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Anisakiasis: Report of 15 Gastric Cases Caused by Anisakis Type I Larvae and a Brief Review of Korean Anisakiasis Cases
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Case Report

Anisakiasis: Report of 15 Gastric Cases Caused by Anisakis Type I Larvae and a Brief Review of Korean Anisakiasis Cases

Woon-Mok Sohn1,*, Byoung-Kuk Na1, Tae Hyo Kim2, Tae-Joon Park3
The Korean Journal of Parasitology 2015;53(4):465-470.
Published online: August 25, 2015

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* Corresponding author (wmsohn@gnu.ac.kr)
• Received: April 29, 2015   • Revised: May 21, 2015   • Accepted: June 16, 2015

© 2015, Korean Society for Parasitology and Tropical Medicine

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  • The present study was performed to report 15 anisakiasis cases in Korea and to review the Korean cases reported in the literature. Total 32 Anisakis type I larvae were detected in the stomach of 15 patients by the endoscopy. Single worm was detected from 12 cases, and even 9 larvae were found from 2 cases. Epigastric pain was most commonly manifested in almost all cases, and hemoptysis and hematemesis were seen in 1 case each. Symptom manifestations began at 10-12 hr after eating fish in 73.3% cases. Endoscopy was performed 1-2 days after the symptom onset in most cases. The common conger, Conger myriaster, was the probable infection source in 7 cases. In the review of Korean anisakiasis cases, thus far, total 645 cases have been reported in 64 articles. Anisakis type I larva was the most frequently detected (81.3%). The favorable infection site of larvae was the stomach (82.4%). The common conger was the most probable source of human infections (38.6%). Among the total 404 cases which revealed the age and sex of patients, 185 (45.8%) were males, and the remaining 219 (54.2%) were female patients. The age prevalence was the highest in forties (34.7%). The seasonal prevalence was highest in winter (38.8%). By the present study, 15 cases of gastric anisakiasis are added as Korean cases, and some epidemiological characteristics of Korean anisakiasis were clarified.
  • Key words: Anisakiasis, Anisakis type I larva, review, Korean anisakiasis
Anisakiasis is one of the fishborne zoonotic diseases, especially in localities, where people have a custom of eating raw marine fish and squids like in Japan and Korea [1,2]. The concept of this disease was first raised by van Thiel et al. [3] in the Netherlands. After then, human infection cases were consequently reported in England, Japan, and the Republic of Korea (Korea) [4-7]. Nowadays, this zoonotic nematode disease is a clinical concern worldwide, including Japan, Korea, the Netherlands, Spain, France, Italy, Germany, and the United States. Especially in Japan, it has been known that more than 2,000 cases occurred annually [1,2].
Since the first human case was reported by Kim et al. [7] in 1971, until now numerous patients have increasingly occurred in Korea. Especially the increasing tendency of cases was accelerated by the common use of endoscopy in the diagnosis and treatment of gastric anisakiasis [8]. Chung et al. [9] and Seol et al. [10] reported 27 and 20 cases that occurred in Busan Metropolitan City. Im et al. [11,12] analyzed 39 and 107 cases of gastric anisakiasis occurred in Jeju-do. Song et al. [13] reported total 39 cases residing in Incheon Metropolitan City. Recently, Lee et al. [14] analyzed total 141 cases diagnosed by the endoscopy in a local clinic in Jinju-si, Gyeongsangnam-do. Most recently, Lim et al. [15] clarified the etiologic agents of 16 human anisakiasis in Korea, 15 of which were confirmed as Anisakis pegreffii larvae and only 1 was Anisakis simplex larva using a molecular analysis. In this study, we report an additional 15 gastric anisakiasis cases that occurred in Gyeongsangnam-do, and then analyzed the epidemiologic and clinical characteristics of Korean anisakiasis cases through a literature review.
Total 15 anisakiasis cases were diagnosed with the gastric endoscopy in the Gyeongsang National University Hospital and a local clinic located in Jinhae-gu, Changwon-si, Gyeongsangnam-do from October 1999 to January 2010. Most of the cases (80%) were men, and only 3 were women. Total 32 Anisakis type I larvae were detected in the stomach of 15 patients. A single worm was detected from 12 cases, 2 worms from 1 case, and even 9 larvae were found from 2 cases. Epigastric pain was the most common symptom in almost all cases, and nausea and vomiting were accompanied in some cases. Hemoptysis and hematemesis occurred in 1 case each. Symptom manifestations began at 10-12 hr after eating fish in most cases (73.3%). Endoscopy was performed in 1-2 days after symptom onset in most cases (66.7%). As the probable source of infection, 7 (46.7%) and 2 (13.3%) cases recalled that they had eaten raw common conger, Conger myriaster, and anchovy, respectively. However, 6 cases could not remember the exact species of fish; several kinds of fish mixed or uncertain. The case information is summarized in Table 1. Among the total 32 Anisakis type I larvae (either the 3rd or 4th-stage), 7 were morphologically observed and measured with a micrometer (Table 2).
Review of Korean anisakiasis cases
The articles of Korean anisakiasis cases were basically searched through PubMed site using the internet. The references in all articles were strictly seen to prevent missing cases. Until now, a total of 645 cases have been reported in 64 articles since the first case recorded by Kim et al. [8] in 1971. During 1990-1999, a total of 249 cases (38.6%) were reported in 25 papers (39.1%). The number of anisakiasis cases reported in the Korean literature is shown in Table 3. The incidence rate was the highest in Jeju-do (34.4%), followed by in Gyeongsangnam-do (22.8%), Seoul (20.0%), Busan (10.1%), Incheon (6.5%), Gyeongsangbuk-do (3.2%), and other 9 administrative regions (0.16-0.79%) (Table 4). Among a total of 404 cases which revealed the age and sex of patients, 185 (45.8%) were men and the remaining 219 (54.2%) were women. The age prevalence was the highest in forties (34.7%), followed by thirties (32.9%), fifties (14.9%), twenties (9.7%), over sixty (6.2%), and teens (1.7%) (Table 5). As the probable source of human infections, the common conger was most frequently mentioned by patients (38.6%), followed by croaker (11.6%), squid (10.3%), yellowtail (9.7%), flatfish (flounder: 5.5%), and the other 12 species of marine fish (Table 6). The etiologic larval type was designated in 203 cases in the literatures. Among them, 165 cases (81.3%) were due to Anisakis type I larvae, 24 (11.8%) were by Terranova type A, and 8 cases (3.9%) were by Anisakis type II. Each of the 3 cases were due to Contracaecum sp. and Anisakis sp. larvae (Table 7). The predilection site was the stomach (82.4%), followed by small intestines (11.4%), gastro-esophageal junction (3.5%), large intestines (1.5%), esophagus (0.5%), and others including the palatine tonsil, ileo-cecal region, and mesocolic lymph node (Table 8). In most cases (65.7%), symptoms were manifested before 12 hr from eating raw flesh of fish (Table 9). The seasonal prevalence was the highest in winter (38.8%), followed by spring (23.1%), autumn (19.9%), and summer (18.2%) (Table 10).
