion production by eosinophils in time- and dose-dependent manners. In contrast, the purified 28 kDa CP did not induce superoxide production and degranulation. These findings suggest that the 27 kDa CP secreted by PwNEM induces superoxide production and degranulation of human eosinophils, which may be involved in eosinophil-mediated tissue inflammatory responses during the larval migration in human paragonimiasis.

Citations

Citations to this article as recorded by  Crossref logo
  • Massive secretions in paragonimiasis pleural effusion: a new finding concerning clinical recognition and treatment
    Yunxuan Zhang, Yimin Xie, Yarui Luo, Shuang Xiang, Wen Zhong, Na Wu, Meng Chen, Xiaojiao Zhou, Shulei Peng, Qiang Chen
    European Journal of Clinical Microbiology & Infectious Diseases.2023; 42(4): 493.     CrossRef
  • Transcriptome Analysis Reveals Possible Virulence Factors of Paragonimus proliferus
    Sheng-Hao Li, Shu-De Li, Kun-Li Wu, Jun-Yi Li, Hong-Juan Li, Wei-Qun Wang, Li-Jun Yang, Jing-Jing Xu, Guo-Ji Chang, Yan-Ling Zhang, Qiu-Hong Shu, Shan-Shan Zhuang, Zhi-Qiang Ma, Shu-Meiqi He, Min Zhu, Wen-Lin Wang, Hong-Li Huang
    Current Bioinformatics.2021; 16(2): 197.     CrossRef
  • Downregulated RPS-30 in Angiostrongylus cantonensis L5 plays a defensive role against damage due to oxidative stress
    Wei-Wei Sun, Xiu-Mei Yan, Qing Shi, Yuan-Jiao Zhang, Jun-Ting Huang, Hui-Cong Huang, Hong-Fei Shi, Bao-Long Yan
    Parasites & Vectors.2020;[Epub]     CrossRef
  • Molecular and immunological characterization of cathepsin L-like cysteine protease of Paragonimus pseudoheterotremus
    Tippayarat Yoonuan, Supaporn Nuamtanong, Paron Dekumyoy, Orawan Phuphisut, Poom Adisakwattana
    Parasitology Research.2016; 115(12): 4457.     CrossRef
  • Conservation and diversification of the transcriptomes of adult Paragonimus westermani and P. skrjabini
    Ben-wen Li, Samantha N. McNulty, Bruce A. Rosa, Rahul Tyagi, Qing Ren Zeng, Kong-zhen Gu, Gary J. Weil, Makedonka Mitreva
    Parasites & Vectors.2016;[Epub]     CrossRef
  • Systems Biology Studies of Adult Paragonimus Lung Flukes Facilitate the Identification of Immunodominant Parasite Antigens
    Samantha N. McNulty, Peter U. Fischer, R. Reid Townsend, Kurt C. Curtis, Gary J. Weil, Makedonka Mitreva, Aaron R. Jex
    PLoS Neglected Tropical Diseases.2014; 8(10): e3242.     CrossRef
  • Eosinophilic Pneumonias
    Praveen Akuthota, Peter F. Weller
    Clinical Microbiology Reviews.2012; 25(4): 649.     CrossRef
  • Eosinophil and Tissue-invasive Parasitic Helminth
    Myeong Heon Shin
    Hanyang Medical Reviews.2010; 30(3): 238.     CrossRef
  • Eosinophil-Mediated Tissue Inflammatory Responses in Helminth Infection
    Myeong Heon Shin, Young Ah Lee, Duk-Young Min
    The Korean Journal of Parasitology.2009; 47(Suppl): S125.     CrossRef
  • The global cysteine peptidase landscape in parasites
    Holly J. Atkinson, Patricia C. Babbitt, Mohammed Sajid
    Trends in Parasitology.2009; 25(12): 573.     CrossRef
  • Parasitic helminths: a pharmacopeia of anti-inflammatory molecules
    M. J. G. JOHNSTON, J. A. MacDONALD, D. M. McKAY
    Parasitology.2009; 136(2): 125.     CrossRef
  • 8,329 View
  • 75 Download
  • Crossref

Original Article

Seroprevalence of Toxocariasis among Healthy People with Eosinophilia
Yong-Hun Kim, Sun Huh, Young-Bae Chung
Korean J Parasitol 2008;46(1):29-32.
Published online March 20, 2008
DOI: https://doi.org/10.3347/kjp.2008.46.1.29

The aim of this study is to determine the Toxocara seropositive rate among healthy people with eosinophilia. A total of 97 people residing in Seoul who were healthy and whose blood eosinophilia was over 10%, as shown by regular health check-ups in 2004, were subjected to this study. Their sera were tested by immunoblotting and ELISA with the antigen of larval Toxocara canis excretory-secretory (ES) protein. Sixty-five sera were band-positive (67.0%). The seropositve control sera were positive to band sizes of 66 kDa, 56 kDa, 32 kDa, and 13 kDa. In ELISA, 63 sera (65.0%) were positive to T. canis ES protein. There was no significant correlation between the IgG ELISA titer and the level of eosinophilia (r = 0.156, P = 0.156). As there were insufficient data to determine whether there were cross-reactions with other helminthic infections, or whether atopy occurred, further studies are required to verify the cause of the seropositive reactions against T. canis ES antigen. Toxocariasis seropositivity is suggested to be the major cause of eosinophilia, since the Toxocara seroprevalence among Korean rural adults was shown to be approximately 5%.

