Parasites, Hosts and Diseases

"spleen"

Case Reports

Subcapsular Splenic Hemorrhage in Vivax Malaria: Jae Hyoung Im, Moon-Hyun Chung, Areum Durey, Jin-Soo Lee, Tong-Soo Kim, Hea Yoon Kwon, Ji Hyeon Baek; Korean J Parasitol 2019;57(4):405-409.
Published online August 31, 2019; DOI: https://doi.org/10.3347/kjp.2019.57.4.405

Abstract
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In malaria, splenic rupture is a serious complication potentially leading to death. Subcapsular hemorrhage of spleen is thought to be an impending sign of splenic rupture; however, the characteristics of subcapsular hemorrhage are not well known. We report 3 cases of subcapsular hemorrhage of the spleen in vivax malaria, with varying degrees of severity. Case 1 showed subcapsular hemorrhage without splenic rupture, was treated by antimalarial drug without any procedure. The healing process of the patient's spleen was monitored through 6 computed tomography follow-up examinations, over 118 days. Case 2 presented subcapsular hemorrhage with splenic rupture, treated only with an antimalarial drug. Case 3 showed subcapsular hemorrhage with splenic rupture and hypotension, treated using splenic artery embolization. They all recovered from subcapsular hemorrhage without any other complications. These 3 cases reveal the process of subcapsular hemorrhage leading to rupture and a potentially fatal outcome. The treatment plan of subcapsular hemorrhage should be determined carefully considering the vital signs, changes in hemoglobin, and bleeding tendency.

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Spontaneous Splenic Rupture in a Vivax Malaria Case Treated with Transcatheter Coil Embolization of the Splenic Artery: Na Hee Kim, Kyung Hee Lee, Yong Sun Jeon, Soon Gu Cho, Jun Ho Kim; Korean J Parasitol 2015;53(2):215-218.
Published online April 22, 2015; DOI: https://doi.org/10.3347/kjp.2015.53.2.215

Abstract
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An enlarged spleen is considered one of the most common signs of malaria, and splenic rupture rarely occurs as an important life-threatening complication. Splenectomy has been recommended as the treatment of choice for hemodynamically unstable patients. However, a very limited number of splenic rupture patients have been treated with transcatheter coil embolization. Here we report a 38-year-old Korean vivax malaria patient with ruptured spleen who was treated successfully by embolization of the splenic artery. The present study showed that angiographic embolization of the splenic artery may be an appropriate option to avoid perioperative harmful effects of splenectomy in malaria patients.

