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Case Report

Asymptomatic Human Paragonimiasis among the Karen People in Tak Province, Thailand: A Case Report

Teera Kusolsuk1,*, Orawan Phuphisut1, Wanna Maipanich1, Somchit Pubampen1, Surapol Sa-nguankiat1, Akkarin Poodeepiyasawat1, Nirundorn Homsuwan1, Srisuchart Mongkolmoo2, Tippayarat Yoonuan1, Poom Adisakwattana1, Udomsak Silachamroon3, Yukifumi Nawa4
The Korean Journal of Parasitology 2020;58(1):57-60.
Published online: February 29, 2020

1Department of Helminthology, Faculty of Tropical Medicine, Mahidol University, Thailand

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*Corresponding author (teera.kus@mahidol.ac.th)
• Received: February 23, 2019   • Revised: August 29, 2019   • Accepted: September 16, 2019

Copyright © 2020 by The Korean Society for Parasitology and Tropical Medicine

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  • During the mobile clinic activities in Tak Province, Thailand, Paragonimus sp. eggs were found in a fecal sample of a 72-year-old Karen resident. Paragonimus DNA was amplified from the stool sample and identified to P. heterotremus. The patient did not have any symptoms. Apparent pulmonary lesion was not found on the chest X-ray. The patient admitted habitual consumption of semi-cooked or roasted waterfall crabs for several years. The waterfall crabs collected from stream near the village were found negative for Paragonimus metacercariae. In northern Thailand, paragonimiasis remains as one of the public health concerns and should be ruled out for asymptomatic pulmonary patients.
  • Key words: Paragonimus heterotremus, paragonimiasis, asymptomatic
Paragonimiasis is a disease caused by adult lung flukes (trematodes) of Paragonimus spp. that form nodular or cavitating lesions in the lungs or other viscera of host mammals. The infection in humans occurs via the consumption of fresh or brackish-water crustaceans or raw meat of paratenic host mammals contaminated with live metacercariae [1]. Among approximately 50 nominal species in the genus Paragonimus, only 2 species, P. heterotremus and P. westermani, have been identified as the human pathogens in Southeast Asia [2].
In Thailand, the first case of human paragonimiasis has been reported from Phetchabun Province [3]. Thereafter, certain endemic areas have been identified in the Saraburi [4] and Nakhon Nayok Provinces [5]. Moreover, sporadic cases have been reported in several places in Thailand, with relatively high incidence in the mountain regions of central, northern, and northeastern Thailand [6]. In northern Thailand, human paragonimiasis cases have been reported from Chiang Mai [7], Chiang Rai [8], Mae Hong Son [9], Phitsanulok [10,11], Lamphun [12], Kanchanaburi [13], and Nan [14] Provinces.
Tak Province is located in northern Thailand, and cases of paragonimiasis have occurred in several neighboring provinces, as listed as above. However, paragonimiasis cases have never been reported in Tak Province. During our mobile clinic services conducted in Tak Province, coproparasitological examination revealed the presence of Paragonimus sp. eggs in 1 of 343 stool specimens; this specimen was from a 72-year-old Karen female participant. To the best of our knowledge, this is the first case of human paragonimiasis recorded in Tak Province, and we describe the case details here.
Parasitological findings
Between December 2013 and February 2014, the Hospital for Tropical Diseases, Mahidol University, provided mobile medical services for villagers in Ban Maelah, Tha Song Yang District, Tak Province, northern Thailand, locating on the Thai–Myanmar border. The villagers comprised Thai and Karen individuals, and most of them were farmers working in the fields and forests. On each occasion, participants were from completely different communities.
We collected 343 fecal samples from villagers for coproparasitological examination using Kato’s thick smear and simple thin smear techniques. The results are given in Supplementary Table S1. In brief, a half of the participants had parasitic infections. Hookworm infection was the most common helminthiasis, followed by ascariasis, trichuriasis, and minute intestinal fluke infections. Other helminthiases were rather rare. Protozoan parasites were less frequently detected than helminths, and they were mostly nonpathogenic species. Three pathogenic protozoans, Entamoeba spp, Giardia, and Blastocystis were detected at low incidence with low intensity. During this coproparasitological examination, Paragonimus sp. eggs with golden brown color, symmetric oval-shape and operculated one end (Fig. 1) were found unexpectedly in a fecal sample of an apparently healthy participant. The average size and ranges of 3 eggs were 86.7 (75.0–95.0) μm in length and 53.3 (50.0–57.5) μm in width.