Citations

Citations to this article as recorded by  Crossref logo
  • Keys to Unlock the Enigma of Ocular Toxocariasis: A Systematic Review and Meta-analysis
    Milad Badri, Aida Vafae Eslahi, Meysam Olfatifar, Sahar Dalvand, Elham Houshmand, Amir Abdoli, Hamidreza Majidiani, Ali Eslami, Mohammad Zibaei, Morteza Ghanbari Johkool, Ali Taghipour, Sima Hashemipour
    Ocular Immunology and Inflammation.2021; 29(7-8): 1265.     CrossRef
  • Urticaria and silent parasitism by Ascaridoidea: Component-resolved diagnosis reinforces the significance of this association
    Marta Viñas, Idoia Postigo, Ester Suñén, Jorge Martínez, Maria Victoria Periago
    PLOS Neglected Tropical Diseases.2020; 14(4): e0008177.     CrossRef
  • A Systematic Review and Meta-analysis of Toxocariasis in Iran: Is it Time to Take it Seriously?
    Mohammad Javad Abbaszadeh Afshar, Farzaneh Zahabiun, Peyman Heydarian, Hossein Mozafar Saadati, Sina Mohtasebi, Farzad Khodamoradi, Vahid Raissi
    Acta Parasitologica.2020; 65(3): 569.     CrossRef
  • Prevalence of Toxocariasis and Its Risk Factors in Patients with Eosinophilia in Korea
    Hyun Beom Song, Deokho Lee, Yan Jin, Jinwoo Kang, Shin-Hyeong Cho, Min Sun Park, Jin-Ho Park, Woo-Jung Song, Hye-Ryun Kang, Sang Hyub Lee, Sung-Tae Hong, Min-Ho Choi
    The Korean Journal of Parasitology.2020; 58(4): 413.     CrossRef
  • Status of common parasitic diseases in Korea in 2019
    Sun Huh
    Journal of the Korean Medical Association.2019; 62(8): 437.     CrossRef
  • First Report of Toxocara canis Seroprevalence in Military Personnel and Their Families with Eosinophilia Referred to a Military Hospital in Tehran, Iran, 2015 - 2016
    Hamid Reza Bitaraf, Faezeh Hamidi, Vajiheh Zarrinpour, Mohsen Rahimi, Seyed Reza Shahrokhi, Aliyar Mirzapour
    Archives of Clinical Infectious Diseases.2018;[Epub]     CrossRef
  • Acute Eosinophilic Monoarthritis in a Patient with Toxocariasis
    Jaehyung Hur, You Jung Ha, Sang Wan Chung, Eun Ha Kang, Yeong Wook Song, Yun Jong Lee
    The Korean Journal of Medicine.2018; 93(4): 409.     CrossRef
  • Eosinophilic Myocarditis-Associated Toxocariasis
    Tae Hyung Kim, Doo Hyun Ko, Jong Wook Kim, Ja Joong Gu, Ji Hong Oh, Baek Hyun Yoon, Jae Beom Lee
    The Korean Journal of Medicine.2018; 93(5): 482.     CrossRef
  • Evaluation of the prevalence and clinical impact of toxocariasis in patients with eosinophilia of unknown origin
    Hong-Beum Kim, Jun-Won Seo, Jun-Hyung Lee, Byung-Seok Choi, Sang-Gon Park
    The Korean Journal of Internal Medicine.2017; 32(3): 523.     CrossRef
  • The Clinical Characteristics of Ocular Toxocariasis in Jeju Island Using Ultra-wide-field Fundus Photography
    Jong Young Lee, Jin Young Kim, Sang-Yoon Lee, Hye Jin Lee, Jin Ho Jeong, Eun Kyoung Lee
    Journal of the Korean Ophthalmological Society.2017; 58(5): 554.     CrossRef
  • In vitro production of Toxocara canis excretory-secretory (TES) antigen
    Divyamol Thomas, N. Jeyathilakan, S. Abdul Basith, T. M. A. Senthilkumar
    Journal of Parasitic Diseases.2016; 40(3): 1038.     CrossRef
  • Latent and AsymptomaticToxocaraInfection among Young Population in Northwest Iran: The Necessity of Informing People as a Potential Health Risk
    Tina Momeni, Mahmoud Mahami-Oskouei, Esmaeil Fallah, Abdolrasoul Safaiyan, Leyla Mahami-Oskouei
    Scientifica.2016; 2016: 1.     CrossRef
  • Seroprevalence of fascioliasis, toxocariasis, strongyloidiasis and cysticercosis in blood samples diagnosed in Medic Medical Center Laboratory, Ho Chi Minh City, Vietnam in 2012
    Toan Nguyen, Fei Wen Cheong, Jonathan Wee Kent Liew, Yee Ling Lau
    Parasites & Vectors.2016;[Epub]     CrossRef
  • Draft Genome of Toxocara canis, a Pathogen Responsible for Visceral Larva Migrans
    Jinhwa Kong, Jungim Won, Jeehee Yoon, UnJoo Lee, Jong-Il Kim, Sun Huh
    The Korean Journal of Parasitology.2016; 54(6): 751.     CrossRef
  • A Systematic Review of Toxocariasis: A Neglected But High-Prevalence Disease in Brazil
    Carlos Roberto Silveira Corrêa, Paula Mayara Matos Fialho
    The American Journal of Tropical Medicine and Hygiene.2016; 94(6): 1193.     CrossRef
  • Clinical characteristics and progression of liver abscess caused by toxocara
    Kyung Ho Ha, Jung Eun Song, Byung Seok Kim, Chang Hyeong Lee
    World Journal of Hepatology.2016; 8(18): 757.     CrossRef
  • SEROPOSITIVITY FOR ASCARIOSIS AND TOXOCARIOSIS AND CYTOKINE EXPRESSION AMONG THE INDIGENOUS PEOPLE IN THE VENEZUELAN DELTA REGION
    Zaida Araujo, Sietze Brandes, Elena Pinelli, María A. Bochichio, Andrea Palacios, Albina Wide, Bruno Rivas-Santiago, Juan Carlos Jiménez
    Revista do Instituto de Medicina Tropical de São Paulo.2015; 57(1): 47.     CrossRef
  • Significance of Serum Antibody Test for Toxocariasis in Healthy Healthcare Examinees with Eosinophilia in Seoul and Gyeongsangnam-do, Korea
    Hong Seok Kim, Yan Jin, Min-Ho Choi, Jae-Hwan Kim, Young Ha Lee, Cheong Ha Yoon, Eui-Hyuk Hwang, Hun Kang, Sang-Yong Ahn, Gi Jin Kim, Sung-Tae Hong
    Journal of Korean Medical Science.2014; 29(12): 1618.     CrossRef
  • Toxocara Optic Neuropathy after Ingestion of Raw Meat Products
    Hee Kyung Yang, Se Joon Woo, Jeong-Min Hwang
    Optometry and Vision Science.2014; 91(11): e267.     CrossRef
  • Ocular toxocariasis: clinical features, diagnosis, treatment, and prevention
    Seong Joon Ahn, Na-Kyung Ryoo, Se Joon Woo
    Asia Pacific Allergy.2014; 4(3): 134.     CrossRef
  • A Case of Ocular Toxocariasis Successfully Treated with Albendazole and Triamcinolon
    San Seong, Daruchi Moon, Dong Kyu Lee, Hyung Eun Kim, Hyun Sup Oh, Soon Hyun Kim, Oh Woong Kwon, Yong Sung You
    The Korean Journal of Parasitology.2014; 52(5): 537.     CrossRef
  • A Comparative Seroprevalence Study of Toxocariasis in Hypereosinophilic and Apparently Healthy Individuals
    Bahador Sarkari, Malihe Lari, Reza Shafiei, Seyed Mahmoud Sadjjadi
    Archives of Pediatric Infectious Diseases.2014;[Epub]     CrossRef
  • Research on Toxocara Canis antibodies obtained from patients with eosinophilia
    E Artinyan, H Kırkoyun Uysal, O Akgul, S Altıparmak, YA Oner
    Indian Journal of Medical Microbiology.2014; 32(4): 383.     CrossRef
  • Chemotherapeutic drugs for common parasitic diseases in Korea
    Sun Huh
    Journal of the Korean Medical Association.2013; 56(6): 513.     CrossRef
  • A Seroepidemiological Survey of Toxocariasis among Eosinophilia Patients in Chungcheongnam-do
    Min Seo, Sung Chul Yoon
    The Korean Journal of Parasitology.2012; 50(3): 249.     CrossRef
  • Seroprevalence of toxocariasis in hypereosinophilic individuals in Ahwaz, south-western Iran
    S. Maraghi, A. Rafiei, R. Hajihossein, S. M. Sadjjadi
    Journal of Helminthology.2012; 86(2): 241.     CrossRef
  • Ultrastructural Localization of Toxocara canis Larval Antigen Reacted with a Seropositive Human Serum
    Soo-Ung Lee, Jae-Ran Yu, Sun Huh
    The Korean Journal of Parasitology.2009; 47(1): 65.     CrossRef
  • Frequency of eosinophilia and risk factors and their association with Toxocara infection in schoolchildren during a health survey in the north of Lima, Peru
    William H. Roldán, Yrma A. Espinoza, Arturo Atúncar, Emperatriz Ortega, América Martinez, Melissa Saravia
    Revista do Instituto de Medicina Tropical de São Paulo.2008; 50(5): 273.     CrossRef
  • 8,940 View
  • 86 Download
  • Crossref