Citations

Citations to this article as recorded by

Malaria-Associated Spontaneous Splenic Rupture With Coagulopathy and Hemodynamic Compromise: A Case Report
Sarah M Mohammad, Esraa O Alsayed, Amal N Alharbi
Cureus.2025;[Epub] CrossRef
Spontaneous splenic rupture as a rare complication of malaria: a case report
Movinraaj Yeoh, Yurkdes A. Sittampalan, Hanif Hussein
MGM Journal of Medical Sciences.2025; 12(3): 622. CrossRef
Atraumatic splenic rupture – unexpected consequences of a world trip
Jule K. Adams, Maike R. Pollmanns, Miriam Haverkamp, Philipp Hohlstein, Jan Clusmann, Christian Trautwein, Samira Abu Jhaisha, Alexander Koch
Zeitschrift für Gastroenterologie.2024; 62(08): 1216. CrossRef
Spontaneous splenic rupture due to falciparum malaria successfully treated with a conservative approach
Lúcia Ribeiro Dias, João Paulo Caldas, João Pedro Araújo Teixeira, Virgília Gomes, Alexandra Babo, Ana Sofia Faustino, Ricardo Baptista, Sofia R. Valdoleiros, Lurdes Santos
Parasitology International.2023; 94: 102736. CrossRef
The effect of secondary passages on cavitation and radial forces in a liquid propellant turbopump
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Proceedings of the Institution of Mechanical Engineers, Part A: Journal of Power and Energy.2023; 237(7): 1423. CrossRef
Antimalarial Activity of Nano Phytomedicine Fraction of Syzygium cumini Fruit in Rodent Malaria
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Research Journal of Pharmacy and Technology.2023; : 4288. CrossRef
Splenic Artery Embolization and Splenectomy for Spontaneous Rupture of Splenic Hemangioma and Its Imaging Features
Jia-Li Lin, Can Lin, Han-Lu Wang, Shao-Jie Wu, Yi Tang, Chang Shun Yang, Jie-Wei Luo, Wu Chi, Zhu-Ting Fang
Frontiers in Cardiovascular Medicine.2022;[Epub] CrossRef
Case report of a spontaneous splenic rupture in a patient with chronic lymphocytic leukaemia treated by arterial splenic embolization
Héloïse Tessely, Stéphane Journe, Raphaël Katz, Jean Lemaitre
International Journal of Surgery Case Reports.2021; 80: 105607. CrossRef
Spontaneous Splenic Rupture as a Complication of Malaria and Incidental Acute Appendicitis: A Case Report
Ahmad Odeh, Abdulmohsen Alsuwaigh, Abdulqader M Albeladi, Zaki Busbaih, Abdullah M Alkhars, Mohammed O Khalid, Aminah H AlAli, Mohmmed T AlAbbad, Kawthar A Boumarah, Hussain M Alkhars, Zainab A Alammar, Ahmed H Almohammedsaleh
Cureus.2021;[Epub] CrossRef
Case Report: Sudden Splenic Rupture in a Plasmodium falciparum-Infected Patient

Nadeem Kassam, Steven Michael, Kamran Hameed, Athar Ali, Salim Surani
International Journal of General Medicine.2020; Volume 13: 595. CrossRef
Atraumatic splenic rupture in chronic pancreatitis with successful embolization
Anooja Abdul Salam, Ben Pearch, Lisa Sorger
The ASEAN Journal of Radiology.2020; : 58. CrossRef
Splenic artery embolization for atraumatic splenic rupture
Zoe A. Miller
Journal of Cardiac Surgery.2020; 35(12): 3642. CrossRef
A Rare Cause of Acute Abdomen; Rupture of Spleen Due to Malarial Infection
Ömer SALT, Eren DUYAR, Mustafa Burak SAYHAN, Selim TETİK
Harran Üniversitesi Tıp Fakültesi Dergisi.2019; 16(2): 410. CrossRef
Status of common parasitic diseases in Korea in 2019
Sun Huh
Journal of the Korean Medical Association.2019; 62(8): 437. CrossRef
Subcapsular Splenic Hemorrhage in Vivax Malaria
Jae Hyoung Im, Moon-Hyun Chung, Areum Durey, Jin-Soo Lee, Tong-Soo Kim, Hea Yoon Kwon, Ji Hyeon Baek
The Korean Journal of Parasitology.2019; 57(4): 405. CrossRef
Spontaneous Splenic Rupture Complicating Severe P. falciparum Infection: A Case Report and Literature Review
Eltaib Saad, Elamin Elsamani, Walid Abdelrahman
Case Reports in Infectious Diseases.2019; 2019: 1. CrossRef
Sudden spleen rupture in a Plasmodium vivax-infected patient undergoing malaria treatment
Aleix Elizalde-Torrent, Fernando Val, Ingrid Cardoso C. Azevedo, Wuelton M. Monteiro, Luiz C. L. Ferreira, Carmen Fernández-Becerra, Hernando A. del Portillo, Marcus V. G. Lacerda
Malaria Journal.2018;[Epub] CrossRef
Blunt abdominal trauma. Spleen injuries. Part 2
A. N. Smoliar
Khirurgiya. Zhurnal im. N.I. Pirogova.2016; (2): 4. CrossRef