By the present study, 15 cases of gastric anisakiasis have been added among the Korean anisakiasis cases. Only 1 anisakid larva was detected in most of the cases. However, interestingly, even 9 worms were recovered from each of 2 cases. Like in the previous studies, epigastric pain was the chief complain and most commonly manifested in almost all cases. However, hemoptysis and hematemesis were revealed in 1 case each. It has been known that severe bleeding can occur due to anisakid larva infection in patients with gastric ulcer [15,17-19]. Therefore, these 2 cases may have had some ulcer lesions in their stomach. Time intervals from fish eating to symptom onset and from symptom onset to endoscopy were 10-12 hr and 1-2 days in most cases. These findings were in accordance with previous studies [11,15]. The common conger, C. myriaster, is suspected as the most probable source of infection in 7 patients (46.7%). Until now, in Korea, a total of 645 cases have been reported in 64 papers since the first case reported by Kim et al. [8]. Accordingly, as 15 cases have been added by this study, the total number of anisakiasis cases in Korea became 660 cases in the Korean literature.
Among 32 Anisakis type I larvae detected, 7 were in the fourth-stage (L4), which had molted in the stomach of the patients. They were similar in size with the third stage larvae (L3), but they can be morphologically differentiated from L3 by the following characteristic features: (1) absence of the boring tooth at the anterior end and the mucron at the posterior end; (2) the presence of the 3 well-defined lips; (3) the appearance of transverse striations on the cuticular body surface; (4) the appearance of altered ventriculus and intestine (Table 2) [20,21].
The number of human anisakiasis cases (38.6%) and papers (39.1%) published in Korea were the highest during 1990-1999, while 163 cases (25.3%) were reported in 10 articles (15.6%) during 2000-2009, and only 77 (11.9%) were recorded in 18 papers (28.1%) during 1980-1989. During 1980-1989, each anisakiasis case was meaningful and could be easily published in journals. However, recently, anisakiasis case reports were done after gathering large numbers of cases to demonstrate something different and unique findings [15,22-24]. So, the number of articles published was not so many during the recent years.
The higher incidence rate was found in coastal areas, such as Jeju-do, Jinju, (Gyeongsangnam-do), Busan, Incheon, and Pohang (Gyeongsangbuk-do), where people favorably consume raw flesh of marine fish. Moreover, the presence of medical authorities, who are able to produce manuscripts describing case reports, is also an important factor [10-15,25,26].
Among total 404 cases that revealed the age and sex of patients, the number of women was slightly more than that of men, with the ratio of women to men of 1.18:1. This finding was largely influenced by the report of Lee et al. [15], who analyzed 141 gastrointestinal anisakiasis cases in a local clinic in Jinju-si, Gyeongsangnam-do. In their study, the number of women (91 cases) was much more than that of men (50) [15]. Meanwhile, Im et al. [13] reported total 107 cases in Jeju-do, the number of women (47 cases) was lesser than that of men (60), with the ratio of women to men of 0.78:1 [13]. Regarding the age prevalence, most of the cases (67.6%) were patients in their thirties and forties.
Various species of marine fish and cephalopods have been known as the sources of human infections. In European countries, especially in The Netherlands and Spain, raw or pickled fish, such as herring, hake, anchovy, and cod, are known to be important infection sources [3,27]. In Japan, some species of flounders, Japanese common squid, the Pacific cod, and the bluefin tuna are the main sources in Hokkaido, and the spotted sardine, the chub mackerel, the horse mackerel, the oceanic bonito, and the chum salmon are important infection sources in Kyushu [28,29]. However in Korea, the common conger was the most frequently mentioned by the patients as the probable source of infections, followed by the croaker, squid, yellowtail, flatfish, and the other 12 species of marine fish.
It has been known that the majority of human infections were caused by the larvae of A. simplex (Anisakis type I), and rarely or occasionally by those of Anisakis physeteris (Anisakis type II), and Pseudoterranova decipiens (Terranova type A) [13,14,30-33]. In the present review, 81.3% cases were due to Anisakis type I larvae, and 11.8% and 3.9% were by Terranova type A and Anisakis type II larvae, respectively. Recently, the etiologic agents of human anisakiasis in Korea, which were morphologically Anisakis type I larvae, were molecularly confirmed to be A. pegreffii larvae [16]. Moreover, most of the Anisakis type I larvae detected in 7 fish species from the Yellow Sea and the South Sea in Korea were also identified as A. pegreffii [34]. Although only 15 human cases were enrolled by Lim et al. [16], it seems that most of the Korean ansakiasis cases may be caused by A. pegreffii based on the above 2 molecular studies. Molecular methods should be more frequently adopted to identify the causative agent of human anisakiasis in the future.
The stomach was the main site of infection in most cases (82.4%). However, anisakid larvae were found rarely in other digestive organs, i.e., esophagus, small intestines, large intestines, and mesocolic lymph node. In most cases, symptoms were manifested before 12 hr from eating of the raw fish flesh. The seasonal prevalence was the highest in winter, followed by in spring, autumn, and summer. This seasonality seemed directly related to the frequency of eating raw fish flesh in each season. The consumption of raw fish meat is more popular in winter season rather than in summer season in Korea because of the anxiety for food poisoning.