Brief Communication

Degranulation of human eosinophils induced by Paragonimus westermani-secreted protease
Myeong Heon Shin, Young-Bae Chung, Hirohito Kita
Korean J Parasitol 2005;43(1):33-37.
Published online March 20, 2005
DOI: https://doi.org/10.3347/kjp.2005.43.1.33

Eosinophil degranulation is considered to be a key effector function for the killing of helminthic worms and tissue inflammation at worm-infected lesion sites. However, relatively little data are available with regard to eosinophil response after stimulation with worm-secreted products which contain a large quantity of cysteine proteases. In this study, we attempted to determine whether the degranulation of human eosinophils could be induced by the direct stimulation of the excretory-secretory products (ESP) of Paragonimus westermani, which causes pulmonary paragonimiasis in human beings. Incubation of eosinophils for 3 hr with Paragonimus-secreted products resulted in marked degranulation, as evidenced by the release of eosinophil-derived neurotoxin (EDN) in the culture supernatants. Moreover, superoxide anion was produced by eosinophils after stimulation of the ESP. The ESP-induced EDN release was found to be significantly inhibited when the ESP was pretreated with protease inhibitor cocktail or the cysteine protease inhibitor, E-64. These findings suggest that human eosinophils become degranulated in response to P. westermani-secreted proteases, which may contribute to in vivo tissue inflammation around the worms.

Citations

Citations to this article as recorded by  Crossref logo
  • Interface Molecules ofAngiostrongylus cantonensis: Their Role in Parasite Survival and Modulation of Host Defenses
    Alessandra L. Morassutti, Carlos Graeff-Teixeira
    International Journal of Inflammation.2012; 2012: 1.     CrossRef
  • Echinococcus multilocularis: Identification and functional characterization of cathepsin B-like peptidases from metacestode
    Yasuhito Sako, Kazuhiro Nakaya, Akira Ito
    Experimental Parasitology.2011; 127(3): 693.     CrossRef
  • Eosinophil and Tissue-invasive Parasitic Helminth
    Myeong Heon Shin
    Hanyang Medical Reviews.2010; 30(3): 238.     CrossRef
  • Eosinophil-Mediated Tissue Inflammatory Responses in Helminth Infection
    Myeong Heon Shin, Young Ah Lee, Duk-Young Min
    The Korean Journal of Parasitology.2009; 47(Suppl): S125.     CrossRef
  • A 27 kDa Cysteine Protease Secreted by Newly Excysted Paragonimus westermani Metacercariae Induces Superoxide Anion Production and Degranulation of Human Eosinophils
    Young-Bae Chung, Hirohito Kita, Myeong Heon Shin
    The Korean Journal of Parasitology.2008; 46(2): 95.     CrossRef
  • Cloning and characterization of cathepsin L-like peptidases of Echinococcus multilocularis metacestodes
    Yasuhito Sako, Hiroshi Yamasaki, Kazuhiro Nakaya, Minoru Nakao, Akira Ito
    Molecular and Biochemical Parasitology.2007; 154(2): 181.     CrossRef
  • Identification of immunodominant excretory–secretory cysteine proteases of adult Paragonimus westermani by proteome analysis
    Eung‐Goo Lee, Byoung‐Kuk Na, Young‐An Bae, Seon‐Hee Kim, Eun‐Young Je, Jeong‐Won Ju, Shin‐Hyeong Cho, Tong‐Soo Kim, Shin‐Yong Kang, Seung‐Yull Cho, Yoon Kong
    PROTEOMICS.2006; 6(4): 1290.     CrossRef
  • Partial characterization of a 29 kDa cysteine protease purified from Taenia solium metacestodes
    Ji-Young Kim, Hyun-Jong Yang, Kwang-Sig Kim, Young-Bae Chung
    The Korean Journal of Parasitology.2005; 43(4): 157.     CrossRef
  • 8,831 View
  • 69 Download
  • Crossref

Original Article

Persistent infection with Strongyloides venezuelensis in the Mongolian gerbil (Meriones unguiculatus)
Byeong-Kirl Baek, In-Soo Whang, M. Khyrul Islam, Byeong-Soo Kim, Ibulaimu Kakoma
Korean J Parasitol 2002;40(4):181-186.
Published online December 30, 2002
DOI: https://doi.org/10.3347/kjp.2002.40.4.181

To examine the fate of Strongyloides venezuelensis, Mongolian gerbils (Meriones unguicalatus) were orally infected with 1,000 L3 larvae per animal. Altogether, 50 gerbils divided into 5 groups of 10 each were monitored for a period of 570 days to document the kinetics of faecal egg output, adults worm population, morphological development, fecundity, and hematological changes including peripheral blood eosinophilia. This study chronicled a life long parasitism of S. venezuelensis in the gerbil host, and showed that S. venezuelensis infection was quite stable throughout the course of infection and the worms maintained their normal development as evidenced by their body dimension. A progressive loss of body condition of the infected gerbils was observed as the level of infection advanced. However, no detectable pathological changes were observed in the gastrointestinal tract. The present findings indicate that an immunocompetent host, such as the Mongolian gerbil, can serve as a life long carrier model of S. venezuelensis if the worms are not expelled within 570 days after infection.