Eggs of Paragonimus spp. were found with golden brown color, symmetric oval-shape and operculated one end (Fig. 1) in a fecal sample from a 72-year-old Karen female participant with no history of this infection. This patient did not exhibit any symptoms of pulmonary infection and appeared healthy. The patient denied suffering from any diseases but reported a smoking habit of hand-made cigarettes. Few years ago, the patient had developed chronic cough with sputum (not bloody) in the morning. The patient was screened for tuberculosis but was confirmed to be negative. Because minimal cough persisted, the patient had received medication and had reduced the amount of cigarette smoking, and, accordingly, her symptoms were improved. Thereafter, the chronic cough of the patient disappeared. The patient reported the habitual consumption of semi-cooked roasted waterfall crabs, in a local dish called “poo ping”, during her employment in the fields several years ago. The results of her physical examination and chest X-ray were normal, and her complete blood examination results were within the normal range.
To detect metacercariae in the intermediate crab hosts in the study area, we collected waterfall crabs, Larnaudia larnaudii, from the rocky canal with a help of local villagers. At the rocky canal, rocks were turned over and crabs were caught by hand and put into a container and carried back to the local Health Promoting Hospital for examination. The carapaces of crabs were removed, and the gills, heart, viscera, and muscles were examined separately by compression between 2 large glass plates under a stereomicroscope [15], However, Paragonimus spp. metacercariae were not found in the crabs examined in this study.
Laboratory findings
The examination of the patient’s sputum was negative for Paragonimus spp. eggs. Chest X-ray was performed, but no obvious imaging abnormalities were recognized in the patient’s chest X-ray images. Copro-DNA was extracted from the patient’s fecal sample. Polymerase chain reaction (PCR) primers were designed from cox-1 sequence of P. heterotremus, in the National Center for Biotechnology Information (NCBI) database accession no. NC039430. The PCR primers used were COX1-F (5′-ACATATCTGCATGACCTTGACTAAT-3′) and COX1-R (5′-CCAAGAAAAAACCTTAATCCCTGTG-3′). The PCR amplicon was approximately 200-bp long. The PCR reaction mixture (final volume 50 μl) contained 1×TopTaqTM Master Mix (Qiagen, Hilden, Germany), 20 ρmol of each primer, and 1 μl of the copro-DNA template at a concentration of 100 ng/μl. The PCR master mix kit was adjusted to the final volume by adding sterile ddH2O. PCR was performed on a C1000TM Thermal Cycler (Bio-Rad, Hercules, California, USA) as follows: initial denaturation at 95°C for 3 min; followed by 34 cycles of 95°C for 30 sec, 53°C for 30 sec, and 72°C for 1 min; and a final step of 72°C for 5 min. A single amplicon of the size expected for Paragonimus heterotremus (≈200 bp) was observed (Fig. 2). The PCR product was purified and submitted to AITbiotech Pte Ltd., Singapore, for sequencing. After blast search against NCBI database, the cox1 sequence of Paragonimus eggs from the feces was completely (100%) identical to the DNA sequence of P. heterotremus species. The result of DNA sequencing was deposited in the NCBI database accession no. MH536114.
A standard treatment regimen of praziquantel at 40 mg/kg, single dose, was administered to the patient infected with P. heterotremus. The participants who were infected with other helminths were treated with albendazole (200 mg; 2 tablets) for ascariasis and hookworm; mebendazole (100 mg) twice daily for 3 days for trichuriasis; albendazole (200 mg; 2 tablets and dose repeated within 2 weeks) for enterobiasis; albendazole (200 mg; 2 tablets twice daily for 5 days) for strongyloidiasis; niclosamide (500 mg; 4 tablets) for taeniasis. Pathogenic protozoan infections were treated with metronidazole (200 mg). The health education program was conducted during our mobile clinic service to the villagers in the community at the Chula-Thammasat school using posters and demonstration of preserved specimens of helminths, such as soil-transmitted helminths, Taenia spp., Paragonimus spp. etc. The school children and the Karen community people were educated regarding infection prevention. Because paragonimiasis was identified in the region, the information was reported to the medical staffs in the community hospital. In addition, discussions with the medical staffs were held for the promotion of further awareness of this parasite in this region.