We have no conflict of interest related to this work.

Table 1.
Summary of the 15 cases of gastric anisakiasis caused by Anisakis type I larvae
Table 1.
Case no. Age Sex Date of occurrence Fish eaten Chief complaints Time from eating fish to symptom onset Time from symptom onset to endoscopy Detection site of worm in stomach
1. 33 M Oct., ’99 Common conger Severe epigastric pain 12 hr 2 days Middle body G.Ca
2. 47 M Feb., ’00 Several kinds of marine fishes Epigastric pain, nausea & vomiting 12 hr 3 days Upper body Anterior wall
3. 37 M Jun., ’00 Common conger Hemoptysis 10 hr 1 day Lower body G.Ca
4. 27 M Jun., ’00 Several kinds of marine fishes Epigastric pain 12 hr 36 hr Upper body G.Ca
5. 41 M Aug., ’00 Several kinds of marine fishes Epigastric pain & nausea 24 hr 3 days Upper body G.Ca
6. 28 M Oct., ’00 Common conger Epigastric pain 6 hr 12 hr Middle body G.Ca
7. 55 M Jun., ’01 Several kinds of marine fishes Severe epigastric pain 12 hr 2 days Lower body G.Ca
8. 59 M Jan., ’02 Common conger Epigastric pain 12 hr 12 hr Middle body G.Ca
9. 45 F Sep., ’02 Common conger & Pacific cutlass fish Epigastric pain & hematemesis 6 hr 3 days Uncertainb
10. 36 F Oct., ’02 Several kinds of marine fishes Severe epigastric pain 12 hr 2 days Lower body G.Ca
11. 42 M Apr., ’03 Anchovy Epigastric pain, nausea & vomiting 10 hr 1 day Upper body Anterior wall
12. 51 M May., ’04 Common conger Severe epigastric pain 12 hr 1 day Uncertainb
13. 61 M Mar., ’09 Anchovy Epigastric pain, nausea & vomiting 10 hr 1 day Upper body lesser curvature
14. 52 M Dec., ’09 Uncertain Epigastric pain & nausea 7 hr 1 day Lower body G.Ca
15. 46 F Jan., ’10 Common conger Severe epigastric pain 12 hr 2 days Uncertain

aGreater curvature.

bNine larvae were detected in each case.

Table 2.
Measurementsa and indices of Anisakis type I larvae from human cases
Table 2.
Items 3rd stage (n = 7) 4th stage (n = 7) Chai et al. (1986) [7]b
Body length 16.55-29.0 (23.98) 17.10-22.75 (20.68) 13.4-25.0 (20.7)
Body width 0.35-0.58 (0.48) 0.45-0.58 (0.50) 0.23-0.54 (0.41)
Esophagus (total) 2.0-3.0 (2.46) 2.35-3.38 (2.88) 1.86-2.70 (2.36)
 Muscular part 1.55-2.08 (1.85) 1.75-2.50 (2.18) 1.27-1.89 (1.65)
 Ventricular part 0.45-0.92 (0.62) 0.55-0.88 (0.71) 0.57-0.83 (0.71)
Tail 0.08-0.12 (0.10) 0.10-0.15 (0.13) 0.07-0.12 (0.10)
Mucron 20-25 (21) μm - -
Indicesc
 α 37.59-58.0 (49.96) 34.20-50.0 (41.36) 43.7-66.3 (50.6)
 β1 7.20-10.04 (9.75) 6.63-8.24 (7.18) 7.02-9.92 (8.73)
 β2 10.08-13.94 (12.96) 8.95-10.56 (9.49) 10.01-14.70 (12.5)
 β3 24.34-40.34 (38.68) 23.58-37.50 (29.13) 25.5-39.4 (29.2)
 γ 157.9-290.0 (239.8) 145.57-186.5 (159.08) 167.6-271.3 (213.4)

aUnit is mm.

bfrom the yellow corvine, Pseudosciaena polyactis.

cLegend: α=Body length/Body width; β1=Body length/Esophagus; β2=Body length/Muscular part of esophagus; β3=Body length/Ventriculus; γ=Body length/Tail.

Table 3.
Number of anisakiasis cases and number of papers reported among the Korean literature
Table 3.
Duration of report No. of cases (%) reported No. of papers (%) published
1971 1 (0.2) 1 (1.6)
1980-1989 77 (11.9) 18 (28.1)
1990-1999 249 (38.6) 25 (39.1)
2000-2009 163 (25.3) 10 (15.6)
2010 and later 155 (24.0) 10 (15.6)
Total 645 (100) 64 (100)
Table 4.
Anisakiasis cases by the occurrence localities
Table 4.
Locality No. of cases (%)
Jeju-do 217 (34.4)
Gyeongsangnam-do (Jinju-si) 144 (22.8)
Seoul 126 (20.0)
Busan 64 (10.1)
Incheon 41 (6.5)
Gyeongsangbuk-do (Pohang-si) 20 (3.2)
Daegu 5 (0.8)
Gwangju 4 (0.6)
Daejeon 2 (0.3)
Jeollabuk-do 2 (0.3)
Gangwon-do 2 (0.3)
Othersa 4 (0.6)
Total 631 (100)

aGyeonggi-do (Uijeongbu-si); Chungcheongbuk-do (Chungju-si), Chungcheongnam-do (Cheonan-si) and Jeollanam-do (Suncheon-si) each 1 case.