Citations

Citations to this article as recorded by  Crossref logo
  • Gastrointestinal effects of ivermectin treatment in rats infected with Strongyloides venezuelensis
    Jalvita C. Mendonça, Loyane A. Gama, Andrieli T. Hauschildt, Luciana A. Corá, Madileine F. Américo
    Acta Tropica.2019; 194: 69.     CrossRef
  • Strongyloides ratti and S. venezuelensis – rodent models of Strongyloides infection
    MARK VINEY, TAISEI KIKUCHI
    Parasitology.2017; 144(3): 285.     CrossRef
  • Parasitological and transcriptomic comparison of Strongyloides ratti infections in natural and in suboptimal permissive hosts
    Tegegn G. Jaleta, Christian Rödelsperger, Adrian Streit
    Experimental Parasitology.2017; 180: 112.     CrossRef
  • Callithrix penicillata as a nonhuman primate model for strongyloidiasis
    Alan Lane de Melo, Vitor Luís Tenório Mati, Wanderlany Amâncio Martins
    Primates.2012; 53(3): 303.     CrossRef
  • Role of angiogenic factors in acute experimental Strongyloides venezuelensis infection
    F. SHARIATI, J. L. PÉREZ-ARELLANO, J. LÓPEZ-ABÁN, A. M. EL BEHAIRY, A. MURO
    Parasite Immunology.2010; 32(6): 430.     CrossRef
  • Migration of Strongyloides venezuelensis in Rats after Oral Inoculation of Free-Living Infective Larvae
    Kiku MATSUDA, Byeong-Su KIM, In-Soo WHANG, Chae-Woong LIM, Byeong-Kirl BAEK
    Journal of Veterinary Medical Science.2003; 65(9): 971.     CrossRef
  • 7,684 View
  • 59 Download
  • Crossref

Mini Review

Mucosal immunity against parasitic gastrointestinal nematodes
Denis Nnabuike Onah, Yukifumi Nawa
Korean J Parasitol 2000;38(4):209-236.
Published online December 31, 2000
DOI: https://doi.org/10.3347/kjp.2000.38.4.209

The last two decades witnessed significant advances in the efforts of immunoparasitologists to elucidate the nature and role of the host mucosal defence mechanisms against intestinal nematode parasites. Aided by recent advances in basic immunology and biotechnology with the concomitant development of well defined laboratory models of infection, immunoparasitologists have more precisely analyzed and defined the different immune effector mechanisms during the infection; resulting in great improvement in our current knowledge and understanding of protective immunity against gastrointestinal (GI) nematode parasites. Much of this current understanding comes from experimental studies in laboratory rodents, which have been used as models of livestock and human GI nematode infections. These rodent studies, which have concentrated on Heligmosomoides polygyrus, Nippostrongylus brasiliensis, Strongyloides ratti/S. venezuelensis, Trichinella spiralis and Trichuris muris infections in mice and rats, have helped in defining the types of T cell responses that regulate effector mechanisms and the effector mechanisms responsible for worm expulsion. In addition, these studies bear indications that traditionally accepted mechanisms of resistance such as eosinophilia and IgE responses may not play as important roles in protection as were previously conceived. In this review, we shall, from these rodent studies, attempt an overview of the mucosal and other effector responses against intestinal nematode parasites beginning with the indices of immune protection as a model of the protective immune responses that may occur in animals and man.

