Studies on efficacy and dosage for schoolchildren of some anthelminthic drugs

Original Article


Korean J Parasitol. 1974 Dec;12(2):147-156. English. Published online Mar 20, 1994. http://dx.doi.org/10.3347/kjp.1974.12.2.147
Copyright © 1974 by The Korean Society for Parasitology


Studies on efficacy and dosage for schoolchildren of some anthelminthic drugs
Jung Kyun Chu and You Jung Cho
Department of Parasitology, School of Medicine, Kyung Hee University, Korea.



Abstract
1. The evaluation of the effects of anthelmintic drug dose was done by the eggs reduction and the eggs negative conversion rate. 2. The drug dose according to the age of the patient was estimated by the formula of Augsberger, the dose according to the body weight of patient was estimated by the Rule of Six, and the dose to the body surface of the patient was estimated by the formula of Costeff. 3. It is considered that the application of the drug dose according to the age of the patient resulted in reduction of dose in the younger patient, and resulted in the excess dose in older patient. The application of the drug dose according to the body weight also resulted in the reduction of dose in the lighter patient and the excess dose in the heavier patient. 4. It is suggested that the application of drug dose according to the body surface is more reasonable than those by the age and the body weight. The value of this application was also proved to be medium value between those of age method and body weight method.

Figures


	Fig. 1 Mean values of serum protein fractions in clonorchiasis and other helminths infection on paper electrophoresis in the Kim-hae area.

Tables


	Table 1 Overall anthelmintic effects of drugs against Ascaris lumbricoides infections.


	Table 2 Negative conversion rate, on egg counting technique four weeks after treatment by various anthelmintic drugs.


	Table 3 Egg reduction rates on egg counting technique four weeks after treatment by various anthelmintic drugs.


	Table 4 Efficacy evaluation of pyrantel pamoate on the rate of egg reduction.


	Table 5 Efficacy evaluation of Koizumin on the rate of egg reduction.


	Table 6 Efficacy evaluation of piperazine adipate (double) on the rate of egg reduction.


	Table 7 Efficacy evaluation of piperazine adipate (triple) on the rate of egg reduction.


	Table 8 Efficacy evaluation of piperazine adipate (control) on the rate of egg reduction.


	Table 9 Comparison of dosage by makers and calculated dose by age.


	Table 10 Comparison of average body weight of urban and rural schoolchildren.


	Table 11 Comparison of dosage by makers and calculated dose by body weight.


	Table 12 Comparison of calculated doses by body weight and surface area.