The Northern Thailand has been known as an endemic area of paragonimiasis [5]. However, cases of human paragonimiasis have never been reported nor has the survey for intermediate hosts ever been conducted in Tak Province. To the best of our knowledge, this is the first case of human paragonimiasis in Tak Province. The patient diagnosed in this study was a Karen ethnicity. In 1991, Ekarohit et al. [9] reported that paragonimiasis patients in Mae Hong Son Province were mostly Thai–Karen villagers who habitually consume raw freshwater crabs and prawns. Although typical clinical symptoms of paragonimiasis are chronic cough and bloody sputum similar to those of human pulmonary tuberculosis, the present patient exhibited no evident symptoms. Approximately 20% of paragonimiasis patients are reported to be asymptomatic [16]. In the present study, despite detection of Paragonimus sp. eggs in the patient’s fecal sample, abnormal lesions were not detected in the chest X-ray images of the patient. Such inconsistency between fecal egg detection and chest X-ray findings has been reported repeatedly [17]. Although computed tomography imaging can improve diagnostic sensitivity [18], its accessibility is problematic for individuals in remote areas and those living in poor economic conditions. Because immunoserological diagnosis has high sensitivity and specificity [19], the use of simple immunodiagnostic methods such as dot blot ELISA [20] or immunochromatography test kits [21] is recommended in the endemic regions. In the present case, unfortunately our mobile clinic did not carry such an immunodiagnostic kit for paragonimiasis. Nor were we allowed to bring back serum samples to our own laboratory. We know that there is a chance to find undigested eggs in the patient’s stool which was accidentally ingested from unidentified environmental sources contaminated with Paragonimus sp. eggs. However, this possibility is rather unlikely because if the environment of our study area was contaminated with Paragonimus eggs, at least some more fecal egg positive cases should be found among over 300 fecal samples of the residents living together with the similar lifestyle in the small place. Paragonimiasis remains a prevalent health problem in certain rural areas in northern Thailand. In cases of asymptomatic patients, a detailed interview regarding dietary habits is vital. Additionally, any indication of a history of chronic cough enables the diagnosis of the suspected cases of infection. In certain cases like a present patient, who had experienced chronic cough a long time ago, had a smoking habit, and was screened negative for tuberculosis, achieving a definitive diagnosis is challenging. We reiterate that the specific clue for this case is the history of consuming raw or semi-cooked waterfall crabs. Egg detection in stool and sputum provides a definite diagnosis, but the sensitivity is rather poor. Immunodiagnosis for paragonimiasis can be performed by several laboratories in Thailand, and this test will aid in obtaining strong suggestive evidence of this disease. A dietary history is critically important to make a decision for further specific investigations to reach definite diagnosis.
Supplementary Table S1
Intestinal parasitic infections by microscopic stool examination in the villagers in Tak Province
Supplementary Table S1
Parasites detected No. of positive (n=343)
Helminthic infections
 Hookworm 46 (13.4%)
 Ascaris lumbricoides 39 (11.4%)
 Trichuris trichiura 26 (7.6%)
 Minute intestinal flukes 23 (6.7%)
 Taenia spp. 6 (1.8%)
 Strongyloides stercoralis 4 (1.1%)
 Enterobius vermicularis 2 (0.6%)
 Paragonimus spp. 1 (0.3%)
Protozoa infections
 Endolimax nana 42 (12.2%)
 Entamoeba coli 41 (12.0%)
 Blastocystis hominis 23 (6.7%)
 Entamoeba histolytica/dispar 20 (5.8%)
 Giardia intestinalis 15 (4.4%)
 Sarcocystis spp. 2 (0.6%)
 Iodamoeba buetschlii 1 (0.3%)