Citations

Citations to this article as recorded by  Crossref logo
  • Mucosal Immunity of Major Gastrointestinal Nematode Infections in Small Ruminants Can Be Harnessed to Develop New Prevention Strategies
    P. G. Ashani S. Palkumbura, Thilini A. N. Mahakapuge, R. R. M. K. Kavindra Wijesundera, Viskam Wijewardana, Richard Thiga Kangethe, R. P. V. Jayanthe Rajapakse
    International Journal of Molecular Sciences.2024; 25(3): 1409.     CrossRef
  • Goats are more susceptible to Haemonchus contortus infection than sheep under similar experimental settings
    Desta Risa, Gezahegne Mamo, Hika Waktole, Geremew Haile, Getachew Terefe
    Scientific Reports.2024;[Epub]     CrossRef
  • Chronic Strongyloides stercoralis infection increases presence of the Ruminococcus torques group in the gut and alters the microbial proteome
    Na T. D. Tran, Apisit Chaidee, Achirawit Surapinit, Manachai Yingklang, Sitiruk Roytrakul, Sawanya Charoenlappanit, Porntip Pinlaor, Nuttanan Hongsrichan, Sirirat Anutrakulchai, Ubon Cha’on, Somchai Pinlaor
    Scientific Reports.2023;[Epub]     CrossRef
  • Mucosal Vaccination With Recombinant Tm-WAP49 Protein Induces Protective Humoral and Cellular Immunity Against Experimental Trichuriasis in AKR Mice
    Junfei Wei, Venkatesh L. Hegde, Ananta V. Yanamandra, Madison P. O’Hara, Brian Keegan, Kathryn M. Jones, Ulrich Strych, Maria Elena Bottazzi, Bin Zhan, K. Jagannadha Sastry, Peter J. Hotez
    Frontiers in Immunology.2022;[Epub]     CrossRef
  • Resistance mesenteric arteries display hypercontractility in the resolution time of Strongyloides venezuelensis infection
    Vanessa Dela Justina, Loyane Almeida Gama, Tatiane Schönholzer, Alecsander F. Bressan, Victor Vitorino Lima, Madileine F. Americo, Fernanda R. Giachini
    Experimental Parasitology.2021; 222: 108078.     CrossRef
  • The latest FAD – Faecal antibody detection in cattle. Protocol and results from three UK beef farms naturally infected with gastrointestinal nematodes
    A. S. Cooke, K. A. Watt, E. R. Morgan, J. A. J. Dungait
    Parasitology.2019; 146(1): 89.     CrossRef
  • Globule Leukocytes and Other Mast Cells in the Mouse Intestine
    Peter Vogel, Laura Janke, David M. Gravano, Meifen Lu, Deepali V. Sawant, Dorothy Bush, E Shuyu, Dario A. A. Vignali, Asha Pillai, Jerold E. Rehg
    Veterinary Pathology.2018; 55(1): 76.     CrossRef
  • Salmon louse rhabdoviruses: Impact on louse development and transcription of selected Atlantic salmon immune genes
    Aina-Cathrine Øvergård, Lars Are Hamre, Sindre Grotmol, Frank Nilsen
    Developmental & Comparative Immunology.2018; 86: 86.     CrossRef
  • Inducible nitric oxide synthase controls experimental Strongyloides infection
    Rosângela Maria Rodrigues, Ana Lúcia Ribeiro Gonçalves, Neide Maria Silva, Cristina Ribeiro de Barros Cardoso, Natália Rodrigues Araújo, Loyane Bertagnolli Coutinho, Ronaldo Alves, Marlene Tiduko Ueta, Julia Maria Costa‐Cruz
    Parasite Immunology.2018;[Epub]     CrossRef
  • The role of IL-33/ST2, IL-4, and eosinophils on the airway hyperresponsiveness induced by Strongyloides venezuelensis in BALB/c mice
    Emilia Souza Araujo, Cintia Aparecida de Jesus Pereira, Ana Terezinha de Moura Pereira, João Marcelo Peixoto Moreira, Michelle Carvalho de Rezende, Jailza Lima Rodrigues, Mauro Martins Teixeira, Deborah Negrão-Corrêa
    Parasitology Research.2016; 115(8): 3107.     CrossRef
  • IL-22 Restrains Tapeworm-Mediated Protection against Experimental Colitis via Regulation of IL-25 Expression
    José L. Reyes, Maria R. Fernando, Fernando Lopes, Gabriella Leung, Nicole L. Mancini, Chelsea E. Matisz, Arthur Wang, Derek M. McKay, Debroski R. Herbert
    PLOS Pathogens.2016; 12(4): e1005481.     CrossRef
  • Strongyloides stercoralisInfection in Alcoholic Patients
    Marcia C. A. Teixeira, Flavia T. F. Pacheco, Joelma N. Souza, Mônica L. S. Silva, Elizabete J. Inês, Neci M. Soares
    BioMed Research International.2016; 2016: 1.     CrossRef
  • Partially Protective Immunity Induced by a 20 kDa Protein Secreted by Trichinella spiralis Stichocytes
    Kuo Bi, Jing Yang, Lei Wang, Yuan Gu, Bin Zhan, Xinping Zhu, Érika Martins Braga
    PLOS ONE.2015; 10(8): e0136189.     CrossRef
  • Strongyloides stercoralis infection in marmosets: replication of complicated and uncomplicated human disease and parasite biology
    Vitor Luís Tenório Mati, Pedro Raso, Alan Lane de Melo
    Parasites & Vectors.2014;[Epub]     CrossRef
  • Strongyloides cebus(Nematoda: Strongyloididae) inLagothrix cana(Primates: Atelidae) from the Brazilian Amazon: Aspects of Clinical Presentation, Anatomopathology, Treatment, and Parasitic Biology
    Vitor Luís Tenório Mati, Francisco Carlos Ferreira Junior, Hudson Alves Pinto, Alan Lane de Melo
    Journal of Parasitology.2013; 99(6): 1009.     CrossRef
  • Increased susceptibility to Strongyloides venezuelensis infection is related to the parasite load and absence of major histocompatibility complex (MHC) class II molecules
    Rosângela Maria Rodrigues, Cristina Ribeiro Cardoso, Ana Lúcia Ribeiro Gonçalves, Neide Maria Silva, Virgínia Massa, Ronaldo Alves, Marlene Tiduko Ueta, João Santana Silva, Julia Maria Costa-Cruz
    Experimental Parasitology.2013; 135(3): 580.     CrossRef
  • Intestinal mast cells and eosinophils in relation to Strongyloides ratti adult expulsion from the small and large intestines of rats
    Y. SHINTOKU, T. KADOSAKA, E. KIMURA, H. TAKAGI, S. KONDO, M. ITOH
    Parasitology.2013; 140(5): 626.     CrossRef
  • Hymenolepis diminuta: Analysis of the expression of Toll-like receptor genes (TLR2 and TLR4) in the small and large intestines of rats
    D.I. Kosik-Bogacka, A. Wojtkowiak-Giera, A. Kolasa, R. Salamatin, P.P. Jagodzinski, E. Wandurska-Nowak
    Experimental Parasitology.2012; 130(3): 261.     CrossRef
  • Iron deficiency reduces serum and in vitro secretion of interleukin-4 in mice independent of altered spleen cell proliferation
    Solo R. Kuvibidila, Maria Velez, Renée Gardner, Kavitha Penugonda, Lawrance C. Chandra, Lolie Yu
    Nutrition Research.2012; 32(2): 107.     CrossRef
  • Immunological mechanisms involved in the protection against intestinal taeniosis elicited by oral immunization with Taenia solium calreticulin
    Sonia Leon-Cabrera, Mayra Cruz-Rivera, Fela Mendlovic, Mirza Romero-Valdovinos, Gilberto Vaughan, Ana María Salazar, Guillermina Avila, Ana Flisser
    Experimental Parasitology.2012; 132(3): 334.     CrossRef
  • Hookworm virulence factors: making the most of the host
    Maria V. Periago, Jeffrey M. Bethony
    Microbes and Infection.2012; 14(15): 1451.     CrossRef
  • Intraepithelial lymphocytes, goblet cells and VIP‐IR submucosal neurons of jejunum rats infected with Toxoplasma gondii
    Débora M. G. Sant’Ana, Marcelo B. Góis, Jacqueline N. Zanoni, Aristeu V. da Silva, Cleverton J. T. da Silva, Eduardo J. A. Araújo
    International Journal of Experimental Pathology.2012; 93(4): 279.     CrossRef
  • Helminth infections: therapeutic potential in autoimmune disorders
    M. EL‐MALKY, N. NABIH, M. HEDER, N. SAUDY, M. EL‐MAHDY
    Parasite Immunology.2011; 33(11): 589.     CrossRef
  • Strongyloides ratti:transplantation of adults recovered from the small intestine at different days after infection into the colon of naive and infection-primed Wistar rats, and the effect of antioxidant treatment on large intestinal parasitism
    Y. SHINTOKU, H. TAKAGI, T. KADOSAKA, F. NAGAOKA, S. KONDO, M. ITOH, S. HONDA, E. KIMURA
    Parasitology.2011; 138(8): 1053.     CrossRef
  • Taenia solium: Immune response against oral or systemic immunization with purified recombinant calreticulin in mice