Table 5.
Age and sex distribution of patients
Table 5.
Age (years) No. of cases (%)
Male Female Total
Below 19 1 6 7 (1.7)
20-29 19 20 39 (9.7)
30-39 62 71 133 (32.9)
40-49 68 72 140 (34.7)
50-59 22 38 60 (14.9)
Over 60 13 12 25 (6.2)
Total 185 (45.8) 219 (54.2) 404 (100)
Table 6.
Fishes or cephalopods, the probable source of infection, consumed by anisakiasis cases
Table 6.
Fishes (scientific name) No. of cases (%)
Common conger (Conger myriaster) 120 (38.6)
Croaker (Pseudosciaena spp.) 36 (11.6)
Squid 32 (10.3)
Yellowtail (Seriola spp.) 30 (9.7)
Flatfish 17 (5.5)
Pacific cod (Gadus macrocephalus) 6 (1.9)
Anchovy (Engraulis japonica) 4 (1.3)
Rockfish (Sebastes spp.) 4 (1.3)
Sea breams 3 (1.0)
Pacific cutlass fish (Trichiurus lepturus) 3 (1.0)
Gizzard shad (Konosirus punctatus) 2 (0.6)
Skates 2 (0.6)
Othersa 5 (1.6)
Several species of fish mixed 47 (15.1)
Total 311 (100)

aHalichoeres tenuispinis (motleystripe rainbowfish), Miichthys miiuy (brown croaker), mullet, tuna and Octopus vulgaris (common octopus) each 1 case.

Table 7.
Morphologic identification of anisakid larvae among the literature
Table 7.
Type of larvae No. (%) of larvae identified
Anisakis type I 165 (81.3)a
Anisakis type II 8 (3.9)
Terranova type A 24 (11.8)
Anisakis sp. 3 (1.5)
Contracaecum sp. 3 (1.5)
Total 203 (100)

a15 cases of A. pegreffii were included.

Table 8.
Location of worms detected
Table 8.
Location No. (%) of cases
Stomach 333 (82.4)
Small intestinea 46 (11.4)
Gastro-esophageal junction 14 (3.5)
Large intestineb 6 (1.5)
Esophagus 2 (0.5)
Othersc 3 (0.7)
Total 404 (100)

aIleum (12 cases); jejunum and duodenum (2 cases each).

bColon (5 cases); cecum (1 case).

cPalatine tonsil, ileo-cecal region and mesocolic lymph node (1 case each).

