Parasites, Hosts and Diseases

"follow-up"

Brief Communication

Quantification of Immunoglobulin G against Trypanosoma cruzi in Individuals with Chronic Chagas Disease Treated with Nifurtimox and Evaluated in Prolonged Follow-Up: Gabriela Mun?oz, Camilo Vergara, Gabriela Marti?nez, Werner Apt, Ine?s Zulantay; Korean J Parasitol 2019;57(1):39-41.
Published online February 26, 2019; DOI: https://doi.org/10.3347/kjp.2019.57.1.39

Abstract
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In the indeterminate chronic period of Chagas disease (ChD) the treatment has not been conclusive, because the serological negativization requires many years. This study aims to evaluate the efficacy of nifurtimox (NF) in the treatment of chronic ChD in prolonged follow-up by serological techniques of indirect immunofluorescence assay (IFA) and enzyme-linked immunosorbent assay (ELISA) IgG comparing 2 groups of patients, treated and non treated. Mann-Whitney test was performed for ELISA and IFA, with significant difference between the groups (P < 0.05). IgG levels were lower in individuals treated compared with untreated patients, indicating chemotherapeutic efficacy in prolonged follow-up.

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Detection of Trypanosoma cruzi by PCR in adults with chronic Chagas disease treated with nifurtimox
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PLOS ONE.2019; 14(8): e0221100. CrossRef
Chronic Chagas disease: Quantification of Trypanosoma cruzi in peripheral blood and dejections of Triatoma infestans fed by xenodiagnosis in patients with and without cardiopathy
Werner Apt, Daniela Carrasco, Cristian Fuentealba, Mauricio Canals, Gabriela Muñoz, Miguel Saavedra, Juan-Paul Castillo, Inés Zulantay
Acta Tropica.2019; 200: 105167. CrossRef

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Original Article

Persisting antibody reaction in paragonimiasis after praziquantel treatment is elicited mainly by egg antigens: Seung-Yull Cho, Yoon Kong, Doo-Hee Yun, Shin-Yong Kang, Lee-Soo Kim, Young-Bae Chung, Hyun-Jong Yang; Korean J Parasitol 2000;38(2):75-84.
Published online June 30, 2000; DOI: https://doi.org/10.3347/kjp.2000.38.2.75

Abstract
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Antibody responses in serum and cerebrospinal fluid (CSF) samples from patients with active and chronic paragonimiasis and in sera from patients on whom follow-up studies were done after praziquantel treatment were analyzed using antigens of Paragonimus westermani prepared from eggs, metacercariae, juveniles of 4- and 7-week old, adult worms and recombinant protein of 28 kDa cruzipain-like cysteine protease (rPw28CCP). The patient sera/CSFs of active and chronic paragonimiasis revealed strong antibody reactions against the crude extracts of 4- and 7-week old juveniles as well as against those from egg and adult. rPw28CCP also showed specific reaction to the sera with active paragonimiasis. After the treatment, levels of specific antibodies in the sera gradually decreased to negative range in most patients. In some cases with persisting high antibody levels, however, the reactions at 27 kDa egg protein were sustained throughout the observation period of 34 months. The reactions at 35 and 32 kDa in adult extract and rPw28CCP disappeared rapidly after the treatment. Persistent antibody reactions even after successful treatment are provoked by continuous antigenic challenge from eggs which were not resolved by treatment.

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Brief Communication

Towards developing a diagnostic regimen for the treatment follow-up of Trypanosoma brucei gambiense: Peter A. Mbati, Kazuko Hirumi, Noboru Inoue, Nanituma H. Situakibanza, Hiroyuki Hirumi; Korean J Parasitol 1999;37(4):289-292.
Published online December 31, 1999; DOI: https://doi.org/10.3347/kjp.1999.37.4.289

Abstract
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BALB/c mice infected with a high virulent strain of Trypanosoma brucei gambiense IL3707 were treated intraperitoneally (ip) with either Melarsoprol (Mel-B) or PSG(+) buffer as controls. The mice were subsequently monitored regularly for parasites by direct microscopic examination of their tail blood or buffy coat and by polymerase chain reaction (PCR). Mel-B was found to be an effective drug for treatment against T.b. gambiense because at the end of the first treatment schedule, all treated mice were negative for parasites even by PCR, while all the control animals were positive. Three of the five Mel-B treated mice, while parasitologically negative, were PCR positive between 53 and 80 days post infection (DPI), indicating that they still harbored an infection. All treated mice were subsequently negative for parasites even by PCR at 88 DPI. A combination of conventional microscopic examination and PCR offers a good prediction of cure following treatment of trypanosomosis.

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Clinical Infectious Diseases.2008; 47(1): 15. CrossRef