    Salvador Fonseca-Coronado, Karina Ruiz-Tovar, Mayra Pérez-Tapia, Fela Mendlovic, Ana Flisser
    Experimental Parasitology.2011; 127(1): 313.     CrossRef
  • Taenia solium: current understanding of laboratory animal models of taeniosis
    A. FLISSER, G. ÁVILA, P. MARAVILLA, F. MENDLOVIC, S. LEÓN-CABRERA, M. CRUZ-RIVERA, A. GARZA, B. GÓMEZ, L. AGUILAR, N. TERÁN, S. VELASCO, M. BENÍTEZ, D. E. JIMENEZ-GONZALEZ
    Parasitology.2010; 137(3): 347.     CrossRef
  • Regulation of immune responses toStrongyloides venezuelensischallenge after primary infection with different larvae doses
    H. C. SCHILTER, A. T. M. PEREIRA, P. D. ESCHENAZI, A. FERNANDES, D. SHIM, A. L. S. SOUSA, M. M. TEIXEIRA, D. NEGRÃO-CORRÊA
    Parasite Immunology.2010; 32(3): 184.     CrossRef
  • Major histocompatibility complex (MHC) class II but not MHC class I molecules are required for efficient control of Strongyloides venezuelensis infection in mice
    Rosângela M. Rodrigues, Neide M. Silva, Ana Lúcia R. Gonçalves, Cristina R. Cardoso, Ronaldo Alves, Flávia A. Gonçalves, Marcelo E. Beletti, Marlene T. Ueta, João S. Silva, Julia M. Costa‐Cruz
    Immunology.2009;[Epub]     CrossRef
  • Cd4+ T-cell-dependent Goblet Cell Proliferation and Expulsion of Gymnophalloides seoi from the Intestine of C57bl/6 Mice
    Sang-Mee Guk, Jun-Haeng Lee, Hyo-Jin Kim, Won-Hee Kim, Eun-Hee Shin, Jong-Yil Chai
    Journal of Parasitology.2009; 95(3): 581.     CrossRef
  • The Immunological Effects of Electrolyzed Reduced Water on the Echinostoma hortense Infection in C57BL/6 Mice
    Kyu Jae Lee, Dan Jin, Byung Soo Chang, Yung Chien Teng, Dong Heui Kim
    Biological and Pharmaceutical Bulletin.2009; 32(3): 456.     CrossRef
  • INCREASED INTESTINAL ENDOTOXIN ABSORPTION DURING ENTERIC NEMATODE BUT NOT PROTOZOAL INFECTIONS THROUGH A MAST CELL-MEDIATED MECHANISM
    Ayman Samir Farid, Fumiko Jimi, Kyoko Inagaki-Ohara, Yoichiro Horii
    Shock.2008; 29(6): 709.     CrossRef
  • Immunolocalization and pathological alterations following Strongyloides venezuelensis infection in the lungs and the intestine of MHC class I or II deficient mice
    A.L.R. Gonçalves, R.M. Rodrigues, N.M. Silva, F.A. Gonçalves, C.R. Cardoso, M.E. Beletti, M.T. Ueta, J.S. Silva, J.M. Costa-Cruz
    Veterinary Parasitology.2008; 158(4): 319.     CrossRef
  • Evaluation of the immune response against Strongyloides venezuelensis in antigen‐immunized or previously infected mice
    A. FERNANDES, A. T. M. PEREIRA, P. D. ESCHENAZI, H. C. SCHILTER, A. L. S. SOUSA, M. M. TEIXEIRA, D. NEGRÃO‐CORRÊA
    Parasite Immunology.2008; 30(3): 139.     CrossRef
  • IL-4/IL-13 independent goblet cell hyperplasia in experimental helminth infections
    Reece G Marillier, Chesney Michels, Elizabeth M Smith, Lizette CE Fick, Mosiuoa Leeto, Benjamin Dewals, William GC Horsnell, Frank Brombacher
    BMC Immunology.2008;[Epub]     CrossRef
  • Expulsion of the gastrointestinal cestode, Hymenolepis diminuta by tolerant rats: evidence for mediation by a Th2 type immune enhanced goblet cell hyperplasia, increased mucin production and secretion
    R. A. WEBB, T. HOQUE, S. DIMAS
    Parasite Immunology.2007; 29(1): 11.     CrossRef
  • Density-dependent immune responses against the gastrointestinal nematode Strongyloides ratti
    Colin Bleay, Clare P. Wilkes, Steve Paterson, Mark E. Viney
    International Journal for Parasitology.2007; 37(13): 1501.     CrossRef
  • Expression of IL-4 receptor on non-bone marrow-derived cells is necessary for the timely elimination of Strongyloides venezuelensis in mice, but not for intestinal IL-4 production
    Deborah Negrão-Corrêa, Vanessa Pinho, Danielle G. Souza, Ana Terezinha M. Pereira, Adriana Fernandes, Karina Scheuermann, Adriano L.S. Souza, Mauro M. Teixeira
    International Journal for Parasitology.2006; 36(10-11): 1185.     CrossRef
  • Trichuris suis population dynamics following a primary experimental infection
    Helene Kringel, Allan Roepstorff
    Veterinary Parasitology.2006; 139(1-3): 132.     CrossRef
  • Microcapsules formulated in the enteric coating copolymer Eudragit L100 as delivery systems for oral vaccination against infections by gastrointestinal nematode parasites
    Maria A. Dea-Ayuela, Sara Rama-Iñiguez, S. Torrado-Santiago, F. Bolas-Fernandez
    Journal of Drug Targeting.2006; 14(8): 567.     CrossRef
  • Haemonchus contortus(Nematoda: Trichostrongylidae) infection in lambs elicits an unequivocal Th2 immune response
    Caroline Lacroux, Thi Hai Chi Nguyen, Olivier Andreoletti, Françoise Prevot, Christelle Grisez, Jean-Paul Bergeaud, Lucas Gruner, Jean-Claude Brunel, Dominique Francois, Philippe Dorchies, Philippe Jacquiet
    Veterinary Research.2006; 37(4): 607.     CrossRef
  • Intestinal strongyloidiasis and hyperinfection syndrome
    Raja S Vadlamudi, David S Chi, Guha Krishnaswamy
    Clinical and Molecular Allergy.2006;[Epub]     CrossRef
  • Haemonchus contortus egg excretion and female length reduction in sheep previously infected with Oestrus ovis (Diptera: Oestridae) larvae
    G. Terefe, H.T. Yacob, C. Grisez, F. Prevot, E. Dumas, J.P. Bergeaud, Ph. Dorchies, H. Hoste, P. Jacquiet
    Veterinary Parasitology.2005; 128(3-4): 271.     CrossRef
  • Interactions between intrinsic and extrinsic mechanisms in a cyclic species: testosterone increases parasite infection in red grouse
    Linzi J Seivwright, Stephen M Redpath, François Mougeot, Fiona Leckie, Peter J Hudson
    Proceedings of the Royal Society B: Biological Sciences.2005; 272(1578): 2299.     CrossRef
  • Separating Behavioral and Physiological Mechanisms in Testosterone‐Mediated Trade‐Offs
    François Mougeot, Stephen M. Redpath, Stuart B. Piertney, Peter J. Hudson
    The American Naturalist.2005; 166(2): 158.     CrossRef
  • Enhanced survival of rats concurrently infected with Trypanosoma brucei and Strongyloides ratti
    D.N Onah, I.W Onyenwe, J.I Ihedioha, O.S Onwumere
    Veterinary Parasitology.2004; 119(2-3): 165.     CrossRef
  • Interleukin (IL) 5 levels and eosinophilia in patients with intestinal parasitic diseases
    Sebnem Ustun
    World Journal of Gastroenterology.2004; 10(24): 3643.     CrossRef
  • Effects of anti-allergic drugs on intestinal mastocytosis and worm expulsion of rats infected with Neodiplostomum seoulense
    Eun-Hee Shin, Tae-Heung Kim, Sung-Jong Hong, Jae-Hwan Park, Sang-Mee Guk, Jong-Yil Chai
    The Korean Journal of Parasitology.2003; 41(2): 81.     CrossRef
  • Role of Intestinal Goblet Cells in the Expulsion of Gymnophalloides seoi From Mice
    M. Seo, S-M. Guk, E-T. Han, J-Y. Chai
    Journal of Parasitology.2003; 89(5): 1080.     CrossRef
  • The relative involvement of Th1 and Th2 associated immune responses in the expulsion of a primary infection of Heligmosomoides polygyrus in mice of differing response phenotype
    A. Ben-Smith, D.A. Lammas, J.M. Behnke
    Journal of Helminthology.2003; 77(2): 133.     CrossRef
  • Food-borne intestinal trematode infections in the Republic of Korea
    Jong-Yil Chai, Soon-Hyung Lee
    Parasitology International.2002; 51(2): 129.     CrossRef
  • Intestinal histopathology and in situ postures of Gymnophalloides seoi in experimentally infected mice
    Jong-Yil Chai, Hong-Soon Lee, Sung-Jong Hong, Jae Hyung Yoo, Sang-Mee Guk, Min Seo, Min-Ho Choi, Soon-Hyung Lee
    The Korean Journal of Parasitology.2001; 39(1): 31.     CrossRef
  • A review of Gymnophalloides seoi (Digenea: Gymnophallidae) and human infections in the Republic of Korea
    Soon-Hyung Lee, Jong-Yil Chai
    The Korean Journal of Parasitology.2001; 39(2): 85.     CrossRef
  • 16,086 View
  • 131 Download
  • Crossref
Original Articles