Table 9.
The time intervals from eating raw flesh of fish to onset of symptoms
Table 9.
Time (hr) No. (%) of cases
≤6 109 (32.4)
7-12 112 (33.3)
13-24 51 (15.2)
25-72 36 (10.7)
≥ 73 (chronic) 28 (8.3)
Total 336 (100)
Table 10.
The frequency of patients by season
Table 10.
Season No. (%) of cases
Spring 71 (23.1)
Summer 56 (18.2)
Autumn 61 (19.9)
Winter 119 (38.8)
Total 307 (100)
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Anisakiasis: Report of 15 Gastric Cases Caused by Anisakis Type I Larvae and a Brief Review of Korean Anisakiasis Cases
Korean J Parasitol. 2015;53(4):465-470.   Published online August 25, 2015
DOI: https://doi.org/10.3347/kjp.2015.53.4.465
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Anisakiasis: Report of 15 Gastric Cases Caused by Anisakis Type I Larvae and a Brief Review of Korean Anisakiasis Cases
Korean J Parasitol. 2015;53(4):465-470.   Published online August 25, 2015
DOI: https://doi.org/10.3347/kjp.2015.53.4.465
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Anisakiasis: Report of 15 Gastric Cases Caused by Anisakis Type I Larvae and a Brief Review of Korean Anisakiasis Cases
Anisakiasis: Report of 15 Gastric Cases Caused by Anisakis Type I Larvae and a Brief Review of Korean Anisakiasis Cases
Case no. Age Sex Date of occurrence Fish eaten Chief complaints Time from eating fish to symptom onset Time from symptom onset to endoscopy Detection site of worm in stomach
1. 33 M Oct., ’99 Common conger Severe epigastric pain 12 hr 2 days Middle body G.Ca
2. 47 M Feb., ’00 Several kinds of marine fishes Epigastric pain, nausea & vomiting 12 hr 3 days Upper body Anterior wall
3. 37 M Jun., ’00 Common conger Hemoptysis 10 hr 1 day Lower body G.Ca
4. 27 M Jun., ’00 Several kinds of marine fishes Epigastric pain 12 hr 36 hr Upper body G.Ca
5. 41 M Aug., ’00 Several kinds of marine fishes Epigastric pain & nausea 24 hr 3 days Upper body G.Ca
6. 28 M Oct., ’00 Common conger Epigastric pain 6 hr 12 hr Middle body G.Ca
7. 55 M Jun., ’01 Several kinds of marine fishes Severe epigastric pain 12 hr 2 days Lower body G.Ca
8. 59 M Jan., ’02 Common conger Epigastric pain 12 hr 12 hr Middle body G.Ca
9. 45 F Sep., ’02 Common conger & Pacific cutlass fish Epigastric pain & hematemesis 6 hr 3 days Uncertainb
10. 36 F Oct., ’02 Several kinds of marine fishes Severe epigastric pain 12 hr 2 days Lower body G.Ca
11. 42 M Apr., ’03 Anchovy Epigastric pain, nausea & vomiting 10 hr 1 day Upper body Anterior wall
12. 51 M May., ’04 Common conger Severe epigastric pain 12 hr 1 day Uncertainb
13. 61 M Mar., ’09 Anchovy Epigastric pain, nausea & vomiting 10 hr 1 day Upper body lesser curvature
14. 52 M Dec., ’09 Uncertain Epigastric pain & nausea 7 hr 1 day Lower body G.Ca
15. 46 F Jan., ’10 Common conger Severe epigastric pain 12 hr 2 days Uncertain