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Original Article

Pro-inflammatory Cytokine Expression of Spleen Dendritic Cells in Mouse Toxoplasmosis: Ho-Woo Nam, Hye-Jin Ahn, Hyun-Jong Yang; Korean J Parasitol 2011;49(2):109-114.
Published online June 14, 2011; DOI: https://doi.org/10.3347/kjp.2011.49.2.109

Abstract
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Dendritic cells have been known as a member of strong innate immune cells against infectious organelles. In this study, we evaluated the cytokine expression of splenic dendritic cells in chronic mouse toxoplasmosis by tissue cyst-forming Me49 strain and demonstrated the distribution of lymphoid dendritic cells by fluorescence-activated cell sorter (FACS). Pro-inflammatory cytokines, such as IL-1α, IL-1β, IL-6, and IL-10 increased rapidly at week 1 post-infection (PI) and peaked at week 3 PI. Serum IL-10 level followed the similar patterns. FACS analysis showed that the number of CD8α⁺/CD11c⁺ splenic dendritic cells increased at week 1 and peaked at week 3 PI. In conclusion, mouse splenic dendritic cells showed early and rapid cytokine changes and may have important protective roles in early phases of murine toxoplasmosis.

Citations

Citations to this article as recorded by

Expression of cytokines and co-stimulatory molecules in the Toxoplasma gondii-infected dendritic cells of C57BL/6 and BALB/c mice
Jae-Hyung Lee, Jae-Min Yuk, Guang-Ho Cha, Young-Ha Lee
Parasites, Hosts and Diseases.2023; 61(2): 138. CrossRef
Impact of intrarectal chromofungin treatment on dendritic cells-related markers in different immune compartments in colonic inflammatory conditions
Kunal Kapoor, Nour Eissa, Diane Tshikudi, Charles N Bernstein, Jean-Eric Ghia
World Journal of Gastroenterology.2021; 27(47): 8138. CrossRef
Multi-Omics Studies Demonstrate Toxoplasma gondii-Induced Metabolic Reprogramming of Murine Dendritic Cells
Kerrie E. Hargrave, Stuart Woods, Owain Millington, Susan Chalmers, Gareth D. Westrop, Craig W. Roberts
Frontiers in Cellular and Infection Microbiology.2019;[Epub] CrossRef
Tissue Fluid Enzyme-Linked Immunosorbant Assay for Piglets Experimentally Infected with Toxoplasma gondii and Survey on Local and Imported Pork in Korean Retail Meat Markets
Won Gi Yoo, Sun-Min Kim, Eun Jeong Won, Ji-Yun Lee, Fuhong Dai, Ho Choon Woo, Ho-Woo Nam, Tae Im Kim, Jeong-Hee Han, Dongmi Kwak, Yun Sang Cho, Seung-Won Kang, Tong-Soo Kim, Xing-Quan Zhu, Chunren Wang, Heejeong Youn, Sung-Jong Hong
The Korean Journal of Parasitology.2018; 56(5): 437. CrossRef
Transcriptional Responses in the Murine Spleen after Toxoplasma gondii Infection: Inflammasome and Mucus-Associated Genes
Eva Znalesniak, Ting Fu, Franz Salm, Ulrike Händel, Werner Hoffmann
International Journal of Molecular Sciences.2017; 18(6): 1245. CrossRef
Toxoplasmosis treatment with diphenyl diselenide in infected mice modulates the activity of purinergic enzymes and reduces inflammation in spleen
Pedro H. Doleski, Maura V. Ten Caten, Daniela F. Passos, Lívia G. Castilhos, Daniela B.R. Leal, Vanessa S. Machado, Nathieli B. Bottari, Fernanda F. Vogel, Ricardo E. Mendes, Aleksandro Schafer da Silva
Experimental Parasitology.2017; 181: 7. CrossRef
Dectin-1-CD37 association regulates IL-6 expression during Toxoplasma gondii infection
Junping Yan, Bin Wu, Bo Huang, Shiguang Huang, Suhua Jiang, Fangli Lu
Parasitology Research.2014; 113(8): 2851. CrossRef