Eosinophils are important effector cells in host defense against parasites. Excretory-secretory product (ESP) produced by helminthic worms plays important roles in the uptake of nutrients, migration in the host tissue, and in immune modulation. However, little is known about the ability of the ESP to directly trigger eosinophil apoptosis. This study investigated whether the ESP of newly excysted metacercariae of Paragonimus westermani could induce apoptosis in human eosinophils. Apoptosis was assayed by staining the cells with FITC-annexin V, and the cells were analyzed by flow cytometry. It was found that the ESP of newly excysted metacercariae of P. westermani induced a direct time- and concentration-dependent increase in the rate of constitutive apoptosis in mature human eosinophils. Eosinophil apoptosis was first apparent 3 hr after treatment with the ESP and continued to increase after 6 hr of incubation with respect to the cells cultured in the absence of the ESP. While only 2.8% of the eosinophils incubated in the medium for 3 hr were apoptotic, 7.6%, 10.9% and 22.6% of the eosinophils treated with 10, 30 and 100 ?g/ml ESP were apoptotic, respectively. This result suggests that the ESP of newly excysted metacercariae of P. westermani directly induce eosinophil apoptosis, which may be important for the survival of the parasites and the reduction of eosinophilic inflammation in vivo.

Citations

Citations to this article as recorded by  Crossref logo
  • Gastric lesions in dolphins stranded along the Eastern Adriatic coast
    J Hrabar, I Bočina, A Gudan Kurilj, M Đuras, I Mladineo
    Diseases of Aquatic Organisms.2017; 125(2): 125.     CrossRef
  • Fasciola hepatica induces eosinophil apoptosis in the migratory and biliary stages of infection in sheep
    A. Escamilla, M.J. Bautista, R. Zafra, I.L. Pacheco, M.T. Ruiz, S. Martínez-Cruz, A. Méndez, A. Martínez-Moreno, V. Molina-Hernández, J. Pérez
    Veterinary Parasitology.2016; 216: 84.     CrossRef
  • Fasciola hepatica products induce apoptosis of peritoneal macrophages
    Lorena Guasconi, Marianela C. Serradell, Diana T. Masih
    Veterinary Immunology and Immunopathology.2012; 148(3-4): 359.     CrossRef
  • Staphylococcus aureus Induces Eosinophil Cell Death Mediated by α-hemolysin
    Lynne R. Prince, Kirstie J. Graham, John Connolly, Sadia Anwar, Robert Ridley, Ian Sabroe, Simon J. Foster, Moira K. B. Whyte, Malcolm James Horsburgh
    PLoS ONE.2012; 7(2): e31506.     CrossRef
  • A 27 kDa Cysteine Protease Secreted by Newly Excysted Paragonimus westermani Metacercariae Induces Superoxide Anion Production and Degranulation of Human Eosinophils
    Young-Bae Chung, Hirohito Kita, Myeong Heon Shin
    The Korean Journal of Parasitology.2008; 46(2): 95.     CrossRef
  • Excretory-secretory products from Fasciola hepatica induce eosinophil apoptosis by a caspase-dependent mechanism
    Marianela C. Serradell, Lorena Guasconi, Laura Cervi, Laura S. Chiapello, Diana T. Masih
    Veterinary Immunology and Immunopathology.2007; 117(3-4): 197.     CrossRef
  • Excretory-Secretory Products Produced by Paragonimus westermani Differentially Regulate the Nitric Oxide Production and Viability of Microglial Cells
    Youngnam Jin, Jae-Chul Lee, In Young Choi, Eun A. Kim, Myeong Heon Shin, Won-Ki Kim
    International Archives of Allergy and Immunology.2006; 139(1): 16.     CrossRef
  • Cysteine Protease Secreted byParagonimus westermaniAttenuates Effector Functions of Human Eosinophils Stimulated with Immunoglobulin G
    W. A. Petri, Myeong Heon Shin, Hirohito Kita, Hae Young Park, Ju Young Seoh
    Infection and Immunity.2001; 69(3): 1599.     CrossRef
  • Proteolytic activity of cysteine protease in excretory–secretory product of Paragonimus westermani newly excysted metacercariae pivotally regulates IL‐8 production of human eosinophils
    Myeong Heon Shin, Soo Young Lee
    Parasite Immunology.2000; 22(10): 529.     CrossRef
  • 8,541 View
  • 71 Download
  • Crossref
Partial cross-resistance between Strongyloides venezuelensis and Nippostrongylus brasiliensis in rats
Byeong-Kirl Baek, M. Khyrul Islam, Jin-Ho Kim, John-Wha Lee, Jin Hur
Korean J Parasitol 1999;37(2):101-107.
Published online June 30, 1999
DOI: https://doi.org/10.3347/kjp.1999.37.2.101