The authors declare that, we have no conflict of interest related to this work.

We would like to thank the Hospital for Tropical Diseases, Faculty of Tropical Medicine, Mahidol University for financial support during mobile medical care services in the rural areas. The extend our most heartfelt thanks to the health officers and villagers in Ban Mae Lah, the Director of Tha Song Yang District Hospital, Tha Song Yang District, Tak Province, Thailand for their kind support during field work. Our gratitude also goes to Mr. Paul R Adams and Glad Rotaru, Office of Research Services, Faculty of Tropical Medicine, Mahidol University, for English editing.
Fig. 1
A Paragonimus spp. egg found in fecal sample of a patient in Ban Mae Lah, Tak province.
kjp-58-1-57f1.jpg
Fig. 2
A PCR product (arrow) amplified on copro-DNA of the patient.
Lane M=Molecular marker. Lane Copro=Amplicon of Paragonimus eggs in a fecal sample.
kjp-58-1-57f2.jpg
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Asymptomatic Human Paragonimiasis among the Karen People in Tak Province, Thailand: A Case Report
Korean J Parasitol. 2020;58(1):57-60.   Published online February 29, 2020
DOI: https://doi.org/10.3347/kjp.2020.58.1.57
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Asymptomatic Human Paragonimiasis among the Karen People in Tak Province, Thailand: A Case Report
Korean J Parasitol. 2020;58(1):57-60.   Published online February 29, 2020
DOI: https://doi.org/10.3347/kjp.2020.58.1.57
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Asymptomatic Human Paragonimiasis among the Karen People in Tak Province, Thailand: A Case Report
Image Image
Fig. 1 A Paragonimus spp. egg found in fecal sample of a patient in Ban Mae Lah, Tak province.
Fig. 2 A PCR product (arrow) amplified on copro-DNA of the patient. Lane M=Molecular marker. Lane Copro=Amplicon of Paragonimus eggs in a fecal sample.

Fig. 1

Fig. 2

Asymptomatic Human Paragonimiasis among the Karen People in Tak Province, Thailand: A Case Report

Intestinal parasitic infections by microscopic stool examination in the villagers in Tak Province

Parasites detected No. of positive (n=343)
Helminthic infections
 Hookworm 46 (13.4%)
 Ascaris lumbricoides 39 (11.4%)
 Trichuris trichiura 26 (7.6%)
 Minute intestinal flukes 23 (6.7%)
 Taenia spp. 6 (1.8%)
 Strongyloides stercoralis 4 (1.1%)
 Enterobius vermicularis 2 (0.6%)
 Paragonimus spp. 1 (0.3%)
Protozoa infections
 Endolimax nana 42 (12.2%)
 Entamoeba coli 41 (12.0%)
 Blastocystis hominis 23 (6.7%)
 Entamoeba histolytica/dispar 20 (5.8%)
 Giardia intestinalis 15 (4.4%)
 Sarcocystis spp. 2 (0.6%)
 Iodamoeba buetschlii 1 (0.3%)
Supplementary Table S1 Intestinal parasitic infections by microscopic stool examination in the villagers in Tak Province

Supplementary Table S1

PHD : Parasites, Hosts and Diseases

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