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Effectiveness of anthelmintic drugs against Clonorchis sinensis infection of rabbits
Han-Jong Rim,Dong Shik Chang,Il Hyun and Sun-Dae Song
Department of Parasitology and Institute for Tropical Endemic Diseases, College of Medicine, Korea University, Seoul, Korea.
Abstract
In order to find a highly efficient compound against Clonorchis infection, the anthelmintic activity of disophenol, Tremerad (SYD-230), dithiazanine iodide, dehydroemetine-late-release tablets(RO 1-9334/20), niridazole (Ambilhar), hexachlorophene (G-11), Hetol(1, 4-bis-trichloromethylbenzol) and Bilevon (niclofolan) was tested against Clonorchis sinensis experimentally infected rabbits. All drugs showed a progressive increase in efficacy as the dose rate. They were highly efficient against Clonorchis infection if sufficiently high, potentially toxic doses were given.
The efficacy was evaluated by the number of detected worms with vital condition at autopsy after the treatment with above drugs. The high efficacy was observed at the following dose rates of each drugs, i.e. disophenol at a single dose of 30 mg/kg, Tremerad at the daily dose of 200 mg/kg for 10 consecutive days, dithiazanine iodide at the daily dose of 50 mg/kg for 6 consecutive days, dehydroemetine at the daily dose of 10 mg/kg for 10 consecutive days, hexachlorophene at the daily dose of 20 mg/kg for 10 to 15 consecutive days, Hetol at the daily doses from 50 to 100 mg/kg for 5 to 10 consecutive days, and Bilevon at a single dose of 8 mg/kg. Moderate effectiveness was shown in niridazole at the dose of 25 mg/kg for 10 days medication.
The use of these anthelmintics for the clinical treatment of Clonorchis sinensis infection is discussed.
Tables
Table 1 Effects of various drugs on C. sinensis in experimentally infected rabbits with 500 metacercariae
Table 2 Effects of hexachlorophene on C. sinensis in experimentally infected rabbits with 500 metacercariae
Table 3 Effects of Hetol on C. sinensis in experimentally infected rabbit with 500 metacercariae
Table 4 Effects of Bilevon on C. sinensis in experimentally infected rabbit with 500 metacercariae
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