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House Dust Mite Allergens in Domestic Homes in Cheonan, Korea

Hae-Seon Nam1, Robert Siebers2, Sun-Hwa Lee1, Joon-Soo Park3, Yong-Bae Kim4, Young-Jin Choi5, Sang-Han Lee6, Julian Crane2
The Korean Journal of Parasitology 2008;46(3):187-189.
Published online: September 20, 2008

1Department of Clinical Parasitology, School of Medicine, Soonchunhyang University, Cheonan 330-090, Korea.

2Wellington Asthma Research Group, School of Medicine and Health Sciences, University of Otago, Wellington 6242, New Zealand.

3Department of Pediatrics, School of Medicine, Soonchunhyang University, Cheonan 330-090, Korea.

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Corresponding author (rob.siebers@otago.ac.nz)
• Received: June 18, 2008   • Accepted: July 28, 2008

Copyright © 2008 by The Korean Society for Parasitology

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  • House dust mites produce inhalant allergens of importance to allergic patients. We measured the major group 1 allergens, Der p 1 and Der f 1, from the house dust mites Dermatophagoides pteronyssinus and Dermatophagoides farina, respectively in 100 randomly selected domestic homes from Cheonan, Korea. Dust samples were collected by vacuuming from the living room floor and 1 mattress in each home. Der p 1 and Der f 1 were measured by double monoclonal ELISA. Der p 1 levels were very low, with geometric mean levels for floors and mattresses being 0.11 µg/g (range: 0.01-4.05) and 0.14 µg/g (range: 0.01-30.0), respectively. Corresponding levels of Der f 1 were higher, 7.46 µg/g (range: 0.01-262.9) and 10.2 µg/g (range: 0.01-230.9) for floors and mattresses, respectively. D. farinae appears to be the dominant house dust mite in Cheonan.
  • Key words: Dermatophagoides pteronyssinus, Dermatophagoides farina, house dust mite, allergen, asthma, Korea
Allergens from house dust mites (HDM) induce IgE mediated sensitization in susceptible individuals and cause asthma symptoms in those sensitized 1-3. However, recent studies have suggested non-linear relationships between allergen exposure and sensitization 4,5. Avoidance to HDM allergens appears to be beneficial 6,7, although some disagree 8. At least 50 species of HDM that have been found in domestic house dust, and the 2 mites of the family Pyroglyphidae, namely Dermatophagoides pteronyssinus and Dermatophagoides farinae, are the most important in temperate climates, both in terms of numbers and of clinical relevance. In Korea both species are present, although geographical variations have been shown 9. In a previous study we measured HDM allergen from pillows and mattresses in 13 Korean households and found only the major group HDM allergen Der f 1, but not Der p 1, suggesting that the HDM, D. farinae, is dominant in Cheonan 10. In the present study, we report on HDM allergen levels from living room floors and mattresses in 100 homes in Cheonan, a city surrounded by small mountains northeast of South Chungcheong province with a population of around 510,000 as of 2004. The average temperature in Cheonan in January is -3℃ rising to an average of 25℃ in August with a yearly average of 11.8℃. Average yearly rainfall is 1,313 mm.
The study was performed between March and December, 2006. Dust samples were collected from living room floors and mattresses from 100 apartments that had mattresses on bedsteads by vacuuming a 1 m2 area for 1 min with a 540 W vacuum cleaner fitted with a 25 µm pore size nylon mesh bag, as previously described 11. The dust samples were weighed and stored at -20℃ before extraction and analysis.
Dust samples were extracted as previously described 12 with phosphate-buffered saline containing 0.05% Tween-20, pH 7.4, shaken for 30 min at room temperature and then centrifuged for 10 min at 3,000 g. A portion of the supernatant was removed and stored at -20℃ for HDM allergens analysis.
The HDM allergens, Der f 1 and Der p 1, were determined by double monoclonal antibody ELISA methodology with commercial kits (Indoor Biotechnologies, Charlottesville, Virginia, USA) as previously described 11. Due to log-normal distribution, HDM allergen levels, expressed as micrograms per gram of dust (µg/g) and per unit area (µg/m2), are reported as geometric means with range of values. Undetectable levels were assigned the detection limit of 0.01 µg/g or µg/m2.
The mean dust weight collected from mattresses was 0.542 g, range: 0.003-3.199, while the mean dust weight collected from living room floors was 0.225 g, range: 0.0008-3.180. However, the amount of dust from carpeted floors (mean: 0.518 g; range: 0.0081-3.180; n = 42) was about 40-fold higher than from uncarpeted floors (mean: 0.013 g; range: 0.0008-0.063; n = 58).