Items 3rd stage (n = 7) 4th stage (n = 7) Chai et al. (1986) [7]b
Body length 16.55-29.0 (23.98) 17.10-22.75 (20.68) 13.4-25.0 (20.7)
Body width 0.35-0.58 (0.48) 0.45-0.58 (0.50) 0.23-0.54 (0.41)
Esophagus (total) 2.0-3.0 (2.46) 2.35-3.38 (2.88) 1.86-2.70 (2.36)
 Muscular part 1.55-2.08 (1.85) 1.75-2.50 (2.18) 1.27-1.89 (1.65)
 Ventricular part 0.45-0.92 (0.62) 0.55-0.88 (0.71) 0.57-0.83 (0.71)
Tail 0.08-0.12 (0.10) 0.10-0.15 (0.13) 0.07-0.12 (0.10)
Mucron 20-25 (21) μm - -
Indicesc
 α 37.59-58.0 (49.96) 34.20-50.0 (41.36) 43.7-66.3 (50.6)
 β1 7.20-10.04 (9.75) 6.63-8.24 (7.18) 7.02-9.92 (8.73)
 β2 10.08-13.94 (12.96) 8.95-10.56 (9.49) 10.01-14.70 (12.5)
 β3 24.34-40.34 (38.68) 23.58-37.50 (29.13) 25.5-39.4 (29.2)
 γ 157.9-290.0 (239.8) 145.57-186.5 (159.08) 167.6-271.3 (213.4)
Duration of report No. of cases (%) reported No. of papers (%) published
1971 1 (0.2) 1 (1.6)
1980-1989 77 (11.9) 18 (28.1)
1990-1999 249 (38.6) 25 (39.1)
2000-2009 163 (25.3) 10 (15.6)
2010 and later 155 (24.0) 10 (15.6)
Total 645 (100) 64 (100)
Locality No. of cases (%)
Jeju-do 217 (34.4)
Gyeongsangnam-do (Jinju-si) 144 (22.8)
Seoul 126 (20.0)
Busan 64 (10.1)
Incheon 41 (6.5)
Gyeongsangbuk-do (Pohang-si) 20 (3.2)
Daegu 5 (0.8)
Gwangju 4 (0.6)
Daejeon 2 (0.3)
Jeollabuk-do 2 (0.3)
Gangwon-do 2 (0.3)
Othersa 4 (0.6)
Total 631 (100)
Age (years) No. of cases (%)
Male Female Total
Below 19 1 6 7 (1.7)
20-29 19 20 39 (9.7)
30-39 62 71 133 (32.9)
40-49 68 72 140 (34.7)
50-59 22 38 60 (14.9)
Over 60 13 12 25 (6.2)
Total 185 (45.8) 219 (54.2) 404 (100)
Fishes (scientific name) No. of cases (%)
Common conger (Conger myriaster) 120 (38.6)
Croaker (Pseudosciaena spp.) 36 (11.6)
Squid 32 (10.3)
Yellowtail (Seriola spp.) 30 (9.7)
Flatfish 17 (5.5)
Pacific cod (Gadus macrocephalus) 6 (1.9)
Anchovy (Engraulis japonica) 4 (1.3)
Rockfish (Sebastes spp.) 4 (1.3)
Sea breams 3 (1.0)
Pacific cutlass fish (Trichiurus lepturus) 3 (1.0)
Gizzard shad (Konosirus punctatus) 2 (0.6)
Skates 2 (0.6)
Othersa 5 (1.6)
Several species of fish mixed 47 (15.1)
Total 311 (100)
Type of larvae No. (%) of larvae identified
Anisakis type I 165 (81.3)a
Anisakis type II 8 (3.9)
Terranova type A 24 (11.8)
Anisakis sp. 3 (1.5)
Contracaecum sp. 3 (1.5)
Total 203 (100)
Location No. (%) of cases
Stomach 333 (82.4)
Small intestinea 46 (11.4)
Gastro-esophageal junction 14 (3.5)
Large intestineb 6 (1.5)
Esophagus 2 (0.5)
Othersc 3 (0.7)
Total 404 (100)
Time (hr) No. (%) of cases
≤6 109 (32.4)
7-12 112 (33.3)
13-24 51 (15.2)
25-72 36 (10.7)
≥ 73 (chronic) 28 (8.3)
Total 336 (100)
Season No. (%) of cases
Spring 71 (23.1)
Summer 56 (18.2)
Autumn 61 (19.9)
Winter 119 (38.8)
Total 307 (100)
Table 1. Summary of the 15 cases of gastric anisakiasis caused by Anisakis type I larvae