Rats were immunized through an initial infection with 1,000 filariform larvae (L3) of Nippostrongylus brasiliensis and after complete expulsion of worms they were challenged with 1,000 L3 of Strongyloides venezuelensis to investigate whether cross-resistance developed against a heterologous parasite. Nippostrongylus brasiliensis-immunized rats developed a partial cross-resistance against S. venezuelensis migrating larvae (MSL3) in the lungs and adult worms in the small intestine. The population of MSL3 in the lungs were significantly lower (P<0.05) in immunized rats (22.0 ± 7.4) compared with controls (105.0 ± 27.6). The populations of adult worms, egg output and fecundity were initially decreased but from day 14 post-challenge they did not show any significant difference between immunized and control rats. However, the length of worm in immunized rat was revealed as retardation. Peripheral blood eosinophilia was significantly decreased (P<0.05) on day 7 post-challenge and then gradually increased, which peaked on day 42 post-challenge when most of the worms were expelled. These results suggest that peripheral blood eosinophilia is strongly involved in the worm establishment and expulsion mechanisms.

Citations

Citations to this article as recorded by  Crossref logo
  • Systemic Immune Modulation by Gastrointestinal Nematodes
    Darshan N. Kasal, Lindsey M. Warner, Astra S. Bryant, Elia Tait Wojno, Jakob von Moltke
    Annual Review of Immunology .2024; 42(1): 259.     CrossRef
  • Intestinal helminth infection transforms the CD4+ T cell composition of the skin
    Cajsa H. Classon, Muzhen Li, Ada Lerma Clavero, Junjie Ma, Xiaogang Feng, Christopher A. Tibbitt, Julian M. Stark, Rebeca Cardoso, Emma Ringqvist, Louis Boon, Eduardo J. Villablanca, Antonio Gigliotti Rothfuchs, Liv Eidsmo, Jonathan M. Coquet, Susanne Nyl
    Mucosal Immunology.2022; 15(2): 257.     CrossRef
  • Nematode-Infected Mice Acquire Resistance to Subsequent Infection With Unrelated Nematode by Inducing Highly Responsive Group 2 Innate Lymphoid Cells in the Lung
    Koubun Yasuda, Takumi Adachi, Atsuhide Koida, Kenji Nakanishi
    Frontiers in Immunology.2018;[Epub]     CrossRef
  • Biotic and abiotic effects on the intestinal helminth community of the brown ratRattus norvegicusfrom Rio de Janeiro, Brazil
    R.O. Simões, J.L. Luque, R. Gentile, M.C.S. Rosa, S. Costa-Neto, A. Maldonado
    Journal of Helminthology.2016; 90(1): 21.     CrossRef
  • Migratory route of Strongyloides venezuelensis in Lewis rats: Comparison of histological analyses and PCR
    Nelson Mendes Marra, Fernanda Chiuso-Minicucci, Gabriel Capella Machado, Sofia Fernanda Gonçalves Zorzella-Pezavento, Thaís Graziela Donegá França, Larissa Lumi Watanabe Ishikawa, Alessandro F.T. Amarante, Alexandrina Sartori, Mônica R.V. Amarante
    Experimental Parasitology.2011; 127(2): 334.     CrossRef
  • Migration of Strongyloides venezuelensis in Rats after Oral Inoculation of Free-Living Infective Larvae
    Kiku MATSUDA, Byeong-Su KIM, In-Soo WHANG, Chae-Woong LIM, Byeong-Kirl BAEK
    Journal of Veterinary Medical Science.2003; 65(9): 971.     CrossRef
  • 8,295 View
  • 52 Download
  • Crossref
Eosinophil and IgE responses of IL-5 transgenic mice experimentally infected with Nippostrongylus brasiliensis
Jong-Yil Chai, Eun-Hee Shin, Kiyoshi Takatsu, Naoki Matsumoto, Somei Kojima
Korean J Parasitol 1999;37(2):93-99.
Published online June 20, 1999
DOI: https://doi.org/10.3347/kjp.1999.37.2.93

Eosinophil and IgE responses of interleukin (IL)-5 transgenic and normal C3H/HeN mice were studied after experimental infection with Nippostrongylus brasiliensis (Nb). Intestinal worms were recovered at day 5 post-infection (PI), and numbers of total white blood cells (WBC) and eosinophils, and total serum IgE and anti-hapten (dinitrophenyl) (DNP) specific IgE titers, were measured at days 0, 14 and 21 PI. IL-5 mice appeared resistant to Nb infection showing a significantly lower worm recovery rate than normal mice (P<0.05). Total WBC and eosinophil counts (/mm3) were significantly increased in Nb infected normal mice (P<0.05), but unchanged (total WBC) or decreased (eosinophils) in IL-5 mice at day 21 PI. The total serum IgE level remarkably increased in normal mice, but only a little in IL-5 mice at days 14 and 21 PI. Priming with DNP brought about more remarkable increases of the total and anti-DNP specific IgE in normal mice than in IL-5 mice. The results show that IL-5 mice are resistant to Nb infection, and that eosinophil and IgE responses in these mice are not augmented by Nb infection.

Citations

Citations to this article as recorded by  Crossref logo
  • In vivo neutralization of α4 and β7 integrins inhibits eosinophil trafficking and prevents lung injury during tropical pulmonary eosinophilia in mice
    Pankaj Sharma, Aditi Sharma, Mrigank Srivastava
    European Journal of Immunology.2017; 47(9): 1501.     CrossRef
  • 8,347 View
  • 66 Download
  • Crossref