Der f 1 was detected in 100% of mattresses and 93% of living room floors while Der p 1 was detected only in 12% of mattresses and in 7% of living room floors. Table 1 shows the geometric mean levels with range of values of Der p 1 and Der f 1 from mattresses and living room floors.
Der f 1 levels from carpeted living room floors (n = 42) were 15-fold higher than from uncarpeted living room floors (n = 58) when expressed per unit area (µg/m2). Geometric mean Der f 1 levels (with range of values) were 1.67 µg/m2 (0.1-295.4) and 0.11 µg/m2 (0.1-0.65), respectively for carpeted and uncarpeted living room floors. Expressed as concentrations (µg/g), there were no significant differences in these levels (data not shown).
Our study showed that the major group allergen Der f 1 from the HDM D. farinae is the dominant allergen in the home environment in Cheonan. Although the geometric mean levels of HDM allergens in Cheonan were low compared to other countries, there were a significant number of individual high levels. Exacerbation of asthma symptoms in those sensitized to HDM can occur at levels of above 10 µg/g 13. In our study, 58% of mattresses and 50% of living room floors had Der f 1 levels above this level. Furthermore, Der f 1 levels from carpeted floors were much higher than those from uncarpeted floors. This has also been demonstrated in New Zealand 11. Almost every Korean home has a hot water floor heating system and therefore does not require carpeting for warmth. However, with an increased westernized life style, more Korean homes have carpets, as evidenced in our study where 42% of homes had carpets in the living room.
Der p 1 levels in homes from Cheonan were much lower than those of Der f 1 levels. Only 2 mattresses had Der p 1 levels above 10 µg/g but no floor samples were above that level. Also, Der p 1 was undetectable in the majority of samples. However, as there were some individuals with very high levels, it would be prudent to analyse allergens from both house dust mite species when assessing allergen exposure.
The geometric mean of Der f 1 from mattresses in the present study was 10.2 µg/g. This is significantly higher than the geometric mean of Der f 1 (1.18 µg/g) from a previous study in the same location 10. However, in that study we had only sampled 13 mattresses, compared to 100 mattresses in the present study which more likely represents a truer level in Cheonan.
The prevalence of doctor-diagnosed asthma in Korean adolescents aged 12 to 15 yr in 2000 was 5.3%, a significant increase from 2.7% in 1995 14. In addition, 74% of Korean asthmatic children are sensitized to HDM 15. As studies have shown that sensitization to HDM is associated with development of asthma in children 1, HDM exposure and the severity of asthma shows a dose response relation 3, and that HDM allergen avoidance can reverse asthma symptoms 6,7, the levels of HDM allergens in Cheonan could be of importance.
In conclusion, the major group 1 allergen from D. farinae is the dominant HDM allergen in Cheonan. Although relatively low in comparison to other countries, such as New Zealand, there were a significant number of homes with high levels that may be of importance to house dust mite sensitized patients.
This study was supported by the Academic Research Service Program of the Korean National Institute of Health, 2006.
    Table 1.
    House dust mite allergen in 100 homes as represented by geometric mean levels with range of values
    Table 1.
    Allergen Mattresses (μg/g) Living room floors (μg/g) Mattresses (μg/m2) Living room floors (μg/m2)
    Der f 1 10.2 (0.01-230.9) 7.5 (0.01-262.9) 4.0 (0.01-112.1) 0.34 (0.01-295.4)
    Der p 1 0.14 (0.01-30.0) 0.11 (0.01-4.1) 0.02 (0.01-8.8) 0.01 (0.01-0.35)

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    House Dust Mite Allergens in Domestic Homes in Cheonan, Korea
    Korean J Parasitol. 2008;46(3):187-189.   Published online September 20, 2008
    DOI: https://doi.org/10.3347/kjp.2008.46.3.187
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    House Dust Mite Allergens in Domestic Homes in Cheonan, Korea
    Korean J Parasitol. 2008;46(3):187-189.   Published online September 20, 2008
    DOI: https://doi.org/10.3347/kjp.2008.46.3.187
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    House Dust Mite Allergens in Domestic Homes in Cheonan, Korea
    House Dust Mite Allergens in Domestic Homes in Cheonan, Korea
    Allergen Mattresses (μg/g) Living room floors (μg/g) Mattresses (μg/m2) Living room floors (μg/m2) Der f 1 10.2 (0.01-230.9) 7.5 (0.01-262.9) 4.0 (0.01-112.1) 0.34 (0.01-295.4) Der p 1 0.14 (0.01-30.0) 0.11 (0.01-4.1) 0.02 (0.01-8.8) 0.01 (0.01-0.35)
    Table 1. House dust mite allergen in 100 homes as represented by geometric mean levels with range of values

    Table 1.

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