Greater curvature.

Nine larvae were detected in each case.

Table 2. Measurementsa and indices of Anisakis type I larvae from human cases

Unit is mm.

from the yellow corvine, Pseudosciaena polyactis.

Legend: α=Body length/Body width; β1=Body length/Esophagus; β2=Body length/Muscular part of esophagus; β3=Body length/Ventriculus; γ=Body length/Tail.

Table 3. Number of anisakiasis cases and number of papers reported among the Korean literature
Table 4. Anisakiasis cases by the occurrence localities

Gyeonggi-do (Uijeongbu-si); Chungcheongbuk-do (Chungju-si), Chungcheongnam-do (Cheonan-si) and Jeollanam-do (Suncheon-si) each 1 case.

Table 5. Age and sex distribution of patients
Table 6. Fishes or cephalopods, the probable source of infection, consumed by anisakiasis cases

Halichoeres tenuispinis (motleystripe rainbowfish), Miichthys miiuy (brown croaker), mullet, tuna and Octopus vulgaris (common octopus) each 1 case.

Table 7. Morphologic identification of anisakid larvae among the literature

15 cases of A. pegreffii were included.

Table 8. Location of worms detected

Ileum (12 cases); jejunum and duodenum (2 cases each).

Colon (5 cases); cecum (1 case).

Palatine tonsil, ileo-cecal region and mesocolic lymph node (1 case each).

Table 9. The time intervals from eating raw flesh of fish to onset of symptoms
Table 10. The frequency of patients by season

Table 1.

Table 2.

Table 3.

Table 4.

Table 5.

Table 6.

Table 7.

Table 8.

Table 9.

Table 10.

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