Chemotherapeutic control of <i>Enterobius vermicularis</i> infection in orphanages

, Hong, Sung Tae; , Cho, Seung Yull; , Seo, Byong Seol; , Yun, Chong Ku

doi:1980.18.1.37

Korean J Parasito > Volume 18(1):1980 > Article

Original Article


Korean J Parasitol. 1980 Jun;18(1):37-44. English. Published online Mar 20, 1994. http://dx.doi.org/10.3347/kjp.1980.18.1.37
Copyright © 1980 by The Korean Society for Parasitology


Chemotherapeutic control of Enterobius vermicularis infection in orphanages
Sung Tae Hong,Seung Yull Cho,Byong Seol Seo and Chong Ku Yun
Department of Parasitology, Institute of Endemic Diseases, College of Medicine, Seoul National University, Korea.
Department of Paediatrics, Institute of Endemic Diseases, College of Medicine, Seoul National University, Korea.


Abstract
To observe the effect of egg-free state in an institute on the endemicity of Enterobius vermicularis, the theoretical condition was made by repeated chemotherapy. Mebendazole or pyrantel pamoate were administered to all orphans and their staffs concomitantly for four times, each 20-day interval. In two low endemic orphanages, in which mean egg positive rates were 18 % and 39 % respectively, the pinworm infection was controlled up to 6-7 months period. And other two highly endemic orphanages, with 70% and 55% of egg positive rates, were controlled up to 90th day after the first treatment. After then up to 7 months, the reinfection occurred, but the endemicity was brought down to about 20 % of egg positivity.

Figures

Fig. 1
Basic scheme of this trial. Arrays of transverse arrow mean the growth of female E. vermicularis in intestine. The arrowhead means perianal migration. By the successive treatment (vertical arrows on the top of figure), the grown females older than 25 days became susceptible to anthelmintics and removed (interrupted transverse arrows).

By this scheme of treatment, the viable eggs can survive up to 35 days after the first treatment (interrupted vertical line). The reinfection cycle within the orphanage is thus broken.


	Fig. 2 Egg positive rates before, during and after the treatment. The vertical arrows indicate the day of treatment.

Tables


	Table 1 Treatment scheme for chemotherapeutic control of pinworm infection


	Table 2 Results of preliminary anal swab examination

References


1.	Akagi K. Progress of Medical Parasitology in Japan 1973;4:229–279.

2.	Cho SY, Ahn YR, Ryang YS, Seo BS. Evaluation of anthelmintic treatment of Enterobius vermicularis infection in highly endemic population by prolonged observation. Korean J Parasitol 1977;15(2):100–108.

3.	Cho SY, Kang SY. Significance Of Scotch-tape Anal Swab Technique In Diagnosis Of Enterobius Vermicularis Infection. Korean J Parasitol 1975;13(2):102–114.

4.	Cram EB. Am J Dis Child 1943;65:46–59.

5.	Fan PC, et al. Yonsei Rep Ttrop Med 1978;9:110.

6.	Hong SH, et al. Seoul J Med 1979;20:163–168.

7.	Jones MF, et al. Am J Hyg 1947;33:88–102.

8.	Lormans JA, Wesel AJ, Vanparus OF. Mebendazole (R 17635) in enterobiasis. A clinical trial in mental retardates. Chemotherapy 1975;21(3-4):255–260.

9.	Matsen JM, Turner JA. Reinfection in enterobiasis (pinworm infection). Simultaneous treatment of family members. Am J Dis Child 1969;118(4):576–581.

*10.*	Oelkers HA. [Studies of oxyurid ova.]. Z Parasitenkd 1950;14(6):574–581.

*11.*	Schueffner W. Muenchen Mediz Wschr 1944;81:411–414.

*12.*	Schueffner W. Zb Bakteriol 1947;152:67–73.